Neuropsychiatric disorder de novo mutations database

Many studies suggest that de novo mutation plays a prominent role in neuropsychiatric diseases. We constructed NPdenovo, a database which integrates de novo mutation of autism spectrum disorders (ASD), intellectual disability (ID), epileptic encephalopathy (EE), schizophrenia (SCZ) and unaffected siblings (Control) detected by whole-genome or whole-exome sequencing. NPdenovo supports different ways to browse and search de novo mutation, neuropsychiatric diseases associated gene, enrichment of function and spatio-temporal expression in human brain. In addition, NPdenovo provides many functional and useful tools to analyze neuropsychiatric and spatio-temporal transcriptome, including BLAT, overlap gene in diseases, custom extreme mutation and co-expression.

NPdenovo quick search

  Quick search support: Gene_symbol: SCN2A    Gene_ID: 6326
  Cytoband: 12q13.13  Gene_locus: chr2:166210819-1662108190

You also can specify your options by Advanced search

NPdenovo will be updated quarterly to provide the research community an up-to-date resource. We welcome your comments and suggestions on NPdenovo through contact information to improve the functionality and accuracy of NPdenovo. We also encourage communities to submit your de novo mutation to the NPdenovo. For more detail and help, please see the documents.

Cite us:
Li J, Cai T, Jiang Y, Chen H, He X, Chen C et al. Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database. Molecular psychiatry 2016; 21(2): 290-297.