Including 120 go accession in ASD, 120 in ID, 120 in EE and 96 in SCZ. |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0007399 | nervous system development | 1724 | 70 | 34.17 | 2.05 | 2.49e-09 | 4.62e-06 | EE ID SCZ | |
GO:0048858 | cell projection morphogenesis | 679 | 34 | 13.46 | 2.53 | 6.36e-07 | 0.0004 | - | |
GO:0048812 | neuron projection morphogenesis | 583 | 30 | 11.56 | 2.60 | 1.75e-06 | 0.0004 | - | |
GO:0016043 | cellular component organization | 4105 | 119 | 81.37 | 1.46 | 1.10e-06 | 0.0004 | ID SCZ | |
GO:0032989 | cellular component morphogenesis | 1000 | 42 | 19.82 | 2.12 | 2.94e-06 | 0.0004 | - | |
GO:0071840 | cellular component organization or biogenesis | 4222 | 120 | 83.69 | 1.43 | 2.79e-06 | 0.0004 | ID SCZ | |
GO:0000902 | cell morphogenesis | 945 | 41 | 18.73 | 2.19 | 1.74e-06 | 0.0004 | ID SCZ | |
GO:0035637 | multicellular organismal signaling | 751 | 35 | 14.89 | 2.35 | 2.24e-06 | 0.0004 | EE ID SCZ | |
GO:0007611 | learning or memory | 155 | 14 | 3.07 | 4.56 | 2.51e-06 | 0.0004 | ID | |
GO:0048667 | cell morphogenesis involved in neuron differentiation | 575 | 29 | 11.40 | 2.54 | 3.91e-06 | 0.0004 | ID | |
GO:0007409 | axonogenesis | 526 | 28 | 10.43 | 2.69 | 2.06e-06 | 0.0004 | - | |
GO:0000904 | cell morphogenesis involved in differentiation | 704 | 33 | 13.95 | 2.36 | 3.95e-06 | 0.0004 | ID SCZ | |
GO:0071842 | cellular component organization at cellular level | 3317 | 100 | 65.75 | 1.52 | 2.48e-06 | 0.0004 | ID SCZ | |
GO:0044708 | single-organism behavior | 334 | 21 | 6.62 | 3.17 | 3.29e-06 | 0.0004 | EE | |
GO:0032990 | cell part morphogenesis | 691 | 34 | 13.70 | 2.48 | 9.47e-07 | 0.0004 | - | |
GO:0030030 | cell projection organization | 934 | 41 | 18.51 | 2.21 | 1.30e-06 | 0.0004 | SCZ | |
GO:0050890 | cognition | 169 | 15 | 3.35 | 4.48 | 1.37e-06 | 0.0004 | ID | |
GO:0071841 | cellular component organization or biogenesis at cellular level | 3420 | 101 | 67.79 | 1.49 | 5.59e-06 | 0.0006 | ID SCZ | |
GO:0019226 | transmission of nerve impulse | 735 | 33 | 14.57 | 2.27 | 9.76e-06 | 0.0010 | EE ID SCZ | |
GO:0044707 | single-multicellular organism process | 5612 | 147 | 111.24 | 1.32 | 1.10e-05 | 0.0010 | SCZ | |
GO:0003001 | generation of a signal involved in cell-cell signaling | 344 | 20 | 6.82 | 2.93 | 1.79e-05 | 0.0014 | - | |
GO:0023061 | signal release | 344 | 20 | 6.82 | 2.93 | 1.79e-05 | 0.0014 | - | |
GO:0048699 | generation of neurons | 1073 | 42 | 21.27 | 1.97 | 1.66e-05 | 0.0014 | ID SCZ | |
GO:0032501 | multicellular organismal process | 5644 | 147 | 111.88 | 1.31 | 1.56e-05 | 0.0014 | SCZ | |
GO:0051899 | membrane depolarization | 78 | 9 | 1.55 | 5.82 | 2.30e-05 | 0.0017 | EE | |
GO:0031175 | neuron projection development | 704 | 31 | 13.95 | 2.22 | 2.69e-05 | 0.0019 | ID SCZ | |
GO:0022008 | neurogenesis | 1140 | 43 | 22.60 | 1.90 | 3.17e-05 | 0.0022 | ID SCZ | |
GO:0007411 | axon guidance | 359 | 20 | 7.12 | 2.81 | 3.30e-05 | 0.0022 | - | |
GO:0042391 | regulation of membrane potential | 248 | 16 | 4.92 | 3.25 | 3.62e-05 | 0.0023 | EE | |
GO:0009653 | anatomical structure morphogenesis | 2055 | 66 | 40.73 | 1.62 | 3.65e-05 | 0.0023 | - | |
GO:0007275 | multicellular organismal development | 4077 | 112 | 80.82 | 1.39 | 4.05e-05 | 0.0023 | ID SCZ | |
GO:0007268 | synaptic transmission | 651 | 29 | 12.90 | 2.25 | 4.02e-05 | 0.0023 | EE ID | |
GO:0016568 | chromatin modification | 428 | 22 | 8.48 | 2.59 | 4.53e-05 | 0.0025 | - | |
GO:0048666 | neuron development | 798 | 33 | 15.82 | 2.09 | 5.09e-05 | 0.0026 | ID SCZ | |
GO:0050877 | neurological system process | 1237 | 45 | 24.52 | 1.84 | 4.89e-05 | 0.0026 | EE | |
GO:0006325 | chromatin organization | 524 | 25 | 10.39 | 2.41 | 4.68e-05 | 0.0026 | SCZ | |
GO:0090276 | regulation of peptide hormone secretion | 153 | 12 | 3.03 | 3.96 | 5.38e-05 | 0.0027 | - | |
GO:0007267 | cell-cell signaling | 1099 | 41 | 21.78 | 1.88 | 6.33e-05 | 0.0029 | EE | |
GO:0002791 | regulation of peptide secretion | 155 | 12 | 3.07 | 3.91 | 6.11e-05 | 0.0029 | - | |
GO:0090087 | regulation of peptide transport | 155 | 12 | 3.07 | 3.91 | 6.11e-05 | 0.0029 | - |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0042995 | cell projection | 1230 | 49 | 22.72 | 2.16 | 2.60e-07 | 7.46e-05 | EE ID | |
GO:0044463 | cell projection part | 639 | 29 | 11.80 | 2.46 | 8.18e-06 | 0.0012 | EE ID | |
GO:0032991 | macromolecular complex | 3864 | 104 | 71.38 | 1.46 | 1.40e-05 | 0.0013 | ID | |
GO:0030424 | axon | 286 | 17 | 5.28 | 3.22 | 2.48e-05 | 0.0015 | EE ID | |
GO:0043005 | neuron projection | 651 | 28 | 12.03 | 2.33 | 3.10e-05 | 0.0015 | EE ID | |
GO:0044459 | plasma membrane part | 1918 | 60 | 35.43 | 1.69 | 2.86e-05 | 0.0015 | EE | |
GO:0005578 | proteinaceous extracellular matrix | 360 | 19 | 6.65 | 2.86 | 4.32e-05 | 0.0015 | - | |
GO:0030425 | dendrite | 355 | 19 | 6.56 | 2.90 | 3.57e-05 | 0.0015 | EE ID | |
GO:0031012 | extracellular matrix | 426 | 21 | 7.87 | 2.67 | 4.65e-05 | 0.0015 | - | |
GO:0030315 | T-tubule | 26 | 5 | 0.48 | 10.41 | 9.96e-05 | 0.0026 | - | |
GO:0034702 | ion channel complex | 203 | 13 | 3.75 | 3.47 | 0.0001 | 0.0026 | EE | |
GO:0034703 | cation channel complex | 132 | 10 | 2.44 | 4.10 | 0.0002 | 0.0038 | EE | |
GO:0043234 | protein complex | 3278 | 87 | 60.55 | 1.44 | 0.0002 | 0.0038 | EE ID | |
GO:0031674 | I band | 84 | 8 | 1.55 | 5.16 | 0.0002 | 0.0038 | EE | |
GO:0097060 | synaptic membrane | 215 | 13 | 3.97 | 3.27 | 0.0002 | 0.0038 | EE | |
GO:0005911 | cell-cell junction | 288 | 15 | 5.32 | 2.82 | 0.0003 | 0.0054 | - | |
GO:0044449 | contractile fiber part | 145 | 10 | 2.68 | 3.73 | 0.0004 | 0.0064 | EE | |
GO:0030018 | Z disc | 72 | 7 | 1.33 | 5.26 | 0.0004 | 0.0064 | EE ID | |
GO:0044456 | synapse part | 370 | 17 | 6.83 | 2.49 | 0.0005 | 0.0072 | EE | |
GO:0030016 | myofibril | 152 | 10 | 2.81 | 3.56 | 0.0005 | 0.0072 | EE | |
GO:0030054 | cell junction | 737 | 27 | 13.61 | 1.98 | 0.0006 | 0.0082 | ID | |
GO:0044420 | extracellular matrix part | 185 | 11 | 3.42 | 3.22 | 0.0007 | 0.0091 | - | |
GO:0045202 | synapse | 489 | 20 | 9.03 | 2.21 | 0.0008 | 0.0100 | ID | |
GO:0043292 | contractile fiber | 162 | 10 | 2.99 | 3.34 | 0.0009 | 0.0106 | EE | |
GO:0043232 | intracellular non-membrane-bounded organelle | 3800 | 94 | 70.19 | 1.34 | 0.0010 | 0.0106 | ID | |
GO:0071062 | alphav-beta3 integrin-vitronectin complex | 3 | 2 | 0.06 | 36.09 | 0.0010 | 0.0106 | - | |
GO:0043228 | non-membrane-bounded organelle | 3800 | 94 | 70.19 | 1.34 | 0.0010 | 0.0106 | ID | |
GO:0005604 | basement membrane | 89 | 7 | 1.64 | 4.26 | 0.0013 | 0.0133 | - | |
GO:0005886 | plasma membrane | 4289 | 103 | 79.23 | 1.30 | 0.0015 | 0.0148 | EE | |
GO:0033268 | node of Ranvier | 14 | 3 | 0.26 | 11.60 | 0.0020 | 0.0191 | EE ID | |
GO:0030017 | sarcomere | 128 | 8 | 2.36 | 3.38 | 0.0026 | 0.0241 | EE | |
GO:0044428 | nuclear part | 3071 | 76 | 56.73 | 1.34 | 0.0036 | 0.0246 | ID | |
GO:0031226 | intrinsic to plasma membrane | 1264 | 37 | 23.35 | 1.58 | 0.0036 | 0.0246 | EE | |
GO:0042734 | presynaptic membrane | 55 | 5 | 1.02 | 4.92 | 0.0034 | 0.0246 | - | |
GO:0005887 | integral to plasma membrane | 1220 | 36 | 22.54 | 1.60 | 0.0036 | 0.0246 | EE | |
GO:0071944 | cell periphery | 4377 | 103 | 80.85 | 1.27 | 0.0029 | 0.0246 | EE | |
GO:0031252 | cell leading edge | 257 | 12 | 4.75 | 2.53 | 0.0031 | 0.0246 | - | |
GO:0000788 | nuclear nucleosome | 5 | 2 | 0.09 | 21.65 | 0.0033 | 0.0246 | - | |
GO:0033267 | axon part | 133 | 8 | 2.46 | 3.26 | 0.0033 | 0.0246 | EE ID | |
GO:0014704 | intercalated disc | 33 | 4 | 0.61 | 6.56 | 0.0031 | 0.0246 | ID |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0005261 | cation channel activity | 273 | 19 | 5.43 | 3.50 | 2.38e-06 | 0.0004 | EE ID | |
GO:0046873 | metal ion transmembrane transporter activity | 373 | 23 | 7.42 | 3.10 | 1.67e-06 | 0.0004 | EE ID | |
GO:0022843 | voltage-gated cation channel activity | 133 | 12 | 2.65 | 4.54 | 1.38e-05 | 0.0007 | EE ID | |
GO:0022803 | passive transmembrane transporter activity | 420 | 22 | 8.35 | 2.63 | 3.64e-05 | 0.0007 | EE ID | |
GO:0032550 | purine ribonucleoside binding | 1838 | 61 | 36.56 | 1.67 | 3.53e-05 | 0.0007 | SCZ | |
GO:0015267 | channel activity | 420 | 22 | 8.35 | 2.63 | 3.64e-05 | 0.0007 | EE ID | |
GO:0032559 | adenyl ribonucleotide binding | 1512 | 53 | 30.07 | 1.76 | 3.02e-05 | 0.0007 | SCZ | |
GO:0005262 | calcium channel activity | 97 | 10 | 1.93 | 5.18 | 2.28e-05 | 0.0007 | - | |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 802 | 34 | 15.95 | 2.13 | 2.59e-05 | 0.0007 | - | |
GO:0005216 | ion channel activity | 393 | 22 | 7.82 | 2.81 | 1.32e-05 | 0.0007 | EE ID | |
GO:0001882 | nucleoside binding | 1852 | 61 | 36.84 | 1.66 | 4.42e-05 | 0.0007 | SCZ | |
GO:0001883 | purine nucleoside binding | 1841 | 61 | 36.62 | 1.67 | 3.71e-05 | 0.0007 | SCZ | |
GO:0005524 | ATP binding | 1482 | 53 | 29.48 | 1.80 | 1.74e-05 | 0.0007 | SCZ | |
GO:0017111 | nucleoside-triphosphatase activity | 760 | 33 | 15.12 | 2.18 | 2.13e-05 | 0.0007 | - | |
GO:0030554 | adenyl nucleotide binding | 1516 | 53 | 30.15 | 1.76 | 3.24e-05 | 0.0007 | SCZ | |
GO:0022838 | substrate-specific channel activity | 402 | 22 | 8.00 | 2.75 | 1.87e-05 | 0.0007 | EE ID | |
GO:0035639 | purine ribonucleoside triphosphate binding | 1829 | 61 | 36.38 | 1.68 | 3.05e-05 | 0.0007 | EE SCZ | |
GO:0016462 | pyrophosphatase activity | 794 | 34 | 15.79 | 2.15 | 2.11e-05 | 0.0007 | - | |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 797 | 34 | 15.85 | 2.14 | 2.28e-05 | 0.0007 | - | |
GO:0032549 | ribonucleoside binding | 1842 | 61 | 36.64 | 1.66 | 3.77e-05 | 0.0007 | SCZ | |
GO:0005515 | protein binding | 7337 | 182 | 145.93 | 1.25 | 1.81e-05 | 0.0007 | ID SCZ | |
GO:0032555 | purine ribonucleotide binding | 1864 | 61 | 37.08 | 1.65 | 5.34e-05 | 0.0008 | SCZ | |
GO:0022832 | voltage-gated channel activity | 179 | 13 | 3.56 | 3.65 | 6.14e-05 | 0.0009 | EE ID | |
GO:0022890 | inorganic cation transmembrane transporter activity | 470 | 23 | 9.35 | 2.46 | 6.91e-05 | 0.0009 | EE | |
GO:0032553 | ribonucleotide binding | 1879 | 61 | 37.37 | 1.63 | 6.74e-05 | 0.0009 | SCZ | |
GO:0005244 | voltage-gated ion channel activity | 179 | 13 | 3.56 | 3.65 | 6.14e-05 | 0.0009 | EE ID | |
GO:0017076 | purine nucleotide binding | 1871 | 61 | 37.21 | 1.64 | 5.96e-05 | 0.0009 | SCZ | |
GO:0015085 | calcium ion transmembrane transporter activity | 113 | 10 | 2.25 | 4.45 | 8.52e-05 | 0.0010 | EE | |
GO:0043167 | ion binding | 5820 | 148 | 115.76 | 1.28 | 9.17e-05 | 0.0010 | SCZ | |
GO:0000166 | nucleotide binding | 2436 | 73 | 48.45 | 1.51 | 0.0001 | 0.0010 | SCZ | |
GO:0022839 | ion gated channel activity | 303 | 17 | 6.03 | 2.82 | 0.0001 | 0.0010 | EE ID | |
GO:0050839 | cell adhesion molecule binding | 56 | 7 | 1.11 | 6.28 | 0.0001 | 0.0010 | - | |
GO:0043168 | anion binding | 2402 | 73 | 47.78 | 1.53 | 9.55e-05 | 0.0010 | EE SCZ | |
GO:0022836 | gated channel activity | 303 | 17 | 6.03 | 2.82 | 0.0001 | 0.0010 | EE ID | |
GO:1901265 | nucleoside phosphate binding | 2437 | 73 | 48.47 | 1.51 | 0.0002 | 0.0019 | SCZ | |
GO:0004386 | helicase activity | 149 | 11 | 2.96 | 3.71 | 0.0002 | 0.0019 | - | |
GO:0022892 | substrate-specific transporter activity | 980 | 36 | 19.49 | 1.85 | 0.0003 | 0.0027 | EE ID | |
GO:0016887 | ATPase activity | 357 | 18 | 7.10 | 2.53 | 0.0003 | 0.0027 | - | |
GO:0036094 | small molecule binding | 2630 | 76 | 52.31 | 1.45 | 0.0003 | 0.0027 | SCZ | |
GO:0042954 | lipoprotein transporter activity | 2 | 2 | 0.04 | 50.28 | 0.0004 | 0.0034 | ID |