Including 120 go accession in ASD, 120 in ID, 120 in EE and 96 in SCZ. |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0071842 | cellular component organization at cellular level | 3317 | 51 | 22.45 | 2.27 | 3.33e-10 | 3.63e-07 | ASD SCZ | |
GO:0016043 | cellular component organization | 4105 | 57 | 27.78 | 2.05 | 6.71e-10 | 3.65e-07 | ASD SCZ | |
GO:0071841 | cellular component organization or biogenesis at cellular level | 3420 | 51 | 23.14 | 2.20 | 1.05e-09 | 3.81e-07 | ASD SCZ | |
GO:0071840 | cellular component organization or biogenesis | 4222 | 57 | 28.57 | 2.00 | 2.13e-09 | 5.80e-07 | ASD SCZ | |
GO:0006996 | organelle organization | 2113 | 38 | 14.30 | 2.66 | 3.51e-09 | 7.64e-07 | SCZ | |
GO:0007399 | nervous system development | 1724 | 30 | 11.67 | 2.57 | 6.27e-07 | 9.75e-05 | EE ASD SCZ | |
GO:0007059 | chromosome segregation | 146 | 9 | 0.99 | 9.11 | 6.19e-07 | 9.75e-05 | - | |
GO:0007062 | sister chromatid cohesion | 32 | 5 | 0.22 | 23.09 | 2.23e-06 | 0.0003 | - | |
GO:0048731 | system development | 3521 | 44 | 23.83 | 1.85 | 6.63e-06 | 0.0008 | - | |
GO:0035637 | multicellular organismal signaling | 751 | 17 | 5.08 | 3.35 | 1.05e-05 | 0.0011 | EE ASD SCZ | |
GO:0048667 | cell morphogenesis involved in neuron differentiation | 575 | 14 | 3.89 | 3.60 | 3.13e-05 | 0.0015 | ASD | |
GO:0048169 | regulation of long-term neuronal synaptic plasticity | 26 | 4 | 0.18 | 22.74 | 2.63e-05 | 0.0015 | - | |
GO:0031175 | neuron projection development | 704 | 16 | 4.76 | 3.36 | 1.88e-05 | 0.0015 | ASD SCZ | |
GO:0048699 | generation of neurons | 1073 | 20 | 7.26 | 2.75 | 2.76e-05 | 0.0015 | ASD SCZ | |
GO:0050890 | cognition | 169 | 8 | 1.14 | 7.00 | 1.88e-05 | 0.0015 | ASD | |
GO:0007612 | learning | 84 | 6 | 0.57 | 10.56 | 2.19e-05 | 0.0015 | - | |
GO:0019226 | transmission of nerve impulse | 735 | 16 | 4.97 | 3.22 | 3.18e-05 | 0.0015 | EE ASD SCZ | |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 1171 | 21 | 7.92 | 2.65 | 2.98e-05 | 0.0015 | - | |
GO:0022008 | neurogenesis | 1140 | 21 | 7.71 | 2.72 | 1.99e-05 | 0.0015 | ASD SCZ | |
GO:0048666 | neuron development | 798 | 17 | 5.40 | 3.15 | 2.30e-05 | 0.0015 | ASD SCZ | |
GO:0048856 | anatomical structure development | 4030 | 47 | 27.27 | 1.72 | 1.78e-05 | 0.0015 | - | |
GO:0007010 | cytoskeleton organization | 796 | 17 | 5.39 | 3.16 | 2.23e-05 | 0.0015 | - | |
GO:0007275 | multicellular organismal development | 4077 | 47 | 27.59 | 1.70 | 2.47e-05 | 0.0015 | ASD SCZ | |
GO:0007063 | regulation of sister chromatid cohesion | 10 | 3 | 0.07 | 44.33 | 3.48e-05 | 0.0016 | - | |
GO:0033044 | regulation of chromosome organization | 93 | 6 | 0.63 | 9.53 | 3.91e-05 | 0.0017 | SCZ | |
GO:0031134 | sister chromatid biorientation | 2 | 2 | 0.01 | 147.78 | 4.53e-05 | 0.0017 | - | |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 1198 | 21 | 8.11 | 2.59 | 4.17e-05 | 0.0017 | - | |
GO:0007064 | mitotic sister chromatid cohesion | 11 | 3 | 0.07 | 40.30 | 4.77e-05 | 0.0017 | - | |
GO:0048167 | regulation of synaptic plasticity | 96 | 6 | 0.65 | 9.24 | 4.67e-05 | 0.0017 | EE | |
GO:0032502 | developmental process | 4572 | 50 | 30.94 | 1.62 | 4.86e-05 | 0.0017 | - | |
GO:0007049 | cell cycle | 1393 | 23 | 9.43 | 2.44 | 4.26e-05 | 0.0017 | - | |
GO:0051276 | chromosome organization | 690 | 15 | 4.67 | 3.21 | 5.87e-05 | 0.0019 | - | |
GO:0000902 | cell morphogenesis | 945 | 18 | 6.39 | 2.81 | 5.63e-05 | 0.0019 | ASD SCZ | |
GO:0060079 | regulation of excitatory postsynaptic membrane potential | 36 | 4 | 0.24 | 16.42 | 9.84e-05 | 0.0021 | EE SCZ | |
GO:0030182 | neuron differentiation | 990 | 18 | 6.70 | 2.69 | 0.0001 | 0.0021 | SCZ | |
GO:0007611 | learning or memory | 155 | 7 | 1.05 | 6.67 | 8.62e-05 | 0.0021 | ASD | |
GO:0000904 | cell morphogenesis involved in differentiation | 704 | 15 | 4.76 | 3.15 | 7.36e-05 | 0.0021 | ASD SCZ | |
GO:0031644 | regulation of neurological system process | 217 | 8 | 1.47 | 5.45 | 0.0001 | 0.0021 | EE | |
GO:0007268 | synaptic transmission | 651 | 14 | 4.41 | 3.18 | 0.0001 | 0.0021 | EE ASD | |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 1179 | 20 | 7.98 | 2.51 | 0.0001 | 0.0021 | - |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0043005 | neuron projection | 651 | 18 | 3.82 | 4.72 | 3.86e-08 | 6.75e-06 | EE ASD | |
GO:0043234 | protein complex | 3278 | 42 | 19.22 | 2.18 | 1.31e-07 | 1.15e-05 | EE ASD | |
GO:0032991 | macromolecular complex | 3864 | 44 | 22.66 | 1.94 | 1.71e-06 | 9.97e-05 | ASD | |
GO:0044464 | cell part | 14643 | 99 | 85.87 | 1.15 | 4.04e-06 | 0.0001 | - | |
GO:0044304 | main axon | 42 | 5 | 0.25 | 20.30 | 4.49e-06 | 0.0001 | EE | |
GO:0005623 | cell | 14644 | 99 | 85.87 | 1.15 | 4.07e-06 | 0.0001 | - | |
GO:0044463 | cell projection part | 639 | 15 | 3.75 | 4.00 | 4.53e-06 | 0.0001 | EE ASD | |
GO:0043229 | intracellular organelle | 10636 | 82 | 62.37 | 1.31 | 1.58e-05 | 0.0002 | - | |
GO:0043226 | organelle | 10651 | 82 | 62.46 | 1.31 | 1.70e-05 | 0.0002 | - | |
GO:0042995 | cell projection | 1230 | 21 | 7.21 | 2.91 | 7.34e-06 | 0.0002 | EE ASD | |
GO:0033267 | axon part | 133 | 7 | 0.78 | 8.98 | 1.31e-05 | 0.0002 | EE ASD | |
GO:0044424 | intracellular part | 12237 | 90 | 71.76 | 1.25 | 7.77e-06 | 0.0002 | - | |
GO:0005622 | intracellular | 12564 | 91 | 73.68 | 1.24 | 1.26e-05 | 0.0002 | SCZ | |
GO:0005634 | nucleus | 5955 | 55 | 34.92 | 1.58 | 3.00e-05 | 0.0003 | - | |
GO:0008328 | ionotropic glutamate receptor complex | 29 | 4 | 0.17 | 23.52 | 2.36e-05 | 0.0003 | - | |
GO:0030054 | cell junction | 737 | 15 | 4.32 | 3.47 | 2.46e-05 | 0.0003 | ASD | |
GO:0014704 | intercalated disc | 33 | 4 | 0.19 | 20.67 | 4.00e-05 | 0.0004 | ASD | |
GO:0005654 | nucleoplasm | 1478 | 22 | 8.67 | 2.54 | 3.66e-05 | 0.0004 | - | |
GO:0030424 | axon | 286 | 9 | 1.68 | 5.37 | 4.64e-05 | 0.0004 | EE ASD | |
GO:0005916 | fascia adherens | 13 | 3 | 0.08 | 39.35 | 5.36e-05 | 0.0004 | - | |
GO:0044291 | cell-cell contact zone | 35 | 4 | 0.21 | 19.49 | 5.07e-05 | 0.0004 | - | |
GO:0033268 | node of Ranvier | 14 | 3 | 0.08 | 36.54 | 6.80e-05 | 0.0005 | EE ASD | |
GO:0043227 | membrane-bounded organelle | 9598 | 75 | 56.28 | 1.33 | 7.75e-05 | 0.0006 | - | |
GO:0043231 | intracellular membrane-bounded organelle | 9587 | 75 | 56.22 | 1.33 | 7.37e-05 | 0.0006 | - | |
GO:0016023 | cytoplasmic membrane-bounded vesicle | 862 | 15 | 5.05 | 2.97 | 0.0001 | 0.0007 | - | |
GO:0030135 | coated vesicle | 254 | 8 | 1.49 | 5.37 | 0.0001 | 0.0007 | - | |
GO:0044428 | nuclear part | 3071 | 33 | 18.01 | 1.83 | 0.0002 | 0.0012 | ASD | |
GO:0005913 | cell-cell adherens junction | 46 | 4 | 0.27 | 14.83 | 0.0002 | 0.0012 | - | |
GO:0031988 | membrane-bounded vesicle | 883 | 15 | 5.18 | 2.90 | 0.0002 | 0.0012 | - | |
GO:0030425 | dendrite | 355 | 9 | 2.08 | 4.32 | 0.0002 | 0.0012 | EE ASD | |
GO:0043232 | intracellular non-membrane-bounded organelle | 3800 | 38 | 22.28 | 1.71 | 0.0003 | 0.0014 | ASD | |
GO:0005667 | transcription factor complex | 291 | 8 | 1.71 | 4.69 | 0.0003 | 0.0014 | - | |
GO:0043228 | non-membrane-bounded organelle | 3800 | 38 | 22.28 | 1.71 | 0.0003 | 0.0014 | ASD | |
GO:0030863 | cortical cytoskeleton | 57 | 4 | 0.33 | 11.97 | 0.0003 | 0.0014 | - | |
GO:0031410 | cytoplasmic vesicle | 928 | 15 | 5.44 | 2.76 | 0.0003 | 0.0014 | - | |
GO:0031981 | nuclear lumen | 2737 | 30 | 16.05 | 1.87 | 0.0003 | 0.0014 | - | |
GO:0044451 | nucleoplasm part | 820 | 14 | 4.81 | 2.91 | 0.0003 | 0.0014 | - | |
GO:0031982 | vesicle | 970 | 15 | 5.69 | 2.64 | 0.0005 | 0.0023 | - | |
GO:0045202 | synapse | 489 | 10 | 2.87 | 3.49 | 0.0006 | 0.0027 | ASD | |
GO:0030018 | Z disc | 72 | 4 | 0.42 | 9.47 | 0.0008 | 0.0035 | EE ASD |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0005488 | binding | 11955 | 94 | 79.78 | 1.18 | 0.0001 | 0.0030 | SCZ | |
GO:0022892 | substrate-specific transporter activity | 980 | 18 | 6.54 | 2.75 | 7.71e-05 | 0.0030 | EE ASD | |
GO:0003682 | chromatin binding | 315 | 10 | 2.10 | 4.76 | 4.78e-05 | 0.0030 | - | |
GO:0042954 | lipoprotein transporter activity | 2 | 2 | 0.01 | 149.84 | 4.41e-05 | 0.0030 | ASD | |
GO:0035254 | glutamate receptor binding | 25 | 4 | 0.17 | 23.97 | 2.12e-05 | 0.0030 | - | |
GO:0035255 | ionotropic glutamate receptor binding | 15 | 3 | 0.10 | 29.97 | 0.0001 | 0.0030 | - | |
GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific) | 3 | 2 | 0.02 | 99.90 | 0.0001 | 0.0030 | - | |
GO:0004970 | ionotropic glutamate receptor activity | 18 | 3 | 0.12 | 24.97 | 0.0002 | 0.0039 | - | |
GO:0022839 | ion gated channel activity | 303 | 9 | 2.02 | 4.45 | 0.0002 | 0.0039 | EE ASD | |
GO:0022836 | gated channel activity | 303 | 9 | 2.02 | 4.45 | 0.0002 | 0.0039 | EE ASD | |
GO:0003677 | DNA binding | 2309 | 30 | 15.41 | 1.95 | 0.0002 | 0.0039 | - | |
GO:0022843 | voltage-gated cation channel activity | 133 | 6 | 0.89 | 6.76 | 0.0003 | 0.0049 | EE ASD | |
GO:0005234 | extracellular-glutamate-gated ion channel activity | 19 | 3 | 0.13 | 23.66 | 0.0003 | 0.0049 | EE | |
GO:0005261 | cation channel activity | 273 | 8 | 1.82 | 4.39 | 0.0005 | 0.0076 | EE ASD | |
GO:0032453 | histone demethylase activity (H3-K4 specific) | 6 | 2 | 0.04 | 49.95 | 0.0007 | 0.0083 | - | |
GO:0008190 | eukaryotic initiation factor 4E binding | 6 | 2 | 0.04 | 49.95 | 0.0007 | 0.0083 | - | |
GO:0008066 | glutamate receptor activity | 26 | 3 | 0.17 | 17.29 | 0.0007 | 0.0083 | - | |
GO:0004972 | N-methyl-D-aspartate selective glutamate receptor activity | 6 | 2 | 0.04 | 49.95 | 0.0007 | 0.0083 | EE | |
GO:0019899 | enzyme binding | 1086 | 17 | 7.25 | 2.35 | 0.0008 | 0.0090 | - | |
GO:0046873 | metal ion transmembrane transporter activity | 373 | 9 | 2.49 | 3.62 | 0.0009 | 0.0091 | EE ASD | |
GO:0005215 | transporter activity | 1196 | 18 | 7.98 | 2.26 | 0.0009 | 0.0091 | EE | |
GO:0001071 | nucleic acid binding transcription factor activity | 1011 | 16 | 6.75 | 2.37 | 0.0010 | 0.0093 | - | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 1009 | 16 | 6.73 | 2.38 | 0.0010 | 0.0093 | - | |
GO:0005216 | ion channel activity | 393 | 9 | 2.62 | 3.43 | 0.0012 | 0.0103 | EE ASD | |
GO:0005244 | voltage-gated ion channel activity | 179 | 6 | 1.19 | 5.02 | 0.0013 | 0.0103 | EE ASD | |
GO:0017124 | SH3 domain binding | 121 | 5 | 0.81 | 6.19 | 0.0013 | 0.0103 | - | |
GO:0022832 | voltage-gated channel activity | 179 | 6 | 1.19 | 5.02 | 0.0013 | 0.0103 | EE ASD | |
GO:0000975 | regulatory region DNA binding | 336 | 8 | 2.24 | 3.57 | 0.0018 | 0.0112 | - | |
GO:0005515 | protein binding | 7337 | 64 | 48.96 | 1.31 | 0.0019 | 0.0112 | ASD SCZ | |
GO:0015267 | channel activity | 420 | 9 | 2.80 | 3.21 | 0.0020 | 0.0112 | EE ASD | |
GO:0001067 | regulatory region nucleic acid binding | 336 | 8 | 2.24 | 3.57 | 0.0018 | 0.0112 | - | |
GO:0022803 | passive transmembrane transporter activity | 420 | 9 | 2.80 | 3.21 | 0.0020 | 0.0112 | EE ASD | |
GO:0005543 | phospholipid binding | 490 | 10 | 3.27 | 3.06 | 0.0016 | 0.0112 | - | |
GO:0022838 | substrate-specific channel activity | 402 | 9 | 2.68 | 3.35 | 0.0015 | 0.0112 | EE ASD | |
GO:0001099 | basal RNA polymerase II transcription machinery binding | 10 | 2 | 0.07 | 29.97 | 0.0019 | 0.0112 | - | |
GO:0001098 | basal transcription machinery binding | 10 | 2 | 0.07 | 29.97 | 0.0019 | 0.0112 | - | |
GO:0003774 | motor activity | 131 | 5 | 0.87 | 5.72 | 0.0018 | 0.0112 | - | |
GO:0044212 | transcription regulatory region DNA binding | 328 | 8 | 2.19 | 3.65 | 0.0016 | 0.0112 | - | |
GO:0070411 | I-SMAD binding | 11 | 2 | 0.07 | 27.24 | 0.0023 | 0.0119 | - | |
GO:0050681 | androgen receptor binding | 39 | 3 | 0.26 | 11.53 | 0.0022 | 0.0119 | - |