Including 120 go accession in ASD, 120 in ID, 120 in EE and 96 in SCZ. |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0035637 | multicellular organismal signaling | 751 | 24 | 4.88 | 4.92 | 4.78e-11 | 4.57e-08 | ID ASD SCZ | |
GO:0019226 | transmission of nerve impulse | 735 | 23 | 4.77 | 4.82 | 2.00e-10 | 9.57e-08 | ID ASD SCZ | |
GO:0007268 | synaptic transmission | 651 | 20 | 4.23 | 4.73 | 5.15e-09 | 1.64e-06 | ID ASD | |
GO:0003008 | system process | 1695 | 32 | 11.01 | 2.91 | 1.08e-08 | 2.58e-06 | SCZ | |
GO:0050877 | neurological system process | 1237 | 26 | 8.03 | 3.24 | 4.87e-08 | 9.32e-06 | ASD | |
GO:0006811 | ion transport | 969 | 22 | 6.29 | 3.50 | 1.80e-07 | 2.87e-05 | - | |
GO:0042391 | regulation of membrane potential | 248 | 11 | 1.61 | 6.83 | 5.93e-07 | 8.11e-05 | ASD | |
GO:0007267 | cell-cell signaling | 1099 | 22 | 7.14 | 3.08 | 1.53e-06 | 0.0002 | ASD | |
GO:0051179 | localization | 4167 | 47 | 27.06 | 1.74 | 1.17e-05 | 0.0011 | SCZ | |
GO:0051899 | membrane depolarization | 78 | 6 | 0.51 | 11.85 | 1.13e-05 | 0.0011 | ASD | |
GO:0006810 | transport | 3338 | 40 | 21.68 | 1.85 | 2.12e-05 | 0.0018 | - | |
GO:0051234 | establishment of localization | 3392 | 40 | 22.03 | 1.82 | 3.15e-05 | 0.0023 | - | |
GO:0001508 | regulation of action potential | 136 | 7 | 0.88 | 7.93 | 2.87e-05 | 0.0023 | - | |
GO:2000463 | positive regulation of excitatory postsynaptic membrane potential | 11 | 3 | 0.07 | 42.00 | 4.21e-05 | 0.0029 | - | |
GO:0044708 | single-organism behavior | 334 | 10 | 2.17 | 4.61 | 6.09e-05 | 0.0039 | ASD | |
GO:0034220 | ion transmembrane transport | 273 | 9 | 1.77 | 5.08 | 6.96e-05 | 0.0042 | - | |
GO:0060079 | regulation of excitatory postsynaptic membrane potential | 36 | 4 | 0.23 | 17.11 | 8.38e-05 | 0.0047 | ID SCZ | |
GO:0045838 | positive regulation of membrane potential | 16 | 3 | 0.10 | 28.87 | 0.0001 | 0.0050 | - | |
GO:0060078 | regulation of postsynaptic membrane potential | 41 | 4 | 0.27 | 15.02 | 0.0001 | 0.0050 | - | |
GO:0007154 | cell communication | 4770 | 48 | 30.97 | 1.55 | 0.0002 | 0.0071 | - | |
GO:0050808 | synapse organization | 135 | 6 | 0.88 | 6.84 | 0.0002 | 0.0071 | - | |
GO:0007399 | nervous system development | 1724 | 24 | 11.19 | 2.14 | 0.0002 | 0.0071 | ID ASD SCZ | |
GO:0023052 | signaling | 4646 | 47 | 30.17 | 1.56 | 0.0002 | 0.0071 | - | |
GO:0044057 | regulation of system process | 455 | 11 | 2.95 | 3.72 | 0.0002 | 0.0071 | - | |
GO:0044700 | single organism signaling | 4646 | 47 | 30.17 | 1.56 | 0.0002 | 0.0071 | - | |
GO:0030029 | actin filament-based process | 465 | 11 | 3.02 | 3.64 | 0.0002 | 0.0071 | - | |
GO:0050804 | regulation of synaptic transmission | 186 | 7 | 1.21 | 5.80 | 0.0002 | 0.0071 | - | |
GO:0007626 | locomotory behavior | 136 | 6 | 0.88 | 6.79 | 0.0003 | 0.0099 | - | |
GO:0050806 | positive regulation of synaptic transmission | 49 | 4 | 0.32 | 12.57 | 0.0003 | 0.0099 | - | |
GO:0072657 | protein localization to membrane | 94 | 5 | 0.61 | 8.19 | 0.0004 | 0.0106 | - | |
GO:0019228 | regulation of action potential in neuron | 98 | 5 | 0.64 | 7.86 | 0.0004 | 0.0106 | - | |
GO:0051969 | regulation of transmission of nerve impulse | 204 | 7 | 1.32 | 5.28 | 0.0004 | 0.0106 | - | |
GO:0048167 | regulation of synaptic plasticity | 96 | 5 | 0.62 | 8.02 | 0.0004 | 0.0106 | ID | |
GO:0043113 | receptor clustering | 23 | 3 | 0.15 | 20.09 | 0.0004 | 0.0106 | SCZ | |
GO:0007270 | neuron-neuron synaptic transmission | 94 | 5 | 0.61 | 8.19 | 0.0004 | 0.0106 | - | |
GO:0051971 | positive regulation of transmission of nerve impulse | 52 | 4 | 0.34 | 11.85 | 0.0004 | 0.0106 | - | |
GO:0031644 | regulation of neurological system process | 217 | 7 | 1.41 | 4.97 | 0.0005 | 0.0123 | ID | |
GO:0031646 | positive regulation of neurological system process | 57 | 4 | 0.37 | 10.81 | 0.0005 | 0.0123 | - | |
GO:0051049 | regulation of transport | 967 | 16 | 6.28 | 2.55 | 0.0005 | 0.0123 | - | |
GO:0060024 | rhythmic synaptic transmission | 6 | 2 | 0.04 | 51.33 | 0.0006 | 0.0144 | - |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0034702 | ion channel complex | 203 | 13 | 1.21 | 10.71 | 2.42e-10 | 4.09e-08 | ASD | |
GO:0033268 | node of Ranvier | 14 | 5 | 0.08 | 59.71 | 1.33e-08 | 1.12e-06 | ID ASD | |
GO:0033267 | axon part | 133 | 9 | 0.80 | 11.31 | 1.01e-07 | 4.27e-06 | ID ASD | |
GO:0034703 | cation channel complex | 132 | 9 | 0.79 | 11.40 | 9.46e-08 | 4.27e-06 | ASD | |
GO:0043194 | axon initial segment | 9 | 4 | 0.05 | 74.31 | 1.49e-07 | 4.90e-06 | - | |
GO:0044304 | main axon | 42 | 6 | 0.25 | 23.88 | 1.74e-07 | 4.90e-06 | ID | |
GO:0043005 | neuron projection | 651 | 17 | 3.89 | 4.37 | 2.93e-07 | 7.07e-06 | ID ASD | |
GO:0042995 | cell projection | 1230 | 23 | 7.36 | 3.13 | 7.37e-07 | 1.56e-05 | ID ASD | |
GO:0030018 | Z disc | 72 | 6 | 0.43 | 13.93 | 4.48e-06 | 8.41e-05 | ID ASD | |
GO:0016605 | PML body | 75 | 6 | 0.45 | 13.37 | 5.69e-06 | 9.62e-05 | - | |
GO:0031674 | I band | 84 | 6 | 0.50 | 11.94 | 1.10e-05 | 0.0002 | ASD | |
GO:0044463 | cell projection part | 639 | 14 | 3.82 | 3.66 | 2.64e-05 | 0.0004 | ID ASD | |
GO:0097060 | synaptic membrane | 215 | 8 | 1.29 | 6.22 | 4.45e-05 | 0.0006 | ASD | |
GO:0030424 | axon | 286 | 9 | 1.71 | 5.26 | 5.43e-05 | 0.0007 | ID ASD | |
GO:0001518 | voltage-gated sodium channel complex | 14 | 3 | 0.08 | 35.83 | 7.21e-05 | 0.0008 | - | |
GO:0045211 | postsynaptic membrane | 184 | 7 | 1.10 | 6.36 | 0.0001 | 0.0009 | - | |
GO:0034706 | sodium channel complex | 17 | 3 | 0.10 | 29.50 | 0.0001 | 0.0009 | - | |
GO:0030017 | sarcomere | 128 | 6 | 0.77 | 7.84 | 0.0001 | 0.0009 | ASD | |
GO:0044449 | contractile fiber part | 145 | 6 | 0.87 | 6.92 | 0.0002 | 0.0018 | ASD | |
GO:0030425 | dendrite | 355 | 9 | 2.12 | 4.24 | 0.0003 | 0.0022 | ID ASD | |
GO:0005886 | plasma membrane | 4289 | 42 | 25.65 | 1.64 | 0.0003 | 0.0022 | ASD | |
GO:0034707 | chloride channel complex | 55 | 4 | 0.33 | 12.16 | 0.0003 | 0.0022 | - | |
GO:0030016 | myofibril | 152 | 6 | 0.91 | 6.60 | 0.0003 | 0.0022 | ASD | |
GO:0071944 | cell periphery | 4377 | 42 | 26.18 | 1.60 | 0.0004 | 0.0027 | ASD | |
GO:0043292 | contractile fiber | 162 | 6 | 0.97 | 6.19 | 0.0004 | 0.0027 | ASD | |
GO:0043083 | synaptic cleft | 7 | 2 | 0.04 | 47.77 | 0.0007 | 0.0046 | - | |
GO:0008076 | voltage-gated potassium channel complex | 70 | 4 | 0.42 | 9.55 | 0.0008 | 0.0048 | - | |
GO:0034705 | potassium channel complex | 70 | 4 | 0.42 | 9.55 | 0.0008 | 0.0048 | - | |
GO:0017146 | N-methyl-D-aspartate selective glutamate receptor complex | 8 | 2 | 0.05 | 41.80 | 0.0010 | 0.0058 | - | |
GO:0043234 | protein complex | 3278 | 33 | 19.61 | 1.68 | 0.0011 | 0.0062 | ID ASD | |
GO:0030288 | outer membrane-bounded periplasmic space | 9 | 2 | 0.05 | 37.15 | 0.0012 | 0.0063 | - | |
GO:0042597 | periplasmic space | 9 | 2 | 0.05 | 37.15 | 0.0012 | 0.0063 | - | |
GO:0016604 | nuclear body | 274 | 7 | 1.64 | 4.27 | 0.0013 | 0.0067 | - | |
GO:0044456 | synapse part | 370 | 8 | 2.21 | 3.61 | 0.0017 | 0.0085 | ASD | |
GO:0044459 | plasma membrane part | 1918 | 22 | 11.47 | 1.92 | 0.0019 | 0.0092 | ASD | |
GO:0005887 | integral to plasma membrane | 1220 | 16 | 7.30 | 2.19 | 0.0023 | 0.0108 | ASD | |
GO:0030313 | cell envelope | 13 | 2 | 0.08 | 25.72 | 0.0026 | 0.0116 | - | |
GO:0044462 | external encapsulating structure part | 13 | 2 | 0.08 | 25.72 | 0.0026 | 0.0116 | - | |
GO:0031226 | intrinsic to plasma membrane | 1264 | 16 | 7.56 | 2.12 | 0.0033 | 0.0143 | ASD | |
GO:0030312 | external encapsulating structure | 16 | 2 | 0.10 | 20.90 | 0.0040 | 0.0169 | - |
GO term accession | GO term name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
GO:0022836 | gated channel activity | 303 | 17 | 1.92 | 8.84 | 6.53e-12 | 6.56e-10 | ID ASD | |
GO:0022839 | ion gated channel activity | 303 | 17 | 1.92 | 8.84 | 6.53e-12 | 6.56e-10 | ID ASD | |
GO:0005216 | ion channel activity | 393 | 18 | 2.49 | 7.22 | 4.30e-11 | 2.88e-09 | ID ASD | |
GO:0022838 | substrate-specific channel activity | 402 | 18 | 2.55 | 7.06 | 6.23e-11 | 3.13e-09 | ID ASD | |
GO:0015267 | channel activity | 420 | 18 | 2.67 | 6.75 | 1.27e-10 | 4.25e-09 | ID ASD | |
GO:0022803 | passive transmembrane transporter activity | 420 | 18 | 2.67 | 6.75 | 1.27e-10 | 4.25e-09 | ID ASD | |
GO:0015075 | ion transmembrane transporter activity | 786 | 23 | 4.99 | 4.61 | 4.99e-10 | 1.43e-08 | - | |
GO:0022891 | substrate-specific transmembrane transporter activity | 845 | 23 | 5.36 | 4.29 | 2.03e-09 | 5.10e-08 | - | |
GO:0046873 | metal ion transmembrane transporter activity | 373 | 15 | 2.37 | 6.34 | 1.23e-08 | 2.47e-07 | ID ASD | |
GO:0022857 | transmembrane transporter activity | 925 | 23 | 5.87 | 3.92 | 1.13e-08 | 2.47e-07 | - | |
GO:0022892 | substrate-specific transporter activity | 980 | 23 | 6.22 | 3.70 | 3.30e-08 | 6.03e-07 | ID ASD | |
GO:0005261 | cation channel activity | 273 | 12 | 1.73 | 6.93 | 1.53e-07 | 2.52e-06 | ID ASD | |
GO:0022843 | voltage-gated cation channel activity | 133 | 9 | 0.84 | 10.66 | 1.63e-07 | 2.52e-06 | ID ASD | |
GO:0022832 | voltage-gated channel activity | 179 | 10 | 1.14 | 8.80 | 1.97e-07 | 2.64e-06 | ID ASD | |
GO:0005244 | voltage-gated ion channel activity | 179 | 10 | 1.14 | 8.80 | 1.97e-07 | 2.64e-06 | ID ASD | |
GO:0022890 | inorganic cation transmembrane transporter activity | 470 | 15 | 2.98 | 5.03 | 2.55e-07 | 3.20e-06 | ASD | |
GO:0008324 | cation transmembrane transporter activity | 568 | 16 | 3.60 | 4.44 | 5.22e-07 | 6.17e-06 | - | |
GO:0005516 | calmodulin binding | 164 | 9 | 1.04 | 8.65 | 9.65e-07 | 1.08e-05 | - | |
GO:0005215 | transporter activity | 1196 | 23 | 7.59 | 3.03 | 1.17e-06 | 1.24e-05 | ID | |
GO:0005230 | extracellular ligand-gated ion channel activity | 73 | 6 | 0.46 | 12.95 | 6.75e-06 | 6.78e-05 | - | |
GO:0022834 | ligand-gated channel activity | 137 | 7 | 0.87 | 8.05 | 2.62e-05 | 0.0002 | - | |
GO:0015276 | ligand-gated ion channel activity | 137 | 7 | 0.87 | 8.05 | 2.62e-05 | 0.0002 | - | |
GO:0005254 | chloride channel activity | 70 | 5 | 0.44 | 11.25 | 8.11e-05 | 0.0007 | - | |
GO:0005253 | anion channel activity | 79 | 5 | 0.50 | 9.97 | 0.0001 | 0.0008 | - | |
GO:0005248 | voltage-gated sodium channel activity | 15 | 3 | 0.10 | 31.51 | 0.0001 | 0.0008 | - | |
GO:0005249 | voltage-gated potassium channel activity | 78 | 5 | 0.50 | 10.10 | 0.0001 | 0.0008 | - | |
GO:0005234 | extracellular-glutamate-gated ion channel activity | 19 | 3 | 0.12 | 24.88 | 0.0002 | 0.0013 | ID | |
GO:0015077 | monovalent inorganic cation transmembrane transporter activity | 318 | 9 | 2.02 | 4.46 | 0.0002 | 0.0013 | - | |
GO:0004890 | GABA-A receptor activity | 19 | 3 | 0.12 | 24.88 | 0.0002 | 0.0013 | - | |
GO:0008509 | anion transmembrane transporter activity | 247 | 8 | 1.57 | 5.10 | 0.0002 | 0.0013 | - | |
GO:0015108 | chloride transmembrane transporter activity | 83 | 5 | 0.53 | 9.49 | 0.0002 | 0.0013 | - | |
GO:0015103 | inorganic anion transmembrane transporter activity | 128 | 6 | 0.81 | 7.39 | 0.0002 | 0.0013 | - | |
GO:0016917 | GABA receptor activity | 22 | 3 | 0.14 | 21.49 | 0.0003 | 0.0017 | - | |
GO:0072509 | divalent inorganic cation transmembrane transporter activity | 139 | 6 | 0.88 | 6.80 | 0.0003 | 0.0017 | - | |
GO:0000146 | microfilament motor activity | 20 | 3 | 0.13 | 23.64 | 0.0003 | 0.0017 | - | |
GO:0043168 | anion binding | 2402 | 29 | 15.24 | 1.90 | 0.0003 | 0.0017 | ASD SCZ | |
GO:0004972 | N-methyl-D-aspartate selective glutamate receptor activity | 6 | 2 | 0.04 | 52.52 | 0.0006 | 0.0033 | ID | |
GO:0005267 | potassium channel activity | 110 | 5 | 0.70 | 7.16 | 0.0007 | 0.0037 | - | |
GO:0015085 | calcium ion transmembrane transporter activity | 113 | 5 | 0.72 | 6.97 | 0.0008 | 0.0041 | ASD | |
GO:0035639 | purine ribonucleoside triphosphate binding | 1829 | 23 | 11.61 | 1.98 | 0.0009 | 0.0044 | ASD SCZ |