Including 64 KEGG pathways in ASD, 26 in ID, 17 in EE and 34 in SCZ. |
KEGG accession | KEGG pathway name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
04020 | Calcium signaling pathway | 177 | 10 | 1.14 | 8.76 | 2.63e-07 | 1.81e-05 | ASD EE | |
05416 | Viral myocarditis | 70 | 6 | 0.45 | 13.30 | 6.31e-06 | 0.0002 | - | |
04270 | Vascular smooth muscle contraction | 116 | 6 | 0.75 | 8.02 | 0.0001 | 0.0017 | ASD | |
04670 | Leukocyte transendothelial migration | 116 | 6 | 0.75 | 8.02 | 0.0001 | 0.0017 | ASD | |
04530 | Tight junction | 132 | 6 | 0.85 | 7.05 | 0.0002 | 0.0028 | ID ASD | |
01100 | Metabolic pathways | 1130 | 18 | 7.28 | 2.47 | 0.0004 | 0.0034 | ID ASD | |
05200 | Pathways in cancer | 326 | 9 | 2.10 | 4.28 | 0.0003 | 0.0034 | ASD | |
04144 | Endocytosis | 201 | 7 | 1.30 | 5.40 | 0.0004 | 0.0034 | EE | |
04912 | GnRH signaling pathway | 101 | 5 | 0.65 | 7.68 | 0.0005 | 0.0038 | ID ASD | |
04141 | Protein processing in endoplasmic reticulum | 165 | 6 | 1.06 | 5.64 | 0.0007 | 0.0048 | - | |
04540 | Gap junction | 90 | 4 | 0.58 | 6.89 | 0.0028 | 0.0114 | ASD | |
04510 | Focal adhesion | 200 | 6 | 1.29 | 4.65 | 0.0020 | 0.0114 | ASD EE | |
04810 | Regulation of actin cytoskeleton | 213 | 6 | 1.37 | 4.37 | 0.0027 | 0.0114 | ASD | |
04970 | Salivary secretion | 89 | 4 | 0.57 | 6.97 | 0.0027 | 0.0114 | ASD EE | |
04512 | ECM-receptor interaction | 85 | 4 | 0.55 | 7.30 | 0.0023 | 0.0114 | ASD | |
04914 | Progesterone-mediated oocyte maturation | 86 | 4 | 0.55 | 7.22 | 0.0024 | 0.0114 | ASD | |
04120 | Ubiquitin mediated proteolysis | 135 | 5 | 0.87 | 5.75 | 0.0019 | 0.0114 | - | |
00770 | Pantothenate and CoA biosynthesis | 16 | 2 | 0.10 | 19.39 | 0.0047 | 0.0180 | - | |
05146 | Amoebiasis | 106 | 4 | 0.68 | 5.85 | 0.0050 | 0.0182 | ASD EE | |
00360 | Phenylalanine metabolism | 17 | 2 | 0.11 | 18.25 | 0.0053 | 0.0183 | - | |
04621 | NOD-like receptor signaling pathway | 58 | 3 | 0.37 | 8.02 | 0.0063 | 0.0207 | - | |
04514 | Cell adhesion molecules (CAMs) | 133 | 4 | 0.86 | 4.67 | 0.0110 | 0.0292 | ASD | |
04730 | Long-term depression | 70 | 3 | 0.45 | 6.65 | 0.0106 | 0.0292 | ASD EE | |
05145 | Toxoplasmosis | 132 | 4 | 0.85 | 4.70 | 0.0107 | 0.0292 | ASD | |
04976 | Bile secretion | 71 | 3 | 0.46 | 6.55 | 0.0110 | 0.0292 | ASD | |
04720 | Long-term potentiation | 70 | 3 | 0.45 | 6.65 | 0.0106 | 0.0292 | ID ASD EE | |
05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 74 | 3 | 0.48 | 6.29 | 0.0123 | 0.0303 | ID ASD | |
04971 | Gastric acid secretion | 74 | 3 | 0.48 | 6.29 | 0.0123 | 0.0303 | ASD | |
05414 | Dilated cardiomyopathy | 90 | 3 | 0.58 | 5.17 | 0.0206 | 0.0490 | ASD EE | |
05340 | Primary immunodeficiency | 35 | 2 | 0.23 | 8.86 | 0.0214 | 0.0492 | - |