Including 209 pathway commons in ASD, 31 in ID, 130 in EE and 190 in SCZ. |
pc accession | pc pathway name | Number of reference genes | Number of genes | Expected number | Ratio of entrichment | Raw P_Value | Adjusted P_Value | Genes related | Other disease |
---|---|---|---|---|---|---|---|---|---|
DB_ID:1637 | Proteoglycan syndecan-mediated signaling events | 1345 | 36 | 10.45 | 3.45 | 1.49e-10 | 4.25e-08 | ID SCZ | |
DB_ID:1499 | Integrin family cell surface interactions | 1378 | 35 | 10.70 | 3.27 | 1.08e-09 | 1.54e-07 | ID SCZ | |
DB_ID:143 | Neuronal System | 188 | 13 | 1.46 | 8.90 | 3.38e-09 | 2.19e-07 | EE ID SCZ | |
DB_ID:1619 | Endothelins | 1307 | 33 | 10.15 | 3.25 | 3.85e-09 | 2.19e-07 | ID SCZ | |
DB_ID:1517 | Beta1 integrin cell surface interactions | 1351 | 34 | 10.49 | 3.24 | 2.39e-09 | 2.19e-07 | ID SCZ | |
DB_ID:1480 | TRAIL signaling pathway | 1328 | 33 | 10.32 | 3.20 | 5.66e-09 | 2.69e-07 | ID SCZ | |
DB_ID:1665 | NOTCH | 57 | 8 | 0.44 | 18.07 | 1.45e-08 | 2.87e-07 | SCZ | |
DB_ID:1556 | Plasma membrane estrogen receptor signaling | 1301 | 32 | 10.11 | 3.17 | 1.24e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1573 | ErbB receptor signaling network | 1312 | 32 | 10.19 | 3.14 | 1.51e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1516 | Signaling events mediated by VEGFR1 and VEGFR2 | 1296 | 32 | 10.07 | 3.18 | 1.13e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1472 | Nectin adhesion pathway | 1295 | 32 | 10.06 | 3.18 | 1.11e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1635 | Sphingosine 1-phosphate (S1P) pathway | 1311 | 32 | 10.18 | 3.14 | 1.48e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1575 | VEGF and VEGFR signaling network | 1304 | 32 | 10.13 | 3.16 | 1.31e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1578 | Alpha9 beta1 integrin signaling events | 1305 | 32 | 10.14 | 3.16 | 1.33e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1454 | Syndecan-1-mediated signaling events | 1300 | 32 | 10.10 | 3.17 | 1.22e-08 | 2.87e-07 | ID SCZ | |
DB_ID:1540 | PDGFR-beta signaling pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1466 | Insulin Pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1497 | PDGF receptor signaling network | 1293 | 31 | 10.04 | 3.09 | 3.77e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1553 | Class I PI3K signaling events | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1509 | Internalization of ErbB1 | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1627 | IL5-mediated signaling events | 1292 | 31 | 10.04 | 3.09 | 3.71e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1648 | Class I PI3K signaling events mediated by Akt | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1554 | Arf6 signaling events | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1461 | GMCSF-mediated signaling events | 1292 | 31 | 10.04 | 3.09 | 3.71e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1564 | IL3-mediated signaling events | 1295 | 31 | 10.06 | 3.08 | 3.90e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1585 | Arf6 downstream pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1550 | EGF receptor (ErbB1) signaling pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1531 | PAR1-mediated thrombin signaling events | 1299 | 31 | 10.09 | 3.07 | 4.18e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1552 | Thrombin/protease-activated receptor (PAR) pathway | 1300 | 31 | 10.10 | 3.07 | 4.26e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1603 | EGFR-dependent Endothelin signaling events | 1289 | 31 | 10.01 | 3.10 | 3.52e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1602 | ErbB1 downstream signaling | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1571 | mTOR signaling pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1529 | IFN-gamma pathway | 1296 | 31 | 10.07 | 3.08 | 3.97e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1459 | Glypican pathway | 1338 | 32 | 10.39 | 3.08 | 2.38e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1482 | IGF1 pathway | 1291 | 31 | 10.03 | 3.09 | 3.64e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1594 | S1P1 pathway | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1519 | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1615 | Arf6 trafficking events | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1491 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | 1293 | 31 | 10.04 | 3.09 | 3.77e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1492 | Glypican 1 network | 1299 | 31 | 10.09 | 3.07 | 4.18e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1574 | Signaling events mediated by focal adhesion kinase | 1288 | 31 | 10.00 | 3.10 | 3.46e-08 | 2.96e-07 | ID SCZ | |
DB_ID:1649 | LKB1 signaling events | 1308 | 31 | 10.16 | 3.05 | 4.88e-08 | 3.31e-07 | ID SCZ | |
DB_ID:1488 | CDC42 signaling events | 757 | 22 | 5.88 | 3.74 | 1.61e-07 | 1.07e-06 | ID SCZ | |
DB_ID:20 | Axon guidance | 219 | 12 | 1.70 | 7.05 | 1.77e-07 | 1.15e-06 | ID SCZ | |
DB_ID:1456 | Regulation of CDC42 activity | 770 | 22 | 5.98 | 3.68 | 2.15e-07 | 1.36e-06 | ID SCZ | |
DB_ID:150 | Transmission across Chemical Synapses | 121 | 9 | 0.94 | 9.58 | 4.87e-07 | 3.02e-06 | EE ID SCZ | |
DB_ID:1604 | Syndecan-4-mediated signaling events | 209 | 11 | 1.62 | 6.78 | 8.58e-07 | 5.20e-06 | ID SCZ | |
DB_ID:1546 | Integrin-linked kinase signaling | 656 | 18 | 5.10 | 3.53 | 4.83e-06 | 2.87e-05 | ID SCZ | |
DB_ID:164 | GABA synthesis, release, reuptake and degradation | 17 | 4 | 0.13 | 30.29 | 7.86e-06 | 4.57e-05 | ID | |
DB_ID:1565 | AP-1 transcription factor network | 623 | 17 | 4.84 | 3.51 | 9.52e-06 | 5.43e-05 | ID SCZ | |
DB_ID:965 | Na+/Cl- dependent neurotransmitter transporters | 18 | 4 | 0.14 | 28.61 | 1.00e-05 | 5.59e-05 | - | |
DB_ID:1535 | Noncanonical Wnt signaling pathway | 182 | 9 | 1.41 | 6.37 | 1.41e-05 | 7.73e-05 | ID SCZ | |
DB_ID:18 | Sema4D induced cell migration and growth-cone collapse | 22 | 4 | 0.17 | 23.41 | 2.34e-05 | 0.0001 | SCZ | |
DB_ID:863 | Deadenylation of mRNA | 22 | 4 | 0.17 | 23.41 | 2.34e-05 | 0.0001 | - | |
DB_ID:1572 | RAC1 signaling pathway | 205 | 9 | 1.59 | 5.65 | 3.60e-05 | 0.0002 | ID | |
DB_ID:466 | Signaling by PDGF | 78 | 6 | 0.61 | 9.90 | 3.37e-05 | 0.0002 | SCZ | |
DB_ID:16 | Sema4D in semaphorin signaling | 27 | 4 | 0.21 | 19.07 | 5.45e-05 | 0.0002 | SCZ | |
DB_ID:937 | Transmembrane transport of small molecules | 379 | 12 | 2.94 | 4.08 | 4.83e-05 | 0.0002 | EE | |
DB_ID:11 | Developmental Biology | 433 | 13 | 3.36 | 3.87 | 4.06e-05 | 0.0002 | ID SCZ | |
DB_ID:1435 | Wnt signaling network | 200 | 9 | 1.55 | 5.79 | 2.97e-05 | 0.0002 | ID SCZ | |
DB_ID:1647 | RhoA signaling pathway | 205 | 9 | 1.59 | 5.65 | 3.60e-05 | 0.0002 | ID | |
DB_ID:1530 | Regulation of RAC1 activity | 205 | 9 | 1.59 | 5.65 | 3.60e-05 | 0.0002 | ID | |
DB_ID:157 | Neurotransmitter Release Cycle | 26 | 4 | 0.20 | 19.81 | 4.67e-05 | 0.0002 | ID | |
DB_ID:1650 | Regulation of RhoA activity | 205 | 9 | 1.59 | 5.65 | 3.60e-05 | 0.0002 | ID | |
DB_ID:1471 | Glypican 3 network | 206 | 9 | 1.60 | 5.62 | 3.74e-05 | 0.0002 | ID SCZ | |
DB_ID:646 | Amine compound SLC transporters | 29 | 4 | 0.23 | 17.76 | 7.29e-05 | 0.0003 | - | |
DB_ID:254 | Signalling by NGF | 143 | 7 | 1.11 | 6.30 | 0.0001 | 0.0004 | SCZ | |
DB_ID:21 | Semaphorin interactions | 64 | 5 | 0.50 | 10.06 | 0.0001 | 0.0004 | SCZ | |
DB_ID:1457 | Notch-mediated HES/HEY network | 94 | 6 | 0.73 | 8.22 | 9.63e-05 | 0.0004 | ID SCZ | |
DB_ID:634 | Metabolism | 824 | 18 | 6.40 | 2.81 | 9.53e-05 | 0.0004 | SCZ | |
DB_ID:331 | Signal Transduction | 1231 | 23 | 9.56 | 2.41 | 0.0001 | 0.0004 | - | |
DB_ID:1625 | Notch signaling pathway | 94 | 6 | 0.73 | 8.22 | 9.63e-05 | 0.0004 | ID SCZ | |
DB_ID:851 | Regulation of Insulin Secretion by Acetylcholine | 3 | 2 | 0.02 | 85.82 | 0.0002 | 0.0007 | - | |
DB_ID:289 | NGF signalling via TRKA from the plasma membrane | 107 | 6 | 0.83 | 7.22 | 0.0002 | 0.0007 | SCZ | |
DB_ID:64 | Hemostasis | 376 | 11 | 2.92 | 3.77 | 0.0002 | 0.0007 | - | |
DB_ID:1542 | Canonical Wnt signaling pathway | 155 | 7 | 1.20 | 5.81 | 0.0002 | 0.0007 | ID SCZ | |
DB_ID:1467 | C-MYC pathway | 149 | 7 | 1.16 | 6.05 | 0.0002 | 0.0007 | SCZ | |
DB_ID:467 | Downstream signal transduction | 75 | 5 | 0.58 | 8.58 | 0.0003 | 0.0011 | SCZ | |
DB_ID:1490 | Syndecan-3-mediated signaling events | 17 | 3 | 0.13 | 22.72 | 0.0003 | 0.0011 | - | |
DB_ID:161 | Reuptake of GABA | 4 | 2 | 0.03 | 64.37 | 0.0004 | 0.0014 | - | |
DB_ID:1621 | Presenilin action in Notch and Wnt signaling | 46 | 4 | 0.36 | 11.19 | 0.0005 | 0.0017 | - | |
DB_ID:862 | Deadenylation-dependent mRNA decay | 46 | 4 | 0.36 | 11.19 | 0.0005 | 0.0017 | - | |
DB_ID:812 | Integration of energy metabolism | 83 | 5 | 0.64 | 7.76 | 0.0005 | 0.0017 | SCZ | |
DB_ID:809 | Regulation of Insulin Secretion | 48 | 4 | 0.37 | 10.73 | 0.0005 | 0.0017 | - | |
DB_ID:482 | G alpha (12/13) signalling events | 21 | 3 | 0.16 | 18.39 | 0.0006 | 0.0020 | - | |
DB_ID:1600 | TNF receptor signaling pathway | 299 | 9 | 2.32 | 3.88 | 0.0006 | 0.0020 | ID | |
DB_ID:450 | Signaling by Notch | 21 | 3 | 0.16 | 18.39 | 0.0006 | 0.0020 | - | |
DB_ID:1547 | Regulation of nuclear beta catenin signaling and target gene transcription | 135 | 6 | 1.05 | 5.72 | 0.0007 | 0.0023 | ID SCZ | |
DB_ID:56 | Platelet activation, signaling and aggregation | 139 | 6 | 1.08 | 5.56 | 0.0008 | 0.0026 | - | |
DB_ID:973 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | 95 | 5 | 0.74 | 6.78 | 0.0009 | 0.0029 | ID | |
DB_ID:562 | Vitamin D (calciferol) metabolism | 7 | 2 | 0.05 | 36.78 | 0.0012 | 0.0037 | - | |
DB_ID:1498 | EphrinB-EPHB pathway | 60 | 4 | 0.47 | 8.58 | 0.0012 | 0.0037 | - | |
DB_ID:1469 | Stabilization and expansion of the E-cadherin adherens junction | 275 | 8 | 2.14 | 3.75 | 0.0015 | 0.0045 | ID SCZ | |
DB_ID:956 | Nephrin interactions | 29 | 3 | 0.23 | 13.32 | 0.0015 | 0.0045 | - | |
DB_ID:1544 | E-cadherin signaling in the nascent adherens junction | 275 | 8 | 2.14 | 3.75 | 0.0015 | 0.0045 | ID SCZ | |
DB_ID:910 | Import of palmitoyl-CoA into the mitochondrial matrix | 8 | 2 | 0.06 | 32.18 | 0.0016 | 0.0046 | - | |
DB_ID:241 | PI3K/AKT activation | 30 | 3 | 0.23 | 12.87 | 0.0016 | 0.0046 | EE | |
DB_ID:446 | Notch receptor binds with a ligand | 8 | 2 | 0.06 | 32.18 | 0.0016 | 0.0046 | - | |
DB_ID:463 | A third proteolytic cleavage releases NICD | 8 | 2 | 0.06 | 32.18 | 0.0016 | 0.0046 | - | |
DB_ID:1617 | E-cadherin signaling events | 280 | 8 | 2.17 | 3.68 | 0.0017 | 0.0048 | ID SCZ | |
DB_ID:472 | Signaling by SCF-KIT | 66 | 4 | 0.51 | 7.80 | 0.0018 | 0.0050 | - | |
DB_ID:325 | Downstream signaling of activated FGFR | 66 | 4 | 0.51 | 7.80 | 0.0018 | 0.0050 | SCZ | |
DB_ID:462 | Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor | 9 | 2 | 0.07 | 28.61 | 0.0021 | 0.0056 | - | |
DB_ID:159 | Serotonin Neurotransmitter Release Cycle | 9 | 2 | 0.07 | 28.61 | 0.0021 | 0.0056 | - | |
DB_ID:1644 | BMP receptor signaling | 226 | 7 | 1.76 | 3.99 | 0.0021 | 0.0056 | - | |
DB_ID:1641 | Effects of Botulinum toxin | 9 | 2 | 0.07 | 28.61 | 0.0021 | 0.0056 | - | |
DB_ID:155 | Dopamine Neurotransmitter Release Cycle | 9 | 2 | 0.07 | 28.61 | 0.0021 | 0.0056 | - | |
DB_ID:530 | Integrin cell surface interactions | 72 | 4 | 0.56 | 7.15 | 0.0024 | 0.0063 | - | |
DB_ID:178 | Potassium Channels | 76 | 4 | 0.59 | 6.78 | 0.0030 | 0.0078 | EE ID | |
DB_ID:158 | Glutamate Neurotransmitter Release Cycle | 11 | 2 | 0.09 | 23.41 | 0.0032 | 0.0081 | - | |
DB_ID:154 | Acetylcholine Neurotransmitter Release Cycle | 11 | 2 | 0.09 | 23.41 | 0.0032 | 0.0081 | - | |
DB_ID:156 | Norepinephrine Neurotransmitter Release Cycle | 11 | 2 | 0.09 | 23.41 | 0.0032 | 0.0081 | - | |
DB_ID:44 | L1CAM interactions | 79 | 4 | 0.61 | 6.52 | 0.0034 | 0.0085 | ID | |
DB_ID:943 | SLC-mediated transmembrane transport | 248 | 7 | 1.93 | 3.63 | 0.0034 | 0.0085 | ID | |
DB_ID:171 | Voltage gated Potassium channels | 39 | 3 | 0.30 | 9.90 | 0.0035 | 0.0087 | EE ID | |
DB_ID:73 | Response to elevated platelet cytosolic Ca2+ | 40 | 3 | 0.31 | 9.66 | 0.0037 | 0.0089 | EE | |
DB_ID:1545 | EPHB forward signaling | 40 | 3 | 0.31 | 9.66 | 0.0037 | 0.0089 | - | |
DB_ID:1494 | N-cadherin signaling events | 251 | 7 | 1.95 | 3.59 | 0.0037 | 0.0089 | ID SCZ | |
DB_ID:1549 | p38 MAPK signaling pathway | 189 | 6 | 1.47 | 4.09 | 0.0037 | 0.0089 | - | |
DB_ID:919 | Fatty acid, triacylglycerol, and ketone body metabolism | 83 | 4 | 0.64 | 6.20 | 0.0041 | 0.0097 | - | |
DB_ID:984 | Metabolism of lipids and lipoproteins | 258 | 7 | 2.00 | 3.49 | 0.0043 | 0.0101 | - | |
DB_ID:130 | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | 89 | 4 | 0.69 | 5.79 | 0.0052 | 0.0121 | EE ID SCZ | |
DB_ID:1475 | Validated nuclear estrogen receptor beta network | 15 | 2 | 0.12 | 17.16 | 0.0059 | 0.0137 | - | |
DB_ID:1660 | Alpha6Beta4Integrin | 48 | 3 | 0.37 | 8.05 | 0.0062 | 0.0143 | - | |
DB_ID:306 | Signaling by FGFR | 95 | 4 | 0.74 | 5.42 | 0.0065 | 0.0148 | SCZ | |
DB_ID:479 | Glucagon-type ligand receptors | 16 | 2 | 0.12 | 16.09 | 0.0067 | 0.0149 | - | |
DB_ID:1659 | Hedgehog | 16 | 2 | 0.12 | 16.09 | 0.0067 | 0.0149 | - | |
DB_ID:1438 | LPA4-mediated signaling events | 16 | 2 | 0.12 | 16.09 | 0.0067 | 0.0149 | SCZ | |
DB_ID:516 | TCR signaling | 50 | 3 | 0.39 | 7.72 | 0.0070 | 0.0155 | - | |
DB_ID:330 | Signaling by EGFR | 98 | 4 | 0.76 | 5.25 | 0.0073 | 0.0160 | SCZ | |
DB_ID:847 | PKA activation in glucagon signalling | 17 | 2 | 0.13 | 15.15 | 0.0076 | 0.0165 | SCZ | |
DB_ID:1501 | Caspase cascade in apoptosis | 52 | 3 | 0.40 | 7.43 | 0.0077 | 0.0166 | ID | |
DB_ID:759 | Activated AMPK stimulates fatty-acid oxidation in muscle | 18 | 2 | 0.14 | 14.30 | 0.0085 | 0.0182 | - | |
DB_ID:1006 | Costimulation by the CD28 family | 55 | 3 | 0.43 | 7.02 | 0.0090 | 0.0191 | - | |
DB_ID:1536 | Regulation of p38-alpha and p38-beta | 164 | 5 | 1.27 | 3.92 | 0.0094 | 0.0197 | - | |
DB_ID:872 | Citric acid cycle (TCA cycle) | 19 | 2 | 0.15 | 13.55 | 0.0094 | 0.0197 | - | |
DB_ID:1512 | Posttranslational regulation of adherens junction stability and dissassembly | 231 | 6 | 1.79 | 3.34 | 0.0097 | 0.0202 | ID SCZ | |
DB_ID:22 | NCAM signaling for neurite out-growth | 57 | 3 | 0.44 | 6.78 | 0.0100 | 0.0207 | - | |
DB_ID:1500 | IL1-mediated signaling events | 234 | 6 | 1.82 | 3.30 | 0.0103 | 0.0211 | - | |
DB_ID:864 | Metabolism of mRNA | 235 | 6 | 1.83 | 3.29 | 0.0105 | 0.0214 | - | |
DB_ID:1458 | p38 signaling mediated by MAPKAP kinases | 21 | 2 | 0.16 | 12.26 | 0.0115 | 0.0231 | - | |
DB_ID:302 | PIP3 activates AKT signaling | 21 | 2 | 0.16 | 12.26 | 0.0115 | 0.0231 | EE | |
DB_ID:515 | Adaptive Immune System | 243 | 6 | 1.89 | 3.18 | 0.0122 | 0.0243 | - | |
DB_ID:484 | G alpha (z) signalling events | 22 | 2 | 0.17 | 11.70 | 0.0125 | 0.0247 | SCZ | |
DB_ID:458 | Signaling by GPCR | 823 | 13 | 6.39 | 2.03 | 0.0130 | 0.0256 | - | |
DB_ID:1444 | Validated targets of C-MYC transcriptional repression | 63 | 3 | 0.49 | 6.13 | 0.0131 | 0.0256 | - | |
DB_ID:935 | Cell-Cell communication | 117 | 4 | 0.91 | 4.40 | 0.0133 | 0.0258 | - | |
DB_ID:116 | NCAM1 interactions | 23 | 2 | 0.18 | 11.19 | 0.0137 | 0.0264 | SCZ | |
DB_ID:981 | Regulation of Water Balance by Renal Aquaporins | 24 | 2 | 0.19 | 10.73 | 0.0148 | 0.0283 | SCZ | |
DB_ID:339 | CaM pathway | 25 | 2 | 0.19 | 10.30 | 0.0160 | 0.0300 | SCZ | |
DB_ID:1070 | Steroid hormones | 25 | 2 | 0.19 | 10.30 | 0.0160 | 0.0300 | - | |
DB_ID:338 | Calmodulin induced events | 25 | 2 | 0.19 | 10.30 | 0.0160 | 0.0300 | SCZ | |
DB_ID:459 | GPCR ligand binding | 338 | 7 | 2.63 | 2.67 | 0.0171 | 0.0319 | - | |
DB_ID:493 | Ca-dependent events | 27 | 2 | 0.21 | 9.54 | 0.0186 | 0.0335 | SCZ | |
DB_ID:336 | DAG and IP3 signaling | 27 | 2 | 0.21 | 9.54 | 0.0186 | 0.0335 | SCZ | |
DB_ID:321 | PI-3K cascade | 27 | 2 | 0.21 | 9.54 | 0.0186 | 0.0335 | EE | |
DB_ID:68 | Cell surface interactions at the vascular wall | 72 | 3 | 0.56 | 5.36 | 0.0187 | 0.0335 | - | |
DB_ID:323 | Phospholipase C-mediated cascade | 27 | 2 | 0.21 | 9.54 | 0.0186 | 0.0335 | SCZ | |
DB_ID:992 | Aquaporin-mediated transport | 27 | 2 | 0.21 | 9.54 | 0.0186 | 0.0335 | SCZ | |
DB_ID:1559 | FAS (CD95) signaling pathway | 130 | 4 | 1.01 | 3.96 | 0.0189 | 0.0337 | ID | |
DB_ID:166 | CREB phosphorylation through the activation of Ras | 28 | 2 | 0.22 | 9.20 | 0.0199 | 0.0352 | ID | |
DB_ID:71 | Platelet degranulation | 29 | 2 | 0.23 | 8.88 | 0.0213 | 0.0370 | EE | |
DB_ID:1523 | Reelin signaling pathway | 29 | 2 | 0.23 | 8.88 | 0.0213 | 0.0370 | ID SCZ | |
DB_ID:337 | EGFR interacts with phospholipase C-gamma | 29 | 2 | 0.23 | 8.88 | 0.0213 | 0.0370 | SCZ | |
DB_ID:1581 | Syndecan-2-mediated signaling events | 77 | 3 | 0.60 | 5.02 | 0.0223 | 0.0385 | - | |
DB_ID:240 | PLC-gamma1 signalling | 30 | 2 | 0.23 | 8.58 | 0.0227 | 0.0387 | SCZ | |
DB_ID:1548 | Ephrin B reverse signaling | 30 | 2 | 0.23 | 8.58 | 0.0227 | 0.0387 | - | |
DB_ID:1664 | EGFR1 | 138 | 4 | 1.07 | 3.73 | 0.0230 | 0.0390 | SCZ | |
DB_ID:865 | Metabolism of RNA | 282 | 6 | 2.19 | 2.74 | 0.0235 | 0.0396 | - | |
DB_ID:1484 | Lissencephaly gene (LIS1) in neuronal migration and development | 31 | 2 | 0.24 | 8.31 | 0.0241 | 0.0399 | - | |
DB_ID:546 | Pyruvate metabolism and Citric Acid (TCA) cycle | 31 | 2 | 0.24 | 8.31 | 0.0241 | 0.0399 | - | |
DB_ID:476 | G alpha (s) signalling events | 31 | 2 | 0.24 | 8.31 | 0.0241 | 0.0399 | SCZ | |
DB_ID:576 | Metabolism of steroid hormones and vitamins A and D | 32 | 2 | 0.25 | 8.05 | 0.0256 | 0.0410 | - | |
DB_ID:1493 | Validated targets of C-MYC transcriptional activation | 81 | 3 | 0.63 | 4.77 | 0.0254 | 0.0410 | ID SCZ | |
DB_ID:308 | GAB1 signalosome | 32 | 2 | 0.25 | 8.05 | 0.0256 | 0.0410 | EE | |
DB_ID:580 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | 32 | 2 | 0.25 | 8.05 | 0.0256 | 0.0410 | - | |
DB_ID:475 | G alpha (i) signalling events | 32 | 2 | 0.25 | 8.05 | 0.0256 | 0.0410 | SCZ | |
DB_ID:43 | Recycling pathway of L1 | 32 | 2 | 0.25 | 8.05 | 0.0256 | 0.0410 | - | |
DB_ID:846 | Glucagon signaling in metabolic regulation | 33 | 2 | 0.26 | 7.80 | 0.0271 | 0.0431 | SCZ | |
DB_ID:1560 | C-MYB transcription factor network | 85 | 3 | 0.66 | 4.54 | 0.0287 | 0.0442 | - | |
DB_ID:140 | Activation of NMDA receptor upon glutamate binding and postsynaptic events | 34 | 2 | 0.26 | 7.57 | 0.0287 | 0.0442 | ID SCZ | |
DB_ID:1024 | RNA Polymerase III Abortive And Retractive Initiation | 34 | 2 | 0.26 | 7.57 | 0.0287 | 0.0442 | - | |
DB_ID:1569 | Glucocorticoid receptor signaling | 85 | 3 | 0.66 | 4.54 | 0.0287 | 0.0442 | SCZ | |
DB_ID:1023 | RNA Polymerase III Transcription | 34 | 2 | 0.26 | 7.57 | 0.0287 | 0.0442 | - | |
DB_ID:142 | Post NMDA receptor activation events | 34 | 2 | 0.26 | 7.57 | 0.0287 | 0.0442 | ID SCZ | |
DB_ID:27 | Signal transduction by L1 | 35 | 2 | 0.27 | 7.36 | 0.0302 | 0.0460 | - | |
DB_ID:1005 | Downstream TCR signaling | 35 | 2 | 0.27 | 7.36 | 0.0302 | 0.0460 | - | |
DB_ID:495 | Amine ligand-binding receptors | 36 | 2 | 0.28 | 7.15 | 0.0319 | 0.0479 | - | |
DB_ID:1000 | CD28 co-stimulation | 36 | 2 | 0.28 | 7.15 | 0.0319 | 0.0479 | - | |
DB_ID:192 | GABA receptor activation | 36 | 2 | 0.28 | 7.15 | 0.0319 | 0.0479 | EE SCZ | |
DB_ID:1611 | Regulation of nuclear SMAD2/3 signaling | 305 | 6 | 2.37 | 2.53 | 0.0327 | 0.0483 | SCZ | |
DB_ID:1440 | Regulation of cytoplasmic and nuclear SMAD2/3 signaling | 305 | 6 | 2.37 | 2.53 | 0.0327 | 0.0483 | SCZ | |
DB_ID:1510 | TGF-beta receptor signaling | 305 | 6 | 2.37 | 2.53 | 0.0327 | 0.0483 | SCZ |