14-3-3epsilon	GO:0019904_13174_3	protein domain specific binding	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]	IEA	molecular_function
14-3-3zeta	GO:0019904_13174_3	protein domain specific binding	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]	IEA	molecular_function
18-w	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
18-w	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
18-w	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
2-Sep	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
2-Sep	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
2-Sep	GO:0031105_3650_2	septin complex	"Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632]	IEA	cellular_component
4EHP	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
4EHP	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
4EHP	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
4EHP	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
5-HT1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
5-HT1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
5-HT2alpha	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
5-HT2alpha	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
5-HT2alpha	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
5-HT2alpha	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
5-HT2beta	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
5-HT2beta	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
5-HT2beta	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
5-HT2beta	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
5-ht7	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
5-ht7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Aats-arg	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-arg	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-arg	GO:0004814_13174_4	arginine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]	IEA	molecular_function
Aats-arg	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-arg	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-arg	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-arg	GO:0006420_6281_4	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-asp	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-asp	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Aats-asp	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-asp	GO:0004815_13174_1	aspartate-tRNA ligase activity	"Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]	IEA	molecular_function
Aats-asp	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-asp	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-asp	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-asp	GO:0006422_6281_1	aspartyl-tRNA aminoacylation	"The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]	IEA	biological_process
Aats-gln	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-gln	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-gln	GO:0004819_13174_1	glutamine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]	IEA	molecular_function
Aats-gln	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-gln	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-gln	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Aats-gln	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-gln	GO:0006425_6281_1	glutaminyl-tRNA aminoacylation	"The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-gln	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
Aats-gln	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
Aats-glupro	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-glupro	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-glupro	GO:0004818_13174_2	glutamate-tRNA ligase activity	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]	IEA	molecular_function
Aats-glupro	GO:0004827_13174_1	proline-tRNA ligase activity	"Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]	IEA	molecular_function
Aats-glupro	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-glupro	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-glupro	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Aats-glupro	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-glupro	GO:0006424_6281_2	glutamyl-tRNA aminoacylation	"The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-glupro	GO:0006433_6281_1	prolyl-tRNA aminoacylation	"The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]	IEA	biological_process
Aats-glupro	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
Aats-glupro	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
Aats-gly	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-gly	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-gly	GO:0004820_13174_2	glycine-tRNA ligase activity	"Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]	IEA	molecular_function
Aats-gly	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-gly	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-gly	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-gly	GO:0006426_6281_2	glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-ile	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-ile	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-ile	GO:0004822_13174_2	isoleucine-tRNA ligase activity	"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]	IEA	molecular_function
Aats-ile	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-ile	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-ile	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-ile	GO:0006428_6281_2	isoleucyl-tRNA aminoacylation	"The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-lys	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-lys	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Aats-lys	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-lys	GO:0004824_13174_1	lysine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6]	IEA	molecular_function
Aats-lys	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-lys	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-lys	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-lys	GO:0006430_6281_1	lysyl-tRNA aminoacylation	"The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-met	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-met	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-met	GO:0004825_13174_2	methionine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]	IEA	molecular_function
Aats-met	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-met	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-met	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-met	GO:0006431_6281_2	methionyl-tRNA aminoacylation	"The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-phe	GO:0000049_13174_4	tRNA binding	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]	IEA	molecular_function
Aats-phe	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-phe	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
Aats-phe	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-phe	GO:0004826_13174_3	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	IEA	molecular_function
Aats-phe	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-phe	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-phe	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-phe	GO:0006432_6281_3	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-phe	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
Aats-phe	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
Aats-ser	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-ser	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-ser	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-ser	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-ser	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-trp	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-trp	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-trp	GO:0004830_13174_2	tryptophan-tRNA ligase activity	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]	IEA	molecular_function
Aats-trp	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-trp	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-trp	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-trp	GO:0006436_6281_2	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-tyr	GO:0000049_13174_4	tRNA binding	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]	IEA	molecular_function
Aats-tyr	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-tyr	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-tyr	GO:0004831_13174_2	tyrosine-tRNA ligase activity	"Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223]	IEA	molecular_function
Aats-tyr	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-tyr	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-tyr	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-tyr	GO:0006437_6281_2	tyrosyl-tRNA aminoacylation	"The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
Aats-val	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Aats-val	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Aats-val	GO:0004832_13174_1	valine-tRNA ligase activity	"Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707]	IEA	molecular_function
Aats-val	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Aats-val	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aats-val	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Aats-val	GO:0006438_6281_1	valyl-tRNA aminoacylation	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
aay	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
aay	GO:0004647_13174_1	phosphoserine phosphatase activity	"Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3]	IEA	molecular_function
aay	GO:0006564_6281_3	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]	IEA	biological_process
aay	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
aay	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
ABC10	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
ABC10	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ABC10	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
ABC10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
ABC10	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABC10	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
ABC10	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABC10	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
ABCB7	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
ABCB7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ABCB7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ABCB7	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
ABCB7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
ABCB7	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABCB7	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
ABCB7	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABCB7	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
ABCC5	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
ABCC5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ABCC5	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
ABCC5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
ABCC5	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABCC5	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
ABCC5	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABCC5	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
ABCG4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
ABCG4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ABCG4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
ABCG4	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ABCG4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Abd-A	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Abd-A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Abd-A	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Abd-A	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Abd-A	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Abd-B	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Abd-B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Abd-B	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Abd-B	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Abd-B	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Abi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Abi	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Abscam	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
abs	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
abs	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
abs	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
abs	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
abs	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ac3	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Ac3	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
Ac3	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Acf1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Acf1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
acj6	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
acj6	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
acj6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
acj6	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
acj6	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
acj6	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Ack	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Ack	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Ack	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Ack	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ack	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ack	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Ack	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Acph-1	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
ACSF2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ACSF2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Actn	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
Actn	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Actn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ada2b	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ada2b	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ada2b	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ada	GO:0009168_6281_5	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Ada	GO:0019239_13174_5	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]	IEA	molecular_function
Adar	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Adar	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
Adar	GO:0004000_13174_2	adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]	IEA	molecular_function
Adar	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Adar	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
adat	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
adat	GO:0004000_13174_2	adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]	IEA	molecular_function
adat	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
adat	GO:0006605_6281_5	protein targeting	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	IEA	biological_process
adat	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
adat	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
adat	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
adat	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
ade2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ade2	GO:0004642_13174_1	phosphoribosylformylglycinamidine synthase activity	"Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17132]	IEA	molecular_function
ade2	GO:0006189_6281_3	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	IEA	biological_process
ade5	GO:0004638_13174_1	phosphoribosylaminoimidazole carboxylase activity	"Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10795]	IEA	molecular_function
ade5	GO:0004639_13174_1	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	"Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22631]	IEA	molecular_function
ade5	GO:0006164_6281_4	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
ade5	GO:0006189_6281_3	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	IEA	biological_process
Adk1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Adk1	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
Adk1	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
Adk2	GO:0004017_13174_4	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	IEA	molecular_function
Adk2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Adk2	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
Adk2	GO:0016776_13174_4	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	IEA	molecular_function
Adk2	GO:0019201_13174_4	nucleotide kinase activity	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]	IEA	molecular_function
Adk2	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
Adk2	GO:0046939_6281_4	nucleotide phosphorylation	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	IEA	biological_process
Adk3	GO:0004017_13174_4	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	IEA	molecular_function
Adk3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Adk3	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
Adk3	GO:0016776_13174_4	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	IEA	molecular_function
Adk3	GO:0019201_13174_4	nucleotide kinase activity	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]	IEA	molecular_function
Adk3	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
Adk3	GO:0046939_6281_4	nucleotide phosphorylation	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	IEA	biological_process
AdoR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
AdoR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
AGLU2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
AGLU2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
AGLU2	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
AGLU3	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
AGLU3	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
AGLU3	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
AGLU-like2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
AGLU-like2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
AGLU-like2	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
AGO1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
AGO1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
AGO2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
AGO2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ago3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Ago3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ago	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
AIF	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
AIF	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
AIF	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Akhr	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Akhr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Akt1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Akt1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Akt1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Akt1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Akt1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Akt1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Akt1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
alc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ALDH1L2	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
ALDH1L2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ALDH1L2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
ALDH1L2	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
ALDH1L2	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
ALDH1L2	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
ALDH1L2	GO:0016742_13174_3	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]	IEA	molecular_function
ALDH1L2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Aldh	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Aldh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Aldh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Aldh-III	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Aldh-III	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Aldh-III	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Alg10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Alg10	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
alpha-Adaptin	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
alpha-Adaptin	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
alpha-Adaptin	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
alpha-Adaptin	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
alpha-Adaptin	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
alpha-Adaptin	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
alpha-Adaptin	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
alpha-Adaptin	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
alpha-Cat	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
alpha-Cat	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
alpha-Cat	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
alphaCop	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
alphaCop	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
alphaCop	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
alphaCop	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
alphaCop	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
alphaCop	GO:0030126_3650_3	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	IEA	cellular_component
alpha-Man-I	GO:0004571_13174_5	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]	IEA	molecular_function
alpha-Man-I	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
alpha-Man-I	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
alpha-Man-IIb	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
alpha-Man-IIb	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
alpha-Man-IIb	GO:0004559_13174_4	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	IEA	molecular_function
alpha-Man-IIb	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
alpha-Man-IIb	GO:0006013_6281_3	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	IEA	biological_process
alpha-Man-IIb	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
alpha-Man-IIb	GO:0015923_13174_3	mannosidase activity	"Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]	IEA	molecular_function
alpha-Man-IIb	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
alpha-Man-II	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
alpha-Man-II	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
alpha-Man-II	GO:0004559_13174_4	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	IEA	molecular_function
alpha-Man-II	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
alpha-Man-II	GO:0006013_6281_3	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	IEA	biological_process
alpha-Man-II	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
alpha-Man-II	GO:0015923_13174_3	mannosidase activity	"Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]	IEA	molecular_function
alpha-Man-II	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
Alr	GO:0016972_13174_2	thiol oxidase activity	"Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]	IEA	molecular_function
Alr	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
AmCG12344	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
AmCG12344	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
AmCG12344	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
AmCG12344	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
AmCG12344	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
AmCG12344	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Amel_8916	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Amel_8916	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Amel_8916	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Amel_8916	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Amel_8916	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Amel_8916	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
amon	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
amon	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Amph	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Amph	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
amx	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
amx	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ank-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ank	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Ank	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ank	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Ank	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
ANKRD50	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Antp	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Antp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Antp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Antp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Antp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Antp	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Aos1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
AP-1sigma	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
AP-1sigma	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
AP-1sigma	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
AP-1sigma	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
AP-1sigma	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
AP-1sigma	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
AP-50	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
AP-50	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
AP-50	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
AP-50	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
AP-50	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
APC7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Apf	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
ap	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
ap	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ap	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
ap	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ap	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
ap	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
aph-1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
aph-1	GO:0016485_6281_2	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	IEA	biological_process
aph-1	GO:0043085_6281_1	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb]	IEA	biological_process
aPKC	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
aPKC	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
aPKC	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
aPKC	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
aPKC	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
aPKC	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
aPKC	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
aPKC	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
aPKC	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Aplip1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
APP-BP1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Appl	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Appl	GO:0008201_13174_2	heparin binding	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Appl	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Appl	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
Aprt	GO:0003999_13174_1	adenine phosphoribosyltransferase activity	"Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7]	IEA	molecular_function
Aprt	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Aprt	GO:0006168_6281_1	adenine salvage	"Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl]	IEA	biological_process
Aprt	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
Aps	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
AQR	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
AQR	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
AQR	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
AQR	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
AQR	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
aralar1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Arc42	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
Arc42	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Arc42	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Arc42	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Arc42	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Arc-p34	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Arc-p34	GO:0030833_6281_4	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	IEA	biological_process
Ard1	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
Ard1	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Argk	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
Argk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
arm	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
arm	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
armi	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
armi	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
armi	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
armi	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
armi	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
armi	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Arp11	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Arp11	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Arp11	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Arp11	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Arp1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Arp8	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
Arp8	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Arpc3A	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Arpc3A	GO:0030833_6281_4	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	IEA	biological_process
Arpc4	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Arpc4	GO:0030041_6281_1	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	IEA	biological_process
Arr1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Arr2	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
arr	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
arr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Art1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Art1	GO:0006479_6281_4	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	IEA	biological_process
Art1	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Art1	GO:0008276_13174_4	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Art3	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Art3	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Art8	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Art8	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Art8	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Art8	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Art8	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
asf1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
asf1	GO:0006333_6281_1	chromatin assembly or disassembly	"The formation or destruction of chromatin structures." [GOC:mah]	IEA	biological_process
As	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
As	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
As	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
ash1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
ash1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ash1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
ash1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
ash1	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
ash2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ash2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
asparagine-synthetase	GO:0004066_13174_2	asparagine synthase (glutamine-hydrolyzing) activity	"Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]	IEA	molecular_function
asparagine-synthetase	GO:0006529_6281_2	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	IEA	biological_process
asparagine-synthetase	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
AST	GO:0005184_13174_4	neuropeptide hormone activity	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]	IEA	molecular_function
Ate1	GO:0004057_13174_1	arginyltransferase activity	"Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8]	IEA	molecular_function
Ate1	GO:0016598_6281_1	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	IEA	biological_process
ATF-3-like	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
ATF-3-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
ATF-3-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ATF-3-like	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
ATF-3-like	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Atf6	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Atf6	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Atf6	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Atf6	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Atg1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Atg1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Atg1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Atg1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Atg1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Atg1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Atg5	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Atg5	GO:0006914_6281_3	autophagy	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464]	IEA	biological_process
Atg6	GO:0006914_6281_3	autophagy	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464]	IEA	biological_process
atl	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
atl	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ATM	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ATM	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ATM	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
Atp5a1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Atp5a1	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
Atp5a1	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Atp5a1	GO:0015992_6281_5	proton transport	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
Atp5a1	GO:0016469_3650_4	proton-transporting two-sector ATPase complex	"A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]	IEA	cellular_component
Atp5a1	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
Atp5a1	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5a1	GO:0045261_3650_4	proton-transporting ATP synthase complex, catalytic core F(1)	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5a1	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
Atp5a1	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
Atp5a1	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Atp5b	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Atp5b	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Atp5b	GO:0008553_13174_1	hydrogen-exporting ATPase activity, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6]	IEA	molecular_function
Atp5b	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
Atp5b	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Atp5b	GO:0015992_6281_5	proton transport	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
Atp5b	GO:0016469_3650_4	proton-transporting two-sector ATPase complex	"A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]	IEA	cellular_component
Atp5b	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
Atp5b	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Atp5b	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5b	GO:0045261_3650_4	proton-transporting ATP synthase complex, catalytic core F(1)	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5b	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
Atp5b	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
Atp5b	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Atp5c1	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
Atp5c1	GO:0045261_3650_4	proton-transporting ATP synthase complex, catalytic core F(1)	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5c1	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
Atp5c1	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Atp5d	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
Atp5d	GO:0045261_3650_4	proton-transporting ATP synthase complex, catalytic core F(1)	"The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5d	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
Atp5d	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Atp5f1	GO:0000276_3650_5	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]	IEA	cellular_component
Atp5f1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Atp5f1	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Atp5f1	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
ATP5G2	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
ATP5G2	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
ATP5G2	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
Atp5i	GO:0000276_3650_5	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]	IEA	cellular_component
Atp5i	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Atp5i	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
ATP7	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
ATP7	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ATP7	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
ATP7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ATP7	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
ATP7	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
ATP7	GO:0006825_6281_2	copper ion transport	"The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
ATP7	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
ATP7	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
ATP7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
ATP7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
ATP7	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
ATP7	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
ATP7	GO:0043682_13174_1	copper-transporting ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl]	IEA	molecular_function
ATP7	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
ATP7	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Atpaf1	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
Atpaf1	GO:0006461_6281_5	protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]	IEA	biological_process
Atpalpha	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Atpalpha	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Atpalpha	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Atpalpha	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Atpalpha	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Atpalpha	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Atpalpha	GO:0015077_13174_3	monovalent inorganic cation transmembrane transporter activity	"Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Atpalpha	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
Atpalpha	GO:0015672_6281_4	monovalent inorganic cation transport	"The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]	IEA	biological_process
Atpalpha	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Atpalpha	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Atpalpha	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
Atpalpha	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
ATPCL	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ATPCL	GO:0003878_13174_2	ATP citrate synthase activity	"Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163]	IEA	molecular_function
ATPCL	GO:0004775_13174_2	succinate-CoA ligase (ADP-forming) activity	"Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]	IEA	molecular_function
ATPCL	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
ATPCL	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
ATPCL	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
ATPCL	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
ATPCL	GO:0046912_13174_3	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	IEA	molecular_function
ATPsyn-Cf6	GO:0000276_3650_5	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]	IEA	cellular_component
ATPsyn-Cf6	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
ATPsyn-Cf6	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
ATPsyn-d	GO:0000276_3650_5	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]	IEA	cellular_component
ATPsyn-d	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
ATPsyn-d	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
aub	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
aub	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ave	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
awd	GO:0004550_13174_4	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	IEA	molecular_function
awd	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
awd	GO:0006165_6281_4	nucleoside diphosphate phosphorylation	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	IEA	biological_process
awd	GO:0006183_6281_4	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
awd	GO:0006228_6281_4	UTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]	IEA	biological_process
awd	GO:0006241_6281_4	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	IEA	biological_process
Awh	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Awh	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Awh	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Awh	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Awh	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Axin	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
Axin	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Axin	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Axin	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Axin	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Axin	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Axin	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
Axin	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
axo	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
axo	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
axo	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
axo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
axo	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
axo	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
axo	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
B52	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
babo	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
babo	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
babo	GO:0004675_13174_5	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	IEA	molecular_function
babo	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
babo	GO:0005024_13174_4	transforming growth factor beta-activated receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	IEA	molecular_function
babo	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
babo	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
babo	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
babo	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
baf	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Baiap3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bai	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
bai	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Bap55	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
Bap55	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Bap60	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bbg	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bbx	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
bbx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bel	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
bel	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
bel	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
bel	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
beta3GalTII	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
beta3GalTII	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
beta3GalTII	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
beta4GalNAcTA	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
beta4GalNAcTA	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
beta4GalNAcTB	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
beta4GalNAcTB	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
beta4GalT7	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
beta4GalT7	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
beta'Cop	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
betaCop	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
betaCop	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
beta'Cop	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
betaCop	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
betaCop	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
beta'Cop	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
betaCop	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
beta'Cop	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
betaCop	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
beta'Cop	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
betaCop	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
betaCop	GO:0030126_3650_3	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	IEA	cellular_component
betaggt-I	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
betaggt-II	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
beta-Spec	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
beta-Spec	GO:0005200_13174_2	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	IEA	molecular_function
beta-Spec	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
beta-Spec	GO:0008091_3650_1	spectrin	"Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]	IEA	cellular_component
Bgb	GO:0003713_13174_4	transcription coactivator activity	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
Bgb	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
bgm	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
bgm	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
bib	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
bib	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
bib	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
BicC	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
BicC	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
BicD	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
BicD	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
BicD	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
BicD	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Bili	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
bl	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Blimp-1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Blimp-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Blimp-1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Blimp-1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Blop	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Blop	GO:0007601_6281_5	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	IEA	biological_process
Blop	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
blow	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
BM-40-SPARC	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
BM-40-SPARC	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
BMS1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
BMS1	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
bol	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
bor	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
bor	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
bor	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
botv	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
botv	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
botv	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
brat	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
brat	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
brat	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Br-c	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Br-c	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Br-c	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Brd7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Brd8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Bre1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Bre1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
brm	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
brm	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
brm	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
brm	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
brm	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
brm	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
brm	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
brm	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
brm	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
brm	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
BRWD3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Bsg	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bs	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
bs	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
bsk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
bsk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
bsk	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
bsk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
bsk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
bsk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
bsk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
BTBD9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
btsz	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
btv	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
btv	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
btv	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
btv	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
btv	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
btv	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
btv	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
btv	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
btv	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
Bub3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
bun	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
bun	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
bur	GO:0003922_13174_1	GMP synthase (glutamine-hydrolyzing) activity	"Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]	IEA	molecular_function
bur	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
bur	GO:0006164_6281_4	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
bur	GO:0006177_6281_1	GMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]	IEA	biological_process
bwa	GO:0006672_6281_1	ceramide metabolic process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]	IEA	biological_process
bwa	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
bwa	GO:0016811_13174_2	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	IEA	molecular_function
bw	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
bw	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
bw	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
bw	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
bw	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Bx42	GO:0000398_6281_4	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	IEA	biological_process
Bx42	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Bx42	GO:0005681_3650_5	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]	IEA	cellular_component
Bx42	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
by	GO:0004180_13174_5	carboxypeptidase activity	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]	IEA	molecular_function
by	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
by	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
by	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
by	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Bzd	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
C1q-VP	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ca-beta	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cac	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
Cac	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Cac	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Cac	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Cac	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Cac	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Cac	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
cact1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cact2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cact3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cad99C-like	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Cad99C-like	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
Cad99C-like	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Cad99C-like	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
Cad99C-like	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
cad	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Cad	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Cad	GO:0004070_13174_1	aspartate carbamoyltransferase activity	"Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016]	IEA	molecular_function
cad	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cad	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
cad	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Cad	GO:0006207_6281_5	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	IEA	biological_process
cad	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Cad	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
Cad	GO:0006543_6281_1	glutamine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	IEA	biological_process
Cad	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
Cad	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Cad	GO:0016597_13174_5	amino acid binding	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	IEA	molecular_function
Cad	GO:0016743_13174_2	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
Cad	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Cad	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
Cad	GO:0016812_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	IEA	molecular_function
cad	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Cad	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Cad	GO:0070409_6281_1	carbamoyl phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph]	IEA	biological_process
CadN	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
CadN	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CadN	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
CadN	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
CadN	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
CadN	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Caf1-105	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Caf1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CAH1	GO:0004089_13174_3	carbonate dehydratase activity	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]	IEA	molecular_function
CAH1	GO:0006730_6281_4	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	IEA	biological_process
CAH1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Calpb	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Calpb	GO:0004198_13174_4	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	IEA	molecular_function
Calpb	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Calpb	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Calpb	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
CalpC	GO:0004198_13174_4	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	IEA	molecular_function
CalpC	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
CalpC	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Calx	GO:0005432_13174_1	calcium:sodium antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	IEA	molecular_function
Calx	GO:0006816_6281_3	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Calx	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
Calx	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Calx	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Calx	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
CaMKI	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
CaMKI	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
CaMKI	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
CaMKI	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
CaMKI	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
CaMKI	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Camkii	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Camkii	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Camkii	GO:0004683_13174_1	calmodulin-dependent protein kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]	IEA	molecular_function
Camkii	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Camkii	GO:0005516_13174_4	calmodulin binding	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	IEA	molecular_function
Camkii	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Camkii	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Camkii	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Camta	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Camta	GO:0005516_13174_4	calmodulin binding	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	IEA	molecular_function
Camta	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Camta	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
CAP-D2	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CAP-D2	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CAP-D2	GO:0007067_6281_4	mitosis	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]	IEA	biological_process
CAP-D2	GO:0030261_6281_1	chromosome condensation	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]	IEA	biological_process
Cap	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cap	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cap	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
Cap	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Cap	GO:0051276_6281_4	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
CAPN7	GO:0004198_13174_4	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	IEA	molecular_function
CAPN7	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
CAPN7	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Caps	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
capu	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
capu	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
capu	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
car	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
car	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Cas	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Cas	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cas	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Cas	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
casp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cat	GO:0004096_13174_3	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	IEA	molecular_function
Cat	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cat	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Cat	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Cat	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cat	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cat	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cat	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Cat	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cat	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Cat	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
cathD	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
cathD	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Catsup	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Catsup	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Catsup	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Catsup	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
cbc	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
cbc	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Cbp80	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Cbp80	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cbp80	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
CBP	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Cbs	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Cbs	GO:0004122_13174_1	cystathionine beta-synthase activity	"Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22]	IEA	molecular_function
Cbs	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Cbs	GO:0006535_6281_2	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	IEA	biological_process
Cbs	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Cbs	GO:0019343_6281_1	cysteine biosynthetic process via cystathionine	"The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]	IEA	biological_process
Cbs	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
CCAPR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
CCAPR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ccar1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
CCS	GO:0004784_13174_5	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1]	IEA	molecular_function
CCS	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
CCS	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
CCS	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
CCS	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Cct5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cct5	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Cct5	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
Cct5	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Cctgamma	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cctgamma	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Cctgamma	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
Cctgamma	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Cda4	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Cda4	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cda4	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Cda4	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cda4	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cda4	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
Cda5	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Cda5	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cda5	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Cda5	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cda5	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cda5	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
cdc14	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
cdc14	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
cdc14	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
cdc14	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
cdc14	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
Cdc27	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cdc2c	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
cdc2c	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
cdc2c	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
cdc2c	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
cdc2c	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
cdc2c	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
cdc2rk	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
cdc2rk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
cdc2rk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
cdc2rk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
cdc2rk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
cdc2rk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
cdc2rk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cdc42	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Cdc42	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Cdc42	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Cdc42	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Cdc42	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Cdc42	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Cdc42	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Cdc42	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Cdc42	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Cdc42	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CDC45L	GO:0006270_6281_1	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]	IEA	biological_process
Cdc6	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Cdc6	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Cdk4	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cdk4	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Cdk4	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Cdk4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cdk4	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cdk4	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cdk5alpha	GO:0016533_3650_1	cyclin-dependent protein kinase 5 holoenzyme complex	"A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]	IEA	cellular_component
Cdk5alpha	GO:0016534_13174_1	cyclin-dependent protein kinase 5 activator activity	"Increases the activity of cyclin-dependent protein kinase 5." [GOC:mah]	IEA	molecular_function
Cdk5	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cdk5	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Cdk5	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Cdk5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cdk5	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cdk5	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cdk7	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cdk7	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Cdk7	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Cdk7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cdk7	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cdk7	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cdk9	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cdk9	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Cdk9	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Cdk9	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cdk9	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cdk9	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
cdm	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CdsA	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CdsA	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Ced-12	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ced-12	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Ced-12	GO:0006909_6281_2	phagocytosis	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	IEA	biological_process
ced-6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cenB1A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cenB1A	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
cenB1A	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
cenB1A	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
cenB1A	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
cenG1A	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
cenG1A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cenG1A	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
cenG1A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
cenG1A	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
cenG1A	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
cenG1A	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
cenG1A	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
cenG1A	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
cenG1A	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
cenG1A	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
cenG1A	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
Cep97	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cetn2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Cetn2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Cetn2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cetn2	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
chb	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
chb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Chd1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Chd1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Chd1	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Chd1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Chd1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Chd1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Chd1	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Chd64	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
chif	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
chif	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
chm	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
chm	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
chm	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
chm	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
chm	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
chp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Chro	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Cht11	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Cht11	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
Cht11	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Cht11	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cht3	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Cht3	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
Cht3	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cht3	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Cht3	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cht3	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cht3	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cht5	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Cht5	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
Cht5	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cht5	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Cht5	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cht5	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cht5	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Ciao1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cib	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
cib	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
cib	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
cic	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
cic	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ci	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Ci	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Ci	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
Ci	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ci	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
Ci	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
cin	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
cin	GO:0032324_6281_1	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	IEA	biological_process
Cka	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CkIIalpha	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
CkIIalpha	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
CkIIalpha	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
CkIIalpha	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
CkIIalpha	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
CkIIalpha	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
CkIIbeta	GO:0005956_3650_1	protein kinase CK2 complex	"A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]	IEA	cellular_component
CkIIbeta	GO:0019887_13174_1	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	IEA	molecular_function
Clc	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
Clc	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Clc	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Clc	GO:0030130_3650_2	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	IEA	cellular_component
Clc	GO:0030132_3650_2	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	IEA	cellular_component
CLCN7	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
CLCN7	GO:0005247_13174_3	voltage-gated chloride channel activity	"Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
CLCN7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CLCN7	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
CLCN7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CLCN7	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Clk	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
Clk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Clk	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Clk	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
cln3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Clp	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Clp	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
c-mos	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
c-mos	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
c-mos	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
c-mos	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
c-mos	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
c-mos	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
cnc	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
cnc	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
cnc	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
cnc	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
cnir	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
cnir	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
cnk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cno	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cno	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Cog3	GO:0005801_3650_3	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	IEA	cellular_component
Cog3	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Cog3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
collier	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Con	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cope	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
cope	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cope	GO:0006890_6281_1	retrograde vesicle-mediated transport, Golgi to ER	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]	IEA	biological_process
cope	GO:0030126_3650_3	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	IEA	cellular_component
Coq2	GO:0004659_13174_3	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	IEA	molecular_function
Coq2	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
Coq2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Coq7	GO:0006744_6281_5	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	IEA	biological_process
Coq7	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Coq7	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
Coq7	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CoRest	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
CoRest	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
cort	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cox10	GO:0004659_13174_3	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	IEA	molecular_function
Cox10	GO:0008495_13174_1	protoheme IX farnesyltransferase activity	"Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [MetaCyc:HEMEOSYN-RXN]	IEA	molecular_function
Cox10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Cox10	GO:0048034_6281_1	heme O biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid]	IEA	biological_process
Cox4I1	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cox5a	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cox5b	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cox5b	GO:0005740_3650_5	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	IEA	cellular_component
Cox6a1	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cox6a1	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
Cox6a1	GO:0005751_3650_2	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
Cox6b1	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cox6b1	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
Cox6c	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
Cp190	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Cp190	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Cpap3-b	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cpap3-b	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cpap3-b	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cpap3-c	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cpap3-c	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cpap3-c	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cpap3-d	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cpap3-d	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cpap3-d	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cpap3-e	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Cpap3-e	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Cpap3-e	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cpn2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CPR13	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR14	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR15	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR17	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR18	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR19	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR1	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR20	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR22	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR23	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR24	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR25	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR26	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR27	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR28	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR2	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR3	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR4	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR5	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR7	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
CPR9	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
Cpsf160	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Cpsf160	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Cpsf73	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
CPTI	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
cpx	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
cpx	GO:0019905_13174_1	syntaxin binding	"Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	IEA	molecular_function
Cralbp	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Cralbp	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
crb	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
crb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
crc	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Crc	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Crc	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
crc	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Crc	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
crc	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
crc	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Crc	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Creb	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Creb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Creb	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Creb	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Creb	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
CREB-H-like	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
CREB-H-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
CREB-H-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
CREB-H-like	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
CREB-H-like	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Cript	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
crl	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
CRMP	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
CRMP	GO:0006208_6281_1	pyrimidine nucleobase catabolic process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators]	IEA	biological_process
CRMP	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
CRMP	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
CRMP	GO:0016812_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	IEA	molecular_function
crn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
crn	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
crn	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
croc	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
croc	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
croc	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Cry2	GO:0003913_13174_3	DNA photolyase activity	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]	IEA	molecular_function
Cry2	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Cryl1	GO:0003857_13174_2	3-hydroxyacyl-CoA dehydrogenase activity	"Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35]	IEA	molecular_function
Cryl1	GO:0006631_6281_5	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	IEA	biological_process
Cryl1	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Cryl1	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Cryl1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Crzr	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Crzr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Csat	GO:0000139_3650_4	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	IEA	cellular_component
Csat	GO:0005338_13174_1	nucleotide-sugar transmembrane transporter activity	"Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]	IEA	molecular_function
Csat	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
Csat	GO:0008643_6281_2	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	IEA	biological_process
Csat	GO:0015780_6281_1	nucleotide-sugar transport	"The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	IEA	biological_process
Csat	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Csat	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Csk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Csk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Csk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Csk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Csk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Csk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Csk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
CSN3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CSN4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CSN5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Csnk1a1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Csnk1a1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Csnk1a1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Csnk1a1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Csnk1a1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Csnk1a1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Csp	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
CstF-64	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
csul	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
csul	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
csw	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
csw	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
csw	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
csw	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
csw	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
CtBP	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
CtBP	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
CtBP	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
CtBP	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
CtBP	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CTCF	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
CTCF	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
ct	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
ct	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
ct	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ct	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
ct	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ct	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
CTL10	GO:0004896_13174_2	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	IEA	molecular_function
CTL10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CTL10	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CTL11	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL12	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL2	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
CTL2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CTL2	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
CTL2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CTL3	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL4	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL4	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
CTL4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CTL4	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
CTL5	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL6	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
CTL6	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
CTL7	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
CTL8	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
CTL8	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
CTL8	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
CTL8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CTL8	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
CTL8	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
CTR9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CT-SOD	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
CT-SOD	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
CT-SOD	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CUBN	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
CUBN	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
CUBN	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
CUBN	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
cul-2	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
cul-2	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
cul-2	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
cul-3	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
cul-3	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
cul-3	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
cul-5	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
cul-5	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
cul-5	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
CUTA	GO:0010038_6281_1	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	IEA	biological_process
cv-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cyc1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Cyc1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Cyc1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CycA	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycA	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CycA	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycA	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CycB3	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycB3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CycB3	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycB3	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CycB	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycB	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CycB	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycB	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CycC	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycC	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
CycC	GO:0016591_3650_2	DNA-directed RNA polymerase II, holoenzyme	"Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]	IEA	cellular_component
CycC	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycC	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CycD	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycD	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CycD	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycD	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CycE	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycE	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
CycE	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycE	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Cyc	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
Cyc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Cyc	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Cyc	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
CycH	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
CycH	GO:0005675_3650_1	holo TFIIH complex	"A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015]	IEA	cellular_component
CycH	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
CycH	GO:0016591_3650_2	DNA-directed RNA polymerase II, holoenzyme	"Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]	IEA	cellular_component
CycH	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
CycH	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
CYLD	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
CYLD	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
CYP15A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP15A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP15A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP15A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP15A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP18A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP18A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP18A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP18A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP18A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP301A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP301A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP301A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP301A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP301A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP302A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP302A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP302A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP302A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP302A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP303A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP303A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP303A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP303A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP303A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP305D1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP305D1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP305D1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP305D1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP305D1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP306A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP306A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP306A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP306A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP306A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP307B1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP307B1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP307B1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP307B1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP307B1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Cyp314a1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Cyp314a1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Cyp314a1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Cyp314a1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Cyp314a1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Cyp314a1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
Cyp314a1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Cyp314a1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Cyp314a1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP315A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP315A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP315A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP315A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP315A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP334A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP334A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP334A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP334A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP334A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP336A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP336A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP336A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP336A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP336A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP342A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP342A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP342A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP342A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP342A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP343A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP343A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP343A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP343A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP343A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP49A1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP49A1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP49A1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP49A1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP49A1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP4AA1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP4AA1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP4AA1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP4AA1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP4AA1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP4AV1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP4AV1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP4AV1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP4AV1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP4AV1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP4AZ1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP4AZ1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP4AZ1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP4AZ1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP4AZ1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Cyp4g11	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Cyp4g11	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Cyp4g11	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
Cyp4g11	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Cyp4g11	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AQ1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AQ1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AQ1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AQ1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AQ1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AR1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AR1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AR1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AR1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AR1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS10	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS10	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS10	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS10	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS10	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS11	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS11	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS11	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS11	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS11	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS12	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS12	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS12	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS12	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS12	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS13	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS13	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS13	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS13	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS13	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS14	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS14	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS14	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS14	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS14	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS15	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS15	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS15	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS15	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS15	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS16P	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS16P	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS16P	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS16P	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS16P	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS17	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS17	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS17	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS17	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS17	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS2	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS2	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS2	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS2	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS3	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS3	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS3	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS3	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS4	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS4	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS4	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS4	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS4	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS7	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS7	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS7	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS7	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS7	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6AS8	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6AS8	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6AS8	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6AS8	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6AS8	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6BD1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6BD1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6BD1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6BD1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6BD1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP6BE1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP6BE1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP6BE1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP6BE1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP6BE1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP9Q1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP9Q1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP9Q1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP9Q1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP9Q1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP9Q2	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP9Q2	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP9Q2	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP9Q2	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP9Q2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP9Q3	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP9Q3	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP9Q3	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP9Q3	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP9Q3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP9R1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP9R1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP9R1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP9R1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP9R1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CYP9S1	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CYP9S1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CYP9S1	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
CYP9S1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
CYP9S1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
CytC	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
CytC	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
CytC	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
DAAM	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
DAAM	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
DAAM	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
DAAM	GO:0017048_13174_3	Rho GTPase binding	"Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]	IEA	molecular_function
DAAM	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Dab	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dad	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dad	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dad	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Dad	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
Dad	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dad	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
dally	GO:0005578_3650_4	proteinaceous extracellular matrix	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
dally	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
dally	GO:0043395_13174_3	heparan sulfate proteoglycan binding	"Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]	IEA	molecular_function
Dap160	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Dap160	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dat	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
Dat	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
Dat	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
Dat	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
Dat	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Dat	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
dbo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dbp80	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Dbp80	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Dbp80	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Dbp80	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Dbx	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dbx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dbx	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dbx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dbx	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Dcp2	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Dcp2	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Dcp2	GO:0030145_13174_4	manganese ion binding	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]	IEA	molecular_function
Dcr-1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Dcr-1	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Dcr-1	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
Dcr-1	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Dcr-1	GO:0004525_13174_5	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	IEA	molecular_function
Dcr-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dcr-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Dcr-1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Dcr-1	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Dcr-1	GO:0016891_13174_3	endoribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	IEA	molecular_function
Dctn2	GO:0005869_3650_1	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	IEA	cellular_component
Dctn2	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
Dctn5	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
Dctn6	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
Ddc	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Ddc	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Ddc	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
DDX17	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
DDX17	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
DDX17	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DDX17	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Ddx1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Ddx1	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ddx1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ddx1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ddx1	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Deaf1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Deaf1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Deaf1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Deaf1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
DebB	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
DebB	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Def1	GO:0006952_6281_4	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	IEA	biological_process
Def2	GO:0006952_6281_4	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	IEA	biological_process
DEG2	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
DEG2	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
DEG2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
DEG4	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
DEG4	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
DEG4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
DEG5	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
DEG5	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
DEG5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
DEG6	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
DEG6	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
DEG6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
deltaCOP	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
deltaCOP	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
deltaCOP	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
deltaCOP	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
deltaCOP	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
Det	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Dfd	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dfd	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dfd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dfd	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dfd	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dfd	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Dg	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Dg	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Dgk-epsilon	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
Dgk-epsilon	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
Dgk-epsilon	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Dgk	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
Dgk	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Dgk	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
Dgk	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Dh31-R1	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
Dh31-R1	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
Dh31-R1	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
Dh31-R1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Dh31-R1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Dh31-R1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Dhap-at	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Dhap-at	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Dhc64C-like	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dhc64C-like	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Dhc64C-like	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
Dhc64C-like	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
Dhfr	GO:0004146_13174_1	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	IEA	molecular_function
Dhfr	GO:0006545_6281_1	glycine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
Dhfr	GO:0009165_6281_3	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
Dhfr	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Dhfr	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Dhpr	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
DHX35	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DHX35	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
DHX35	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
DHX35	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DHX35	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
DHX35	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
dia	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
dia	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
dia	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dia	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
dia	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
dia	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
dia	GO:0017048_13174_3	Rho GTPase binding	"Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]	IEA	molecular_function
dia	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Dic	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
DIP2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
DIP2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Dip-C	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Dip-C	GO:0030145_13174_4	manganese ion binding	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]	IEA	molecular_function
disco-r	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
disco-r	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
disp	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Dl-2	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dl-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dl-2	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dl-2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
DLC-A	GO:0005875_3650_3	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	IEA	cellular_component
DLC-A	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
DLC-B	GO:0005875_3650_3	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	IEA	cellular_component
DLC-B	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
DLC-D	GO:0005875_3650_3	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	IEA	cellular_component
DLC-D	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
Dl	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dl	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Dl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dl	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dl	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dl	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
Dl	GO:0007219_6281_4	Notch signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	IEA	biological_process
Dl	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Dl	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Dl	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
dlp	GO:0005578_3650_4	proteinaceous extracellular matrix	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
dlp	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
dlp	GO:0043395_13174_3	heparan sulfate proteoglycan binding	"Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]	IEA	molecular_function
DMAP1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
DMAP1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
DMAP1	GO:0045892_6281_5	negative regulation of transcription, DNA-dependent	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
DNAH1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNAH1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
DNAH1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
DNAH2	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNAH2	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
DNAH2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DNAH2	GO:0006605_6281_5	protein targeting	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	IEA	biological_process
DNAH2	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
DNAH2	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
DNAH2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
DNAH2	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
DNAH2	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
DNAH2	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
DNAH3	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNAH3	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
DNAH3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DNAH3	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
DNAH3	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
DNAH3	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
DNAH3	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
DNAH5	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNAH5	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
DNAH5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DNAH5	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
DNAH5	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
DNAH5	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
DNAH5	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
DNAH7	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNAH7	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
DNAH7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
DNAH7	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
DNAH7	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
DNAH7	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
DNAH7	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
DNApol-alpha50	GO:0003896_13174_4	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094]	IEA	molecular_function
DNApol-alpha50	GO:0006269_6281_2	DNA replication, synthesis of RNA primer	"The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402]	IEA	biological_process
DNApol-alpha60	GO:0003896_13174_4	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094]	IEA	molecular_function
DNApol-alpha60	GO:0006269_6281_2	DNA replication, synthesis of RNA primer	"The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402]	IEA	biological_process
DNApol-alpha73	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
DNApol-alpha73	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
DNApol-alpha73	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
DNApol-delta	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNApol-delta	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
DNApol-delta	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
DNApol-delta	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
DNApol-delta	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
DNApol-delta	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
DNApol-epsilon	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
DNApol-epsilon	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
DNApol-epsilon	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
DNApol-epsilon	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
DNApol-epsilon	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
DNApol-epsilon	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
DNApol-epsilon	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
DNApol-epsilon	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
DNApol-eta	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
DNApol-eta	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
DNApol-eta	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
DNApol-iota	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
DNApol-iota	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
DNApol-iota	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
DNaseII	GO:0004531_13174_1	deoxyribonuclease II activity	"Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]	IEA	molecular_function
DNaseII	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
dnc	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
dnc	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
dnc	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
dnc	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
dnk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
dnk	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
dnk	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
Dnmt1.1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dnmt1.1	GO:0003886_13174_2	DNA (cytosine-5-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]	IEA	molecular_function
Dnmt1.1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dnmt1.1	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
Dnmt1.1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dnmt1.1	GO:0090116_6281_2	C-5 methylation of cytosine	"The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]	IEA	biological_process
Dnmt1a	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dnmt1a	GO:0003886_13174_2	DNA (cytosine-5-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]	IEA	molecular_function
Dnmt1a	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dnmt1a	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
Dnmt1a	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dnmt1a	GO:0090116_6281_2	C-5 methylation of cytosine	"The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]	IEA	biological_process
Dnmt2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dnmt2	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
Dnmt3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dnmt3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dnmt3	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
Dnmt3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
dnr1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dnr1	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
dnr1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dnt	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Dnt	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Dnt	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Dnt	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Dnt	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Dnt	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
dock	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dop3	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Dop3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
DopEcR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
DopEcR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
dor	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
dor	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dor	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
dor	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
dor	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
dos	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dpck	GO:0004140_13174_1	dephospho-CoA kinase activity	"Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18248]	IEA	molecular_function
Dpck	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Dpck	GO:0015937_6281_4	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	IEA	biological_process
dp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
dp	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
dp	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
dp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dp	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
dp	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
dp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dp	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
dp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
dp	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
dp	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
dp	GO:0048544_6281_1	recognition of pollen	"The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb]	IEA	biological_process
Dph5	GO:0004164_13174_1	diphthine synthase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98]	IEA	molecular_function
Dph5	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Dph5	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Dph5	GO:0017183_6281_3	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040]	IEA	biological_process
D-PIAS	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dpit47	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dpp	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
dpp	GO:0040007_6281_3	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	IEA	biological_process
dre4	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
Drep-1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Drep-1	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
Drep-2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Drep-2	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
drk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Drl2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Drl2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Drl2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Drl2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Drl2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Drl2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Droj2	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Droj2	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
Droj2	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
drongo	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
drongo	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
drongo	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
drosha	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
drosha	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
drosha	GO:0004525_13174_5	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	IEA	molecular_function
drosha	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
drosha	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Drp1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Drp1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
drpr	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
drpr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dscam	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dscam	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
dsd	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
dsd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dsd	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Dsf	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Dsf	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Dsf	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dsf	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dsf	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dsf	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Dsf	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
dsh	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
dsh	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dsh	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
dsh	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
dsh	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Dsor1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Dsor1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Dsor1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Dsor1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Dsor1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Dsor1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Dsp1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Dsp1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dsx	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Dsx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Dsx	GO:0007548_6281_5	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	IEA	biological_process
Dsx	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Duox	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
Duox	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Duox	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Duox	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Duox	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Duox	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Duox	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Duox	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Duox	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Duox	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
dx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dx	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Dyb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dyb	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
dys	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
dys	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Dys	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
dys	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Dys	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
E2f2	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
E2f2	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
E2f2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
E74	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
E74	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
E74	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
E75	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
E75	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
E75	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
E75	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
E75	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
E75	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
E75	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Eaat-2	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Eaat-2	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
Eaat-2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Eaat-2	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
Eaat-2	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Eaat-3	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
Eaat-3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Eaat-3	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
Eaat-4	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
Eaat-4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Eaat-4	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
Eaat-5	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
Eaat-5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Eaat-5	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
eag	GO:0000155_13174_3	two-component sensor activity	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]	IEA	molecular_function
eag	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
eag	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
eag	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
eag	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
eag	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
eag	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
eag	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
eag	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
ebi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ebony	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
ebony	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ebony	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
ec	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
ec	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
ec	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
ec	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
Echs1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Echs1	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Ecr	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Ecr	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Ecr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Ecr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ecr	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ecr	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Ecr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Ect4	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ect4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ect4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Ect4	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Ect4	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Edem1	GO:0004571_13174_5	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]	IEA	molecular_function
Edem1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Edem1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Edem2	GO:0004571_13174_5	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]	IEA	molecular_function
Edem2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Edem2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
EDTP	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
EDTP	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
EDTP	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
eEF1delta	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
eEF1delta	GO:0005853_3650_3	eukaryotic translation elongation factor 1 complex	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]	IEA	cellular_component
eEF1delta	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
Ef-1a-f1	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
Ef-1a-f1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Ef-1a-f1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Ef-1a-f1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Ef-1a-f1	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
EF1a-F2	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
EF1a-F2	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
EF1a-F2	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
EF1a-F2	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
EF1a-F2	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
Ef1beta	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
Ef1beta	GO:0005853_3650_3	eukaryotic translation elongation factor 1 complex	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]	IEA	cellular_component
Ef1beta	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
egg	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
egg	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
egg	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
egg	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
egg	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
egg	GO:0034968_6281_4	histone lysine methylation	"The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah]	IEA	biological_process
Eg	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Eg	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Eg	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Eg	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Eg	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
egl	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
egl	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
egl	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
egl	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
Egm	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
Egm	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Egm	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Egm	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Eh	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
Eh	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Eh	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Eh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
eIF-1A	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
eIF-1A	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF-1A	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
EIF2AK4	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
EIF2AK4	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
EIF2AK4	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
EIF2AK4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
EIF2AK4	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
EIF2AK4	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
eIF2B-alpha	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
eIF2B-beta	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
eIF-2beta	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF-2beta	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
eIF2B-gamma	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
eIF2B-gamma	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
eIF-3p66	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF-3p66	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
eIF3-S10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
eIF3-S8	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF3-S8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
eIF3-S8	GO:0005852_3650_1	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	IEA	cellular_component
eIF3-S8	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
eIF3-S8	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
eIF3-S8	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
eIF3-S9	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
eIF3-S9	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
eIF3-S9	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF3-S9	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
eIF-4E	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
eIF-4E	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF-4E	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
eIF-4E	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
Eif4g	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Eif4g	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Eif4g	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
eIF5B	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
eIF5B	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
eIF5	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
eIF5	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
eIF5	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
eIF6	GO:0042256_6281_1	mature ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]	IEA	biological_process
eIF6	GO:0043022_13174_2	ribosome binding	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]	IEA	molecular_function
Elf	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Elf	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
elgi	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
elgi	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
elgi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
elgi	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
elgi	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
elgi	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
elgi	GO:0031386_13174_1	protein tag	"Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]	IEA	molecular_function
elk	GO:0000155_13174_3	two-component sensor activity	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]	IEA	molecular_function
elk	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
elk	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
elk	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
elk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
elk	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
elk	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
elk	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
elk	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
elk	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
elm	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
EloA	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
EloA	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
EloA	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
EloA	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
EloA	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Elongin-B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Elongin-C	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
emb	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
emb	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
emb	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
ems	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
ems	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ems	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
ems	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ems	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
enc	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
endoA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
endoA	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
endoB	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
endoB	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
En	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
En	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
En	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
En	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
En	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Ensembl Gene ID	GO Term Accession_1_1	GO Term Name	GO Term Definition	GO Term Evidence Code	GO domain
Ent1	GO:0005337_13174_3	nucleoside transmembrane transporter activity	"Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Ent1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Ent1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ent2	GO:0005337_13174_3	nucleoside transmembrane transporter activity	"Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Ent2	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Ent2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ent3	GO:0005337_13174_3	nucleoside transmembrane transporter activity	"Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Ent3	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Ent3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
EphR	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
EphR	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
EphR	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
EphR	GO:0005003_13174_1	ephrin receptor activity	"Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]	IEA	molecular_function
EphR	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
EphR	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
EphR	GO:0005887_3650_1	integral to plasma membrane	"Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]	IEA	cellular_component
EphR	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
EphR	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
EphR	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
EphR	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Eps-15	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Eps-15	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ercc1	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Ercc1	GO:0004519_13174_5	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Ercc1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Ercc1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
e(r)	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
erk7	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
erk7	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
erk7	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
erk7	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
erk7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
erk7	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
erk7	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Ero1L	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
Ero1L	GO:0006467_6281_1	protein thiol-disulfide exchange	"Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond, according to the reaction RS-SR + R'SH = R'S-SR + RSH." [GOC:jsg, GOC:mah]	IEA	biological_process
Ero1L	GO:0016671_13174_2	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	IEA	molecular_function
Ero1L	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Ero1L	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
ERp60	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
ERp60	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
ERp60	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Err	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Err	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Err	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Err	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Err	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Err	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Err	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Esyt2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Etfdh	GO:0004174_13174_1	electron-transferring-flavoprotein dehydrogenase activity	"Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1]	IEA	molecular_function
Etfdh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Etfdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ethr	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Ethr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ets97D-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Ets97D-like	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ets97D-like	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Ets97D-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ets97D-like	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
eve	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
eve	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
eve	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
eve	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
eve	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
exba	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
exd	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
exd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
exd	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
exd	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
exd	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Exn	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
Exn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Exn	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Exn	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
exo84	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Exp6	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Exp6	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Exp6	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Ext2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ext2	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
Ext2	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
eya	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
eya	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
eya	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Eyg	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Eyg	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Eyg	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Eyg	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Eyg	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Eyg	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
E(z)	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
E(z)	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Faa	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Faa	GO:0004334_13174_1	fumarylacetoacetase activity	"Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247]	IEA	molecular_function
Faa	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Faa	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
fab1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
fab1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
fab1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
fab1	GO:0016307_13174_3	phosphatidylinositol phosphate kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]	IEA	molecular_function
fab1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
fab1	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
fab1	GO:0046488_6281_3	phosphatidylinositol metabolic process	"The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]	IEA	biological_process
fab1	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Fabp	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Fabp	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Fabp	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Fabp	GO:0008289_13174_3	lipid binding	"Interacting selectively and non-covalently with a lipid." [GOC:ai]	IEA	molecular_function
faf	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
faf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Faf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
faf	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
FAR1	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
FAR1	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
FAR1	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
FAR1	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
FAR1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
FATP	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
FATP	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
fat-spondin	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
fbl	GO:0004594_13174_3	pantothenate kinase activity	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]	IEA	molecular_function
fbl	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
fbl	GO:0015937_6281_4	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	IEA	biological_process
FBN2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
FBN2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
fbp	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
fbp	GO:0042578_13174_5	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	IEA	molecular_function
Fbxl4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fdh	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Fdh	GO:0006069_6281_1	ethanol oxidation	"An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21]	IEA	biological_process
Fdh	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Fdh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Fdh	GO:0051903_13174_1	S-(hydroxymethyl)glutathione dehydrogenase activity	"Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]	IEA	molecular_function
Fdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Fdxh	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Fdxh	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Fdxh	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Fem-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fer1HCH	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
Fer1HCH	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
Fer1HCH	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Fer1HCH	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
Fer1HCH	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Fer2LCH	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
Fer2LCH	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
Fer2LCH	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Fer2LCH	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
Fer2LCH	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Fer3HCH	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
Fer3HCH	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
Fer3HCH	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Fer3HCH	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
Fer3HCH	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
ferrochelatase	GO:0004325_13174_1	ferrochelatase activity	"Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22587]	IEA	molecular_function
ferrochelatase	GO:0006783_6281_1	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl]	IEA	biological_process
Fib	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Fib	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
Fib	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
Fib	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Fibp	GO:0017134_13174_1	fibroblast growth factor binding	"Interacting selectively and non-covalently with a fibroblast growth factor." [PMID:9806903]	IEA	molecular_function
Fibroin1	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
FIG4	GO:0042578_13174_5	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	IEA	molecular_function
Fim	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
Fim	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Fim	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
FK506-bp1	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
FK506-bp2	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
FKBP59	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
FKBP59	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
flfl	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
flfl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
fliI	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
fliI	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
flr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fmr1	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
fng	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
fng	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
For	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
For	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
For	GO:0004692_13174_1	cGMP-dependent protein kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]	IEA	molecular_function
For	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
For	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
For	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
For	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
form3	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
form3	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
form3	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
foxo	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
foxo	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
foxo	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
fra	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
fra	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
fra	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
FR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
FR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
frtz	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
frtz	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Fru	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Fru	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fru	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Fru	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Fsn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fstl5	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Fstl5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ft	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
ft	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ft	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
ft	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
ft	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
ft	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
ftz-f1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
ftz-f1	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
ftz-f1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
ftz-f1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ftz-f1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
ftz-f1	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
ftz-f1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Fuca	GO:0004560_13174_1	alpha-L-fucosidase activity	"Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51]	IEA	molecular_function
Fuca	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Fuca	GO:0006004_6281_1	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	IEA	biological_process
FucT6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fucta	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
Fucta	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
Fucta	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
Fucta	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Fucta	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Fucta	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
Fucta	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Fucta	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Fucta	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
Fucta	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Fuctb	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
Fuctb	GO:0008417_13174_4	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
Fuctb	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Fuctc	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
Fuctc	GO:0008417_13174_4	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
Fuctc	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
fu	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
fu	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
fu	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
fu	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
fu	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
fu	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
fu	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Fur1	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
Fur1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
fus	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
fz2	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
fz2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
fz2	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
fz2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
fz	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
fz	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
fz	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
fz	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
fzy	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GABA-B-R1	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
GABA-B-R1	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GABA-B-R1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GABA-B-R1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GABA-B-R1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GABA-B-R2	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GABA-B-R2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GABA-B-R2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GABA-B-R3	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GABA-B-R3	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GABA-B-R3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GABA-B-R3	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GABA-B-R3	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GABA-B-R3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GABA-B-R3	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GABP-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GABPI	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Gad1	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Gad1	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Gad1	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
galectin2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
gammaCop	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
gammaCop	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
gammaCop	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gammaCop	GO:0005798_3650_1	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	IEA	cellular_component
gammaCop	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
gammaCop	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
gammaCop	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
Gapdh	GO:0006006_6281_2	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	IEA	biological_process
Gapdh	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
Gapdh	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
Gapdh	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Gapdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GARNL3	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
GARNL3	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
GARNL3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GARNL3	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
garz	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
garz	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
garz	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
garz	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
Gas41	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Gas41	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Gat-1B	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
Gat-1B	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
Gat-1B	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gat-a	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
Gat-a	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
Gat-a	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
gatA	GO:0016884_13174_4	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]	IEA	molecular_function
GB10011	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
GB10011	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB10011	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
GB10011	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
GB10020	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
GB10020	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB10038	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10047	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB10064	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB10064	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10064	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB10085	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB10085	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB10085	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB10095	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
GB10095	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
GB10095	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
GB10095	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
GB10095	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
GB10103	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
GB10125	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
GB10125	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB10125	GO:0042602_13174_1	riboflavin reductase (NADPH) activity	"Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [EC:1.5.1.30]	IEA	molecular_function
GB10125	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB10131	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB10131	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB10131	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
GB10159	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10159	GO:0006865_6281_3	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10159	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10159	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB10159	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB10167	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB10167	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB10197	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB10197	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10291	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10313	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB10313	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10313	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB10313	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10313	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB10324	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10328	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10335	GO:0008360_6281_1	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
GB10344	GO:0005740_3650_5	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	IEA	cellular_component
GB10344	GO:0006122_6281_5	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	IEA	biological_process
GB10344	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
GB10366	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10366	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
GB10375	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB10375	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10375	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB10375	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10375	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB10375	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB10401	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB10401	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB10404	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
GB10412	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10415	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10415	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB10415	GO:0031167_6281_2	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	IEA	biological_process
GB10415	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
GB10427	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10427	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10434	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10479	GO:0000156_13174_3	two-component response regulator activity	"Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]	IEA	molecular_function
GB10479	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
GB10479	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB10479	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10479	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB10479	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB10486	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10486	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10486	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB10486	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
GB10486	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
GB10486	GO:0033890_13174_1	ribonuclease D activity	"Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5]	IEA	molecular_function
GB10489	GO:0005391_13174_5	sodium:potassium-exchanging ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]	IEA	molecular_function
GB10489	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10489	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10489	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10489	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
GB10495	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB10495	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB10497	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB10497	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10518	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10536	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB10548	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB10556	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10556	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB10578	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
GB10578	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10578	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB10582	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
GB10582	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10582	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB10592	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10601	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10605	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10605	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB10605	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
GB10627	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB10627	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB10627	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10630	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10630	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10630	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10638	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10638	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
GB10639	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB10639	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
GB10656	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10656	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10656	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10656	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB10656	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10678	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10678	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10678	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10682	GO:0009166_6281_4	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
GB10682	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB10688	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB10688	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB10688	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB10688	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10697	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB10697	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10703	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB10703	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB10710	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB10710	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10710	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB10710	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB10727	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10756	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
GB10788	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB10788	GO:0003964_13174_3	RNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]	IEA	molecular_function
GB10788	GO:0006278_6281_3	RNA-dependent DNA replication	"A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB10802	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10814	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB10814	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB10814	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB10814	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB10816	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
GB10816	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
GB10816	GO:0005751_3650_2	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
GB10837	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10837	GO:0004520_13174_1	endodeoxyribonuclease activity	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB10837	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB10837	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB10837	GO:0008821_13174_1	crossover junction endodeoxyribonuclease activity	"Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4]	IEA	molecular_function
GB10847	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10847	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10847	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB10847	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB10847	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10847	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10847	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB10847	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB10847	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB10847	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB10847	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB10867	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10867	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB10868	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB10868	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
GB10879	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB10879	GO:0030695_13174_3	GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]	IEA	molecular_function
GB10885	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB10885	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB10890	GO:0015204_13174_1	urea transmembrane transporter activity	"Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732]	IEA	molecular_function
GB10890	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB10890	GO:0071918_6281_1	urea transmembrane transport	"The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	IEA	biological_process
GB10895	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10901	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10922	GO:0004357_13174_1	glutamate-cysteine ligase activity	"Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288]	IEA	molecular_function
GB10922	GO:0006750_6281_3	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732]	IEA	biological_process
GB10930	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB10930	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB10930	GO:0015074_6281_4	DNA integration	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	IEA	biological_process
GB10942	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10963	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB10975	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB10975	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB10975	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
GB10981	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB10990	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB10990	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB10990	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB10990	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB10994	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11015	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB11015	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
GB11018	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB11018	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
GB11018	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB11018	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB11018	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11018	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
GB11018	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11018	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
GB11018	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
GB11018	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB11018	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB11018	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
GB11018	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB11018	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11018	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB11044	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
GB11044	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB11081	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11081	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11090	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
GB11090	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
GB11090	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11090	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11090	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
GB11141	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11141	GO:0005664_3650_1	nuclear origin of replication recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]	IEA	cellular_component
GB11141	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB11164	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11164	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11164	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11164	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11168	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11168	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
GB11168	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB11170	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11173	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB11173	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11173	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11178	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11178	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11178	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11178	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11179	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11179	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11179	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11179	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11193	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11193	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11193	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11193	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11196	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB11207	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB11207	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11207	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11207	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11207	GO:0015074_6281_4	DNA integration	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	IEA	biological_process
GB11218	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
GB11218	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
GB11218	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
GB11218	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
GB11218	GO:0045263_3650_1	proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]	IEA	cellular_component
GB11237	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
GB11237	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB11243	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB11243	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
GB11243	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
GB11245	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB11255	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB11255	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11280	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
GB11280	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB11280	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11287	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
GB11287	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11293	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11293	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11295	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11295	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11295	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11307	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11307	GO:0003918_13174_3	DNA topoisomerase (ATP-hydrolyzing) activity	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]	IEA	molecular_function
GB11307	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB11307	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
GB11307	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
GB11314	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB11314	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB11314	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11314	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB11330	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11330	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11330	GO:0044212_13174_1	transcription regulatory region DNA binding	"Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]	IEA	molecular_function
GB11384	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB11384	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB11384	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB11384	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB11384	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB11389	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB11416	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB11416	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB11416	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11416	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB11419	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB11419	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB11419	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB11419	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB11419	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB11419	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB11424	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11424	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
GB11424	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11424	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11424	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
GB11428	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
GB11428	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
GB11442	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
GB11442	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
GB11442	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB11442	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB11474	GO:0003810_13174_3	protein-glutamine gamma-glutamyltransferase activity	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]	IEA	molecular_function
GB11474	GO:0018149_6281_3	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	IEA	biological_process
GB11481	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11491	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11491	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11491	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11491	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11491	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB11493	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB11493	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB11493	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB11501	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11523	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB11523	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11523	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
GB11524	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11524	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11524	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11524	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11524	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB11539	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB11539	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11539	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB11559	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB11559	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB11575	GO:0000150_13174_4	recombinase activity	"Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]	IEA	molecular_function
GB11575	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11575	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11575	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB11599	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB11599	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
GB11599	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB11599	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB11599	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
GB11599	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB11602	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11602	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11602	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11602	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11607	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB11620	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB11620	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB11620	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB11620	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB11620	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB11635	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11635	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11635	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11653	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11653	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB11657	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11679	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB11694	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11694	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11694	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11694	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11694	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB11709	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB11722	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB11722	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB11730	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11736	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11736	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB11736	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11736	GO:0006417_6281_1	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]	IEA	biological_process
GB11761	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB11761	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11761	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11761	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB11776	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
GB11776	GO:0008073_13174_2	ornithine decarboxylase inhibitor activity	"The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl]	IEA	molecular_function
GB11798	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB11798	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB11798	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB11798	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB11798	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB11824	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB11824	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB11824	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
GB11824	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB11833	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB11833	GO:0004523_13174_5	ribonuclease H activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	IEA	molecular_function
GB11844	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11844	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11844	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11868	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB11868	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB11871	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11880	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11880	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11880	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB11880	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11904	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11904	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11904	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11904	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11917	GO:0000150_13174_4	recombinase activity	"Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]	IEA	molecular_function
GB11917	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11917	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11917	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB11918	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11924	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11924	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11931	GO:0004127_13174_1	cytidylate kinase activity	"Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]	IEA	molecular_function
GB11931	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB11931	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB11937	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB11937	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB11937	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB11937	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11938	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB11938	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11940	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB11940	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB11942	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB11948	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
GB11968	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB11997	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB11997	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB11997	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
GB12007	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB12025	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12035	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB12035	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
GB12035	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
GB12040	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB12040	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB12040	GO:0007548_6281_5	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	IEA	biological_process
GB12040	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB12062	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB12062	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB12062	GO:0017176_13174_2	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	IEA	molecular_function
GB12064	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12064	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB12065	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB12065	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB12065	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB12065	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12082	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB12084	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12108	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12153	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12158	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB12158	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB12158	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
GB12158	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB12158	GO:0008289_13174_3	lipid binding	"Interacting selectively and non-covalently with a lipid." [GOC:ai]	IEA	molecular_function
GB12158	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12158	GO:0042157_6281_1	lipoprotein metabolic process	"The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]	IEA	biological_process
GB12159	GO:0000150_13174_4	recombinase activity	"Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]	IEA	molecular_function
GB12159	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12159	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB12168	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12177	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB12177	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB12177	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB12192	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12192	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB12192	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB12192	GO:0008170_13174_3	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	IEA	molecular_function
GB12192	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB12194	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12194	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB12204	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB12204	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB12204	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB12204	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12207	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB12207	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB12207	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB12207	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
GB12207	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB12207	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB12207	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
GB12207	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12207	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB12234	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB12234	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB12234	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB12234	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB12235	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB12235	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB12237	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB12255	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB12255	GO:0015074_6281_4	DNA integration	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	IEA	biological_process
GB12257	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB12257	GO:0035299_13174_1	inositol pentakisphosphate 2-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316]	IEA	molecular_function
GB12258	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12258	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB12265	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
GB12265	GO:0005099_13174_1	Ras GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah]	IEA	molecular_function
GB12265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12265	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12265	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB12265	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB12265	GO:0009405_6281_3	pathogenesis	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]	IEA	biological_process
GB12265	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
GB12278	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12278	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB12294	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB12328	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12378	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
GB12378	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12405	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
GB12405	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12405	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB12405	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
GB12411	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12415	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB12415	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB12415	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB12415	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12421	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12454	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB12454	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12458	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12458	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB12458	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
GB12458	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB12458	GO:0016987_13174_1	sigma factor activity	"A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH]	IEA	molecular_function
GB12471	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB12471	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12480	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12480	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12524	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB12543	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB12543	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB12543	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB12543	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB12555	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB12555	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12578	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12583	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB12583	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
GB12583	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12583	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
GB12583	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12583	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
GB12584	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12588	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12588	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12588	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12609	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB12609	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12610	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12612	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB12612	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB12612	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12645	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB12645	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB12653	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB12653	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB12657	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB12659	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB12661	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB12661	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB12661	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB12664	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB12664	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12664	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12664	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB12664	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12670	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB12670	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB12696	GO:0001682_6281_1	tRNA 5'-leader removal	"Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]	IEA	biological_process
GB12696	GO:0004526_13174_2	ribonuclease P activity	"Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]	IEA	molecular_function
GB12696	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
GB12728	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB12728	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB12728	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB12730	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
GB12730	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB12735	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12742	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
GB12742	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12757	GO:0006865_6281_3	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB12757	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB12763	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB12763	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12763	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB12763	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12776	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12783	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12802	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB12802	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB12826	GO:0004042_13174_1	acetyl-CoA:L-glutamate N-acetyltransferase activity	"Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24295]	IEA	molecular_function
GB12826	GO:0004358_13174_1	glutamate N-acetyltransferase activity	"Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15352]	IEA	molecular_function
GB12826	GO:0006526_6281_2	arginine biosynthetic process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732]	IEA	biological_process
GB12843	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB12843	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12843	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12843	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB12868	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB12868	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
GB12915	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB12928	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB12928	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB12928	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB12937	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
GB12937	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB12937	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB12937	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB12958	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB12958	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12973	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12985	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB12990	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB12993	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB12993	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13020	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB13020	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB13020	GO:0009103_6281_4	lipopolysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]	IEA	biological_process
GB13020	GO:0019143_13174_1	3-deoxy-manno-octulosonate-8-phosphatase activity	"Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11503]	IEA	molecular_function
GB13025	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB13053	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
GB13079	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB13079	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13086	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB13086	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB13086	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
GB13086	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
GB13088	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13092	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB13092	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13092	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13114	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB13114	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13120	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
GB13120	GO:0008417_13174_4	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
GB13120	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13121	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB13121	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB13121	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13121	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13131	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB13131	GO:0016861_13174_1	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]	IEA	molecular_function
GB13151	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB13151	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB13151	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
GB13162	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13163	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13163	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13163	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB13163	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13163	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB13172	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13172	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13172	GO:0008800_13174_1	beta-lactamase activity	"Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6]	IEA	molecular_function
GB13172	GO:0017001_6281_1	antibiotic catabolic process	"The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]	IEA	biological_process
GB13174	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13177	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13177	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13181	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13197	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13202	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13208	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB13212	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13212	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13215	GO:0004375_13174_1	glycine dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]	IEA	molecular_function
GB13215	GO:0006544_6281_2	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
GB13215	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB13217	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13217	GO:0005778_3650_2	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	IEA	cellular_component
GB13217	GO:0007031_6281_4	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	IEA	biological_process
GB13217	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13233	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB13233	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13233	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13244	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB13244	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13247	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB13247	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB13247	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB13247	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB13247	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB13248	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB13248	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB13248	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13248	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13250	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB13250	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
GB13250	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
GB13258	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB13258	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13258	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
GB13258	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB13267	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB13267	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
GB13267	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB13270	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13270	GO:0004519_13174_5	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB13270	GO:0009307_6281_1	DNA restriction-modification system	"A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680]	IEA	biological_process
GB13296	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13296	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB13296	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB13296	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB13306	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13316	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB13316	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB13316	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB13326	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB13326	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
GB13326	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB13352	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13352	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13352	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB13364	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB13364	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB13364	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13364	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13391	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13396	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB13396	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB13411	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
GB13411	GO:0005923_3650_3	tight junction	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]	IEA	cellular_component
GB13422	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB13428	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13428	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13438	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13439	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB13439	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB13439	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13447	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13447	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13447	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB13447	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13448	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13490	GO:0003747_13174_4	translation release factor activity	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]	IEA	molecular_function
GB13490	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB13490	GO:0006415_6281_4	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	IEA	biological_process
GB13490	GO:0016149_13174_2	translation release factor activity, codon specific	"A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]	IEA	molecular_function
GB13498	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13498	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13498	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB13498	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13498	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB13523	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13523	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13532	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB13532	GO:0045892_6281_5	negative regulation of transcription, DNA-dependent	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13541	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
GB13541	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB13547	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB13547	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB13547	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13547	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB13549	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
GB13566	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB13566	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB13566	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13566	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13574	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB13574	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB13585	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
GB13585	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13585	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13585	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
GB13586	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13590	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB13590	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB13590	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
GB13590	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB13611	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13611	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13632	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB13632	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB13632	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB13632	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13639	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB13639	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13640	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13640	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13664	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB13664	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB13671	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13671	GO:0008191_13174_1	metalloendopeptidase inhibitor activity	"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	IEA	molecular_function
GB13687	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB13694	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13694	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
GB13694	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB13694	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB13694	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
GB13694	GO:0009380_3650_1	excinuclease repair complex	"Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705]	IEA	cellular_component
GB13694	GO:0009381_13174_1	excinuclease ABC activity	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705]	IEA	molecular_function
GB13750	GO:0000775_3650_3	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	IEA	cellular_component
GB13750	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB13750	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13752	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
GB13752	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
GB13752	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13764	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13788	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13788	GO:0022904_6281_2	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	IEA	biological_process
GB13790	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13793	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13795	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB13795	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB13795	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB13795	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB13795	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB13795	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB13814	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB13854	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13874	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13874	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB13874	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB13874	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB13941	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13950	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13957	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB13957	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13973	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB13973	GO:0015269_13174_4	calcium-activated potassium channel activity	"Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	IEA	molecular_function
GB13973	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB13978	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB13978	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
GB13978	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB13978	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB13978	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB13978	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB13978	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB13983	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13984	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB13984	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB13984	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB13986	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB13986	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB13986	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB13986	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
GB13997	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
GB13997	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB13997	GO:0006461_6281_5	protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]	IEA	biological_process
GB13997	GO:0008154_6281_2	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	IEA	biological_process
GB13997	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
GB14020	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB14020	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
GB14020	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
GB14020	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
GB14036	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14036	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB14041	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14041	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB14041	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14041	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB14043	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB14043	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
GB14081	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB14081	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB14081	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14081	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB14082	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
GB14082	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
GB14082	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14090	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14090	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14090	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14120	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14120	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14134	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14134	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14134	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14147	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14155	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14155	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14155	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB14168	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14168	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14168	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14168	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
GB14168	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
GB14176	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB14179	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14181	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB14181	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB14181	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14186	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14186	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB14186	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14186	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB14196	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14204	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14204	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14213	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB14221	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GB14221	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB14225	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB14239	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14239	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB14239	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14245	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14257	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14257	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
GB14257	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB14257	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB14291	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB14291	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB14291	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB14313	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14313	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14325	GO:0005199_13174_1	structural constituent of cell wall	"The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah]	IEA	molecular_function
GB14329	GO:0005164_13174_2	tumor necrosis factor receptor binding	"Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai]	IEA	molecular_function
GB14329	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14329	GO:0006955_6281_5	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]	IEA	biological_process
GB14329	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14334	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB14334	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
GB14335	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB14335	GO:0017089_13174_2	glycolipid transporter activity	"Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
GB14335	GO:0046836_6281_2	glycolipid transport	"The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB14335	GO:0051861_13174_2	glycolipid binding	"Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1]	IEA	molecular_function
GB14336	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14336	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14336	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14339	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14339	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB14339	GO:0016776_13174_4	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	IEA	molecular_function
GB14339	GO:0019201_13174_4	nucleotide kinase activity	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]	IEA	molecular_function
GB14339	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
GB14339	GO:0046939_6281_4	nucleotide phosphorylation	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	IEA	biological_process
GB14363	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14385	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14386	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14386	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14386	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB14386	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB14386	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14387	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14387	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB14387	GO:0045893_6281_4	positive regulation of transcription, DNA-dependent	"Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB14393	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB14393	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB14393	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB14393	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14406	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14406	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14419	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
GB14430	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB14430	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB14430	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB14430	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14440	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
GB14440	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
GB14440	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
GB14440	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
GB14440	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
GB14463	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14464	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
GB14464	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB14464	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB14464	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14467	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB14467	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB14467	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB14467	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
GB14467	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
GB14467	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB14471	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB14471	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14471	GO:0019281_6281_2	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine	"The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators]	IEA	biological_process
GB14479	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14487	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
GB14487	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB14487	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14487	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
GB14487	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
GB14487	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
GB14487	GO:0007229_6281_3	integrin-mediated signaling pathway	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
GB14487	GO:0008305_3650_3	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	IEA	cellular_component
GB14487	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14504	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB14504	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
GB14504	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14504	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB14504	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
GB14515	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB14515	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
GB14516	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB14516	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14516	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB14516	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB14516	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB14519	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB14519	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
GB14532	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14536	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB14536	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB14536	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB14536	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB14536	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
GB14544	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14544	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14556	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14590	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB14590	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB14590	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14590	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB14590	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14609	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14610	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14610	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14625	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14625	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB14625	GO:0005666_3650_1	DNA-directed RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	IEA	cellular_component
GB14625	GO:0006383_6281_1	transcription from RNA polymerase III promoter	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB14635	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14635	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14655	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14657	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB14657	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB14659	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14660	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB14660	GO:0004559_13174_4	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	IEA	molecular_function
GB14660	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB14670	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB14675	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14675	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14676	GO:0005740_3650_5	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	IEA	cellular_component
GB14676	GO:0006122_6281_5	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	IEA	biological_process
GB14676	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
GB14684	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB14692	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14692	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14692	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14695	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14699	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB14699	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB14699	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB14699	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14711	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
GB14712	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14712	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB14712	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB14712	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB14712	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14712	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
GB14722	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14722	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14722	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14725	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14725	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB14725	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB14739	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB14739	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB14739	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB14739	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14746	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14748	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14761	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB14785	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14800	GO:0042393_13174_2	histone binding	"Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]	IEA	molecular_function
GB14823	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14836	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB14836	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB14836	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB14836	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB14836	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB14844	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14844	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14850	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB14854	GO:0005795_3650_4	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14854	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
GB14859	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14864	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14867	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14867	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14868	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
GB14868	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB14868	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14868	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
GB14868	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB14868	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB14868	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB14868	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14878	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14883	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB14892	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
GB14892	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB14892	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB14892	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
GB14893	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB14893	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB14893	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB14899	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB14899	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB14899	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
GB14899	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB14932	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB14932	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB14932	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB14945	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB14952	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14974	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB14974	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB14974	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB14974	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB14974	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB14994	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB14994	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB14994	GO:0008170_13174_3	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	IEA	molecular_function
GB14995	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB14995	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB14996	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB14996	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB14996	GO:0003964_13174_3	RNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]	IEA	molecular_function
GB14996	GO:0006278_6281_3	RNA-dependent DNA replication	"A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB14996	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15012	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
GB15012	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
GB15017	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15022	GO:0000150_13174_4	recombinase activity	"Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]	IEA	molecular_function
GB15022	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB15022	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15022	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB15041	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB15041	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15041	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15042	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15042	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15063	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB15074	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15074	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15074	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15074	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15078	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15112	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15112	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15112	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15112	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15125	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15138	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15146	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
GB15146	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15156	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15156	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15162	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15162	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB15162	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
GB15175	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15175	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15182	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
GB15182	GO:0008417_13174_4	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
GB15182	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15183	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15183	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB15183	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB15205	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
GB15205	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15205	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
GB15206	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB15206	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB15206	GO:0015412_13174_1	molybdate transmembrane-transporting ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29]	IEA	molecular_function
GB15206	GO:0015689_6281_1	molybdate ion transport	"The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai]	IEA	biological_process
GB15206	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
GB15208	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB15208	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB15208	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
GB15208	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15209	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB15228	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15228	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15228	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15228	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15251	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB15251	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
GB15256	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15256	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB15267	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15274	GO:0042981_6281_3	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	IEA	biological_process
GB15293	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15293	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
GB15330	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
GB15330	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB15330	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
GB15348	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB15348	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
GB15368	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
GB15368	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB15368	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15369	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB15369	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
GB15369	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB15376	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15376	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15376	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB15385	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB15385	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15385	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
GB15392	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB15392	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB15415	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
GB15415	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
GB15418	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB15418	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
GB15418	GO:0019478_6281_1	D-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]	IEA	biological_process
GB15425	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15425	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15449	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15451	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB15451	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB15456	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15456	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15456	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15456	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15484	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB15484	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15484	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
GB15491	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB15491	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15500	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB15500	GO:0004637_13174_1	phosphoribosylamine-glycine ligase activity	"Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456]	IEA	molecular_function
GB15500	GO:0004641_13174_1	phosphoribosylformylglycinamidine cyclo-ligase activity	"Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035]	IEA	molecular_function
GB15500	GO:0004644_13174_1	phosphoribosylglycinamide formyltransferase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]	IEA	molecular_function
GB15500	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB15500	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB15500	GO:0006189_6281_3	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	IEA	biological_process
GB15500	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB15500	GO:0009113_6281_2	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB15500	GO:0016742_13174_3	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]	IEA	molecular_function
GB15500	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB15515	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB15515	GO:0004540_13174_5	ribonuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB15515	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
GB15517	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
GB15517	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB15517	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15517	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
GB15517	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15522	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15533	GO:0016670_13174_1	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	IEA	molecular_function
GB15533	GO:0030328_6281_1	prenylcysteine catabolic process	"The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]	IEA	biological_process
GB15533	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15534	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15540	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15540	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15544	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
GB15556	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15570	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15570	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15571	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB15571	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15571	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15571	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB15571	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB15580	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15617	GO:0007026_6281_3	negative regulation of microtubule depolymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]	IEA	biological_process
GB15639	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15654	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB15672	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB15672	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB15672	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15672	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15672	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB15672	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB15705	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB15731	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB15739	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB15739	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15739	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15739	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15753	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15753	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
GB15766	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15766	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15801	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB15801	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15819	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB15819	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15819	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB15819	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB15821	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB15821	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB15823	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB15842	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15842	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15842	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15842	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15844	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB15844	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB15844	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB15844	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB15844	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15868	GO:0008839_13174_1	dihydrodipicolinate reductase activity	"Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26]	IEA	molecular_function
GB15868	GO:0009089_6281_1	lysine biosynthetic process via diaminopimelate	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]	IEA	biological_process
GB15868	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15868	GO:0070402_13174_1	NADPH binding	"Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
GB15879	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15891	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB15897	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
GB15897	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
GB15899	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB15899	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB15899	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB15899	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB15926	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB15926	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15926	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB15926	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB15929	GO:0000012_6281_1	single strand break repair	"The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html]	IEA	biological_process
GB15929	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
GB15929	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB15929	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB15929	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB15929	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB15929	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB15929	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB15938	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB15938	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB15938	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB15938	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB15938	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB15941	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB15951	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB15976	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB15976	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB15976	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16004	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB16004	GO:0003908_13174_2	methylated-DNA-[protein]-cysteine S-methyltransferase activity	"Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]	IEA	molecular_function
GB16004	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB16012	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16022	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16022	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16058	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16059	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16059	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16059	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16095	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB16095	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
GB16095	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB16105	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
GB16105	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16105	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16105	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
GB16116	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16116	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16116	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB16116	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16126	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB16126	GO:0004018_13174_2	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	"Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2]	IEA	molecular_function
GB16126	GO:0006188_6281_2	IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]	IEA	biological_process
GB16127	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
GB16127	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
GB16127	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16127	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16127	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
GB16131	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB16131	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16131	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16166	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB16171	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB16171	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB16171	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB16171	GO:0022900_6281_4	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]	IEA	biological_process
GB16175	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16177	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB16177	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB16177	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB16188	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16228	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16228	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB16233	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB16247	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16248	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
GB16248	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB16256	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16278	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16279	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB16279	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB16279	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB16279	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16301	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB16301	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB16301	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB16301	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16307	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16307	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16307	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16314	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16314	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB16332	GO:0000213_13174_2	tRNA-intron endonuclease activity	"Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]	IEA	molecular_function
GB16332	GO:0006388_6281_3	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	IEA	biological_process
GB16357	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB16357	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16359	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB16359	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB16359	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB16359	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16370	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB16370	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB16370	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB16391	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB16391	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB16391	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16391	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB16406	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB16428	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB16428	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16455	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16455	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB16455	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB16455	GO:0006309_6281_1	apoptotic DNA fragmentation	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:tb, ISBN:0721639976]	IEA	biological_process
GB16455	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
GB16455	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB16457	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16457	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16462	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16462	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16463	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB16463	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16467	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB16467	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB16475	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16475	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
GB16475	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB16478	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16481	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB16481	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16489	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB16489	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB16489	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16489	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB16489	GO:0015417_13174_1	polyamine-transporting ATPase activity	"Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31]	IEA	molecular_function
GB16489	GO:0015846_6281_1	polyamine transport	"The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]	IEA	biological_process
GB16489	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16489	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
GB16489	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB16489	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB16489	GO:0043190_3650_1	ATP-binding cassette (ABC) transporter complex	"A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]	IEA	cellular_component
GB16491	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16501	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
GB16501	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB16510	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB16510	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB16510	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB16510	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16518	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB16518	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16521	GO:0008444_13174_1	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12596]	IEA	molecular_function
GB16521	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
GB16521	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16521	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16521	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
GB16544	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16544	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB16544	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
GB16569	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB16573	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16581	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB16581	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB16581	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB16581	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB16581	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16596	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16609	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
GB16609	GO:0032580_3650_2	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	IEA	cellular_component
GB16610	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16610	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB16610	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB16610	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB16610	GO:0008170_13174_3	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	IEA	molecular_function
GB16610	GO:0009007_13174_2	site-specific DNA-methyltransferase (adenine-specific) activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]	IEA	molecular_function
GB16610	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
GB16610	GO:0032775_6281_2	DNA methylation on adenine	"The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf]	IEA	biological_process
GB16612	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16612	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16612	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB16622	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16631	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16652	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16672	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16672	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16672	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB16672	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16674	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB16674	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
GB16674	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
GB16674	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
GB16674	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
GB16695	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB16695	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16696	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16698	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB16698	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB16698	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB16698	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB16698	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16703	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
GB16703	GO:0042773_6281_3	ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]	IEA	biological_process
GB16703	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16709	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16709	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB16710	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB16714	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16714	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
GB16714	GO:0030272_13174_2	5-formyltetrahydrofolate cyclo-ligase activity	"Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10491]	IEA	molecular_function
GB16732	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
GB16732	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
GB16736	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB16736	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16736	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB16736	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16736	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB16736	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB16740	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16743	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB16743	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16749	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB16749	GO:0003964_13174_3	RNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]	IEA	molecular_function
GB16749	GO:0006278_6281_3	RNA-dependent DNA replication	"A DNA replication process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB16761	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB16761	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16761	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB16761	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB16769	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB16794	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB16798	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16819	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
GB16841	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16841	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16847	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16847	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16849	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB16849	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB16849	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16851	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB16851	GO:0004820_13174_2	glycine-tRNA ligase activity	"Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]	IEA	molecular_function
GB16851	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16851	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB16851	GO:0006426_6281_2	glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
GB16854	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB16855	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16855	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
GB16874	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB16874	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB16874	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB16874	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16908	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16908	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB16915	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB16915	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB16915	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB16915	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB16915	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16915	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
GB16922	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB16922	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16934	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB16934	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16938	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB16938	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB16938	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16941	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB16941	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16947	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB16947	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB16947	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB16947	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB16947	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB16947	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB16948	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16948	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB16956	GO:0004152_13174_2	dihydroorotate dehydrogenase activity	"Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076]	IEA	molecular_function
GB16956	GO:0004158_13174_2	dihydroorotate oxidase activity	"Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444]	IEA	molecular_function
GB16956	GO:0006207_6281_5	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	IEA	biological_process
GB16956	GO:0006222_6281_2	UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]	IEA	biological_process
GB16956	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB16956	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB16960	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB16960	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB16960	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB16993	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB16993	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB16993	GO:0008276_13174_4	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB16993	GO:0009236_6281_2	cobalamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB16997	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
GB16997	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB17009	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
GB17009	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB17009	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17009	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
GB17009	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB17009	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB17009	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB17009	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB17019	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB17033	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17033	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB17033	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB17046	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17048	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17048	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17048	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17048	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17048	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17053	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB17053	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17053	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17053	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17053	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB17055	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17055	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17055	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17055	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17078	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17083	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17083	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17083	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17083	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB17083	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17094	GO:0019028_3650_3	viral capsid	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]	IEA	cellular_component
GB17111	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17119	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17119	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17127	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17128	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17140	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17140	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17170	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17170	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17171	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17171	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17197	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB17197	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB17197	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB17197	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB17197	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB17205	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17205	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17213	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17213	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17227	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB17227	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
GB17232	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17232	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
GB17232	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
GB17257	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17264	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
GB17264	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB17264	GO:0008253_13174_2	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	IEA	molecular_function
GB17265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17266	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17266	GO:0045892_6281_5	negative regulation of transcription, DNA-dependent	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17296	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB17296	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17296	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
GB17297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17297	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB17297	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
GB17298	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB17298	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17310	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB17310	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17314	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
GB17314	GO:0008924_13174_1	malate dehydrogenase (quinone) activity	"Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN]	IEA	molecular_function
GB17314	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB17314	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB17318	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB17326	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17326	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
GB17332	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17332	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB17337	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB17337	GO:0003678_13174_3	DNA helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]	IEA	molecular_function
GB17337	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17337	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB17337	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB17339	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB17344	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB17344	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB17344	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB17344	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17344	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB17344	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB17382	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB17382	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB17382	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB17391	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17391	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17416	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17440	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
GB17440	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17440	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB17440	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17440	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB17440	GO:0005578_3650_4	proteinaceous extracellular matrix	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
GB17445	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17452	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
GB17452	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB17452	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB17454	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
GB17454	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
GB17454	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
GB17479	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17497	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB17497	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17497	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17497	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17527	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17527	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17527	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17527	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17527	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17527	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB17540	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17540	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB17540	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
GB17543	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17543	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17543	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17556	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB17556	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB17556	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB17556	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17556	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB17556	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB17561	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB17561	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17561	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB17561	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB17565	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB17567	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17567	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17567	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB17567	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17577	GO:0005795_3650_4	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB17577	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
GB17578	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB17578	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17578	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17578	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17578	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB17580	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB17580	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB17580	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB17580	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB17581	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB17581	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17581	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17581	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17596	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17596	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
GB17598	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB17598	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB17636	GO:0005673_3650_1	transcription factor TFIIE complex	"A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]	IEA	cellular_component
GB17636	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
GB17663	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17671	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17671	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17671	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17677	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17677	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17677	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17682	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17682	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB17682	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
GB17682	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB17697	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17698	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17704	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17715	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB17715	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17715	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB17715	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB17716	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17723	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB17723	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB17723	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB17732	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB17732	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB17732	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB17755	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
GB17755	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB17755	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17765	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB17765	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB17765	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB17765	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB17777	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB17777	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB17777	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB17808	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB17808	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
GB17808	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB17808	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
GB17814	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB17814	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
GB17814	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17814	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB17814	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17814	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
GB17814	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB17833	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
GB17833	GO:0000922_3650_5	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	IEA	cellular_component
GB17833	GO:0005815_3650_5	microtubule organizing center	"A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]	IEA	cellular_component
GB17841	GO:0007267_6281_4	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]	IEA	biological_process
GB17841	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB17857	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB17910	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB17910	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17910	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB17910	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB17910	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB17935	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB17935	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB17975	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB17997	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB18002	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18006	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
GB18006	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18022	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB18022	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB18022	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB18031	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18061	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18061	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18061	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18061	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18073	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB18079	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB18090	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18090	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18100	GO:0004489_13174_1	methylenetetrahydrofolate reductase (NADPH) activity	"Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]	IEA	molecular_function
GB18100	GO:0006555_6281_2	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB18100	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB18114	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
GB18114	GO:0006633_6281_4	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB18114	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18114	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB18114	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB18117	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18117	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB18117	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB18117	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB18117	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB18119	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18119	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB18155	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB18155	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
GB18164	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB18164	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB18164	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB18166	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18166	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18190	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18193	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18202	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18228	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
GB18237	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
GB18237	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB18237	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18237	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
GB18237	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB18237	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
GB18237	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB18237	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18246	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18246	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB18246	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB18246	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB18246	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB18246	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB18257	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18257	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18261	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
GB18261	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
GB18261	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB18261	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
GB18297	GO:0005267_13174_2	potassium channel activity	"Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB18297	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18297	GO:0071805_6281_2	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	IEA	biological_process
GB18308	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB18338	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18338	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18339	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18340	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB18340	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB18340	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18343	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18343	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB18345	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB18345	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18349	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18349	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB18349	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB18349	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
GB18351	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
GB18351	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18351	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
GB18351	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
GB18351	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
GB18361	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB18361	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18375	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18382	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18382	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB18410	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18410	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18410	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18410	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18424	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18424	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18428	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18428	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18448	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18449	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18449	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB18449	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB18449	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18451	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB18464	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18464	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18464	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18464	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18472	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
GB18509	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB18509	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18509	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB18509	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18509	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB18519	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18519	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
GB18519	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18519	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
GB18530	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18530	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB18530	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB18542	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GB18542	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GB18542	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB18551	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18551	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB18551	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18551	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB18566	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
GB18566	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18566	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB18566	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
GB18566	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
GB18573	GO:0008612_6281_2	peptidyl-lysine modification to hypusine	"The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	IEA	biological_process
GB18587	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
GB18591	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18591	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18593	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB18593	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB18593	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18593	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB18600	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18606	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18606	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB18638	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB18638	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB18638	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18638	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18665	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB18665	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB18665	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
GB18672	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB18672	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB18672	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB18672	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB18672	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB18687	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18711	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18711	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18711	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18711	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18716	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18716	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18716	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18716	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18718	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18722	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB18722	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB18736	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB18736	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18759	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB18759	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB18779	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB18779	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB18780	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18780	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18787	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18787	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18787	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18787	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18803	GO:0008430_13174_3	selenium binding	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]	IEA	molecular_function
GB18804	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB18804	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18804	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB18804	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
GB18804	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB18804	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB18811	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
GB18811	GO:0042773_6281_3	ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]	IEA	biological_process
GB18811	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB18834	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
GB18834	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB18834	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
GB18834	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
GB18853	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18866	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18876	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB18876	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18884	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB18884	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB18884	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB18884	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18884	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB18884	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
GB18885	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18885	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18909	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18909	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18909	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB18918	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB18918	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB18918	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB18918	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18918	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB18918	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB18918	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB18918	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB18925	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB18925	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB18947	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18953	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB18953	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB18961	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB18961	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB18961	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB18961	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB18980	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB18980	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB18980	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB18980	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19032	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
GB19044	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GB19044	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GB19044	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB19049	GO:0000808_3650_2	origin recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]	IEA	cellular_component
GB19049	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB19049	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB19052	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19052	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB19055	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB19055	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB19055	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB19055	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB19055	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB19063	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19067	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19098	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GB19098	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB19098	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19110	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB19127	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB19127	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB19127	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
GB19134	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB19134	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB19134	GO:0019281_6281_2	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine	"The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators]	IEA	biological_process
GB19135	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19136	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB19136	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB19136	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB19136	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB19136	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB19136	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
GB19138	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19138	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19138	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19153	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19153	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB19153	GO:0015074_6281_4	DNA integration	"The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	IEA	biological_process
GB19164	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19165	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB19165	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB19165	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB19220	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19220	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19231	GO:0009007_13174_2	site-specific DNA-methyltransferase (adenine-specific) activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]	IEA	molecular_function
GB19231	GO:0032775_6281_2	DNA methylation on adenine	"The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf]	IEA	biological_process
GB19249	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19261	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19266	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
GB19266	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
GB19266	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
GB19269	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
GB19269	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19272	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19277	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19287	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19288	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB19288	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
GB19288	GO:0004525_13174_5	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	IEA	molecular_function
GB19288	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19288	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
GB19294	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19319	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19319	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB19319	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19319	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB19323	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB19323	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB19323	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB19323	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19329	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB19329	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB19329	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB19335	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19335	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19336	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB19336	GO:0007601_6281_5	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	IEA	biological_process
GB19336	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19340	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB19340	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB19361	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
GB19365	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19367	GO:0004383_13174_4	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	IEA	molecular_function
GB19367	GO:0004590_13174_2	orotidine-5'-phosphate decarboxylase activity	"Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599]	IEA	molecular_function
GB19367	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB19367	GO:0006182_6281_4	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	IEA	biological_process
GB19367	GO:0006207_6281_5	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	IEA	biological_process
GB19367	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
GB19367	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
GB19367	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB19386	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19409	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
GB19409	GO:0005923_3650_3	tight junction	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]	IEA	cellular_component
GB19434	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB19434	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB19434	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB19434	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB19434	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB19434	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB19439	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19439	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19439	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB19439	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19440	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB19445	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB19445	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB19445	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19445	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB19451	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19451	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB19454	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB19458	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19466	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
GB19466	GO:0008255_13174_1	ecdysis-triggering hormone activity	"The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043]	IEA	molecular_function
GB19466	GO:0018990_6281_1	ecdysis, chitin-based cuticle	"The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]	IEA	biological_process
GB19470	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19470	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19470	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19472	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19496	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19496	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB19496	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB19521	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19521	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19535	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB19535	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB19535	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB19535	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19535	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19535	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB19537	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB19537	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19537	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB19537	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB19555	GO:0009228_6281_1	thiamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732]	IEA	biological_process
GB19562	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB19562	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19562	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19567	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB19567	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB19567	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB19577	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB19577	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19597	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB19597	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19615	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19617	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB19617	GO:0030151_13174_4	molybdenum ion binding	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]	IEA	molecular_function
GB19617	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB19620	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19628	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19628	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19628	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19641	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB19641	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB19647	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB19647	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19650	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19679	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19679	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB19691	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB19691	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB19703	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB19703	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB19703	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB19703	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19721	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB19721	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19721	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19764	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19768	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB19768	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
GB19814	GO:0000213_13174_2	tRNA-intron endonuclease activity	"Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]	IEA	molecular_function
GB19814	GO:0006388_6281_3	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	IEA	biological_process
GB19842	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19848	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB19848	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
GB19848	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
GB19848	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
GB19848	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19856	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB19856	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB19856	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB19881	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19881	GO:0008017_13174_2	microtubule binding	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]	IEA	molecular_function
GB19894	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB19899	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19899	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19932	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB19932	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB19932	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19944	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB19944	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB19944	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB19963	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19963	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19963	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19971	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB19971	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB19971	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB19972	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
GB19978	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB19978	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB19978	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB19978	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB19985	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
GB19985	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
GB19998	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB19998	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB19998	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB19998	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB20009	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB20009	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB20009	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB20009	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB20009	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB20016	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB20016	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB20016	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
GB20016	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB20022	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB20040	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
GB20040	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB20051	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB20051	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB20091	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB20132	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB20135	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
GB20135	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB20135	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
GB20135	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
GB20153	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30005	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB30005	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30005	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30007	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30008	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30008	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB30008	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30008	GO:0006605_6281_5	protein targeting	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	IEA	biological_process
GB30008	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
GB30008	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
GB30008	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30008	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30008	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30008	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
GB30012	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30012	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30014_2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30014_2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30014	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30014	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30015	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30019	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30021	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30021	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30022	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30022	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30022	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30022	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30024	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30024	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB30025	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30026	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB30026	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30026	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30028	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30028	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30028	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30029	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30031_2	GO:0004499_13174_4	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]	IEA	molecular_function
GB30031_2	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GB30031_2	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
GB30031_2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30031_3	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30031_3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30031	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30031	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30032	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30032	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30032	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30032	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30032	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30032	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30033	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30033	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30033	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30033	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30033	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30033	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30033	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30033	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30035	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30035	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30035	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30035	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30037	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30037	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30037	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30037	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30038	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30038	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30038	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30038	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30042	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB30045	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
GB30047	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30047	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30049	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB30049	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30050	GO:0004594_13174_3	pantothenate kinase activity	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]	IEA	molecular_function
GB30050	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30050	GO:0015937_6281_4	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	IEA	biological_process
GB30053	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30056	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30056	GO:0016798_13174_3	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	IEA	molecular_function
GB30062	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB30062	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30062	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30064	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
GB30064	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30064	GO:0005581_3650_5	collagen	"Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]	IEA	cellular_component
GB30065	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB30065	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30066	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
GB30066	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
GB30066	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30067	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30067	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30067	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30067	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30067	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30067	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30068	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB30068	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30069	GO:0015105_13174_2	arsenite transmembrane transporter activity	"Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
GB30069	GO:0015137_13174_2	citrate transmembrane transporter activity	"Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]	IEA	molecular_function
GB30069	GO:0015746_6281_2	citrate transport	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
GB30069	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30069	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30070_2	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
GB30070_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30070_2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30070_2	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
GB30070_2	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB30070	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30070	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30071	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30073	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30073	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30073	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30073	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
GB30073	GO:0034968_6281_4	histone lysine methylation	"The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah]	IEA	biological_process
GB30074	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30074	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30074	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30074	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30074	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30074	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30074	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30074	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB30075	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30077	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30077	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30077	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30077	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30077	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30077	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30079	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30080	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
GB30080	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB30080	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30082	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30083	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30083	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30083	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30083	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30083	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB30084	GO:0004649_13174_3	poly(ADP-ribose) glycohydrolase activity	"Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]	IEA	molecular_function
GB30084	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30086	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30086	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30086	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30090	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30090	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30092	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30092	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30092	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30092	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
GB30092	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30093	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
GB30093	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
GB30093	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30094	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
GB30094	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
GB30094	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30095	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30097	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30097	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30097	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30098	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30098	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30099	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30099	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30099	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30099	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30099	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30100	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB30100	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30100	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30101	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
GB30101	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30101	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30101	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30101	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB30101	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30102	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30103	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30103	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30103	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB30103	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
GB30103	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
GB30105	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30105	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30105	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30105	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
GB30106	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
GB30107	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30107	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30107	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30107	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30108	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
GB30108	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
GB30109	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30109	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30110	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30110	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
GB30110	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30110	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30110	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30110	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
GB30110	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30111	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30111	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30111	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30111	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30111	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30111	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30112	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30112	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30114	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30114	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30114	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30114	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30116	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30116	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30116	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30116	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30117	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30117	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30117	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30117	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30118	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30118	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30118	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30118	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30119	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30119	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30119	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30119	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30120	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30120	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30120	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30120	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30122	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30122	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30122	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30122	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB30122	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30122	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30123	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30123	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30123	GO:0009416_6281_1	response to light stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]	IEA	biological_process
GB30125	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
GB30125	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30125	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
GB30126	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30126	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30126	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30126	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
GB30126	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB30126	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30126	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
GB30127	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30127	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
GB30127	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30127	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
GB30127	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB30127	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30128	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30128	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30132	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30132	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30132	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30132	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30134	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30134	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30134	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30134	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30135	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30135	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30135	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30135	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30136	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30136	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30136	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30136	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30137	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30137	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30137	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30137	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30138	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30139	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB30139	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30139	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30139	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30140	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB30140	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30141	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30141	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30141	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30141	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB30141	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30142	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30142	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30142	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30142	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
GB30142	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30142	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
GB30142	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30142	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
GB30144	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30144	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30144	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30144	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30144	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30145	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30145	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30145	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30145	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30148	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30148	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30148	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30148	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30148	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30148	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB30148	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30149	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB30149	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB30149	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB30149	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30149	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30150	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30150	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30150	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30151	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30151	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30151	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30151	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30152	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30152	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30152	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30152	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30153	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30153	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30153	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30153	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30154	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30154	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30154	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30154	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30155	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30155	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30155	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30155	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30156	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30156	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30156	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30156	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30158	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30158	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30158	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30158	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30160	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30160	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30160	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30160	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30162	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30162	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB30163	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30163	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30165	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30165	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30165	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30165	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30165	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30165	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
GB30166	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30166	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30166	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
GB30166	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30167	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB30167	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30167	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
GB30168	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30168	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30168	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30168	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30174	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30174	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30174	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30174	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30175	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30175	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30175	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30175	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30176	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30176	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30176	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30176	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30178	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30178	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30178	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30178	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30185	GO:0000156_13174_3	two-component response regulator activity	"Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]	IEA	molecular_function
GB30185	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
GB30185	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30185	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
GB30185	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB30185	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30185	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30186_2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30186	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30187	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30187	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30187	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30187	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30189	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30189	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30189	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30189	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30189	GO:0016602_3650_2	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851]	IEA	cellular_component
GB30190	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30190	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30193	GO:0000123_3650_2	histone acetyltransferase complex	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]	IEA	cellular_component
GB30193	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB30193	GO:0003713_13174_4	transcription coactivator activity	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB30193	GO:0004402_13174_4	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	IEA	molecular_function
GB30193	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30193	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30193	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30193	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30193	GO:0016573_6281_2	histone acetylation	"The modification of a histone by the addition of an acetyl group." [GOC:ai]	IEA	biological_process
GB30195	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30197	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30197	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30197	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30197	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30198	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30198	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30198	GO:0007219_6281_4	Notch signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	IEA	biological_process
GB30198	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB30198	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30198	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30198	GO:0030154_6281_4	cell differentiation	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	IEA	biological_process
GB30198	GO:0050793_6281_2	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	IEA	biological_process
GB30199	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30199	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
GB30199	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
GB30199	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
GB30199	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30201	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30201	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30201	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30201	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30205	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30205	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30206	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30207	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30207	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30207	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30209	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30209	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
GB30210	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30210	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30213	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
GB30213	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
GB30213	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30213	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB30213	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
GB30214	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB30214	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30214	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
GB30215	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30215	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30215	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30215	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30215	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB30216	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30216	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30216	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30216	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30217	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30217	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30218	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB30218	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB30218	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB30218	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30218	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30219	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30219	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30219	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30219	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30222	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30222	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB30222	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30222	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30222	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB30223	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30223	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30223	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
GB30225	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30226	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30226	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
GB30226	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30226	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30226	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30226	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
GB30226	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30227_2	GO:0004096_13174_3	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	IEA	molecular_function
GB30227_2	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
GB30227_2	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30227_2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30227	GO:0004096_13174_3	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	IEA	molecular_function
GB30227	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
GB30227	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30227	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30228	GO:0006952_6281_4	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	IEA	biological_process
GB30233	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB30233	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB30233	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30233	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30233	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30233	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
GB30234	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30234	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30234	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30235	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB30235	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB30235	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB30235	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30235	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30236	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30236	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30236	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30237	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30237	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30237	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30237	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30237	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30238	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30238	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30239	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30239	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
GB30239	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
GB30239	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30239	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30239	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GB30239	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
GB30241	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30241	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30241	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30241	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30241	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30241	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30245	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30245	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30245	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30245	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30247	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30247	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30248	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
GB30248	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GB30248	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
GB30248	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30248	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30248	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30249	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30251	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30251	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30251	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30251	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30252	GO:0005184_13174_4	neuropeptide hormone activity	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]	IEA	molecular_function
GB30253	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30253	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30253	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30253	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30253	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30253	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30255	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30255	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30255	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30255	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30256	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30256	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30260	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30260	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30260	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30260	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30261	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30261	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30261	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30261	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30263	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30263	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30263	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30263	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30264	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30264	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30264	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30264	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30265	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30265	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30265	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30265	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30265	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30267	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
GB30267	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30267	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30268	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30269	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30269	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30271	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30271	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30271	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30271	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30272	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30272	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30272	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30272	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30274	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30274	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30274	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30274	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30275	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30275	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30275	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30275	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30276	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30276	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30276	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30276	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30277	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30277	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30277	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30277	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30278	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30278	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30278	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30278	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30279	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30279	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30279	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30279	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30280	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30280	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30280	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30280	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30281	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30281	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30281	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30281	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30282	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30282	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30282	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30282	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30283	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30283	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30283	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30283	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30283	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
GB30284	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30284	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30284	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30284	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30286	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30286	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30286	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30286	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30286	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30286	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30287	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30287	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30287	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30287	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30289_2	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30289_2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30289_2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30289_2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30289_2	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30289_2	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB30289_2	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30289	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30289	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
GB30289	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
GB30289	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30289	GO:0004525_13174_5	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	IEA	molecular_function
GB30289	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30289	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30289	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30289	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
GB30289	GO:0016891_13174_3	endoribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	IEA	molecular_function
GB30290	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB30290	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30290	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
GB30291	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30291	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30291	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30292	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30292	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30293	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30293	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30293	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30294	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30294	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30294	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30294	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
GB30294	GO:0045893_6281_4	positive regulation of transcription, DNA-dependent	"Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30297_2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30297_2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30297_2	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30297_2	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
GB30297	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30297	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30298	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30298	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
GB30298	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30298	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30298	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30298	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
GB30298	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30300	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
GB30300	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30300	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30300	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30301	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30301	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB30301	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30302	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30302	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB30302	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30303	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30303	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30304	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30304	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30304	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30306	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30306	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30306	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30306	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30306	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30306	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30306	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB30306	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30308	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30308	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30308	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30308	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30309	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30309	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30310	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
GB30310	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30310	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30310	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30314	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30314	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30314	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30314	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30314	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30314	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30314	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30315	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30317	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB30317	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB30317	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB30317	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30317	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30318	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30319	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB30319	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
GB30319	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
GB30320	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30320	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30321	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30321	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30322	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30322	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30322	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30322	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30322	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30322	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30323	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30323	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30323	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30323	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
GB30325	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30325	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30325	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30325	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30326	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30326	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30326	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
GB30327	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30327	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30329	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30329	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
GB30329	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30329	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30329	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30329	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30329	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB30329	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
GB30329	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30330	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30330	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30330	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30330	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30331	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
GB30331	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30331	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
GB30331	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
GB30333	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30334	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30335	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30337	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30340	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
GB30341	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
GB30341	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30341	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30341	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
GB30341	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30342	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30342	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30342	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30342	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30345	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30345	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30345	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30345	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30346	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30346	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30346	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30346	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30347	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30347	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30347	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30347	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30349	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30349	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30349	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30350	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
GB30350	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30352	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30353	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30353	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30353	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30353	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30353	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30354	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
GB30354	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30354	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30354	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30354	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
GB30354	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30358	GO:0008440_13174_5	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]	IEA	molecular_function
GB30359	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30361	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
GB30361	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
GB30361	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
GB30361	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
GB30361	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30362	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
GB30362	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30363	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30364	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30364	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30365	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30366	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30367	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30371	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30371	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30372	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30373	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30373	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30373	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30373	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30373	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30373	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30375	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30375	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30375	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30376	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30376	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30377	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30377	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30378	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30378	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB30378	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30379	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30379	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
GB30379	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30380	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
GB30380	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
GB30381	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30381	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30381	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30383	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
GB30383	GO:0008897_13174_1	holo-[acyl-carrier-protein] synthase activity	"Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]	IEA	molecular_function
GB30383	GO:0009059_6281_1	macromolecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]	IEA	biological_process
GB30384	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30384	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30384	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30384	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30385	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB30385	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30385	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB30385	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB30385	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30385	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30385	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30387	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30387	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30387	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30387	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30387	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30387	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30389	GO:0008830_13174_2	dTDP-4-dehydrorhamnose 3,5-epimerase activity	"Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16972]	IEA	molecular_function
GB30389	GO:0009103_6281_4	lipopolysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]	IEA	biological_process
GB30390	GO:0008879_13174_2	glucose-1-phosphate thymidylyltransferase activity	"Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15228]	IEA	molecular_function
GB30390	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB30390	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
GB30390	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
GB30392	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30392	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30392	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
GB30392	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
GB30392	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30392	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30392	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
GB30393	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
GB30393	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30393	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
GB30393	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
GB30397	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30397	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30397	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30397	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30399	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30399	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30402	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30402	GO:0003909_13174_3	DNA ligase activity	"Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]	IEA	molecular_function
GB30402	GO:0003910_13174_5	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	IEA	molecular_function
GB30402	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30402	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB30402	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
GB30402	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
GB30402	GO:0051103_6281_3	DNA ligation involved in DNA repair	"The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]	IEA	biological_process
GB30404	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30404	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30405	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30405	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30408	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30408	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30408	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30408	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30410	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB30410	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB30412	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30413	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30413	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30416	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30417	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30419	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
GB30420	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30420	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
GB30426	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30426	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30426	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30426	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30439	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30439	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30439	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30439	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30441	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30441	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30441	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30441	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30444	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30444	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30444	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30444	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30445	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30445	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30445	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30445	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30446	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30446	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30446	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30446	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30450	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30450	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30450	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30450	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30450	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30450	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30451	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30451	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30451	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30451	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30452	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30452	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30452	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30452	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30454	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30454	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30454	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30454	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30455	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30455	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30455	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30455	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30456	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30456	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30456	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30456	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30457	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30457	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30457	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30457	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30458_2	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
GB30458_2	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
GB30458_2	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
GB30458_2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30460	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
GB30460	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30460	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30462	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30462	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30463_2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30463_2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30463	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
GB30463	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30471	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30471	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30471	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30471	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB30471	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30471	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
GB30478	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30483	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
GB30483	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
GB30483	GO:0045980_6281_2	negative regulation of nucleotide metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]	IEA	biological_process
GB30484	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30484	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30484	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30484	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30484	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30485	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30485	GO:0016012_3650_4	sarcoglycan complex	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]	IEA	cellular_component
GB30485	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30489	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
GB30489	GO:0009435_6281_3	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	IEA	biological_process
GB30489	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
GB30492_2	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30492_2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30492_2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30492	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30492	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30492	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30493_2	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
GB30493_2	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
GB30493_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30493_2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30493_2	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
GB30504	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30504	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
GB30504	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30504	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30504	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30504	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
GB30504	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
GB30504	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30506	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30506	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
GB30506	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
GB30506	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
GB30507	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30507	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30507	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
GB30507	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30507	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30507	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30507	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30507	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB30507	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
GB30507	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
GB30508	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30508	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30508	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30508	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB30509_2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
GB30509_2	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
GB30509_2	GO:0016539_6281_1	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	IEA	biological_process
GB30509	GO:0007267_6281_4	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]	IEA	biological_process
GB30509	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
GB30510	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30511_2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30511_2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30511_2	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
GB30511_3	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
GB30511_3	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30511	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GB30511	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GB30511	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
GB30513_2	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
GB30513_2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30513_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30513_2	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
GB30513_2	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30513_2	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
GB30513_2	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB30513	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
GB30513	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
GB30513	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
GB30513	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
GB30513	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
GB30513	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB30514	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30515	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30515	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30515	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30515	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30515	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30515	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
GB30518	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30518	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30518	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30518	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30520_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30520_2	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
GB30520_2	GO:0032040_3650_5	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	IEA	cellular_component
GB30520	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30528_2	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
GB30528_2	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB30528	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
GB30528	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
GB30529	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
GB30529	GO:0003997_13174_3	acyl-CoA oxidase activity	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]	IEA	molecular_function
GB30529	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
GB30529	GO:0006631_6281_5	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	IEA	biological_process
GB30529	GO:0006635_6281_4	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	IEA	biological_process
GB30529	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30529	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GB30529	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GB30529	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GB30530_2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
GB30530_2	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30533	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30533	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30533	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30540_2	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
GB30540_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30540_2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30540_2	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
GB30540	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30541_2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30541_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30541_2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30541_2	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
GB30541	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30541	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30541	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
GB30541	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
GB30542	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
GB30543	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
GB30548	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30549	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30550	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30551_2	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
GB30551_2	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
GB30551_2	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30551	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30551	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30551	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30551	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30551	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30551	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30553	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
GB30553	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
GB30553	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30555_2	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
GB30555_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30556	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
GB30556	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GB30556	GO:0008271_13174_3	secondary active sulfate transmembrane transporter activity	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]	IEA	molecular_function
GB30556	GO:0008272_6281_3	sulfate transport	"The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
GB30556	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30556	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30556	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GB30557	GO:0005787_3650_4	signal peptidase complex	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]	IEA	cellular_component
GB30557	GO:0006465_6281_5	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	IEA	biological_process
GB30557	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
GB30557	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GB30560	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
GB30560	GO:0006366_6281_4	transcription from RNA polymerase II promoter	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	IEA	biological_process
GB30562	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30563	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
GB30567	GO:0005272_13174_9	sodium channel activity	"Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GB30567	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GB30567	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30574	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
GB30574	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
GB30574	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GB30574	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
GB30579_2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30579_2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30579_2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GB30579_2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30579_2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30579_2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30579	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GB30579	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GB30579	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GB30579	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30579	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GB30579	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GB30580_2	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB30580_2	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB30580	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30580	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
GB30580	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
GB30580	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
GB30580	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
GB30580	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
GB30582_2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
GB30583	GO:0000176_3650_2	nuclear exosome (RNase complex)	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]	IEA	cellular_component
GB30583	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30583	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
GB30583	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
GB30583	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
GB30583	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
GB30585_2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
GB30595	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
GB30595	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GB30595	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GB30595	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
GB30595	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
gbb	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
gbb	GO:0040007_6281_3	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	IEA	biological_process
Gbeta5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GC	GO:0008488_13174_1	gamma-glutamyl carboxylase activity	"Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]	IEA	molecular_function
GC	GO:0017187_6281_1	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	IEA	biological_process
GckIII	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
GckIII	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
GckIII	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
GckIII	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
GckIII	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
GckIII	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
gcl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Gdch	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
Gdch	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Gdch	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Gdch	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Gdch	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gdh	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
Gdh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Gdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ge-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gek	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
gek	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
gek	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
gek	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
gek	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
gek	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
gek	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gek	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
gek	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
gek	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
gek	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
gek	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
gek	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Gem3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Gem3	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Gem3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Gem3	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
geminin	GO:0008156_6281_1	negative regulation of DNA replication	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]	IEA	biological_process
Gfat2	GO:0004360_13174_1	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	"Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13240]	IEA	molecular_function
Gfat2	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Gfat2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Gfat2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Gfat2	GO:0016051_6281_1	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	IEA	biological_process
Gfr	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Gga	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Gga	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Gga	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Gga	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
Gga	GO:0044431_3650_2	Golgi apparatus part	"Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]	IEA	cellular_component
Ggamma1	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
Ggamma1	GO:0005834_3650_5	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]	IEA	cellular_component
Ggamma1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
g	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
g	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
g	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
g	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
g	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
gig	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
gig	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
gig	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gig	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
gig	GO:0043547_6281_1	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl]	IEA	biological_process
gig	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
Gint3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gish	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
gish	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
gish	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
gish	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
gish	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
gish	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
GlcAT-I	GO:0015018_13174_2	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]	IEA	molecular_function
GlcAT-I	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GlcAT-P	GO:0015018_13174_2	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]	IEA	molecular_function
GlcAT-P	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Gld2	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
Gld2	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
Gld2	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Gld2	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Gld2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gld	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
Gld	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
Gld	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Gld	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Gld	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Gld	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GlnS	GO:0004356_13174_2	glutamate-ammonia ligase activity	"Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]	IEA	molecular_function
GlnS	GO:0006542_6281_2	glutamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	IEA	biological_process
GlnS	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
GluCl	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
GluCl	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
GluCl	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
GluCl	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
GluCl	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
GluCl	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Glurb	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
Glurb	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Glurb	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Glut1	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Glut1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Glut1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Glut1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Glut1	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Glut1	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Glut1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
GlyP	GO:0004645_13174_1	phosphorylase activity	"Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]	IEA	molecular_function
GlyP	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
GlyP	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Gmap	GO:0000042_6281_4	protein targeting to Golgi	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]	IEA	biological_process
Gmap	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GMCOX10	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX10	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX10	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX10	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX10	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX11	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX11	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX11	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX12	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX12	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX12	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX12	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX12	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX13	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX13	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX13	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX13	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX13	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX14	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX14	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX14	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX14	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX14	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX15	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX15	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX15	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX15	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX15	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX17	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX17	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX17	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX17	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX17	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX18	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX18	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX18	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX18	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX18	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX1	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX1	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX1	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX1	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX2	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX2	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX2	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX2	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX3	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX3	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX3	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX3	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX4	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX4	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX4	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX4	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX4	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX5	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX5	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX5	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX5	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX5	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX6	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX6	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX6	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX6	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX6	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX7	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX7	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX7	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX7	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX7	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
GMCOX9	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
GMCOX9	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
GMCOX9	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
GMCOX9	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
GMCOX9	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gmer	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Gmer	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
Gmer	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
Gnf1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Gnf1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Gnf1	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
Gnf1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Gnf1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Gnf1	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
Gnf1	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Gnf1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Gos28	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Gos28	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Got2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Got2	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
Got2	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Got2	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Gp150	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Gpdh	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Gpdh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Gpdh	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Gpdh	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Gpdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gprk1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Gprk1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Gprk1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Gprk1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Gprk1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Gprk1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Gprk1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Gprk1	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
Gprk2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Gprk2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Gprk2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Gprk2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Gprk2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Gprk2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Gprk2	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
gprs	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GPS1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Gr10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gr10	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Gr1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gr1	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Gr2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gr2	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Gr3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gr3	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Gr7	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
Gr7	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
Gr7	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
Gr7	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Gr7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Gr7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Gr7	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Grd	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Grd	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Grd	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Grd	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Grd	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Grd	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Grip75	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
Grip75	GO:0000922_3650_5	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	IEA	cellular_component
Grip75	GO:0005815_3650_5	microtubule organizing center	"A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]	IEA	cellular_component
Grip84	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
Grip84	GO:0000922_3650_5	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	IEA	cellular_component
Grip84	GO:0005815_3650_5	microtubule organizing center	"A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]	IEA	cellular_component
Grip84	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Grip	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
gro	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
grp	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
grp	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
grp	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
grp	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
grp	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
grp	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Grx1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Grx1	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Grx1	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Grx2	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Grx2	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Grx2	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Grx-like1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Grx-like1	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Grx-like1	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Gsc	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Gsc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Gsc	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Gsc	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Gsc	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
GstD1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstO1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstO2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstS1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstS3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstS4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstT1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstU1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstZ1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
GstZ1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
GstZ1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
GstZ1	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
gt	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
gt	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
gt	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
gt	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Gtp-bp	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Gtp-bp	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Gtp-bp	GO:0005047_13174_1	signal recognition particle binding	"Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732]	IEA	molecular_function
Gtp-bp	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Gtp-bp	GO:0005785_3650_1	signal recognition particle receptor complex	"A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732]	IEA	cellular_component
Gtp-bp	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Gtp-bp	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
Gtp-bp	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Gtp-bp	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Gtp-bp	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Gtpx1	GO:0004602_13174_2	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]	IEA	molecular_function
Gtpx1	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Gtpx1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gtpx2	GO:0004602_13174_2	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]	IEA	molecular_function
Gtpx2	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Gtpx2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Gycbeta1	GO:0004383_13174_4	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	IEA	molecular_function
Gycbeta1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Gycbeta1	GO:0006182_6281_4	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	IEA	biological_process
Gycbeta1	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Gycbeta1	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
Gycbeta1	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Gycbeta1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Haspin	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Haspin	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Haspin	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Haspin	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
hay	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
hay	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
hay	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
hay	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
hay	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
hay	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
hay	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
hay	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Hbg2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Hbg2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Hbg2	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
Hbg3	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Hbg3	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Hbg3	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
Hb	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Hb	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Hb	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hb	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
hbn	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
hbn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
hbn	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
hbn	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
hbn	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hcf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Hcs	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Hcs	GO:0004077_13174_1	biotin-[acetyl-CoA-carboxylase] ligase activity	"Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15]	IEA	molecular_function
Hcs	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
HDAC1	GO:0004407_13174_3	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, PMID:9893272]	IEA	molecular_function
HDAC1	GO:0016575_6281_2	histone deacetylation	"The modification of histones by removal of acetyl groups." [GOC:ai]	IEA	biological_process
Hdac3	GO:0004407_13174_3	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, PMID:9893272]	IEA	molecular_function
Hdac3	GO:0016575_6281_2	histone deacetylation	"The modification of histones by removal of acetyl groups." [GOC:ai]	IEA	biological_process
HDAC4	GO:0000118_3650_1	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	IEA	cellular_component
HDAC4	GO:0004407_13174_3	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, PMID:9893272]	IEA	molecular_function
HDAC4	GO:0016568_6281_2	chromatin modification	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]	IEA	biological_process
HDAC6	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hdc	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Hdc	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Hdc	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
HEATR1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
hem	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
hem	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
hem	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
hem	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
hem	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
hem	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
heph	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
heph	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
heph	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
heph	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
HERC2	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
HERC2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
HERC2	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
HERC2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
HERC2	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
HERC2	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
HERC2	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
HERC2	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Hex110	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Hex110	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
HEX70b	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
HEX70b	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Hex70c	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Hex70c	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Hexo2	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Hexo2	GO:0004563_13174_3	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	IEA	molecular_function
Hexo2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
h	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
h	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
hgo	GO:0004411_13174_2	homogentisate 1,2-dioxygenase activity	"Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15452]	IEA	molecular_function
hgo	GO:0006559_6281_3	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	IEA	biological_process
hgo	GO:0006570_6281_2	tyrosine metabolic process	"The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	IEA	biological_process
hgo	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
hig	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Hil	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hip14	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Hip14	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hip1	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
Hip1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Hip1	GO:0005543_13174_2	phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	molecular_function
hipk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
hipk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
hipk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
hipk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
hipk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
hipk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
His2Av	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
His2Av	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
His2Av	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
His2Av	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
Hiscl1	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Hiscl1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Hiscl1	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Hiscl1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Hiscl1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Hiscl1	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Hiscl2	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Hiscl2	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Hiscl2	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Hiscl2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Hiscl2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Hiscl2	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Hk	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Hk	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Hk	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Hlc	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Hlc	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Hlc	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Hlc	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Hmgcr	GO:0004420_13174_1	hydroxymethylglutaryl-CoA reductase (NADPH) activity	"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992]	IEA	molecular_function
Hmgcr	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
Hmgcr	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
Hmgcr	GO:0015936_6281_1	coenzyme A metabolic process	"The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	IEA	biological_process
Hmgcr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Hmgcr	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Hmgcr	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
Hmgcr	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
Hmgcr	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Hmgs	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Hmgs	GO:0004421_13174_1	hydroxymethylglutaryl-CoA synthase activity	"Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191]	IEA	molecular_function
Hmgs	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Hmgs	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
Hmgs	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
Hmgs	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Hml	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Hml	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Hml	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Hml	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Hml	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Hml	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
Hmt-1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Hmt-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Hmt-1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Hmt-1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Hmt-1	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Hmt-1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Hmt-1	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Hmt-1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Hmu	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
Hmu	GO:0016844_13174_1	strictosidine synthase activity	"Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016]	IEA	molecular_function
Ho	GO:0004392_13174_1	heme oxygenase (decyclizing) activity	"Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3]	IEA	molecular_function
Ho	GO:0006788_6281_1	heme oxidation	"The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]	IEA	biological_process
Ho	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
hoip	GO:0030529_3650_4	ribonucleoprotein complex	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]	IEA	cellular_component
hoip	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
hop	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
hop	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
hop	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
hop	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
hop	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
hop	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
hop	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
hop	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
how	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
hppy	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
hppy	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
hppy	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
hppy	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
hppy	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
hppy	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
hppy	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Hr39	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr39	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr39	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr39	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr39	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr39	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr39	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr46	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr46	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr46	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr46	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr46	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr46	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr46	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr4	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr4	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr4	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr4	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr4	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr51	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr51	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr51	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr51	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr51	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr51	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr51	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr78	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr78	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr78	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr78	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr78	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr78	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr78	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr83	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr83	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr83	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr83	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr83	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hr96	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hr96	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Hr96	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hr96	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hr96	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Hr96	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Hr96	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
hrg	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
hrg	GO:0004652_13174_1	polynucleotide adenylyltransferase activity	"Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]	IEA	molecular_function
hrg	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
hrg	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
hrg	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
hrg	GO:0031123_6281_1	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	IEA	biological_process
hrg	GO:0043631_6281_1	RNA polyadenylation	"The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]	IEA	biological_process
Hrs	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hrs	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
Hrs	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Hrs	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Hs3st-A	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
Hs3st-B	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
Hsc70-5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Hsc70-5	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Hsc70-5	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Hsf	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Hsf	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Hsf	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Hsf	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Hsp90	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Hsp90	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Hsp90	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
Hsp90	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
HsTRPA	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
HsTRPA	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
HsTRPA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
HsTRPA	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
HsTRPA	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
HsTRPA	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
HsTRPA	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
HsTRPA	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
HsTRPA	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
htl	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
htl	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
htl	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
htl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
htl	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
htl	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
htl	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
HtrA2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
HtrA2	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
HtrA2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
HtrA2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
HUWE1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
HUWE1	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
HUWE1	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
hyd	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
hyd	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
hyd	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
hyd	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
hyd	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
hyd	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Hydr1	GO:0004091_13174_4	carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1]	IEA	molecular_function
Hydr2	GO:0004091_13174_4	carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1]	IEA	molecular_function
Ial	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Ial	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Ial	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Ial	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ial	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Ial	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Iap2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Iap2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Iap2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Iav	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Iav	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Iav	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Iav	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Iav	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
ics	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Idh	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
Idh	GO:0004450_13174_1	isocitrate dehydrogenase (NADP+) activity	"Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42]	IEA	molecular_function
Idh	GO:0006102_6281_1	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	IEA	biological_process
Idh	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Idh	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Idh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
IF-2mt	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
IF-2mt	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
IF-2mt	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
IF-2mt	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
IF-2mt	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
IF-2mt	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
IFT122	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IFT80	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-11	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-12	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-13	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-14	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-15	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
IGFn3-15	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-15	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
IGFn3-15	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
IGFn3-15	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
IGFn3-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
IGFn3-1	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
IGFn3-1	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
IGFn3-1	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
IGFn3-2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
IGFn3-2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
IGFn3-2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
IGFn3-2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
IGFn3-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
IGFn3-2	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
IGFn3-2	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
IGFn3-2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
IGFn3-2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
IGFn3-2	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
IGFn3-4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IGFn3-9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
igl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ik2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
ik2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
ik2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
ik2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ik2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
ik2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
IKKgamma	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
IKKgamma	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
ILP-2	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
ILP-2	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Imp	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Imp	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
ImpL2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
inaD	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
inaE	GO:0004806_13174_2	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3]	IEA	molecular_function
inaE	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
in	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Inos	GO:0004512_13174_1	inositol-3-phosphate synthase activity	"Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10719]	IEA	molecular_function
Inos	GO:0006021_6281_1	inositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684]	IEA	biological_process
Inos	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
insc	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ints12	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ints12	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
INTS8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Invadolysin	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Invadolysin	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Invadolysin	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Invadolysin	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Invadolysin	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
inx2	GO:0005921_3650_4	gap junction	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]	IEA	cellular_component
inx3	GO:0005921_3650_4	gap junction	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]	IEA	cellular_component
inx7	GO:0005921_3650_4	gap junction	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]	IEA	cellular_component
Ip3k	GO:0008440_13174_5	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]	IEA	molecular_function
Ipk2	GO:0008440_13174_5	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]	IEA	molecular_function
Ipo9	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ipo9	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Ipo9	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Ipp	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
IR-2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
IR-2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
IR-2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
IR-2	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
IR-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IR-2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
IR-2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
IR-2	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
IR-2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
IR-2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
IR-B	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
IR-B	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
IR-B	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
IR-B	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
IR-B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IR-B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
IR-B	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
IR-B	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
IR-B	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
IR-B	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ird1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
ird1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
ird1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
ird1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ird1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ird1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
ird1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ird5	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
ird5	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
ird5	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
ird5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ird5	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
ird5	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ire-1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
ire-1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
ire-1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
ire-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ire-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ire-1	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
ire-1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
ire-1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ire-1	GO:0016891_13174_3	endoribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	IEA	molecular_function
IRP30	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
IRS	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
IRS	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Iscu	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Iscu	GO:0016226_6281_4	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	IEA	biological_process
Iscu	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
isopeptidase-T-3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Iswi	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Iswi	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Iswi	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Iswi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Iswi	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Iswi	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Iswi	GO:0006338_6281_2	chromatin remodeling	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]	IEA	biological_process
Iswi	GO:0016585_3650_2	chromatin remodeling complex	"Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]	IEA	cellular_component
Iswi	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Iswi	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
Iswi	GO:0031491_13174_1	nucleosome binding	"Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	IEA	molecular_function
Iswi	GO:0043044_6281_1	ATP-dependent chromatin remodeling	"Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]	IEA	biological_process
itp	GO:0005184_13174_4	neuropeptide hormone activity	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]	IEA	molecular_function
itp	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Itpr1	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Itpr1	GO:0005262_13174_2	calcium channel activity	"Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	IEA	molecular_function
Itpr1	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Itpr1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Itpr1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Itpr1	GO:0070588_6281_3	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	IEA	biological_process
Jarid2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Jarid2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Jarid2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
jhamt	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
jhamt	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
JIL-1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
JIL-1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
JIL-1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
JIL-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
JIL-1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
JIL-1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
jim	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
jim	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
jim	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Jra	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Jra	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Jra	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Jra	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Jra	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Jtb	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Kap3	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Kap3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Kap-alpha1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Kap-alpha1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Kap-alpha1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Kap-alpha1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Kap-alpha1	GO:0006606_6281_4	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	IEA	biological_process
Kap-alpha1	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Kap-alpha1	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Kap-alpha3	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Kap-alpha3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Kap-alpha3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Kap-alpha3	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Kap-alpha3	GO:0006606_6281_4	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	IEA	biological_process
Kap-alpha3	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Kap-alpha3	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
kappaB-Ras	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
kappaB-Ras	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
kappaB-Ras	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
kappaB-Ras	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
kappaB-Ras	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
kappaB-Ras	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
kappaB-Ras	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
kappaB-Ras	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
KAT2A	GO:0004402_13174_4	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	IEA	molecular_function
KAT2A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
KAT2A	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
KAT2A	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
KAT2A	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
KAT2A	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
kat80	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Kay	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Kay	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Kay	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Kay	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Kay	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
KCNQ	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
KCNQ	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
KCNQ	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
KCNQ	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
KdelR	GO:0006621_6281_1	protein retention in ER lumen	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]	IEA	biological_process
KdelR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
KdelR	GO:0046923_13174_1	ER retention sequence binding	"Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]	IEA	molecular_function
kek1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kek2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kek6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kel	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ken	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ken	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ken	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Khc	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Khc	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Khc	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
Khc	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Khc	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
kin17	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
kin17	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
kin17	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
kin17	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
kin17	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
kinesin-11	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-11	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-11	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-12	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-12	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-12	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-13	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-13	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-13	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-14	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-14	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-14	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-2A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-2A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-2A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-2B	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-2B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-2B	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-2C	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
kinesin-2C	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-2C	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-2C	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-2C	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
kinesin-3A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-3A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kinesin-3A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-3A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-3B	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-3B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kinesin-3B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-3B	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-3C	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-3C	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kinesin-3C	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-3C	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-3D	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-3D	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kinesin-3D	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-3D	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-3D	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
kinesin-3D	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
kinesin-3E	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-3E	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-3E	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-4A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-4A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kinesin-4A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-4A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-4B	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-4B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-4B	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-5A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-5A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-5A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-5B	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-5B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-5B	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-6A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-6A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-6A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-6B	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-6B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-6B	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-7A	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-7A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-7A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-7A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-7A	GO:0051015_13174_2	actin filament binding	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	IEA	molecular_function
kinesin-8	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-8	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-8	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-9	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-9	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-9	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-A	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-A	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-A	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
kinesin-A	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
kinesin-C	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
kinesin-C	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
kinesin-C	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kinesin-C	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
kinesin-C	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
kinesin-C	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Klc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
KLHL10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
KLHL10	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
KLHL5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Knr	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Knr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Knr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Knr	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Knr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Knrl	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Knrl	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Knrl	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Knrl	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Knrl	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
kon	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
kon	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
kon	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
KPNB1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
KPNB1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
KPNB1	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
KPNB1	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Kr	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Kr	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Kr-h2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
ksr	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
ksr	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
ksr	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
ksr	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
ksr	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
ksr	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
ksr	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
kst	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
kst	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
kuz	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
kuz	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
kuz	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
kz	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
kz	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
kz	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
kz	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
kz	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
kz	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
lab	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
lab	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
lab	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
lab	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
lab	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Lac2	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
Lac2	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Lac2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
lack	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
lack	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
lack	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
lack	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Lag1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
La	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LanA	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LanA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LanB1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LanB2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LanB2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LanB2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LanB2	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
lap	GO:0005543_13174_2	phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	molecular_function
Las	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Las	GO:0009107_6281_3	lipoate biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]	IEA	biological_process
Las	GO:0016992_13174_1	lipoate synthase activity	"Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]	IEA	molecular_function
Las	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Las	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Lbx1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Lbx1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Lbx1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Lbx1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Lbx1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LCCH3	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LCCH3	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LCCH3	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LCCH3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LCCH3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LCCH3	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
ldbr	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
ldbr	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
ldbr	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
lds	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
lds	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
lds	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
lds	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
lds	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Lerp	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Lerp	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Lerp	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Lerp	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
lid	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
lid	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
lid	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
lid	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
lid	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
lid	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
lid	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
lig3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
lig3	GO:0003909_13174_3	DNA ligase activity	"Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]	IEA	molecular_function
lig3	GO:0003910_13174_5	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	IEA	molecular_function
lig3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
lig3	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
lig3	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
lig3	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
lig3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
lig3	GO:0051103_6281_3	DNA ligation involved in DNA repair	"The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]	IEA	biological_process
Lig4	GO:0003910_13174_5	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	IEA	molecular_function
Lig4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Lig4	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Lig4	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
lilli	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Lim1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Lim1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Lim1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Lim1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Lim1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Lim1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Lim3	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Lim3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Lim3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Lim3	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Lim3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Lim3	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LIMK1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LIMK1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Lis-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Lk6	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Lk6	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Lk6	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Lk6	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Lk6	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Lk6	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
lkb1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
lkb1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
lkb1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
lkb1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
lkb1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
lkb1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Lkr	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Lkr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LKR	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LKR	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Lman2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Lmpt	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC100379261	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC406081	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
LOC406081	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
LOC406081	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC406081	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC406081	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC406097	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC406097	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC406097	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC406097	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC406097	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
LOC406097	GO:0007229_6281_3	integrin-mediated signaling pathway	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC406097	GO:0008305_3650_3	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	IEA	cellular_component
LOC406097	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC406114	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC406114	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC406114	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
LOC406118	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC406132	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC406132	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC406132	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC406132	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC406132	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC406144	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC406144	GO:0042381_6281_1	hemolymph coagulation	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]	IEA	biological_process
LOC406146	GO:0004415_13174_1	hyalurononglucosaminidase activity	"Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]	IEA	molecular_function
LOC406146	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC406147	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC406147	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC406152	GO:0004301_13174_1	epoxide hydrolase activity	"Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10]	IEA	molecular_function
LOC406152	GO:0009636_6281_1	response to toxin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus." [GOC:lr]	IEA	biological_process
LOC406152	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC406152	GO:0033961_13174_1	cis-stilbene-oxide hydrolase activity	"Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]	IEA	molecular_function
LOC408265	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408265	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408272	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408272	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408274	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408275	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408282	GO:0004649_13174_3	poly(ADP-ribose) glycohydrolase activity	"Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]	IEA	molecular_function
LOC408282	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC408284	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
LOC408284	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408284	GO:0008308_13174_4	voltage-gated anion channel activity	"Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408284	GO:0044070_6281_4	regulation of anion transport	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
LOC408284	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408285	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408285	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408286	GO:0004591_13174_3	oxoglutarate dehydrogenase (succinyl-transferring) activity	"Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]	IEA	molecular_function
LOC408286	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC408286	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408286	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC408286	GO:0030976_13174_4	thiamine pyrophosphate binding	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]	IEA	molecular_function
LOC408286	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408288	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC408288	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408288	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408288	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC408288	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408291	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408291	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408291	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408292	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408299	GO:0004731_13174_1	purine-nucleoside phosphorylase activity	"Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]	IEA	molecular_function
LOC408299	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC408302	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC408302	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408302	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408302	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408302	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408302	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408305	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408305	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408305	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408305	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC408305	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408305	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC408311	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408311	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
LOC408311	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408311	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408311	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408311	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
LOC408311	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC408311	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC408314	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408315	GO:0003951_13174_4	NAD+ kinase activity	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]	IEA	molecular_function
LOC408315	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
LOC408315	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC408315	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408318	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408319	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC408319	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408319	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408319	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408319	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408319	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC408321	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408328	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
LOC408328	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC408328	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408328	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408328	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
LOC408329	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408329	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408332	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408332	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408332	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408332	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408333	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408333	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408333	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408336	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408336	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408336	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC408336	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
LOC408339	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC408339	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
LOC408339	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408339	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408339	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
LOC408340	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408340	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408340	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408343	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408343	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408343	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408343	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408343	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408343	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC408343	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408343	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408344	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408344	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC408345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408345	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408345	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408348	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408348	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408348	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC408348	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC408348	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC408349	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408349	GO:0051205_6281_2	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane." [GOC:ai]	IEA	biological_process
LOC408350	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408352	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
LOC408352	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408352	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408352	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
LOC408353	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC408353	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC408353	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC408353	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC408355	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408358	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408368	GO:0004013_13174_2	adenosylhomocysteinase activity	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]	IEA	molecular_function
LOC408368	GO:0006730_6281_4	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	IEA	biological_process
LOC408372	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC408373	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408373	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408373	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408374	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408382	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408382	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408382	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC408382	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC408384	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408384	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408384	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408386	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408387	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408388	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC408388	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408388	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC408388	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC408388	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC408388	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC408388	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC408389	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC408389	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408389	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408389	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408390	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408391	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408391	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408391	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC408391	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC408391	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
LOC408393	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408393	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408394	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC408394	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC408394	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
LOC408394	GO:0005581_3650_5	collagen	"Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]	IEA	cellular_component
LOC408394	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC408394	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408396	GO:0001726_3650_1	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	IEA	cellular_component
LOC408396	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC408396	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
LOC408396	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC408396	GO:0005200_13174_2	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	IEA	molecular_function
LOC408396	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC408396	GO:0005925_3650_2	focal adhesion	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]	IEA	cellular_component
LOC408396	GO:0007016_6281_1	cytoskeletal anchoring at plasma membrane	"A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]	IEA	biological_process
LOC408396	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC408396	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
LOC408397	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408408	GO:0007267_6281_4	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]	IEA	biological_process
LOC408411	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408411	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408413	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408417	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408417	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC408420	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408420	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408420	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408421	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408422	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408422	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408422	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408422	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC408422	GO:0015979_6281_4	photosynthesis	"The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]	IEA	biological_process
LOC408422	GO:0015995_6281_4	chlorophyll biosynthetic process	"The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]	IEA	biological_process
LOC408422	GO:0016851_13174_4	magnesium chelatase activity	"Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]	IEA	molecular_function
LOC408422	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC408422	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC408428	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC408428	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC408431	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408432	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
LOC408432	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
LOC408432	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408433	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408439	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408439	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408441	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408443	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC408443	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408443	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408443	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408443	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC408445	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC408445	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC408445	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC408445	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC408445	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC408445	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC408445	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408446	GO:0003994_13174_1	aconitate hydratase activity	"Catalysis of the reactions: citrate = cis-aconitate + H2O, and cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]	IEA	molecular_function
LOC408446	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC408446	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408446	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC408456	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC408456	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408456	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408456	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408456	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408456	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408461	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408461	GO:0004588_13174_1	orotate phosphoribosyltransferase activity	"Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]	IEA	molecular_function
LOC408461	GO:0004590_13174_2	orotidine-5'-phosphate decarboxylase activity	"Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11599]	IEA	molecular_function
LOC408461	GO:0006207_6281_5	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	IEA	biological_process
LOC408461	GO:0006221_6281_2	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC408461	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408461	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
LOC408461	GO:0044205_6281_1	'de novo' UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl]	IEA	biological_process
LOC408464	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408465	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408465	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC408467	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC408467	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408467	GO:0005247_13174_3	voltage-gated chloride channel activity	"Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408467	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408467	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408467	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC408467	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408467	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408470	GO:0003951_13174_4	NAD+ kinase activity	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]	IEA	molecular_function
LOC408470	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408471	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC408471	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408471	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
LOC408474	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408474	GO:0009166_6281_4	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
LOC408474	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408474	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC408474	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC408478	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408478	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408478	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408483	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408483	GO:0016052_6281_1	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	IEA	biological_process
LOC408483	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC408497	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408497	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408497	GO:0005635_3650_3	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	IEA	cellular_component
LOC408503	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408507	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408510	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408519	GO:0004499_13174_4	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]	IEA	molecular_function
LOC408519	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408519	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408519	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408519	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408519	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408519	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408519	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC408519	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
LOC408519	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408520	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408522	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408522	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408522	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC408522	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC408522	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408528	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408532	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408533	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408533	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408533	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408533	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408533	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408533	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408533	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408535	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408535	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408535	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408535	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408535	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC408536	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC408536	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC408536	GO:0008241_13174_4	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC408536	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408538	GO:0003848_13174_2	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	"Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415]	IEA	molecular_function
LOC408538	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
LOC408539	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408539	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408539	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408539	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408542	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408542	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408543	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408543	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408546	GO:0042578_13174_5	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	IEA	molecular_function
LOC408548	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408548	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408551	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
LOC408551	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408551	GO:0005581_3650_5	collagen	"Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]	IEA	cellular_component
LOC408552	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC408552	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
LOC408552	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408552	GO:0005581_3650_5	collagen	"Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]	IEA	cellular_component
LOC408552	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408552	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408552	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408552	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC408557	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC408557	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC408558	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC408558	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC408559	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408559	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408559	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408562	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408562	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC408564	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408564	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408565	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408565	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408565	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408567	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC408567	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408567	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408567	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC408567	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408568	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC408568	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408568	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408568	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408568	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408569	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408570	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408577	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408577	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408577	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408577	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC408578	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408578	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408579	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC408579	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC408579	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC408580	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC408580	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC408580	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC408590	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408590	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408591	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408591	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408591	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408591	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408591	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408591	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408591	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC408591	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408591	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC408597	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408597	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408600	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408601	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408601	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408601	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408602	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408604	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC408604	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408604	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC408607	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC408614	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC408614	GO:0030141_3650_2	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]	IEA	cellular_component
LOC408615	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408615	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408615	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408615	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC408615	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC408617	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408617	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408618	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC408618	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
LOC408618	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408618	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408618	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408618	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC408618	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
LOC408618	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408619	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC408619	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC408619	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408620	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408621	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC408622	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
LOC408622	GO:0004505_13174_1	phenylalanine 4-monooxygenase activity	"Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1]	IEA	molecular_function
LOC408622	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC408622	GO:0006559_6281_3	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	IEA	biological_process
LOC408622	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408622	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
LOC408622	GO:0016597_13174_5	amino acid binding	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	IEA	molecular_function
LOC408622	GO:0016714_13174_4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
LOC408622	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408625	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408625	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408625	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408625	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408625	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408625	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408625	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408625	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408625	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC408625	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408625	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408626	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408626	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC408626	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
LOC408626	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC408626	GO:0004535_13174_1	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	IEA	molecular_function
LOC408626	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408626	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408626	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408626	GO:0006402_6281_1	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	IEA	biological_process
LOC408626	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
LOC408626	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC408631	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408632	GO:0000398_6281_4	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	IEA	biological_process
LOC408632	GO:0005681_3650_5	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]	IEA	cellular_component
LOC408633	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408633	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408634	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408634	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408635	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408642	GO:0003951_13174_4	NAD+ kinase activity	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]	IEA	molecular_function
LOC408642	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408643	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408643	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408645	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC408645	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408645	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408646	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408646	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408648	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408648	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408649	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408650	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC408650	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408650	GO:0019310_6281_1	inositol catabolic process	"The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators]	IEA	biological_process
LOC408650	GO:0050113_13174_1	inositol oxygenase activity	"Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699]	IEA	molecular_function
LOC408650	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408656	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408656	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408656	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408656	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408657	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408657	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408661	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408661	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408668	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408668	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC408668	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC408670	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408672	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408674	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408674	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408678	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408678	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408687	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408687	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC408687	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC408688	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408690	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408690	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408693	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408693	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408693	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC408695	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC408695	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC408696	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC408696	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC408697	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408699	GO:0000156_13174_3	two-component response regulator activity	"Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]	IEA	molecular_function
LOC408699	GO:0000160_6281_6	two-component signal transduction system (phosphorelay)	"A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]	IEA	biological_process
LOC408699	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408699	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
LOC408699	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC408699	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408699	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408701	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408701	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC408701	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC408701	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC408705	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408705	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC408707	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408707	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408708	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC408710	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC408711	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408711	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408711	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408714	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408715	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408718	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408718	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408718	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408718	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
LOC408718	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408718	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408718	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408718	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
LOC408718	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408718	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408719	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408721	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408722	GO:0005391_13174_5	sodium:potassium-exchanging ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]	IEA	molecular_function
LOC408722	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408722	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408722	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408722	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
LOC408724	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408725	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408725	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408725	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC408727	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408727	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408729	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC408729	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC408729	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408730	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC408731	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408731	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408734	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC408734	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC408734	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408734	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC408734	GO:0022900_6281_4	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]	IEA	biological_process
LOC408734	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC408734	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408742	GO:0016884_13174_4	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]	IEA	molecular_function
LOC408749	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408749	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408749	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC408749	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC408751	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408751	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408751	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC408752	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408752	GO:0003909_13174_3	DNA ligase activity	"Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]	IEA	molecular_function
LOC408752	GO:0003910_13174_5	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	IEA	molecular_function
LOC408752	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408752	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC408752	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC408752	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
LOC408752	GO:0051103_6281_3	DNA ligation involved in DNA repair	"The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]	IEA	biological_process
LOC408754	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408754	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408754	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408754	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408754	GO:0042981_6281_3	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	IEA	biological_process
LOC408767	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC408767	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC408767	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC408767	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC408767	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408773	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408774	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408774	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408774	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408774	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
LOC408775	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408780	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC408780	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408780	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408780	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC408780	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC408782	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC408782	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408782	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC408782	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC408782	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC408782	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC408782	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC408785	GO:0004719_13174_3	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	IEA	molecular_function
LOC408785	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC408787	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408787	GO:0042802_13174_2	identical protein binding	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]	IEA	molecular_function
LOC408788	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408788	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408789	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC408789	GO:0040007_6281_3	growth	"The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]	IEA	biological_process
LOC408792	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC408799	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC408799	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408799	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC408799	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC408803	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408805	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408809	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408809	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
LOC408809	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408809	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408809	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC408809	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408809	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC408810	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC408810	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408810	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408810	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408810	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC408810	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC408817	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC408817	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408818	GO:0004396_13174_2	hexokinase activity	"Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]	IEA	molecular_function
LOC408818	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408818	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC408818	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC408818	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408820	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408822	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408822	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408822	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408822	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408828	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408828	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408831	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC408831	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408833	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408836	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408840	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408840	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408840	GO:0004534_13174_1	5'-3' exoribonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC408840	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408840	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC408840	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC408840	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408841	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408841	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408842	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408842	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408842	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC408842	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC408843	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408847	GO:0004852_13174_1	uroporphyrinogen-III synthase activity	"Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]	IEA	molecular_function
LOC408847	GO:0033014_6281_4	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]	IEA	biological_process
LOC408850	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408850	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408850	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC408851	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC408851	GO:0004869_13174_1	cysteine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]	IEA	molecular_function
LOC408851	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC408851	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC408852	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC408852	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408852	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408852	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408857	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408859	GO:0004735_13174_2	pyrroline-5-carboxylate reductase activity	"Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]	IEA	molecular_function
LOC408859	GO:0006561_6281_4	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	IEA	biological_process
LOC408859	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408859	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408860	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408860	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408860	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408863	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC408864	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC408864	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC408865	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC408865	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408865	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408865	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408866	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408866	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408866	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408866	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408866	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408868	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC408870	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408870	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408870	GO:0006479_6281_4	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	IEA	biological_process
LOC408870	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC408870	GO:0008276_13174_4	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408870	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC408871	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408871	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408871	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408878	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
LOC408883	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408883	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408883	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408883	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC408884	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408884	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408887	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408888	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408889	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408892	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408892	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408894	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408900	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC408900	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC408900	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC408900	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC408902	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408904	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408904	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408904	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408904	GO:0032934_13174_3	sterol binding	"Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]	IEA	molecular_function
LOC408911	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC408911	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC408913	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC408913	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC408913	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC408913	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408913	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC408913	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408913	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408914	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408914	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC408914	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408920	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408920	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408922	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC408922	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC408922	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC408922	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC408922	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC408922	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408923	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC408923	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC408923	GO:0005669_3650_3	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	IEA	cellular_component
LOC408923	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC408923	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC408925	GO:0006479_6281_4	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	IEA	biological_process
LOC408925	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC408932	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408933	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408933	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408933	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC408934	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC408935	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC408935	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC408935	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408935	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408936	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC408938	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408938	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC408939	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC408944	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408945	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408945	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC408945	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408945	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC408949	GO:0000159_3650_3	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	IEA	cellular_component
LOC408949	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408949	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC408949	GO:0008601_13174_3	protein phosphatase type 2A regulator activity	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]	IEA	molecular_function
LOC408950	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC408950	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC408950	GO:0006108_6281_3	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC408950	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC408950	GO:0016615_13174_3	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	IEA	molecular_function
LOC408950	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC408950	GO:0030060_13174_2	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	IEA	molecular_function
LOC408950	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC408950	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408953	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC408953	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
LOC408953	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC408953	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC408955	GO:0003867_13174_1	4-aminobutyrate transaminase activity	"Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]	IEA	molecular_function
LOC408955	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC408955	GO:0009448_6281_1	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	IEA	biological_process
LOC408955	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC408963	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC408963	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC408963	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC408963	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC408964	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC408964	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC408966	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC408968	GO:0004408_13174_1	holocytochrome-c synthase activity	"Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17]	IEA	molecular_function
LOC408968	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC408969	GO:0004046_13174_1	aminoacylase activity	"Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]	IEA	molecular_function
LOC408969	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC408969	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC408969	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC408969	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC408969	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC408969	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC408983	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC408983	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
LOC408983	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC408983	GO:0030127_3650_3	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	IEA	cellular_component
LOC408985	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC408985	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408989	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC408989	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC408990	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC408992	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
LOC408992	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC408992	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC408992	GO:0030301_6281_2	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409000	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409011	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC409011	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409021	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC409021	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409021	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409023	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC409023	GO:0044249_6281_2	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC409027	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409039	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409043	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409043	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409043	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409043	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409046	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409046	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409046	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409046	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409056	GO:0005315_13174_1	inorganic phosphate transmembrane transporter activity	"Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]	IEA	molecular_function
LOC409056	GO:0006817_6281_1	phosphate ion transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC409056	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409058	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409058	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409058	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409061	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409061	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409061	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409061	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409061	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409061	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409061	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC409061	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409061	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409062	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409063	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
LOC409063	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
LOC409063	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409064	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409065	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409066	GO:0004733_13174_2	pyridoxamine-phosphate oxidase activity	"Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]	IEA	molecular_function
LOC409066	GO:0008615_6281_1	pyridoxine biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]	IEA	biological_process
LOC409066	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
LOC409066	GO:0016638_13174_2	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC409066	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409068	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409068	GO:0005544_13174_4	calcium-dependent phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	IEA	molecular_function
LOC409071	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409071	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409074	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC409074	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC409074	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC409075	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409075	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409076	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC409076	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC409077	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC409077	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409079	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC409079	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC409079	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409079	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC409081	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409081	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409082	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409083	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409083	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409084	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409084	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC409084	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409084	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409084	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409084	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC409087	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409087	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409090	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
LOC409090	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC409090	GO:0045980_6281_2	negative regulation of nucleotide metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]	IEA	biological_process
LOC409100	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409100	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC409102	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC409102	GO:0017150_13174_4	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]	IEA	molecular_function
LOC409102	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC409102	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409106	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409107	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409111	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409111	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409111	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409111	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409111	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409111	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409112	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC409112	GO:0004809_13174_1	tRNA (guanine-N2-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]	IEA	molecular_function
LOC409112	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC409126	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409126	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409126	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409126	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409126	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409126	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409126	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409126	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC409126	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409126	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409126	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC409126	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409126	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409127	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409127	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409127	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409127	GO:0004715_13174_2	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]	IEA	molecular_function
LOC409127	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409127	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409127	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409127	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409129	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC409129	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409129	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC409129	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC409131	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409131	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409132	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409132	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC409132	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC409134	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409134	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC409134	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
LOC409134	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC409136	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC409137	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409139	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409141	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409144	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409144	GO:0005247_13174_3	voltage-gated chloride channel activity	"Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409144	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409144	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC409144	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409144	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409145	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409145	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409145	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC409145	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409152	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409152	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409153	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409153	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409153	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409154	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409154	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC409154	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC409155	GO:0004149_13174_1	dihydrolipoyllysine-residue succinyltransferase activity	"Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]	IEA	molecular_function
LOC409155	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC409155	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409155	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409155	GO:0045252_3650_1	oxoglutarate dehydrogenase complex	"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]	IEA	cellular_component
LOC409157	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409157	GO:0008410_13174_1	CoA-transferase activity	"Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409157	GO:0046952_6281_1	ketone body catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732]	IEA	biological_process
LOC409159	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC409159	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409162	GO:0004185_13174_4	serine-type carboxypeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC409162	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409163	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409163	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
LOC409163	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409166	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409166	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409166	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409166	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409166	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409166	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409166	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409167	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409167	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409169	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409172	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC409177	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409177	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409177	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409177	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409177	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409177	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409178	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409178	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409178	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409178	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409178	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409178	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409178	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409178	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC409179	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409179	GO:0006084_6281_2	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	IEA	biological_process
LOC409180	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409180	GO:0006084_6281_2	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	IEA	biological_process
LOC409183	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409183	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409186	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
LOC409186	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409186	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409187	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409192	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC409192	GO:0004012_13174_5	phospholipid-translocating ATPase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]	IEA	molecular_function
LOC409192	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409192	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409192	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC409192	GO:0015914_6281_5	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	IEA	biological_process
LOC409192	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409192	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409196	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC409196	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409196	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409199	GO:0004370_13174_3	glycerol kinase activity	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]	IEA	molecular_function
LOC409199	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409199	GO:0006072_6281_5	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409199	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409200	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409200	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409200	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409201	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC409203	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409203	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409206	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
LOC409206	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409206	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409206	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409206	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
LOC409207	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409207	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409207	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409212	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409212	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409212	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC409212	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409212	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC409212	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC409212	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409212	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC409214	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409217	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC409217	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC409217	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409217	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409217	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC409217	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409225	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409231	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409231	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC409231	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC409231	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC409235	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409240	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409240	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409241	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409244	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC409247	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC409247	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409247	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409247	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC409247	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409247	GO:0045893_6281_4	positive regulation of transcription, DNA-dependent	"Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409250	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409250	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC409251	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409251	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409255	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409255	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC409255	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC409255	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC409255	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409255	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409255	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409255	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409255	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC409255	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409256	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409256	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409260	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409260	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409261	GO:0004370_13174_3	glycerol kinase activity	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]	IEA	molecular_function
LOC409261	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409261	GO:0006072_6281_5	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409261	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409264	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409264	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409264	GO:0071722_6281_1	detoxification of arsenic-containing substance	"Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439]	IEA	biological_process
LOC409265	GO:0004576_13174_1	oligosaccharyl transferase activity	"Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
LOC409265	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
LOC409265	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409268	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409268	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC409268	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409270	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409270	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409272	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409272	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409272	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409272	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409272	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409272	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409272	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409273	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409276	GO:0016307_13174_3	phosphatidylinositol phosphate kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]	IEA	molecular_function
LOC409276	GO:0046488_6281_3	phosphatidylinositol metabolic process	"The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]	IEA	biological_process
LOC409278	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409279	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC409279	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
LOC409279	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
LOC409280	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409282	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409282	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409283	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409292	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC409292	GO:0004449_13174_3	isocitrate dehydrogenase (NAD+) activity	"Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]	IEA	molecular_function
LOC409292	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC409292	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC409292	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC409292	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409295	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409295	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409298	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409299	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC409299	GO:0004019_13174_1	adenylosuccinate synthase activity	"Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756]	IEA	molecular_function
LOC409299	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409299	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409299	GO:0006164_6281_4	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409303	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC409303	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409303	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409303	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC409303	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC409304	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409304	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409305	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409305	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409306	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409306	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409308	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409309	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409310	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409311	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409311	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409312	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409312	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409312	GO:0044238_6281_1	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	IEA	biological_process
LOC409313	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409315	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409316	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409318	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409318	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409320	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409324	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409324	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409325	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409329	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC409329	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC409329	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC409331	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409331	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409331	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409333	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409334	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC409334	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409335	GO:0006505_6281_2	GPI anchor metabolic process	"The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]	IEA	biological_process
LOC409335	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409335	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC409335	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
LOC409336	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409336	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409340	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
LOC409340	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409340	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409340	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
LOC409340	GO:0043161_6281_1	proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	IEA	biological_process
LOC409342	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409342	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409342	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409342	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409342	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409348	GO:0004356_13174_2	glutamate-ammonia ligase activity	"Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]	IEA	molecular_function
LOC409348	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409348	GO:0006542_6281_2	glutamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	IEA	biological_process
LOC409348	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409350	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409350	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409353	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC409353	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409353	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409353	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409365	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409365	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC409365	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
LOC409365	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409365	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409365	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
LOC409365	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409367	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409368	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409379	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409382	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409382	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409382	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC409382	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409382	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409384	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409384	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409384	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC409384	GO:0042026_6281_1	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	IEA	biological_process
LOC409384	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
LOC409385	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409385	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409385	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC409385	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409389	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC409389	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC409392	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409392	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409392	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409392	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC409392	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409392	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409394	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409394	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409394	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC409394	GO:0008641_13174_3	small protein activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409394	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409394	GO:0045116_6281_1	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	IEA	biological_process
LOC409395	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409395	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409396	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC409396	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409403	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC409403	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC409404	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC409404	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409406	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409406	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409409	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409409	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409409	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409409	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409409	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409409	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409417	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409417	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409417	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC409420	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC409424	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409424	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409424	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409424	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409424	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409424	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409424	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409425	GO:0003810_13174_3	protein-glutamine gamma-glutamyltransferase activity	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]	IEA	molecular_function
LOC409425	GO:0018149_6281_3	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	IEA	biological_process
LOC409427	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409429	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409430	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC409437	GO:0004767_13174_1	sphingomyelin phosphodiesterase activity	"Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]	IEA	molecular_function
LOC409437	GO:0006685_6281_1	sphingomyelin catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]	IEA	biological_process
LOC409437	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC409439	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409439	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
LOC409439	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409439	GO:0030127_3650_3	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	IEA	cellular_component
LOC409444	GO:0003876_13174_1	AMP deaminase activity	"Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6]	IEA	molecular_function
LOC409444	GO:0006188_6281_2	IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]	IEA	biological_process
LOC409444	GO:0009168_6281_5	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409444	GO:0019239_13174_5	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]	IEA	molecular_function
LOC409448	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC409448	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC409454	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409454	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC409454	GO:0008479_13174_4	queuine tRNA-ribosyltransferase activity	"Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]	IEA	molecular_function
LOC409454	GO:0008616_6281_4	queuosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409455	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409455	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409455	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409455	GO:0007548_6281_5	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	IEA	biological_process
LOC409455	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC409456	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409456	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409456	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409456	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409456	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409456	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409456	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409456	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC409456	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409456	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409456	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC409456	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409456	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409457	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409457	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409459	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409459	GO:0004176_13174_3	ATP-dependent peptidase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]	IEA	molecular_function
LOC409459	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC409459	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409459	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409459	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409459	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409460	GO:0000103_6281_2	sulfate assimilation	"The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]	IEA	biological_process
LOC409460	GO:0004781_13174_2	sulfate adenylyltransferase (ATP) activity	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]	IEA	molecular_function
LOC409460	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409460	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409460	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409463	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409467	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409467	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409467	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409467	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409468	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409468	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409470	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409470	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409472	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409481	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409481	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409481	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409481	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409481	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409485	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409485	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC409486	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409487	GO:0003952_13174_1	NAD+ synthase (glutamine-hydrolyzing) activity	"Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1]	IEA	molecular_function
LOC409487	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409487	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409487	GO:0009435_6281_3	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	IEA	biological_process
LOC409487	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC409488	GO:0004719_13174_3	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	IEA	molecular_function
LOC409488	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC409493	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409494	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409494	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409495	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409497	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409497	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409499	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409499	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC409499	GO:0003978_13174_2	UDP-glucose 4-epimerase activity	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]	IEA	molecular_function
LOC409499	GO:0006012_6281_5	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	IEA	biological_process
LOC409499	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC409499	GO:0008831_13174_4	dTDP-4-dehydrorhamnose reductase activity	"Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]	IEA	molecular_function
LOC409499	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC409499	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC409499	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC409499	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
LOC409499	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC409499	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409501	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409501	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409501	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409502	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409504	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409507	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409507	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409509	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC409509	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC409509	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409515	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409515	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409517	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409517	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409517	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC409521	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409521	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409527	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409527	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409527	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409527	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC409527	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409527	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409527	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409527	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409527	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC409529	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409529	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409529	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409529	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409529	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409529	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC409529	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409529	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409529	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409529	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409530	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC409530	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409530	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409530	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
LOC409531	GO:0006897_6281_3	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]	IEA	biological_process
LOC409531	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409533	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409533	GO:0005544_13174_4	calcium-dependent phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	IEA	molecular_function
LOC409536	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC409536	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409536	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC409536	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
LOC409536	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409536	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409536	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC409536	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
LOC409538	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409539	GO:0007026_6281_3	negative regulation of microtubule depolymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC409546	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409547	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409548	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC409548	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409548	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409553	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
LOC409553	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409553	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409559	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409559	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409560	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409564	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC409564	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC409564	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409564	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC409565	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409565	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409565	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409569	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409571	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409573	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409573	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC409573	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409573	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409573	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409573	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC409578	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409581	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC409581	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409581	GO:0008290_3650_2	F-actin capping protein complex	"A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]	IEA	cellular_component
LOC409581	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409593	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409593	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409594	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC409595	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC409595	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409595	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409595	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC409600	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409604	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409607	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409608	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409610	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409610	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409613	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409613	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409613	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409613	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409614	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
LOC409614	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409614	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC409614	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC409614	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
LOC409617	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC409617	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409617	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC409619	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC409619	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409620	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409624	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409624	GO:0003987_13174_1	acetate-CoA ligase activity	"Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]	IEA	molecular_function
LOC409624	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409624	GO:0016208_13174_1	AMP binding	"Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]	IEA	molecular_function
LOC409633	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409633	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409633	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409633	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409633	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409633	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409633	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409633	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409638	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409642	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409642	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC409642	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409642	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC409646	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC409646	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409646	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409646	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409646	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409647	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409647	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409649	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409649	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409649	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409649	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409649	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409650	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409650	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409650	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409655	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409660	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409660	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409660	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409660	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409660	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409660	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409660	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409665	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409666	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409666	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409666	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409666	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409666	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409667	GO:0005740_3650_5	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	IEA	cellular_component
LOC409667	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409667	GO:0043065_6281_1	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	IEA	biological_process
LOC409670	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409670	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409670	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409670	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409670	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409670	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409671	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409671	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409675	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409680	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409680	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409681	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409686	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409686	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC409686	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC409686	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409686	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409686	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409686	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC409686	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC409686	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409688	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409691	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC409691	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409692	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409692	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409693	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC409696	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409696	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409697	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC409697	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409698	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC409698	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409698	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
LOC409699	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409701	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409701	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409701	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409702	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC409702	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC409702	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC409707	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409708	GO:0004348_13174_2	glucosylceramidase activity	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]	IEA	molecular_function
LOC409708	GO:0005764_3650_2	lysosome	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	IEA	cellular_component
LOC409708	GO:0006665_6281_2	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409708	GO:0007040_6281_2	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	IEA	biological_process
LOC409709	GO:0004348_13174_2	glucosylceramidase activity	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]	IEA	molecular_function
LOC409709	GO:0005764_3650_2	lysosome	"A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	IEA	cellular_component
LOC409709	GO:0006665_6281_2	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409709	GO:0007040_6281_2	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	IEA	biological_process
LOC409711	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409712	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC409712	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409712	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409712	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC409712	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409713	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC409714	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC409714	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC409714	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC409714	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC409715	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409715	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409715	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC409715	GO:0015377_13174_3	cation:chloride symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]	IEA	molecular_function
LOC409715	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409715	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409715	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409717	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409717	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409718	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409718	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409718	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409718	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409718	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409721	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC409721	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409721	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409722	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409722	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409722	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409725	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409726	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409729	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409729	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409731	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC409731	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC409731	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409731	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409731	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409736	GO:0004491_13174_1	methylmalonate-semialdehyde dehydrogenase (acylating) activity	"Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27]	IEA	molecular_function
LOC409736	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409736	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409736	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409739	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC409743	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409751	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC409753	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409753	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409753	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409755	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409757	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409757	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC409757	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409757	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC409759	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC409759	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC409759	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC409759	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409759	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409759	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC409759	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409766	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409766	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC409766	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
LOC409766	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409768	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
LOC409770	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC409770	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC409774	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409774	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409775	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC409777	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC409777	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409777	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409778	GO:0016812_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	IEA	molecular_function
LOC409780	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409781	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409781	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409781	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409782	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409782	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409783	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409783	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
LOC409783	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409786	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC409786	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409786	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
LOC409786	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409787	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409787	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC409787	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
LOC409788	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409789	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409789	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
LOC409789	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409789	GO:0006955_6281_5	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]	IEA	biological_process
LOC409789	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC409789	GO:0030247_13174_2	polysaccharide binding	"Interacting selectively and non-covalently with any polysaccharide, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [GOC:mah]	IEA	molecular_function
LOC409789	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC409790	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409792	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409792	GO:0005452_13174_2	inorganic anion exchanger activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]	IEA	molecular_function
LOC409792	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409792	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409792	GO:0008509_13174_2	anion transmembrane transporter activity	"Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409792	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409792	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409794	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409804	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC409807	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409807	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409809	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409809	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC409809	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
LOC409809	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC409810	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409811	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC409811	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409811	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC409811	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC409811	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC409811	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409814	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC409814	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409822	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC409822	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC409829	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409831	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409831	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC409831	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC409833	GO:0000154_6281_3	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC409833	GO:0000179_13174_3	rRNA (adenine-N6,N6-)-dimethyltransferase activity	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]	IEA	molecular_function
LOC409833	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409833	GO:0006479_6281_4	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	IEA	biological_process
LOC409833	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409833	GO:0008276_13174_4	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409833	GO:0008649_13174_3	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	IEA	molecular_function
LOC409833	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC409835	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409836	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409836	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409836	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409841	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
LOC409841	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409841	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409841	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409841	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409847	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409847	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409847	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409847	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC409847	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC409848	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409848	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409848	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409856	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC409856	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409856	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409856	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC409860	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409860	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409862	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409866	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409866	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409866	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409866	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409866	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409866	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409868	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC409868	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409868	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
LOC409868	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409868	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC409868	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409868	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
LOC409868	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409868	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC409868	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409868	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC409870	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC409870	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409871	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409878	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409878	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409879	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC409879	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409879	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409879	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409879	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409882	GO:0016998_6281_3	cell wall macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]	IEA	biological_process
LOC409884	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409884	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409885	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409885	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC409885	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409885	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409886	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409888	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC409888	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409890	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC409890	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC409892	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409892	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC409893	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409896	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC409896	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC409896	GO:0043169_13174_10	cation binding	"Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]	IEA	molecular_function
LOC409897	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409897	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409897	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409897	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409897	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409897	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC409897	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC409897	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409898	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC409899	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409899	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409899	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409899	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409900	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC409900	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC409902	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC409902	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409903	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409903	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409903	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409903	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409903	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409903	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409903	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409903	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409904	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409905	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC409912	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC409912	GO:0005834_3650_5	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]	IEA	cellular_component
LOC409912	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC409912	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC409912	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC409918	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC409918	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409919	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC409919	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409919	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
LOC409920	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC409924	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC409924	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409924	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409924	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC409924	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409924	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409932	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC409932	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC409932	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC409932	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409932	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC409936	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409936	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409936	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409941	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC409942	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409949	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409950	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC409950	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409950	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC409950	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC409950	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC409950	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409952	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409952	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409952	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409952	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409952	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409952	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409953	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409955	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409961	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC409965	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC409965	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC409965	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC409965	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC409965	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC409965	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC409966	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC409966	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC409966	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC409966	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC409966	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC409966	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC409966	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC409966	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC409966	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC409966	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC409969	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC409969	GO:0017150_13174_4	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]	IEA	molecular_function
LOC409969	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC409969	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC409970	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409970	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC409970	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC409978	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409978	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409978	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC409978	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC409985	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC409985	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC409985	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC409986	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC409986	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409986	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC409986	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC409986	GO:0032934_13174_3	sterol binding	"Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]	IEA	molecular_function
LOC409989	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC409989	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC409989	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC409991	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC409999	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC410001	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410001	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410001	GO:0017137_13174_2	Rab GTPase binding	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]	IEA	molecular_function
LOC410003	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410004	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410004	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410004	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC410022	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410022	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410022	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410022	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410022	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410023	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410024	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC410024	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410024	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC410024	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC410026	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410026	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410026	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410026	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410026	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410026	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410026	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC410027	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410027	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410027	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410027	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC410030	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410034	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410037	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410037	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC410038	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC410038	GO:0005201_13174_6	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	IEA	molecular_function
LOC410038	GO:0005581_3650_5	collagen	"Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]	IEA	cellular_component
LOC410038	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410039	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC410039	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410039	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
LOC410040	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410042	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410042	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410042	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
LOC410042	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC410042	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410043	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410044	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410044	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410045	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410045	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410054	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410057	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410059	GO:0004108_13174_1	citrate (Si)-synthase activity	"Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073]	IEA	molecular_function
LOC410059	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC410059	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC410059	GO:0046912_13174_3	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	IEA	molecular_function
LOC410060	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410060	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410060	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410060	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410060	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410060	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC410060	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410060	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410061	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410067	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410067	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410071	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410071	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410071	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410071	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410074	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410074	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC410074	GO:0008241_13174_4	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC410074	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410075	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410076	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410076	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410076	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC410076	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC410078	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410079	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410079	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410079	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410080	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410080	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410085	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410085	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410091	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410091	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410091	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC410094	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410095	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410095	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410095	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC410095	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC410095	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
LOC410095	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC410096	GO:0003840_13174_3	gamma-glutamyltransferase activity	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]	IEA	molecular_function
LOC410097	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410097	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410097	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
LOC410097	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC410097	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC410098	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410098	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410102	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410102	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410102	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410102	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC410103	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410106	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC410106	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410107	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410107	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410108	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410108	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410109	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC410109	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410109	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC410114	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410114	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410114	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410114	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410116	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC410116	GO:0005834_3650_5	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]	IEA	cellular_component
LOC410116	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC410117	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410117	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC410117	GO:0006071_6281_4	glycerol metabolic process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC410117	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC410117	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC410117	GO:0008889_13174_3	glycerophosphodiester phosphodiesterase activity	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]	IEA	molecular_function
LOC410117	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC410118	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410118	GO:0006024_6281_1	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	IEA	biological_process
LOC410118	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410118	GO:0016857_13174_1	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	IEA	molecular_function
LOC410119	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410119	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410119	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410119	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410119	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410119	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410121	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC410128	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410132	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410132	GO:0042765_3650_2	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	IEA	cellular_component
LOC410134	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410136	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410136	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410144	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410144	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410144	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410144	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC410148	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410148	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410148	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410148	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410148	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC410149	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410149	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410149	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC410149	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410155	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410158	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC410158	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410158	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410158	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410159	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC410159	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410159	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
LOC410162	GO:0008242_13174_5	omega peptidase activity	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]	IEA	molecular_function
LOC410165	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410166	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410166	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410166	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410167	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410167	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410167	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410170	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410170	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410171	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC410171	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410172	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410178	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410178	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC410178	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC410178	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410179	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410179	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410192	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410192	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
LOC410192	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410192	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410192	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC410195	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410195	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410198	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410198	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410200	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410200	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
LOC410203	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410203	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410203	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410203	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410203	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410203	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC410204	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410204	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410205	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410206	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC410207	GO:0004152_13174_2	dihydroorotate dehydrogenase activity	"Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076]	IEA	molecular_function
LOC410207	GO:0004158_13174_2	dihydroorotate oxidase activity	"Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444]	IEA	molecular_function
LOC410207	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410207	GO:0006207_6281_5	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	IEA	biological_process
LOC410207	GO:0006222_6281_2	UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]	IEA	biological_process
LOC410207	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC410207	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410207	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC410207	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410208	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410208	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410208	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410208	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410208	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410208	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410208	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410216	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC410218	GO:0005787_3650_4	signal peptidase complex	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]	IEA	cellular_component
LOC410218	GO:0006465_6281_5	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC410218	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC410218	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410220	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410225	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410225	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410227	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410227	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410234	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410234	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC410234	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC410234	GO:0008831_13174_4	dTDP-4-dehydrorhamnose reductase activity	"Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]	IEA	molecular_function
LOC410234	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410234	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC410234	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
LOC410234	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC410234	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410237	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410237	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410237	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410240	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410246	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410246	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410256	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410259	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410259	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410259	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410259	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
LOC410259	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC410259	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410259	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC410261	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410261	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC410264	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC410264	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410264	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC410264	GO:0017150_13174_4	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]	IEA	molecular_function
LOC410264	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC410264	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410266	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410266	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410266	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
LOC410266	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410266	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
LOC410266	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC410266	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410269	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410269	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410269	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410269	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410269	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410269	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410269	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410269	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410272	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC410272	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410272	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410272	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410272	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410274	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410274	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410274	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC410274	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410274	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC410274	GO:0032784_6281_3	regulation of DNA-dependent transcription, elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	IEA	biological_process
LOC410282	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410286	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC410289	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410289	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410289	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410289	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410289	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410289	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410289	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410289	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410289	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410289	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC410291	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410291	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC410291	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC410291	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC410294	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC410295	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC410295	GO:0008479_13174_4	queuine tRNA-ribosyltransferase activity	"Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]	IEA	molecular_function
LOC410295	GO:0008616_6281_4	queuosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC410296	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC410296	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410296	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410296	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410296	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410297	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC410297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410297	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410297	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC410297	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC410297	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC410297	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC410299	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410304	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410304	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410304	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410304	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410304	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410304	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410304	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410304	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410304	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410304	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410304	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC410304	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410306	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410306	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410306	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410306	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410306	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410306	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410306	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410306	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410306	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410308	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC410318	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410318	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410318	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410318	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410318	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410318	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410318	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC410320	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410325	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410325	GO:0003857_13174_2	3-hydroxyacyl-CoA dehydrogenase activity	"Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35]	IEA	molecular_function
LOC410325	GO:0004300_13174_1	enoyl-CoA hydratase activity	"Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17]	IEA	molecular_function
LOC410325	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC410325	GO:0006631_6281_5	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	IEA	biological_process
LOC410325	GO:0006635_6281_4	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	IEA	biological_process
LOC410325	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410325	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410325	GO:0016507_3650_1	mitochondrial fatty acid beta-oxidation multienzyme complex	"A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]	IEA	cellular_component
LOC410325	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410325	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410326	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410326	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410326	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC410326	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410328	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410328	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410328	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410330	GO:0006659_6281_1	phosphatidylserine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]	IEA	biological_process
LOC410332	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC410332	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410332	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410332	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410334	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410334	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410336	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410336	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410336	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410337	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410337	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410337	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410340	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410341	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC410341	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410341	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC410341	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC410343	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
LOC410343	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410350	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410352	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410352	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410352	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410352	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410353	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410362	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410362	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
LOC410362	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC410362	GO:0016715_13174_3	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
LOC410362	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410363	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC410363	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410363	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC410366	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410366	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410366	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410368	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC410368	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC410368	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC410368	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC410368	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410371	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410371	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410371	GO:0005388_13174_3	calcium-transporting ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]	IEA	molecular_function
LOC410371	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410371	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC410371	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410371	GO:0006816_6281_3	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410371	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410371	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC410371	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410371	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410371	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410373	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410373	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410373	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410376	GO:0003747_13174_4	translation release factor activity	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]	IEA	molecular_function
LOC410376	GO:0006415_6281_4	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	IEA	biological_process
LOC410377	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410377	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410381	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410383	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410383	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410383	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410383	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC410385	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410385	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410385	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC410385	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC410388	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410388	GO:0005575_3650_2	cellular_component	"The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]	IEA	cellular_component
LOC410388	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410388	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC410388	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC410388	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC410388	GO:0043412_6281_1	macromolecule modification	"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]	IEA	biological_process
LOC410388	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC410388	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC410390	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410390	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410390	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC410390	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC410393	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410393	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410393	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410394	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410394	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410394	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
LOC410394	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC410395	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410396	GO:0004449_13174_3	isocitrate dehydrogenase (NAD+) activity	"Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]	IEA	molecular_function
LOC410396	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC410396	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410396	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410399	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410399	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410403	GO:0008537_3650_1	proteasome activator complex	"A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]	IEA	cellular_component
LOC410406	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410406	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410406	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC410406	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410410	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410410	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410412	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410412	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410412	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410412	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410412	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410412	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410413	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410413	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410413	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410414	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410414	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410414	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410414	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410415	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410415	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410415	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410415	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410415	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410415	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC410415	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410415	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410415	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410415	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410417	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC410417	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410417	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC410417	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC410417	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410419	GO:0004170_13174_1	dUTP diphosphatase activity	"Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23]	IEA	molecular_function
LOC410419	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410419	GO:0046080_6281_1	dUTP metabolic process	"The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]	IEA	biological_process
LOC410420	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410420	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410428	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC410428	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC410432	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410432	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC410432	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC410432	GO:0008831_13174_4	dTDP-4-dehydrorhamnose reductase activity	"Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]	IEA	molecular_function
LOC410432	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410432	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC410432	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
LOC410432	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC410432	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410438	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410438	GO:0004379_13174_2	glycylpeptide N-tetradecanoyltransferase activity	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]	IEA	molecular_function
LOC410438	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410439	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410442	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC410442	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410442	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC410442	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410442	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
LOC410442	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC410442	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410446	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410448	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410448	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410448	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410449	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410449	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410451	GO:0004185_13174_4	serine-type carboxypeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410451	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410452	GO:0004180_13174_5	carboxypeptidase activity	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC410452	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC410452	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410452	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410454	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410454	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410454	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410454	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410456	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410462	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410462	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410467	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC410467	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC410475	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC410475	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410475	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC410475	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC410477	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410479	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410480	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410480	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410480	GO:0008093_13174_2	cytoskeletal adaptor activity	"The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]	IEA	molecular_function
LOC410480	GO:0017124_13174_2	SH3 domain binding	"Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	IEA	molecular_function
LOC410480	GO:0046847_6281_2	filopodium assembly	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]	IEA	biological_process
LOC410482	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410482	GO:0004018_13174_2	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	"Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2]	IEA	molecular_function
LOC410482	GO:0009152_6281_1	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC410484	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410484	GO:0004555_13174_2	alpha,alpha-trehalase activity	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]	IEA	molecular_function
LOC410484	GO:0005991_6281_2	trehalose metabolic process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]	IEA	biological_process
LOC410485	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410487	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC410487	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410493	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410493	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410493	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410494	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410494	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC410494	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC410496	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410497	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410498	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410498	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410498	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410498	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410501	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410501	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410501	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410507	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410507	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410507	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410507	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410509	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC410509	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC410509	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410514	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410514	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410515	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC410515	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
LOC410515	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC410515	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410516	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410516	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410516	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410520	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410520	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410520	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410527	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410527	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410527	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410527	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410527	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410527	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC410527	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410527	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410527	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410527	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410529	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410529	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410529	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410530	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410530	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410530	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC410532	GO:0001882_13174_2	nucleoside binding	"Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]	IEA	molecular_function
LOC410532	GO:0005415_13174_1	nucleoside:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
LOC410532	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410532	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410533	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410533	GO:0017089_13174_2	glycolipid transporter activity	"Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC410533	GO:0046836_6281_2	glycolipid transport	"The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410533	GO:0051861_13174_2	glycolipid binding	"Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1]	IEA	molecular_function
LOC410534	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410534	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410534	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410535	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410535	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410535	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410537	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410537	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410537	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410537	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC410537	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410537	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC410539	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410539	GO:0009166_6281_4	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
LOC410539	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410539	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC410539	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410541	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410541	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410542	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410550	GO:0004047_13174_3	aminomethyltransferase activity	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]	IEA	molecular_function
LOC410550	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410550	GO:0006546_6281_3	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
LOC410552	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410552	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410552	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410552	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410552	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410554	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC410555	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410559	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410559	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410559	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC410559	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410559	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC410559	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC410559	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC410562	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410562	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410562	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410562	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410562	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410562	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410563	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410565	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC410565	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
LOC410565	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
LOC410566	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410566	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410567	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410567	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410567	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC410567	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410570	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410570	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC410570	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410571	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410571	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410571	GO:0003916_13174_3	DNA topoisomerase activity	"Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]	IEA	molecular_function
LOC410571	GO:0003917_13174_3	DNA topoisomerase type I activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	IEA	molecular_function
LOC410571	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
LOC410571	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
LOC410571	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410573	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410577	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410582	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC410582	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410585	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC410585	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC410585	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC410585	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC410585	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410587	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410587	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410587	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410587	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410587	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410587	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC410587	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410587	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC410587	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC410591	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410595	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410601	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410601	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
LOC410601	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410603	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC410603	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC410603	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC410603	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410606	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC410609	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410609	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410609	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410613	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410613	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410616	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC410616	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410617	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410617	GO:0006461_6281_5	protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]	IEA	biological_process
LOC410617	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410617	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC410617	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410622	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
LOC410622	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410623	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC410623	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410623	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410626	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410626	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410626	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410626	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410627	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410627	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410627	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410627	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410630	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410630	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
LOC410630	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410630	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410630	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC410633	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410633	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410633	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410635	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410635	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410636	GO:0043231_3650_2	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	IEA	cellular_component
LOC410636	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC410639	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410639	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
LOC410639	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
LOC410639	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410639	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410644	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410644	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410644	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410644	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410644	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC410649	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410649	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410649	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410649	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410649	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410649	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410649	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410654	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC410654	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410655	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410659	GO:0000042_6281_4	protein targeting to Golgi	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]	IEA	biological_process
LOC410659	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410659	GO:0006952_6281_4	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	IEA	biological_process
LOC410659	GO:0009279_3650_1	cell outer membrane	"A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254]	IEA	cellular_component
LOC410662	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410665	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410672	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410682	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410683	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410683	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410683	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410683	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410685	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410685	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410685	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410685	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410685	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410685	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410685	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410687	GO:0004499_13174_4	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]	IEA	molecular_function
LOC410687	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC410687	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
LOC410687	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410688	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410688	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410688	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410688	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410689	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410689	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410690	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410690	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410696	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410696	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC410702	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410702	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC410702	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410702	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410705	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410705	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410710	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410718	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC410718	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410718	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410718	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC410723	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410723	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410723	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410723	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC410723	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410724	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410724	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410726	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC410726	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410726	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410728	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410729	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410729	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC410730	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC410732	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410732	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410732	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410732	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410732	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410732	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410732	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410740	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410740	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410744	GO:0006066_6281_19	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]	IEA	biological_process
LOC410744	GO:0008812_13174_19	choline dehydrogenase activity	"Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436]	IEA	molecular_function
LOC410744	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC410744	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC410744	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410752	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410752	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410753	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410753	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410753	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
LOC410755	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC410755	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410756	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410756	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410761	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410761	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410761	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410763	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410765	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC410766	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410766	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410766	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410771	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410772	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410772	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410772	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410775	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410775	GO:0005604_3650_1	basement membrane	"A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]	IEA	cellular_component
LOC410775	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC410777	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC410777	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410777	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410777	GO:0051020_13174_2	GTPase binding	"Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	IEA	molecular_function
LOC410780	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410780	GO:0015299_13174_5	solute:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	IEA	molecular_function
LOC410780	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410780	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410784	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410784	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410784	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410784	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410788	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC410788	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410788	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410789	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC410789	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410789	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410789	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410789	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410789	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
LOC410792	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC410792	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410792	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC410792	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC410793	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
LOC410793	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC410793	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410793	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410793	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC410793	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
LOC410793	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410795	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410795	GO:0004555_13174_2	alpha,alpha-trehalase activity	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]	IEA	molecular_function
LOC410795	GO:0005991_6281_2	trehalose metabolic process	"The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]	IEA	biological_process
LOC410796	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410796	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410799	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410799	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410801	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410801	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC410803	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410803	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410804	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC410804	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410804	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410804	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC410804	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410806	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410806	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC410806	GO:0004821_13174_1	histidine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]	IEA	molecular_function
LOC410806	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410806	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC410806	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC410806	GO:0006427_6281_1	histidyl-tRNA aminoacylation	"The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC410807	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410807	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410807	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410807	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410811	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC410811	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410811	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410811	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410811	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC410812	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410812	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410812	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410812	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410812	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410812	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC410812	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410812	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410812	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410812	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410816	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410816	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410816	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410816	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410816	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410825	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410826	GO:0004616_13174_4	phosphogluconate dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]	IEA	molecular_function
LOC410826	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
LOC410826	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410826	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC410826	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410828	GO:0004833_13174_1	tryptophan 2,3-dioxygenase activity	"Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]	IEA	molecular_function
LOC410828	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC410828	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410828	GO:0019441_6281_1	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	IEA	biological_process
LOC410828	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410829	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410829	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410829	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410829	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410829	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410829	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410829	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410832	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410832	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410838	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC410844	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410848	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410848	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410848	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410849	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
LOC410849	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC410852	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410853	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410855	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410861	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410861	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410862	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410862	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410865	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410865	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410866	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410867	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410877	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC410877	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410882	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410882	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410882	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410882	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410883	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410885	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC410885	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410885	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC410886	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC410886	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410886	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410886	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC410888	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410895	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410897	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410904	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC410904	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410904	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
LOC410904	GO:0017048_13174_3	Rho GTPase binding	"Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]	IEA	molecular_function
LOC410904	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410906	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC410906	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC410906	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC410910	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410910	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410910	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410910	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410910	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410910	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410910	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC410913	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410913	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC410913	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410913	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC410913	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410913	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410913	GO:0015077_13174_3	monovalent inorganic cation transmembrane transporter activity	"Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410913	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC410913	GO:0015672_6281_4	monovalent inorganic cation transport	"The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]	IEA	biological_process
LOC410913	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410913	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410913	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
LOC410913	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC410915	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC410915	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410915	GO:0006833_6281_3	water transport	"The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410915	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410915	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410915	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410918	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC410918	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410918	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410918	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC410920	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410920	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410920	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410922	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410933	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC410933	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC410933	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC410933	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410933	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC410933	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC410936	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410936	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC410936	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC410940	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410941	GO:0002098_6281_1	tRNA wobble uridine modification	"The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]	IEA	biological_process
LOC410941	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC410941	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC410943	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410943	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410943	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410943	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410943	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410943	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC410943	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410943	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410943	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410943	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410951	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC410952	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC410952	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410957	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC410957	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410957	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC410964	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410967	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC410967	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC410967	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410967	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC410967	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC410969	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410969	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410969	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC410969	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410969	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC410969	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC410969	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC410969	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC410969	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC410969	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC410976	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC410976	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC410986	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC410989	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC410990	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC410990	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC410994	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410994	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410994	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC410994	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410994	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC410994	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC410994	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC410995	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410995	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410995	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410995	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC410995	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC410996	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC410996	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC410996	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC410996	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC410996	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC410996	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC410996	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC410997	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC410997	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC410997	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC410999	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC410999	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411002	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411003	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411003	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC411003	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411003	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411003	GO:0008289_13174_3	lipid binding	"Interacting selectively and non-covalently with a lipid." [GOC:ai]	IEA	molecular_function
LOC411003	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411003	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411005	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
LOC411005	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411005	GO:0008308_13174_4	voltage-gated anion channel activity	"Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411005	GO:0044070_6281_4	regulation of anion transport	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
LOC411005	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411009	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411009	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411011	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC411011	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411011	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC411014	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411014	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411014	GO:0006108_6281_3	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC411014	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411014	GO:0016615_13174_3	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	IEA	molecular_function
LOC411014	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411014	GO:0030060_13174_2	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	IEA	molecular_function
LOC411014	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC411014	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411019	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411021	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411021	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411022	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC411022	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
LOC411022	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411022	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
LOC411023	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411023	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC411023	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411023	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC411023	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411024	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411026	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411026	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC411026	GO:0032040_3650_5	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	IEA	cellular_component
LOC411030	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC411030	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC411030	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411035	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411035	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411035	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411036	GO:0005267_13174_2	potassium channel activity	"Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411036	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411036	GO:0071805_6281_2	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	IEA	biological_process
LOC411044	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411044	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411046	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC411048	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411048	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
LOC411049	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC411049	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC411049	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411049	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411049	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411050	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC411050	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411050	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411052	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411052	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411058	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411058	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411059	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411059	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411059	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411065	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411065	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411070	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411070	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411070	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
LOC411071	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC411071	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC411071	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411072	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC411072	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411072	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411073	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411073	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC411077	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC411080	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411080	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411080	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411080	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411080	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411080	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411081	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411081	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411085	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411085	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411085	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411085	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC411085	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC411085	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411085	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC411085	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411085	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411090	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC411090	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC411091	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411093	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411093	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411093	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411093	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411093	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411093	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411095	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411095	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411095	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411095	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411099	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411099	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411099	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC411100	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411100	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411104	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411104	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411104	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411104	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411104	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411105	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411105	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411106	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC411113	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411113	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411113	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC411113	GO:0015377_13174_3	cation:chloride symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]	IEA	molecular_function
LOC411113	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411113	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411113	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411115	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC411115	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411115	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411115	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC411115	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC411116	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411121	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411122	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411122	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC411122	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411126	GO:0004017_13174_4	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	IEA	molecular_function
LOC411126	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411126	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411126	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411133	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411133	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411133	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411140	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411140	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411140	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411141	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411141	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411141	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411141	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC411141	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC411141	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411141	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411141	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411145	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411145	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC411145	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC411154	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411154	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411154	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC411155	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411155	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411155	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411155	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411155	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411155	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411155	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC411156	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411156	GO:0033588_3650_1	Elongator holoenzyme complex	"A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA, and exerts direct effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:jh, GOC:mah, GOC:vw, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837]	IEA	cellular_component
LOC411157	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411157	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411157	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC411157	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411157	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC411157	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411158	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411163	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411164	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411164	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC411164	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC411167	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411167	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC411167	GO:0004817_13174_2	cysteine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]	IEA	molecular_function
LOC411167	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411167	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411167	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC411167	GO:0006423_6281_2	cysteinyl-tRNA aminoacylation	"The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC411171	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411172	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411175	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411176	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411185	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411185	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411185	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411185	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411185	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411185	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC411185	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411185	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC411185	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC411185	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411186	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411186	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411186	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411187	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411187	GO:0004459_13174_2	L-lactate dehydrogenase activity	"Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27]	IEA	molecular_function
LOC411187	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411187	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411187	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC411187	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411187	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411187	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411188	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411188	GO:0004459_13174_2	L-lactate dehydrogenase activity	"Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27]	IEA	molecular_function
LOC411188	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411188	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411188	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC411188	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411188	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411188	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC411188	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411189	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411189	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411189	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411189	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411189	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC411189	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411191	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC411191	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC411192	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411192	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
LOC411194	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411197	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411201	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411201	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411201	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411201	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411201	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411201	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411201	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411202	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411202	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411204	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411206	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411206	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411206	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC411206	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC411209	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411209	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411209	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411209	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411209	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411209	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC411209	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411209	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411209	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC411209	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC411209	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411209	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411209	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411212	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411213	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411214	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411214	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411214	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411214	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC411214	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411219	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411219	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411219	GO:0008093_13174_2	cytoskeletal adaptor activity	"The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]	IEA	molecular_function
LOC411219	GO:0017124_13174_2	SH3 domain binding	"Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	IEA	molecular_function
LOC411219	GO:0046847_6281_2	filopodium assembly	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]	IEA	biological_process
LOC411220	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC411220	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC411220	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411220	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411220	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411220	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
LOC411227	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC411227	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC411227	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC411227	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC411229	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411229	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC411229	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411233	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411233	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC411233	GO:0030529_3650_4	ribonucleoprotein complex	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]	IEA	cellular_component
LOC411242	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411245	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC411245	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411245	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411245	GO:0051020_13174_2	GTPase binding	"Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	IEA	molecular_function
LOC411249	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411249	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411249	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411249	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC411250	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411250	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411250	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411250	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411252	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411255	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC411260	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411260	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411260	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411260	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC411260	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC411260	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC411260	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411260	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC411260	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411260	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411261	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411261	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411261	GO:0030151_13174_4	molybdenum ion binding	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]	IEA	molecular_function
LOC411261	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411265	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411265	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411267	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411267	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411267	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC411269	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411269	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411272	GO:0000062_13174_4	fatty-acyl-CoA binding	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411273	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC411273	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC411273	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411276	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411276	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411276	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411280	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411280	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411285	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411290	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411292	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411292	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411293	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411293	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411293	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411295	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC411295	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC411295	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411295	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
LOC411296	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411296	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411296	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC411296	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411296	GO:0019904_13174_3	protein domain specific binding	"Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]	IEA	molecular_function
LOC411296	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411298	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411298	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411299	GO:0000062_13174_4	fatty-acyl-CoA binding	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411299	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411299	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411301	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411301	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC411301	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411301	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC411301	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411301	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411301	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC411301	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411304	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411304	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411304	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411305	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411305	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC411305	GO:0004830_13174_2	tryptophan-tRNA ligase activity	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]	IEA	molecular_function
LOC411305	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411305	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411305	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC411305	GO:0006436_6281_2	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC411306	GO:0008440_13174_5	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]	IEA	molecular_function
LOC411307	GO:0009063_6281_1	cellular amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	IEA	biological_process
LOC411315	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411315	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411315	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411315	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411315	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411315	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC411315	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411317	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411317	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411317	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC411317	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411320	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC411320	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
LOC411320	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC411320	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC411330	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411330	GO:0043546_13174_2	molybdopterin cofactor binding	"Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	IEA	molecular_function
LOC411330	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411331	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC411331	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411331	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411331	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411331	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411331	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411332	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411338	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411339	GO:0005578_3650_4	proteinaceous extracellular matrix	"A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]	IEA	cellular_component
LOC411339	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411339	GO:0043395_13174_3	heparan sulfate proteoglycan binding	"Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]	IEA	molecular_function
LOC411340	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411340	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411343	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC411343	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC411343	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411347	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411347	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411347	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411347	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411347	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411347	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411349	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
LOC411349	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC411351	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
LOC411351	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411351	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411351	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411351	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
LOC411353	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC411355	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411355	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411355	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411355	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411355	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411359	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC411359	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC411359	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411361	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411361	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411362	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC411362	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC411364	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411364	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411364	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411364	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC411372	GO:0004363_13174_2	glutathione synthase activity	"Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560]	IEA	molecular_function
LOC411372	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411372	GO:0006750_6281_3	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC411373	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411373	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411373	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411373	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411373	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411373	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411374	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411374	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC411374	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411374	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411374	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411374	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC411376	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC411378	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411378	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411378	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411381	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411381	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411381	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
LOC411381	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC411385	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411387	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411391	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC411392	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC411393	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411403	GO:0005375_13174_3	copper ion transmembrane transporter activity	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC411403	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411403	GO:0035434_6281_3	copper ion transmembrane transport	"The directed movement of copper (Cu) ions across a membrane by means of some agent such as a transporter or pore." [GOC:vw]	IEA	biological_process
LOC411406	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411406	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411406	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC411406	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411407	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411408	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC411408	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411408	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
LOC411410	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC411410	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
LOC411410	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411410	GO:0030127_3650_3	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	IEA	cellular_component
LOC411412	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411412	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411414	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411417	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411417	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411419	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411419	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411419	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411419	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC411419	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411447	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411447	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC411447	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC411447	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411447	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411450	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411450	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC411450	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411450	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411450	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411452	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC411459	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411459	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411463	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC411463	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411463	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411463	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
LOC411466	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411466	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411466	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411466	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411467	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411469	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411473	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411476	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411477	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC411477	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411477	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC411484	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411484	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411484	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
LOC411486	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411486	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411486	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411488	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411488	GO:0004134_13174_1	4-alpha-glucanotransferase activity	"Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25]	IEA	molecular_function
LOC411488	GO:0004135_13174_1	amylo-alpha-1,6-glucosidase activity	"Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732]	IEA	molecular_function
LOC411488	GO:0005978_6281_2	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	IEA	biological_process
LOC411490	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC411490	GO:0004563_13174_3	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	IEA	molecular_function
LOC411490	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411492	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411492	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411492	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411492	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411492	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411492	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411495	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411495	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411496	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411496	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411496	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411506	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411507	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411507	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411507	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411507	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411507	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411507	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411509	GO:0016429_13174_1	tRNA (adenine-N1-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]	IEA	molecular_function
LOC411509	GO:0030488_6281_1	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	IEA	biological_process
LOC411510	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411510	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC411510	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC411510	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC411519	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411519	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411519	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC411519	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC411519	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC411519	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC411519	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC411520	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411520	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411520	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC411520	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC411525	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411525	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC411529	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411529	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411529	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411529	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411529	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411529	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411531	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC411533	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC411533	GO:0008201_13174_2	heparin binding	"Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411533	GO:0050750_13174_1	low-density lipoprotein particle receptor binding	"Interacting selectively and non-covalently with a low-density lipoprotein receptor." [GOC:ai]	IEA	molecular_function
LOC411534	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC411534	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411534	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411534	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411535	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411535	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411535	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411535	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411537	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411537	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC411537	GO:0030145_13174_4	manganese ion binding	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]	IEA	molecular_function
LOC411538	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411538	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411540	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC411540	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411540	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411540	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC411541	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC411541	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411541	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411541	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC411541	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC411548	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411556	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC411556	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411556	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411568	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411569	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411569	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411572	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC411572	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411572	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC411573	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411575	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411575	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411575	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411575	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411575	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411575	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411579	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC411579	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411582	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411582	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411582	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411582	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411582	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411582	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411582	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411586	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411586	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
LOC411592	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411592	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411592	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411596	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411596	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411596	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411599	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411599	GO:0004850_13174_1	uridine phosphorylase activity	"Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]	IEA	molecular_function
LOC411599	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411599	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
LOC411599	GO:0009166_6281_4	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
LOC411600	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411600	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411600	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC411602	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411602	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC411602	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411602	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC411602	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411602	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411602	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC411603	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411604	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411610	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC411610	GO:0042586_13174_1	peptide deformylase activity	"Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]	IEA	molecular_function
LOC411611	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411611	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411613	GO:0042981_6281_3	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	IEA	biological_process
LOC411614	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411614	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411616	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411616	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411616	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411616	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411629	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411629	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411629	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411629	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411631	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411632	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411632	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411633	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411633	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC411633	GO:0003978_13174_2	UDP-glucose 4-epimerase activity	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]	IEA	molecular_function
LOC411633	GO:0006012_6281_5	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	IEA	biological_process
LOC411633	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC411633	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411633	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC411633	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411633	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411633	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC411633	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC411633	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411640	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411640	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411640	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411640	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC411640	GO:0015979_6281_4	photosynthesis	"The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]	IEA	biological_process
LOC411640	GO:0015995_6281_4	chlorophyll biosynthetic process	"The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]	IEA	biological_process
LOC411640	GO:0016851_13174_4	magnesium chelatase activity	"Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]	IEA	molecular_function
LOC411640	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411644	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC411644	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411644	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411644	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC411644	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411644	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411646	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411646	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411649	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411649	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411649	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411649	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
LOC411649	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411651	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411652	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411652	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411652	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411652	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC411652	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411653	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411653	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411653	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411653	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411654	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411654	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411657	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411657	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411657	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC411660	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411661	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411661	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411661	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411662	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411662	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411662	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411663	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411664	GO:0004675_13174_5	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	IEA	molecular_function
LOC411664	GO:0005024_13174_4	transforming growth factor beta-activated receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	IEA	molecular_function
LOC411664	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411670	GO:0004176_13174_3	ATP-dependent peptidase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]	IEA	molecular_function
LOC411670	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411670	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411670	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411672	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411672	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411674	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411674	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411678	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411678	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411678	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411678	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411678	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411678	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411678	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411679	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411683	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411685	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411685	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411685	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411685	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411685	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411685	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411685	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411685	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411685	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411690	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC411691	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411691	GO:0009056_6281_1	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	IEA	biological_process
LOC411691	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC411692	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411693	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411694	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411694	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411696	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411696	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411696	GO:0008446_13174_1	GDP-mannose 4,6-dehydratase activity	"Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23823]	IEA	molecular_function
LOC411696	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411696	GO:0019673_6281_1	GDP-mannose metabolic process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	IEA	biological_process
LOC411696	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC411696	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC411698	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC411698	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411698	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
LOC411700	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411700	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC411700	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
LOC411700	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411704	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC411704	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411704	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411704	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411704	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC411704	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC411706	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC411706	GO:0016298_13174_5	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]	IEA	molecular_function
LOC411706	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC411707	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411707	GO:0004818_13174_2	glutamate-tRNA ligase activity	"Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]	IEA	molecular_function
LOC411707	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411707	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411707	GO:0006424_6281_2	glutamyl-tRNA aminoacylation	"The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC411707	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
LOC411707	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
LOC411711	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411714	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411714	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411714	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411714	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411714	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC411715	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411715	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411717	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411720	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411724	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411724	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411725	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC411725	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC411730	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411730	GO:0004573_13174_1	mannosyl-oligosaccharide glucosidase activity	"Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]	IEA	molecular_function
LOC411730	GO:0009311_6281_1	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	IEA	biological_process
LOC411731	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411731	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411731	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC411731	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC411732	GO:0005261_13174_1	cation channel activity	"Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411732	GO:0015672_6281_4	monovalent inorganic cation transport	"The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]	IEA	biological_process
LOC411732	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411736	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411736	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC411738	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411738	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC411738	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411742	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411748	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC411748	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411748	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411748	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC411748	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC411750	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411750	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC411750	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC411752	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411752	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411757	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC411757	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411766	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411766	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411766	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411771	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
LOC411771	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
LOC411771	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411772	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC411772	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411772	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411772	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411772	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411776	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411779	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411779	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411779	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411779	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411779	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411779	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411780	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411780	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411780	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411781	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411781	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411793	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411794	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411794	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411796	GO:0004372_13174_1	glycine hydroxymethyltransferase activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]	IEA	molecular_function
LOC411796	GO:0006544_6281_2	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
LOC411796	GO:0006563_6281_1	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]	IEA	biological_process
LOC411796	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411797	GO:0004176_13174_3	ATP-dependent peptidase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]	IEA	molecular_function
LOC411797	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411805	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC411805	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC411805	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411805	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC411806	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC411806	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411806	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411806	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC411807	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411807	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC411807	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC411807	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411808	GO:0004657_13174_1	proline dehydrogenase activity	"Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]	IEA	molecular_function
LOC411808	GO:0006537_6281_2	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	IEA	biological_process
LOC411808	GO:0006562_6281_1	proline catabolic process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC411808	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411809	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411809	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411809	GO:0008967_13174_3	phosphoglycolate phosphatase activity	"Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372]	IEA	molecular_function
LOC411809	GO:0019509_6281_1	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	IEA	biological_process
LOC411809	GO:0043874_13174_1	acireductone synthase activity	"Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]	IEA	molecular_function
LOC411809	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC411811	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411812	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411812	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411812	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411812	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411812	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411812	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411827	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411836	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC411836	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC411837	GO:0016888_13174_2	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	IEA	molecular_function
LOC411843	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411845	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411846	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411846	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411846	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC411849	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC411849	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411849	GO:0030151_13174_4	molybdenum ion binding	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]	IEA	molecular_function
LOC411849	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411858	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411858	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411858	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411861	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411861	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411863	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411863	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411871	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC411871	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC411871	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC411871	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411871	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC411871	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411875	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC411879	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411881	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411881	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411881	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC411882	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411889	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411889	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC411891	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411891	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC411891	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411891	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC411894	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411894	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC411894	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC411894	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411894	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411894	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC411894	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411894	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC411894	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC411896	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC411896	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411896	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC411901	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411903	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411903	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411906	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411909	GO:0005098_13174_1	Ran GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah]	IEA	molecular_function
LOC411909	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411909	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411910	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC411910	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC411910	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411910	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC411910	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411916	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411916	GO:0008890_13174_1	glycine C-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20739]	IEA	molecular_function
LOC411916	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC411916	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC411916	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC411916	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411920	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC411920	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC411920	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411922	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC411922	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC411922	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC411922	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411923	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411923	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411923	GO:0004813_13174_2	alanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]	IEA	molecular_function
LOC411923	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411923	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC411923	GO:0006419_6281_2	alanyl-tRNA aminoacylation	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC411923	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
LOC411923	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
LOC411927	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411927	GO:0004523_13174_5	ribonuclease H activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	IEA	molecular_function
LOC411930	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411930	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411930	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411930	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411930	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411935	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC411935	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC411935	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC411935	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411935	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411936	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC411936	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC411936	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC411939	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411943	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC411943	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC411955	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411955	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC411955	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411955	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC411955	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC411959	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
LOC411959	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC411959	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC411959	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411959	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC411959	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC411959	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC411959	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411960	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411960	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC411960	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411960	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411961	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411961	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411972	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411972	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC411976	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC411976	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC411978	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC411978	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC411980	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411980	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC411982	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC411982	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC411982	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411982	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC411982	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC411982	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC411983	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC411983	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC411983	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC411983	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC411983	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC411985	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411985	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411986	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC411986	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411989	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411989	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC411989	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411989	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411991	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC411996	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC411997	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC411997	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC411997	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC411997	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC411997	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC412002	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412002	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412005	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412007	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412007	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC412007	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412007	GO:0003905_13174_1	alkylbase DNA N-glycosylase activity	"Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]	IEA	molecular_function
LOC412007	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC412007	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC412007	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412007	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC412007	GO:0006284_6281_3	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	IEA	biological_process
LOC412007	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC412007	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC412007	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412007	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412007	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412007	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412011	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC412011	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412015	GO:0003874_13174_1	6-pyruvoyltetrahydropterin synthase activity	"Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051]	IEA	molecular_function
LOC412015	GO:0006729_6281_3	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC412015	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412016	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412016	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412016	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412016	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412020	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC412020	GO:0003997_13174_3	acyl-CoA oxidase activity	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]	IEA	molecular_function
LOC412020	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
LOC412020	GO:0006631_6281_5	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	IEA	biological_process
LOC412020	GO:0006635_6281_4	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	IEA	biological_process
LOC412020	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412020	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC412020	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC412020	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412024	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412025	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC412025	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412025	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412025	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC412025	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412030	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC412030	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412030	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412030	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC412030	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC412030	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC412030	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412030	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC412030	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412030	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412033	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412041	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412041	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412041	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412041	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412041	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412041	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412045	GO:0004579_13174_3	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]	IEA	molecular_function
LOC412045	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC412045	GO:0008250_3650_1	oligosaccharyltransferase complex	"A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887]	IEA	cellular_component
LOC412045	GO:0018279_6281_2	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	IEA	biological_process
LOC412051	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412056	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412056	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412056	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412056	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412056	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412057	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412059	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC412059	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412059	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412059	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412070	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412070	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412070	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412070	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412070	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412070	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412074	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412074	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412074	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412074	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412074	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412074	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC412074	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412074	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412074	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC412074	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412074	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412077	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412077	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412080	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412082	GO:0006744_6281_5	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	IEA	biological_process
LOC412082	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412082	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC412082	GO:0008425_13174_1	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	"Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]	IEA	molecular_function
LOC412084	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412088	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC412088	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC412088	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412091	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412091	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412091	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC412091	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412091	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412091	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC412108	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412108	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412108	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412108	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412108	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412108	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412111	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC412112	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412112	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412112	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412112	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412112	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412112	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412114	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC412114	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC412116	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412117	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412118	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC412118	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC412127	GO:0004045_13174_2	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	IEA	molecular_function
LOC412128	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412130	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC412130	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412130	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC412135	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412135	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412135	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412137	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412143	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412143	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC412143	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412143	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412143	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412143	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC412143	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412143	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC412144	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412144	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412144	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC412144	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412147	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412149	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412149	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC412149	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC412149	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC412149	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC412149	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC412149	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412150	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412150	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC412150	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
LOC412150	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC412154	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412154	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412155	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412159	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412159	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC412161	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412161	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412161	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412161	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412162	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412162	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412163	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412163	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412164	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412166	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC412172	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412174	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412177	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC412177	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412180	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412180	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
LOC412180	GO:0031105_3650_2	septin complex	"Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632]	IEA	cellular_component
LOC412187	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412189	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412190	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412190	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412190	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412190	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412190	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412190	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412192	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412193	GO:0004091_13174_4	carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1]	IEA	molecular_function
LOC412193	GO:0016023_3650_1	cytoplasmic membrane-bounded vesicle	"A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]	IEA	cellular_component
LOC412193	GO:0018738_13174_1	S-formylglutathione hydrolase activity	"Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964]	IEA	molecular_function
LOC412200	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412200	GO:0004185_13174_4	serine-type carboxypeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC412200	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC412200	GO:0004829_13174_1	threonine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]	IEA	molecular_function
LOC412200	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412200	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412200	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC412200	GO:0006435_6281_1	threonyl-tRNA aminoacylation	"The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC412200	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412200	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
LOC412200	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
LOC412201	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412205	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412205	GO:0019835_6281_1	cytolysis	"The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]	IEA	biological_process
LOC412215	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC412217	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412217	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412217	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412217	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412217	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412217	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412217	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC412217	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412217	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412220	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412220	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412220	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412220	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412220	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412221	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC412231	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412231	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412231	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412232	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412232	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412232	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC412233	GO:0016798_13174_3	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	IEA	molecular_function
LOC412234	GO:0004735_13174_2	pyrroline-5-carboxylate reductase activity	"Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]	IEA	molecular_function
LOC412234	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412234	GO:0006561_6281_4	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	IEA	biological_process
LOC412234	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412234	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC412234	GO:0046168_6281_4	glycerol-3-phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	IEA	biological_process
LOC412234	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC412234	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412235	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412235	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412235	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
LOC412235	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC412236	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412236	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412247	GO:0001510_6281_1	RNA methylation	"Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd]	IEA	biological_process
LOC412247	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412247	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC412247	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC412254	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412254	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412254	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412256	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412256	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412256	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412256	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412259	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412259	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412259	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412259	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC412259	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412259	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412260	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412260	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412260	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412260	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412260	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412260	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412262	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC412262	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412262	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412262	GO:0008017_13174_2	microtubule binding	"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]	IEA	molecular_function
LOC412263	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC412263	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412272	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC412272	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC412272	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
LOC412272	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412276	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412276	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC412276	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC412277	GO:0004482_13174_1	mRNA (guanine-N7-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56]	IEA	molecular_function
LOC412277	GO:0006370_6281_3	7-methylguanosine mRNA capping	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]	IEA	biological_process
LOC412279	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC412279	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412281	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC412281	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412281	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412281	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412282	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412282	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC412282	GO:0004823_13174_1	leucine-tRNA ligase activity	"Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691]	IEA	molecular_function
LOC412282	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412282	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412282	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC412282	GO:0006429_6281_1	leucyl-tRNA aminoacylation	"The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC412284	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412286	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412286	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412286	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412290	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC412290	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC412293	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC412293	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412299	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC412299	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412301	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC412303	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412303	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC412303	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC412304	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412304	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412308	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412308	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412308	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
LOC412308	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC412308	GO:0008409_13174_1	5'-3' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]	IEA	molecular_function
LOC412308	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC412309	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC412309	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412309	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412309	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC412309	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC412309	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC412309	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412309	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC412309	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412309	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412315	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
LOC412316	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412316	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412318	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412319	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC412319	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412319	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412326	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC412326	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412331	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412338	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412338	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412340	GO:0004148_13174_2	dihydrolipoyl dehydrogenase activity	"Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]	IEA	molecular_function
LOC412340	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412340	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412340	GO:0016668_13174_3	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC412340	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC412340	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC412340	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412341	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412341	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412342	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412343	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412344	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC412344	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC412353	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412354	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC412354	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412354	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412354	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC412355	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
LOC412355	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412355	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC412355	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412360	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC412366	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC412366	GO:0016226_6281_4	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	IEA	biological_process
LOC412366	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC412372	GO:0004047_13174_3	aminomethyltransferase activity	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]	IEA	molecular_function
LOC412372	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412372	GO:0006546_6281_3	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
LOC412372	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412372	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412378	GO:0016888_13174_2	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	IEA	molecular_function
LOC412386	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412386	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412386	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412388	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412393	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412393	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412393	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC412393	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC412393	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC412393	GO:0034701_13174_1	tripeptidase activity	"Catalysis of the hydrolysis of a tripeptide." [GOC:mah]	IEA	molecular_function
LOC412397	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412399	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412399	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412399	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412407	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412407	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
LOC412407	GO:0030272_13174_2	5-formyltetrahydrofolate cyclo-ligase activity	"Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10491]	IEA	molecular_function
LOC412409	GO:0005744_3650_2	mitochondrial inner membrane presequence translocase complex	"The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]	IEA	cellular_component
LOC412409	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC412409	GO:0015450_13174_5	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412409	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412409	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC412410	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412410	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC412419	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412419	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412419	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412419	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412419	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412419	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412423	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC412423	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412423	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC412426	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
LOC412426	GO:0006744_6281_5	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	IEA	biological_process
LOC412426	GO:0016709_13174_1	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
LOC412426	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC412426	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412430	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412430	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412431	GO:0005542_13174_2	folic acid binding	"Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412431	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412431	GO:0008518_13174_1	reduced folate carrier activity	"Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]	IEA	molecular_function
LOC412431	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412442	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412442	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412443	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412446	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412446	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412446	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412446	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412446	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412446	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412446	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412446	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412448	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412448	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412448	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC412448	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412451	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412454	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412455	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412455	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412455	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412455	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412455	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412455	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412455	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC412458	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412458	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412458	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412458	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC412458	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC412459	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412460	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC412460	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412467	GO:0003937_13174_1	IMP cyclohydrolase activity	"Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10]	IEA	molecular_function
LOC412467	GO:0004643_13174_1	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3]	IEA	molecular_function
LOC412467	GO:0006164_6281_4	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC412472	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412476	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412476	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412476	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412476	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412487	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412487	GO:0005544_13174_4	calcium-dependent phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	IEA	molecular_function
LOC412489	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC412489	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC412489	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412491	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC412491	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412496	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412496	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412496	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412496	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412505	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC412505	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412505	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC412510	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412510	GO:0005635_3650_3	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	IEA	cellular_component
LOC412515	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC412515	GO:0016298_13174_5	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]	IEA	molecular_function
LOC412515	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC412522	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412522	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412526	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC412526	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC412540	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412540	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412540	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412540	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412540	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412540	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412541	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412541	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412544	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412545	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412545	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412546	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412546	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412546	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412546	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC412546	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC412548	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412548	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC412550	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412550	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412550	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412554	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412554	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412569	GO:0004591_13174_3	oxoglutarate dehydrogenase (succinyl-transferring) activity	"Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]	IEA	molecular_function
LOC412569	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC412569	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412569	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC412569	GO:0030976_13174_4	thiamine pyrophosphate binding	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]	IEA	molecular_function
LOC412569	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412573	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412573	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
LOC412573	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412573	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412573	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC412574	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412574	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412574	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412574	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412579	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC412579	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412579	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC412579	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412579	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412588	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412588	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412588	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412588	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412588	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412588	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412588	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412593	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412593	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412596	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412602	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412602	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC412606	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412606	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412606	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC412607	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412607	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412607	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412610	GO:0004363_13174_2	glutathione synthase activity	"Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560]	IEA	molecular_function
LOC412610	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412610	GO:0006750_6281_3	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC412612	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC412613	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412613	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412613	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
LOC412613	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412616	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412616	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412616	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412616	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC412616	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412617	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412619	GO:0004044_13174_1	amidophosphoribosyltransferase activity	"Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908]	IEA	molecular_function
LOC412619	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412619	GO:0009113_6281_2	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC412619	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
LOC412620	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412620	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412620	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412620	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412620	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412624	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412624	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC412629	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412637	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC412637	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412637	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412641	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412643	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412644	GO:0008242_13174_5	omega peptidase activity	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]	IEA	molecular_function
LOC412647	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412647	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
LOC412648	GO:0008104_6281_3	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	IEA	biological_process
LOC412651	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC412651	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC412651	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC412655	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412655	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC412655	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC412655	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC412661	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412665	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412665	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412665	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412667	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412667	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412667	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412667	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
LOC412667	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412667	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC412667	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412667	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412670	GO:0004648_13174_1	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	"Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52]	IEA	molecular_function
LOC412670	GO:0006564_6281_3	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]	IEA	biological_process
LOC412670	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412676	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412679	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412679	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412681	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412681	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC412681	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412684	GO:0004335_13174_2	galactokinase activity	"Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556]	IEA	molecular_function
LOC412684	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412684	GO:0006012_6281_5	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	IEA	biological_process
LOC412684	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC412684	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
LOC412684	GO:0046835_6281_2	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	IEA	biological_process
LOC412701	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412701	GO:0008104_6281_3	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	IEA	biological_process
LOC412707	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412715	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412727	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC412727	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412727	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412728	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412728	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412731	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412731	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC412731	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC412734	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412735	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC412741	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC412741	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412741	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412741	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412741	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412741	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC412741	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412741	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412741	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC412741	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412744	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412745	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412745	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC412745	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
LOC412745	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC412746	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412751	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412755	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412759	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412764	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412764	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412770	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412770	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
LOC412770	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412771	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC412774	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC412774	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
LOC412774	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC412774	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412777	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412777	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412784	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412784	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412796	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412796	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412797	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412797	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412797	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412797	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412797	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412797	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412798	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412801	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC412801	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412801	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC412801	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC412804	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC412804	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
LOC412804	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC412806	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC412808	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC412808	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412809	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412809	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412809	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412810	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC412810	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC412810	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC412813	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412815	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
LOC412815	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412815	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412815	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412815	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC412815	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412815	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC412815	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412817	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412817	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412817	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412817	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412817	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC412817	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC412817	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC412827	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412829	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412829	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412829	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC412835	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412837	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412837	GO:0004523_13174_5	ribonuclease H activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	IEA	molecular_function
LOC412837	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC412840	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412840	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412840	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412840	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412840	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412840	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC412842	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412842	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC412842	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC412844	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC412844	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC412844	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
LOC412844	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC412844	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC412850	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412850	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412850	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412850	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412851	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC412851	GO:0006071_6281_4	glycerol metabolic process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC412851	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC412851	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC412851	GO:0008889_13174_3	glycerophosphodiester phosphodiesterase activity	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]	IEA	molecular_function
LOC412851	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412858	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412858	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412859	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412862	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412863	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412865	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC412865	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412865	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC412865	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC412876	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412876	GO:0004075_13174_4	biotin carboxylase activity	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]	IEA	molecular_function
LOC412876	GO:0004736_13174_1	pyruvate carboxylase activity	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]	IEA	molecular_function
LOC412876	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412876	GO:0006094_6281_3	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	IEA	biological_process
LOC412876	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412876	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC412876	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC412878	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412878	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412878	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412878	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC412880	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC412880	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC412881	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412881	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412883	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC412883	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412884	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC412884	GO:0005794_3650_2	Golgi apparatus	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]	IEA	cellular_component
LOC412884	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC412884	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC412884	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC412884	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC412884	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
LOC412884	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
LOC412884	GO:0044431_3650_2	Golgi apparatus part	"Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]	IEA	cellular_component
LOC412886	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC412886	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC412886	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC412886	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC412886	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC412886	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC412886	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC412887	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412887	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412887	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412887	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC412888	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412888	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412888	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412888	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412888	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC412889	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412889	GO:0004084_13174_1	branched-chain-amino-acid transaminase activity	"Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah]	IEA	molecular_function
LOC412889	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412889	GO:0009081_6281_1	branched-chain amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai]	IEA	biological_process
LOC412890	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC412890	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412890	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC412890	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412892	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412892	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412914	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC412914	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC412914	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC412914	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
LOC412917	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412917	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412917	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412917	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412917	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412917	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412918	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC412918	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC412918	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC412923	GO:0004055_13174_1	argininosuccinate synthase activity	"Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]	IEA	molecular_function
LOC412923	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412923	GO:0006526_6281_2	arginine biosynthetic process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732]	IEA	biological_process
LOC412925	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412925	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412926	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC412926	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC412926	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC412926	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC412929	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412930	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC412930	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
LOC412930	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC412931	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412932	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412937	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412941	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412941	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412941	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC412944	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412944	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412948	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412948	GO:0004349_13174_1	glutamate 5-kinase activity	"Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14880]	IEA	molecular_function
LOC412948	GO:0004350_13174_1	glutamate-5-semialdehyde dehydrogenase activity	"Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19544]	IEA	molecular_function
LOC412948	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC412948	GO:0006561_6281_4	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	IEA	biological_process
LOC412948	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC412948	GO:0008652_6281_1	cellular amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]	IEA	biological_process
LOC412948	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC412948	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412949	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC412949	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC412949	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412949	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC412949	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412949	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
LOC412950	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
LOC412950	GO:0016973_6281_1	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	IEA	biological_process
LOC412955	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC412955	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412960	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC412960	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC412960	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC412960	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC412968	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412969	GO:0019028_3650_3	viral capsid	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]	IEA	cellular_component
LOC412972	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412975	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC412975	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC412975	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC412976	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC412976	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC412976	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC412986	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC412986	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC412986	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC412986	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC412986	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC412988	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC412988	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC412988	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC412988	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC412988	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC412988	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC412988	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC412988	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC412988	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC412993	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC412993	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC412993	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC412994	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC412994	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC412997	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413002	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC413002	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413002	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC413006	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413006	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413006	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413006	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413011	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413011	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC413011	GO:0004828_13174_1	serine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]	IEA	molecular_function
LOC413011	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413011	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413011	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC413011	GO:0006434_6281_1	seryl-tRNA aminoacylation	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC413021	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC413021	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
LOC413021	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413021	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC413021	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC413021	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC413021	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC413021	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC413023	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413023	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC413023	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413023	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC413024	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413029	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413029	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413029	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413029	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413029	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413029	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413043	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413043	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC413046	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413047	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC413047	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413048	GO:0000103_6281_2	sulfate assimilation	"The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]	IEA	biological_process
LOC413048	GO:0004781_13174_2	sulfate adenylyltransferase (ATP) activity	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]	IEA	molecular_function
LOC413048	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413048	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC413048	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413051	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413051	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413053	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413054	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC413054	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413054	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
LOC413054	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC413054	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413055	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413055	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413055	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413060	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413060	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413060	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413060	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413064	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413064	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413064	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413064	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC413064	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413087	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413087	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413087	GO:0008173_13174_2	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	IEA	molecular_function
LOC413089	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413089	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413091	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413092	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC413092	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413092	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413092	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC413092	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC413096	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413096	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413096	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC413096	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC413097	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413097	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC413097	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413097	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413097	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413097	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC413097	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC413097	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413097	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413097	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC413103	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413103	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413103	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413108	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413109	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413109	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413110	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413110	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC413110	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413110	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC413112	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC413112	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413112	GO:0004743_13174_2	pyruvate kinase activity	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]	IEA	molecular_function
LOC413112	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC413112	GO:0030955_13174_2	potassium ion binding	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]	IEA	molecular_function
LOC413113	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC413120	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413120	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC413122	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC413123	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC413123	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413123	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC413123	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413125	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413125	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413127	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC413127	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC413129	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413129	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC413129	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC413138	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413138	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC413138	GO:0004012_13174_5	phospholipid-translocating ATPase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]	IEA	molecular_function
LOC413138	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413138	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413138	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC413138	GO:0015914_6281_5	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	IEA	biological_process
LOC413138	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413138	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413138	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413145	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413149	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413153	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413153	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413153	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413153	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413153	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413153	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413159	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413159	GO:0015269_13174_4	calcium-activated potassium channel activity	"Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	IEA	molecular_function
LOC413159	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413161	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413161	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC413161	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC413161	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC413164	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC413168	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413168	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413173	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413176	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413176	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413177	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413181	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413185	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
LOC413189	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413189	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413190	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413190	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413190	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413190	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413190	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413190	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413192	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413193	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413195	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413199	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC413199	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413199	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413199	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC413199	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413207	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413209	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413209	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413209	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC413210	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413210	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC413210	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC413210	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC413210	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413213	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC413213	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC413215	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413222	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413222	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413226	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413228	GO:0003870_13174_1	5-aminolevulinate synthase activity	"Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924]	IEA	molecular_function
LOC413228	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC413228	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413228	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413228	GO:0033014_6281_4	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]	IEA	biological_process
LOC413233	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413233	GO:0004075_13174_4	biotin carboxylase activity	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]	IEA	molecular_function
LOC413233	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413233	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413233	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC413233	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413240	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413241	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413241	GO:0005787_3650_4	signal peptidase complex	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]	IEA	cellular_component
LOC413241	GO:0006465_6281_5	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC413241	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413241	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC413241	GO:0008271_13174_3	secondary active sulfate transmembrane transporter activity	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]	IEA	molecular_function
LOC413241	GO:0008272_6281_3	sulfate transport	"The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC413241	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413241	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413241	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413242	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC413245	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413245	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413245	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413248	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC413248	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413248	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413248	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC413250	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413250	GO:0005575_3650_2	cellular_component	"The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]	IEA	cellular_component
LOC413250	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC413250	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC413252	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413252	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413252	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413252	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413253	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC413255	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413255	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC413263	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413263	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413266	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC413266	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413266	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413266	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
LOC413266	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413270	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413274	GO:0004383_13174_4	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	IEA	molecular_function
LOC413274	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413274	GO:0006182_6281_4	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	IEA	biological_process
LOC413274	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC413274	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC413274	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC413274	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC413280	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413285	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413285	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413286	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413286	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413286	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413286	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413286	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413286	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413294	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413295	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413295	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC413295	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC413295	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC413295	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC413295	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC413295	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC413295	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413299	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413299	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413314	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413324	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413324	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC413324	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413324	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413328	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC413328	GO:0004012_13174_5	phospholipid-translocating ATPase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]	IEA	molecular_function
LOC413328	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413328	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413328	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC413328	GO:0015914_6281_5	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	IEA	biological_process
LOC413328	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413328	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413333	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413336	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413336	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC413337	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413337	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413337	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413341	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413341	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413341	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413341	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413341	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413341	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413341	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413341	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413341	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC413343	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413345	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413346	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413346	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413346	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413350	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413351	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413354	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413354	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413354	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413354	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413354	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413354	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413354	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413356	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC413356	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC413356	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413357	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC413357	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC413362	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413362	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413362	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413362	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
LOC413362	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413363	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413366	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413366	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413366	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413366	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413366	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413368	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413368	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413370	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413372	GO:0006537_6281_2	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	IEA	biological_process
LOC413372	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413372	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413372	GO:0015930_13174_1	glutamate synthase activity	"Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-]	IEA	molecular_function
LOC413372	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413372	GO:0016638_13174_2	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC413372	GO:0016639_13174_1	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC413372	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC413372	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413376	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413376	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413376	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413387	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC413387	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413387	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413388	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413388	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413388	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413388	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413388	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
LOC413388	GO:0034968_6281_4	histone lysine methylation	"The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah]	IEA	biological_process
LOC413390	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413390	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413390	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413390	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413391	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413391	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413391	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413391	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413391	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413394	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413394	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413394	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC413399	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413404	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413425	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413425	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413425	GO:0005942_3650_3	phosphatidylinositol 3-kinase complex	"A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K)." [GOC:bf]	IEA	cellular_component
LOC413425	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC413425	GO:0016303_13174_3	1-phosphatidylinositol-3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]	IEA	molecular_function
LOC413425	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413425	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC413425	GO:0035004_13174_4	phosphatidylinositol 3-kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]	IEA	molecular_function
LOC413425	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC413425	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC413425	GO:0048015_6281_3	phosphatidylinositol-mediated signaling	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	biological_process
LOC413429	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC413429	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC413429	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413433	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413435	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC413435	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC413440	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413444	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413450	GO:0019867_3650_1	outer membrane	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]	IEA	cellular_component
LOC413451	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413451	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC413460	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413460	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC413460	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC413460	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC413462	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413462	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413462	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413462	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413462	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413462	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413462	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413462	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC413464	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413464	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413464	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413464	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413464	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413464	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413464	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413467	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413467	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413467	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413467	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413467	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413467	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413468	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413468	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413471	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413471	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413471	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413471	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC413471	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413471	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413471	GO:0015077_13174_3	monovalent inorganic cation transmembrane transporter activity	"Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC413471	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC413471	GO:0015672_6281_4	monovalent inorganic cation transport	"The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]	IEA	biological_process
LOC413471	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413471	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413471	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
LOC413471	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413472	GO:0005921_3650_4	gap junction	"A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]	IEA	cellular_component
LOC413478	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413478	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413481	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413481	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC413481	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC413481	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413481	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413481	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413481	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413484	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413484	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413484	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413486	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC413488	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC413488	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413488	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413488	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC413488	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC413491	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC413494	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413494	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413499	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413499	GO:0005680_3650_1	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	IEA	cellular_component
LOC413499	GO:0030071_6281_1	regulation of mitotic metaphase/anaphase transition	"Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]	IEA	biological_process
LOC413507	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413507	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413510	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413510	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413510	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413510	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413510	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413510	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413512	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413515	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413515	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413515	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413527	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413527	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413531	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC413531	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413532	GO:0000176_3650_2	nuclear exosome (RNase complex)	"Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]	IEA	cellular_component
LOC413532	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413532	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413532	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC413532	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413532	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
LOC413533	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC413533	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC413533	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC413533	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413539	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413539	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC413539	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC413539	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413539	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413542	GO:0000175_13174_1	3'-5'-exoribonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413542	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413542	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413545	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413547	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413549	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC413549	GO:0032580_3650_2	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	IEA	cellular_component
LOC413550	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413550	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413553	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413553	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413553	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC413553	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413555	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413556	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413556	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413556	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413556	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413562	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC413562	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413562	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC413567	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413567	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413567	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413567	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC413567	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC413568	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC413568	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413568	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413574	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413575	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413575	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413575	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413575	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413575	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC413575	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC413575	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413576	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413576	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413576	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413576	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413576	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC413576	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC413576	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413577	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413577	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413577	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413577	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413577	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413577	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413578	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413578	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413579	GO:0004571_13174_5	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]	IEA	molecular_function
LOC413579	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413579	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413582	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413582	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413585	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413592	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413592	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413592	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413613	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC413613	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC413613	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413618	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413619	GO:0004721_13174_4	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]	IEA	molecular_function
LOC413619	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413619	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC413631	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413631	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC413633	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413633	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413633	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413633	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413633	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413633	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413635	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413635	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413643	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413643	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC413648	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC413648	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC413648	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC413650	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413650	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413650	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413650	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413650	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413650	GO:0006406_6281_1	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	IEA	biological_process
LOC413650	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413650	GO:0051028_6281_3	mRNA transport	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413652	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413652	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413652	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413652	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413652	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413653	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413653	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413653	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413655	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413655	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413655	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413660	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413660	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413660	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413660	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413660	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413660	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413660	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC413663	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413663	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC413663	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413663	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413663	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC413663	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC413663	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413663	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC413666	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413666	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413666	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413666	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
LOC413666	GO:0007031_6281_4	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	IEA	biological_process
LOC413666	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413668	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413668	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC413669	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413670	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413672	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413677	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC413677	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413677	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413677	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC413678	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413683	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413683	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC413683	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413683	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC413686	GO:0030515_13174_1	snoRNA binding	"Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah]	IEA	molecular_function
LOC413686	GO:0031120_6281_1	snRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah]	IEA	biological_process
LOC413686	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
LOC413689	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413689	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413689	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413691	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413693	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413697	GO:0004371_13174_1	glycerone kinase activity	"Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15776]	IEA	molecular_function
LOC413697	GO:0006071_6281_4	glycerol metabolic process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC413700	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
LOC413700	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413700	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413702	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413702	GO:0008203_6281_1	cholesterol metabolic process	"The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732]	IEA	biological_process
LOC413702	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
LOC413702	GO:0016298_13174_5	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]	IEA	molecular_function
LOC413702	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC413705	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC413705	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC413705	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC413705	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC413705	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413705	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413705	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413709	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413713	GO:0009103_6281_4	lipopolysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]	IEA	biological_process
LOC413714	GO:0043461_6281_1	proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]	IEA	biological_process
LOC413724	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413724	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413724	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413724	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
LOC413724	GO:0034968_6281_4	histone lysine methylation	"The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah]	IEA	biological_process
LOC413732	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413736	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413736	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413736	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413736	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413736	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413736	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413737	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC413737	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC413738	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
LOC413739	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413739	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413740	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413746	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC413746	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC413746	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC413753	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC413753	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413758	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC413758	GO:0032040_3650_5	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	IEA	cellular_component
LOC413759	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413759	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC413759	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC413759	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC413759	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413759	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413759	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413759	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC413759	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC413759	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413759	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413762	GO:0005759_3650_2	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	IEA	cellular_component
LOC413768	GO:0004591_13174_3	oxoglutarate dehydrogenase (succinyl-transferring) activity	"Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]	IEA	molecular_function
LOC413768	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC413768	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413768	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC413768	GO:0030976_13174_4	thiamine pyrophosphate binding	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]	IEA	molecular_function
LOC413768	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413785	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413785	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC413789	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413791	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC413791	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413791	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC413795	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413796	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413796	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC413796	GO:0004825_13174_2	methionine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]	IEA	molecular_function
LOC413796	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413796	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413796	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC413796	GO:0006431_6281_2	methionyl-tRNA aminoacylation	"The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC413802	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413805	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC413805	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413805	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413805	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC413805	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC413810	GO:0004326_13174_1	tetrahydrofolylpolyglutamate synthase activity	"Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]	IEA	molecular_function
LOC413810	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413810	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC413810	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
LOC413810	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC413812	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413812	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413812	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC413815	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413815	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC413815	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC413816	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413816	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413816	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413816	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413817	GO:0008440_13174_5	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11023]	IEA	molecular_function
LOC413822	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC413825	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413825	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413827	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC413827	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC413827	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413827	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC413827	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC413827	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC413827	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC413827	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC413827	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413827	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413827	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC413829	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC413829	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC413829	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC413829	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC413829	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413829	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413831	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413831	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC413831	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC413840	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413840	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413844	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413844	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413844	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413845	GO:0005742_3650_1	mitochondrial outer membrane translocase complex	"A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]	IEA	cellular_component
LOC413845	GO:0006605_6281_5	protein targeting	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	IEA	biological_process
LOC413845	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC413852	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC413852	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC413855	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC413855	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC413858	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413869	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413869	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413874	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413874	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC413874	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413874	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC413877	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC413879	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413879	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413879	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC413879	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
LOC413880	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413881	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413881	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC413881	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC413881	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413881	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC413881	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
LOC413885	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC413885	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
LOC413889	GO:0000049_13174_4	tRNA binding	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]	IEA	molecular_function
LOC413889	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413889	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC413889	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC413889	GO:0034227_6281_2	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	IEA	biological_process
LOC413892	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413892	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC413898	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413899	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413900	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413906	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413906	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413907	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413907	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC413914	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC413914	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413917	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413917	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC413917	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
LOC413924	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC413924	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413926	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC413926	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC413929	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC413929	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413929	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC413929	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
LOC413929	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
LOC413929	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC413930	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413933	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC413934	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC413934	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC413934	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413934	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC413935	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413936	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC413942	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC413942	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC413944	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC413944	GO:0004540_13174_5	ribonuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413955	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413955	GO:0042802_13174_2	identical protein binding	"Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]	IEA	molecular_function
LOC413957	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413966	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC413966	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC413966	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC413968	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC413968	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC413968	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413968	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC413968	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC413971	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413973	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC413973	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC413977	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC413977	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC413977	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413984	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC413984	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC413994	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC413994	GO:0015269_13174_4	calcium-activated potassium channel activity	"Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	IEA	molecular_function
LOC413994	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC413997	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC413998	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC413998	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC414009	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC414009	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414009	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC414017	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC414017	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC414017	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC414017	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC414017	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC414017	GO:0045892_6281_5	negative regulation of transcription, DNA-dependent	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC414021	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC414021	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
LOC414021	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC414021	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC414025	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414026	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC414027	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC414027	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC414028	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC414028	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414028	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC414028	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC414029	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC414029	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC414029	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC414029	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC414029	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC414029	GO:0007283_6281_2	spermatogenesis	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]	IEA	biological_process
LOC414029	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC414029	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC414032	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC414032	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC414035	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414036	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414038	GO:0006505_6281_2	GPI anchor metabolic process	"The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732]	IEA	biological_process
LOC414038	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC414038	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC414038	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
LOC414042	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC414043	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC414051	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC414051	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC414051	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC414051	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC414051	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC414052	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC414052	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC550651	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC550651	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC550651	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC550651	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC550651	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC550659	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC550663	GO:0004616_13174_4	phosphogluconate dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]	IEA	molecular_function
LOC550663	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
LOC550663	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC550663	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC550668	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550668	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC550682	GO:0000015_3650_2	phosphopyruvate hydratase complex	"A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]	IEA	cellular_component
LOC550682	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC550682	GO:0004634_13174_2	phosphopyruvate hydratase activity	"Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]	IEA	molecular_function
LOC550682	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC550689	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550689	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550691	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC550691	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC550692	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC550692	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC550692	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
LOC550698	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
LOC550698	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
LOC550701	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550701	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC550706	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550706	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC550712	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC550712	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC550712	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC550712	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550712	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC550712	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC550716	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC550716	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC550716	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC550716	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC550716	GO:0030130_3650_2	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	IEA	cellular_component
LOC550716	GO:0030132_3650_2	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	IEA	cellular_component
LOC550726	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550748	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC550748	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550748	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC550780	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550780	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC550785	GO:0004332_13174_2	fructose-bisphosphate aldolase activity	"Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13]	IEA	molecular_function
LOC550785	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC550789	GO:0008898_13174_2	homocysteine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10]	IEA	molecular_function
LOC550794	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC550794	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550794	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC550794	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC550794	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC550794	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC550795	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550798	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC550801	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC550801	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC550801	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550801	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC550804	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550804	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550808	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550816	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC550816	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550816	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550818	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC550818	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC550818	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC550818	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC550818	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC550818	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC550824	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC550824	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC550827	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC550827	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC550827	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC550827	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC550827	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC550827	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC550827	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC550828	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC550830	GO:0009168_6281_5	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC550830	GO:0019239_13174_5	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]	IEA	molecular_function
LOC550835	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC550835	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC550835	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550835	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC550858	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC550865	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550869	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550869	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550869	GO:0008449_13174_1	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	IEA	molecular_function
LOC550869	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC550869	GO:0030203_6281_1	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981]	IEA	biological_process
LOC550870	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550884	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550884	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550884	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC550885	GO:0004516_13174_1	nicotinate phosphoribosyltransferase activity	"Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396]	IEA	molecular_function
LOC550885	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC550885	GO:0009435_6281_3	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	IEA	biological_process
LOC550885	GO:0019358_6281_1	nicotinate nucleotide salvage	"The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators]	IEA	biological_process
LOC550885	GO:0019363_6281_1	pyridine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw]	IEA	biological_process
LOC550901	GO:0004091_13174_4	carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1]	IEA	molecular_function
LOC550906	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550915	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC550915	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC550915	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC550915	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC550920	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550926	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550926	GO:0004615_13174_1	phosphomannomutase activity	"Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11143]	IEA	molecular_function
LOC550926	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC550926	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550926	GO:0019307_6281_1	mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]	IEA	biological_process
LOC550929	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC550929	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC550929	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC550929	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550929	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC550929	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC550938	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
LOC550940	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC550940	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC550940	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC550940	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC550940	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550940	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC550940	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC550940	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC550964	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC550964	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC550964	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC550964	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550964	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC550964	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC550964	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC550964	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC550964	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC550966	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC550966	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC550966	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC550966	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC550966	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC550969	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC550969	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC550969	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC550969	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC550969	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC550970	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC550970	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC550970	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC550973	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC550976	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC550976	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550977	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC550977	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550977	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC550977	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550984	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550987	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC550987	GO:0016462_13174_1	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]	IEA	molecular_function
LOC550989	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550992	GO:0008430_13174_3	selenium binding	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]	IEA	molecular_function
LOC550992	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC550997	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC550997	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC550998	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC550998	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551005	GO:0004396_13174_2	hexokinase activity	"Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]	IEA	molecular_function
LOC551005	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551005	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551005	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC551005	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551007	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551011	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551011	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC551011	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC551011	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC551011	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551016	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551016	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551016	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551016	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551016	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551016	GO:0006461_6281_5	protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]	IEA	biological_process
LOC551016	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551016	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551017	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551020	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551020	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC551020	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC551020	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC551029	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551029	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551031	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC551033	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551033	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551034	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC551034	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551034	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551034	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC551034	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC551034	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551034	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC551034	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551034	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551039	GO:0004148_13174_2	dihydrolipoyl dehydrogenase activity	"Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]	IEA	molecular_function
LOC551039	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551039	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC551039	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551039	GO:0016668_13174_3	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC551039	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC551039	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC551039	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551041	GO:0004370_13174_3	glycerol kinase activity	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]	IEA	molecular_function
LOC551041	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551041	GO:0006072_6281_5	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551041	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551045	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551045	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551047	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551053	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551053	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551053	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551053	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551053	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551053	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551054	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551054	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551059	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551061	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551061	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551061	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551061	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551061	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551061	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551061	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551061	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551065	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551067	GO:0008104_6281_3	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	IEA	biological_process
LOC551071	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551071	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551071	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551071	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551071	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551071	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC551072	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551072	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551083	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC551083	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551083	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC551083	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC551086	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551086	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551086	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551087	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551088	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551088	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551088	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC551088	GO:0004816_13174_2	asparagine-tRNA ligase activity	"Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183]	IEA	molecular_function
LOC551088	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551088	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551088	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC551088	GO:0006421_6281_2	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC551089	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551089	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
LOC551089	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551093	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551093	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551093	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC551093	GO:0015992_6281_5	proton transport	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
LOC551093	GO:0016469_3650_4	proton-transporting two-sector ATPase complex	"A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]	IEA	cellular_component
LOC551093	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
LOC551093	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551093	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC551093	GO:0033180_3650_4	proton-transporting V-type ATPase, V1 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
LOC551093	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
LOC551093	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
LOC551093	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
LOC551094	GO:0016884_13174_4	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]	IEA	molecular_function
LOC551098	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551101	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551101	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC551101	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551101	GO:0004826_13174_3	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	IEA	molecular_function
LOC551101	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551101	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551101	GO:0006432_6281_3	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC551102	GO:0004478_13174_1	methionine adenosyltransferase activity	"Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6]	IEA	molecular_function
LOC551102	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551102	GO:0006556_6281_1	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551103	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551103	GO:0016624_13174_6	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	IEA	molecular_function
LOC551113	GO:0003842_13174_1	1-pyrroline-5-carboxylate dehydrogenase activity	"Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12]	IEA	molecular_function
LOC551113	GO:0005759_3650_2	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	IEA	cellular_component
LOC551113	GO:0006561_6281_4	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	IEA	biological_process
LOC551113	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551113	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551113	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551114	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551114	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC551115	GO:0007026_6281_3	negative regulation of microtubule depolymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC551121	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551121	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC551121	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC551121	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC551125	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC551125	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551125	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC551125	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC551129	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551129	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551137	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551137	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551139	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
LOC551139	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551139	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551139	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC551139	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551139	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC551139	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC551141	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC551141	GO:0004564_13174_1	beta-fructofuranosidase activity	"Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985]	IEA	molecular_function
LOC551141	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551141	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551142	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551142	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC551142	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551142	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC551144	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
LOC551144	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
LOC551147	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC551147	GO:0017150_13174_4	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]	IEA	molecular_function
LOC551147	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC551147	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551151	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551154	GO:0004347_13174_1	glucose-6-phosphate isomerase activity	"Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9]	IEA	molecular_function
LOC551154	GO:0006094_6281_3	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	IEA	biological_process
LOC551154	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC551160	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551160	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551167	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551167	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551167	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551167	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551167	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551167	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551167	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551167	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551169	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC551169	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC551169	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551169	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC551169	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC551169	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551171	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551176	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551177	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551180	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC551180	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551182	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551182	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551182	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551182	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551182	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
LOC551182	GO:0035004_13174_4	phosphatidylinositol 3-kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]	IEA	molecular_function
LOC551185	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC551185	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551187	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551188	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC551188	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551188	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551188	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551188	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC551188	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC551189	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC551193	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC551193	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551193	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC551194	GO:0003840_13174_3	gamma-glutamyltransferase activity	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]	IEA	molecular_function
LOC551204	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551204	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551204	GO:0004519_13174_5	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551204	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC551204	GO:0006284_6281_3	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	IEA	biological_process
LOC551204	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC551205	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC551205	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551207	GO:0004721_13174_4	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]	IEA	molecular_function
LOC551207	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551207	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551207	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551208	GO:0004616_13174_4	phosphogluconate dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]	IEA	molecular_function
LOC551208	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
LOC551208	GO:0008442_13174_1	3-hydroxyisobutyrate dehydrogenase activity	"Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31]	IEA	molecular_function
LOC551208	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC551208	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551211	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
LOC551211	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551211	GO:0005853_3650_3	eukaryotic translation elongation factor 1 complex	"A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]	IEA	cellular_component
LOC551211	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
LOC551213	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551217	GO:0005375_13174_3	copper ion transmembrane transporter activity	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC551217	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551217	GO:0035434_6281_3	copper ion transmembrane transport	"The directed movement of copper (Cu) ions across a membrane by means of some agent such as a transporter or pore." [GOC:vw]	IEA	biological_process
LOC551220	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551220	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551224	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC551224	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551226	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551229	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC551229	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC551229	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551229	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC551232	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC551232	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
LOC551232	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551232	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC551232	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551232	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
LOC551232	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC551240	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551240	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC551240	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551240	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC551242	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551243	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551243	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551243	GO:0004813_13174_2	alanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]	IEA	molecular_function
LOC551243	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551243	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551243	GO:0006419_6281_2	alanyl-tRNA aminoacylation	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC551243	GO:0016876_13174_6	ligase activity, forming aminoacyl-tRNA and related compounds	"Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]	IEA	molecular_function
LOC551243	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
LOC551248	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551249	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551254	GO:0016538_13174_2	cyclin-dependent protein kinase regulator activity	"Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875]	IEA	molecular_function
LOC551254	GO:0051302_6281_1	regulation of cell division	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]	IEA	biological_process
LOC551254	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC551256	GO:0000079_6281_9	regulation of cyclin-dependent protein kinase activity	"Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]	IEA	biological_process
LOC551256	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
LOC551258	GO:0000159_3650_3	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	IEA	cellular_component
LOC551258	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551258	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551258	GO:0008601_13174_3	protein phosphatase type 2A regulator activity	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]	IEA	molecular_function
LOC551263	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551263	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551265	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC551265	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551269	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC551269	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551273	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551273	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC551275	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551275	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551275	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
LOC551275	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC551279	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551279	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551281	GO:0004484_13174_2	mRNA guanylyltransferase activity	"Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]	IEA	molecular_function
LOC551281	GO:0006370_6281_3	7-methylguanosine mRNA capping	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]	IEA	biological_process
LOC551281	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC551282	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551290	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551290	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551290	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC551291	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551297	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC551297	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC551297	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC551300	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551300	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC551300	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551300	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
LOC551300	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551303	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC551306	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC551312	GO:0006541_6281_2	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	IEA	biological_process
LOC551312	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551313	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551319	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC551319	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551319	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551324	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551327	GO:0004180_13174_5	carboxypeptidase activity	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC551327	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC551327	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551327	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551331	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551331	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551339	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551340	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC551340	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551340	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC551340	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC551342	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551344	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC551344	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC551344	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551344	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC551345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551350	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551353	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC551354	GO:0000145_3650_2	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]	IEA	cellular_component
LOC551354	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
LOC551354	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551358	GO:0016765_13174_2	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551361	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC551361	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551363	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551363	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC551363	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551365	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551365	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551365	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC551365	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551365	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551365	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551366	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC551366	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC551366	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC551369	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551374	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551374	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551375	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC551375	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC551375	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC551375	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC551376	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551376	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551376	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551376	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551376	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC551376	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC551378	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551379	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC551380	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551380	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC551380	GO:0008173_13174_2	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	IEA	molecular_function
LOC551385	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551386	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551386	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551386	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551386	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551386	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551386	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC551387	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551389	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551395	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551395	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551395	GO:0008610_6281_2	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
LOC551395	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551396	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551396	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551396	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551396	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551396	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551399	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551399	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551399	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC551399	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551399	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551399	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551399	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551405	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551405	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551407	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551407	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551407	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551412	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551413	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551414	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551414	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC551421	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551422	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551423	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551423	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551428	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551428	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551428	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551428	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551428	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551428	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551430	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551430	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC551432	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551432	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551434	GO:0008430_13174_3	selenium binding	"Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]	IEA	molecular_function
LOC551436	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551436	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551436	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
LOC551436	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC551438	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551441	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551442	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551442	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551442	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551446	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551446	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551447	GO:0004476_13174_1	mannose-6-phosphate isomerase activity	"Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8]	IEA	molecular_function
LOC551447	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551447	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551448	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC551448	GO:0004749_13174_2	ribose phosphate diphosphokinase activity	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]	IEA	molecular_function
LOC551448	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
LOC551448	GO:0009156_6281_1	ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551448	GO:0009165_6281_3	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
LOC551448	GO:0044249_6281_2	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC551449	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC551449	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC551449	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC551449	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC551450	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551453	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551453	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551453	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC551453	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551454	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC551454	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551454	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC551454	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC551454	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551458	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551459	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551461	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551461	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC551461	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC551462	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551465	GO:0004411_13174_2	homogentisate 1,2-dioxygenase activity	"Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15452]	IEA	molecular_function
LOC551465	GO:0006559_6281_3	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	IEA	biological_process
LOC551465	GO:0006570_6281_2	tyrosine metabolic process	"The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	IEA	biological_process
LOC551465	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551466	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551466	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551466	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551469	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551474	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551475	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551475	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551476	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551476	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551476	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC551476	GO:0004816_13174_2	asparagine-tRNA ligase activity	"Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183]	IEA	molecular_function
LOC551476	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551476	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551476	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC551476	GO:0006421_6281_2	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC551479	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC551479	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551479	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC551479	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC551480	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551486	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551486	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC551486	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC551487	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551489	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551489	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551493	GO:0000398_6281_4	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	IEA	biological_process
LOC551493	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551493	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551493	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551493	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC551500	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551500	GO:0005942_3650_3	phosphatidylinositol 3-kinase complex	"A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K)." [GOC:bf]	IEA	cellular_component
LOC551500	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551500	GO:0016303_13174_3	1-phosphatidylinositol-3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]	IEA	molecular_function
LOC551500	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551500	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551500	GO:0035004_13174_4	phosphatidylinositol 3-kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]	IEA	molecular_function
LOC551500	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC551500	GO:0046934_13174_1	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21295]	IEA	molecular_function
LOC551500	GO:0048015_6281_3	phosphatidylinositol-mediated signaling	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	biological_process
LOC551504	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551505	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551507	GO:0003884_13174_2	D-amino-acid oxidase activity	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]	IEA	molecular_function
LOC551507	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551507	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551508	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC551508	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551510	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551513	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
LOC551513	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551513	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC551518	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC551518	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551519	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551519	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551519	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC551524	GO:0004180_13174_5	carboxypeptidase activity	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC551524	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC551524	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551524	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551527	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC551529	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC551530	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551530	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551530	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551530	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551530	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551530	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551531	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551531	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551531	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC551532	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551532	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC551532	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC551532	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
LOC551533	GO:0004733_13174_2	pyridoxamine-phosphate oxidase activity	"Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]	IEA	molecular_function
LOC551533	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
LOC551533	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551536	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551537	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551537	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551541	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
LOC551541	GO:0005746_3650_1	mitochondrial respiratory chain	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	IEA	cellular_component
LOC551541	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC551545	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551545	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551547	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551548	GO:0004067_13174_1	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	IEA	molecular_function
LOC551548	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551548	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC551553	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551553	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551553	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551553	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551553	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551553	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551558	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551562	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551562	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC551562	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551562	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551562	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551562	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC551562	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551562	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551562	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC551566	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551566	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551566	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551566	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551566	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551570	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551571	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC551571	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551575	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551578	GO:0000030_13174_1	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	IEA	molecular_function
LOC551578	GO:0006493_6281_1	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	IEA	biological_process
LOC551578	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551579	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC551580	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551580	GO:0034227_6281_2	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	IEA	biological_process
LOC551581	GO:0004335_13174_2	galactokinase activity	"Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556]	IEA	molecular_function
LOC551581	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551581	GO:0006012_6281_5	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	IEA	biological_process
LOC551581	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC551581	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
LOC551581	GO:0046835_6281_2	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	IEA	biological_process
LOC551583	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551586	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551587	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551588	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC551588	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551591	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551591	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC551595	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551597	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC551599	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551599	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551605	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551606	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551606	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC551613	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551613	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551613	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551616	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551616	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551616	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551616	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551616	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551616	GO:0016568_6281_2	chromatin modification	"The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]	IEA	biological_process
LOC551616	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC551618	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC551620	GO:0000398_6281_4	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	IEA	biological_process
LOC551620	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551620	GO:0005681_3650_5	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]	IEA	cellular_component
LOC551621	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551621	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC551621	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551622	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC551622	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC551623	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551624	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551624	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551624	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
LOC551630	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551633	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551633	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551633	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC551633	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC551634	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551634	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC551634	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC551634	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551636	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551637	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551637	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551637	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551637	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551637	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551637	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC551637	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC551637	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551638	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551638	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551638	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551640	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551640	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551641	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551641	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC551641	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551641	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551641	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551641	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551642	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551642	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551642	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
LOC551645	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC551645	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551645	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC551650	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551653	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551653	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551654	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551659	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551659	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551659	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551659	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC551659	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551659	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551659	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551659	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551660	GO:0003954_13174_2	NADH dehydrogenase activity	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]	IEA	molecular_function
LOC551660	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC551660	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC551661	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551665	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551665	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551670	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551670	GO:0004056_13174_1	argininosuccinate lyase activity	"Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1]	IEA	molecular_function
LOC551670	GO:0042450_6281_1	arginine biosynthetic process via ornithine	"The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]	IEA	biological_process
LOC551671	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551671	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551671	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551674	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551674	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551674	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551683	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC551683	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC551683	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551683	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551685	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551685	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551685	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC551685	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551685	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551685	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551686	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551687	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551687	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551687	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC551690	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC551690	GO:0006884_6281_1	cell volume homeostasis	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
LOC551692	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551694	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551696	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC551697	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC551697	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551697	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551698	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551700	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC551700	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551700	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC551700	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC551704	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC551704	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551704	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551710	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC551710	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC551712	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551712	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC551714	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551714	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551714	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC551714	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551714	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551714	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551715	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551715	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551715	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC551716	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
LOC551716	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC551718	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551720	GO:0001671_13174_1	ATPase activator activity	"Functions to increase the rate of ATP hydrolysis." [GOC:ajp]	IEA	molecular_function
LOC551720	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551720	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
LOC551720	GO:0051087_13174_4	chaperone binding	"Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]	IEA	molecular_function
LOC551721	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551721	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC551721	GO:0015992_6281_5	proton transport	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
LOC551721	GO:0016469_3650_4	proton-transporting two-sector ATPase complex	"A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]	IEA	cellular_component
LOC551721	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
LOC551721	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC551721	GO:0033180_3650_4	proton-transporting V-type ATPase, V1 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
LOC551721	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
LOC551721	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
LOC551721	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
LOC551723	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC551723	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551724	GO:0004014_13174_1	adenosylmethionine decarboxylase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984]	IEA	molecular_function
LOC551724	GO:0006597_6281_1	spermine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators]	IEA	biological_process
LOC551724	GO:0008295_6281_1	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551726	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC551726	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551726	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551726	GO:0032957_6281_1	inositol trisphosphate metabolic process	"The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah]	IEA	biological_process
LOC551726	GO:0047325_13174_1	inositol tetrakisphosphate 1-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN]	IEA	molecular_function
LOC551726	GO:0052725_13174_1	inositol-1,3,4-trisphosphate 6-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]	IEA	molecular_function
LOC551726	GO:0052726_13174_1	inositol-1,3,4-trisphosphate 5-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134]	IEA	molecular_function
LOC551728	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551728	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551732	GO:0008318_13174_2	protein prenyltransferase activity	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]	IEA	molecular_function
LOC551732	GO:0018342_6281_2	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	IEA	biological_process
LOC551743	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551749	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551750	GO:0015238_13174_1	drug transmembrane transporter activity	"Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732]	IEA	molecular_function
LOC551750	GO:0015893_6281_1	drug transport	"The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551750	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551750	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551753	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551754	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551757	GO:0006122_6281_5	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	IEA	biological_process
LOC551757	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
LOC551758	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551758	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551758	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC551760	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC551760	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC551762	GO:0004013_13174_2	adenosylhomocysteinase activity	"Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]	IEA	molecular_function
LOC551762	GO:0006730_6281_4	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	IEA	biological_process
LOC551768	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC551768	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC551768	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551773	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC551773	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC551773	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551773	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC551773	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC551775	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551775	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551775	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551776	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551781	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551781	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
LOC551785	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551785	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
LOC551785	GO:0017057_13174_1	6-phosphogluconolactonase activity	"Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559]	IEA	molecular_function
LOC551788	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC551788	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551788	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551788	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551788	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC551790	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551790	GO:0008060_13174_9	ARF GTPase activator activity	"Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]	IEA	molecular_function
LOC551790	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551790	GO:0032312_6281_9	regulation of ARF GTPase activity	"Any process that modulates the activity of the GTPase ARF." [GOC:mah]	IEA	biological_process
LOC551792	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC551792	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551792	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551795	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551796	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC551796	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551796	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551796	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551796	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551800	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551803	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551803	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551803	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551803	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC551804	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC551804	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC551804	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC551805	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC551805	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC551806	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551806	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551806	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551808	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551808	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551808	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551808	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551812	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551812	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC551812	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551812	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551812	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC551812	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551818	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551822	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551822	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551822	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551822	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551823	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551823	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551823	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551823	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC551824	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551826	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551827	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551830	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551830	GO:0016714_13174_4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
LOC551830	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551832	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551832	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551832	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551835	GO:0003883_13174_1	CTP synthase activity	"Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2]	IEA	molecular_function
LOC551835	GO:0006221_6281_2	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551838	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551838	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551839	GO:0010309_13174_1	acireductone dioxygenase [iron(II)-requiring] activity	"Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24507]	IEA	molecular_function
LOC551839	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551841	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551841	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC551841	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC551841	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC551841	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC551842	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551842	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551843	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551844	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551845	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551845	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551845	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551845	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551845	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551845	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC551845	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551845	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551848	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC551848	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC551848	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551848	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551848	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC551848	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC551848	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC551848	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC551848	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC551848	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC551848	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551848	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551855	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC551855	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC551857	GO:0004757_13174_1	sepiapterin reductase activity	"Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153]	IEA	molecular_function
LOC551857	GO:0006729_6281_3	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551857	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551859	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551859	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551860	GO:0003950_13174_3	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	IEA	molecular_function
LOC551863	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551863	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551871	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC551871	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC551871	GO:0015105_13174_2	arsenite transmembrane transporter activity	"Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC551871	GO:0015137_13174_2	citrate transmembrane transporter activity	"Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]	IEA	molecular_function
LOC551871	GO:0015746_6281_2	citrate transport	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC551871	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551871	GO:0016117_6281_1	carotenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]	IEA	biological_process
LOC551871	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551871	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC551871	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC551871	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551871	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551872	GO:0004418_13174_1	hydroxymethylbilane synthase activity	"Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188]	IEA	molecular_function
LOC551872	GO:0018160_6281_1	peptidyl-pyrromethane cofactor linkage	"The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252]	IEA	biological_process
LOC551872	GO:0033014_6281_4	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]	IEA	biological_process
LOC551873	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551873	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551874	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551875	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC551877	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551877	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551879	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC551879	GO:0016298_13174_5	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]	IEA	molecular_function
LOC551879	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC551880	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551880	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551883	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551883	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551883	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551883	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551884	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551886	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551886	GO:0004488_13174_3	methylenetetrahydrofolate dehydrogenase (NADP+) activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]	IEA	molecular_function
LOC551886	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
LOC551886	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551887	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
LOC551887	GO:0009168_6281_5	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551887	GO:0019239_13174_5	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]	IEA	molecular_function
LOC551893	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551893	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC551893	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC551897	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551899	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC551899	GO:0004012_13174_5	phospholipid-translocating ATPase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]	IEA	molecular_function
LOC551899	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC551899	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551899	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC551899	GO:0015914_6281_5	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	IEA	biological_process
LOC551899	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551899	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551904	GO:0004368_13174_1	glycerol-3-phosphate dehydrogenase activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]	IEA	molecular_function
LOC551904	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC551904	GO:0006072_6281_5	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551904	GO:0009331_3650_2	glycerol-3-phosphate dehydrogenase complex	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]	IEA	cellular_component
LOC551904	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551904	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551907	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551911	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC551911	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC551914	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC551914	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC551915	GO:0004462_13174_1	lactoylglutathione lyase activity	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]	IEA	molecular_function
LOC551915	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC551917	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC551917	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC551917	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551917	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC551917	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551919	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551927	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551927	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551928	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC551928	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551928	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551928	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC551928	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC551930	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC551930	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551930	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC551930	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC551930	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC551930	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC551930	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551930	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551931	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551931	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC551931	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC551932	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551934	GO:0004862_13174_1	cAMP-dependent protein kinase inhibitor activity	"Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah]	IEA	molecular_function
LOC551934	GO:0006469_6281_1	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	IEA	biological_process
LOC551936	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551936	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551936	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551936	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551936	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551936	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551936	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551937	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC551937	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551938	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551940	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551947	GO:0004649_13174_3	poly(ADP-ribose) glycohydrolase activity	"Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]	IEA	molecular_function
LOC551947	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551947	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551947	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551947	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC551947	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551947	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC551950	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551952	GO:0006044_6281_2	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	IEA	biological_process
LOC551952	GO:0008448_13174_1	N-acetylglucosamine-6-phosphate deacetylase activity	"Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25]	IEA	molecular_function
LOC551952	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC551954	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551955	GO:0004367_13174_1	glycerol-3-phosphate dehydrogenase [NAD+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8]	IEA	molecular_function
LOC551955	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551955	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC551955	GO:0006072_6281_5	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551955	GO:0009331_3650_2	glycerol-3-phosphate dehydrogenase complex	"An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3]	IEA	cellular_component
LOC551955	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551955	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC551955	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC551955	GO:0046168_6281_4	glycerol-3-phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	IEA	biological_process
LOC551955	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC551955	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551957	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551957	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC551957	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551957	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC551957	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551957	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC551957	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551958	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551958	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551960	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC551962	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC551967	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC551967	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC551968	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC551968	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC551972	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC551973	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551974	GO:0005681_3650_5	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]	IEA	cellular_component
LOC551974	GO:0007067_6281_4	mitosis	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]	IEA	biological_process
LOC551978	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC551979	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC551979	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC551980	GO:0001539_6281_1	ciliary or flagellar motility	"Cell motility due to movement of cilia or flagella." [GOC:hjd]	IEA	biological_process
LOC551980	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC551980	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC551980	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC551980	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC551980	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551980	GO:0009288_3650_1	bacterial-type flagellum	"A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060]	IEA	cellular_component
LOC551984	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC551986	GO:0004139_13174_1	deoxyribose-phosphate aldolase activity	"Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824]	IEA	molecular_function
LOC551986	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC551986	GO:0009264_6281_1	deoxyribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC551986	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
LOC551994	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC551994	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC551994	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC551994	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC551995	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC551995	GO:0006909_6281_2	phagocytosis	"An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	IEA	biological_process
LOC551996	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552000	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552000	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552002	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552005	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552007	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552007	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552007	GO:0004743_13174_2	pyruvate kinase activity	"Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]	IEA	molecular_function
LOC552007	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC552007	GO:0030955_13174_2	potassium ion binding	"Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]	IEA	molecular_function
LOC552012	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC552012	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552012	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552014	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552015	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552018	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552018	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552019	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552019	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552019	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC552022	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552022	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552022	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552023	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552023	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552023	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552024	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552024	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552024	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552025	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552025	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC552025	GO:0004831_13174_2	tyrosine-tRNA ligase activity	"Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223]	IEA	molecular_function
LOC552025	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552025	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552025	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC552025	GO:0006437_6281_2	tyrosyl-tRNA aminoacylation	"The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC552026	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552027	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552031	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552031	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552031	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552031	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552031	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552031	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552031	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552031	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552031	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552031	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552031	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC552037	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552039	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552040	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552042	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552042	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552042	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552042	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552042	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552042	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552042	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552042	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552042	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552042	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC552042	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552042	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552042	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552043	GO:0000154_6281_3	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC552043	GO:0000179_13174_3	rRNA (adenine-N6,N6-)-dimethyltransferase activity	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]	IEA	molecular_function
LOC552043	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC552043	GO:0008649_13174_3	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	IEA	molecular_function
LOC552043	GO:0016433_13174_1	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [EC:2.1.1.-]	IEA	molecular_function
LOC552049	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC552049	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552049	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552051	GO:0004579_13174_3	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]	IEA	molecular_function
LOC552051	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC552051	GO:0018279_6281_2	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	IEA	biological_process
LOC552054	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552054	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552061	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC552061	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC552061	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC552061	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552061	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC552061	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552063	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552064	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552064	GO:0005794_3650_2	Golgi apparatus	"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]	IEA	cellular_component
LOC552064	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552064	GO:0006897_6281_3	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]	IEA	biological_process
LOC552064	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC552064	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552064	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC552064	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
LOC552066	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552066	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552068	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552068	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC552068	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC552068	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC552070	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552073	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552073	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552073	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC552074	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552074	GO:0004012_13174_5	phospholipid-translocating ATPase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]	IEA	molecular_function
LOC552074	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552074	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552074	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC552074	GO:0015914_6281_5	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	IEA	biological_process
LOC552074	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552074	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552075	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552075	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552078	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC552078	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552084	GO:0004109_13174_1	coproporphyrinogen oxidase activity	"Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260]	IEA	molecular_function
LOC552084	GO:0006779_6281_3	porphyrin-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552084	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552085	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552085	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552086	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552086	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552086	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC552086	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC552087	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552087	GO:0017183_6281_3	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040]	IEA	biological_process
LOC552088	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552089	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552089	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552091	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC552091	GO:0008374_13174_1	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC552094	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552096	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC552096	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552096	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552101	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552108	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC552108	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC552108	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552108	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC552108	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC552108	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552110	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552110	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC552110	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC552110	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC552110	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552112	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552114	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552114	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552114	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
LOC552114	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
LOC552114	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552114	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
LOC552116	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC552116	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552116	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC552117	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
LOC552117	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552117	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552117	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552117	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC552120	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552120	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552120	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552120	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552121	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552121	GO:0016813_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	IEA	molecular_function
LOC552125	GO:0006744_6281_5	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	IEA	biological_process
LOC552126	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552126	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552128	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552128	GO:0004449_13174_3	isocitrate dehydrogenase (NAD+) activity	"Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]	IEA	molecular_function
LOC552128	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC552128	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC552128	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC552128	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552132	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552134	GO:0008531_13174_1	riboflavin kinase activity	"Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14360]	IEA	molecular_function
LOC552134	GO:0009231_6281_1	riboflavin biosynthetic process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]	IEA	biological_process
LOC552138	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552138	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552138	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552138	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552138	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552138	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC552138	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552138	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552138	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552138	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552139	GO:0003841_13174_2	1-acylglycerol-3-phosphate O-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51]	IEA	molecular_function
LOC552139	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552139	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC552139	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552139	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552140	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552142	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC552142	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC552142	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC552142	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC552142	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
LOC552142	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552142	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552143	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552143	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552144	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552144	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552145	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552145	GO:0016480_6281_1	negative regulation of transcription from RNA polymerase III promoter	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]	IEA	biological_process
LOC552146	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552146	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552147	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552148	GO:0004798_13174_1	thymidylate kinase activity	"Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9]	IEA	molecular_function
LOC552148	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552148	GO:0006233_6281_1	dTDP biosynthetic process	"The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732]	IEA	biological_process
LOC552149	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552149	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552149	GO:0006833_6281_3	water transport	"The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552149	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552149	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552149	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552150	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552150	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552151	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552151	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552151	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC552157	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552157	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552157	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552157	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552157	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552158	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552158	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552159	GO:0008013_13174_2	beta-catenin binding	"Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]	IEA	molecular_function
LOC552160	GO:0003849_13174_1	3-deoxy-7-phosphoheptulonate synthase activity	"Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720]	IEA	molecular_function
LOC552160	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC552160	GO:0009073_6281_1	aromatic amino acid family biosynthetic process	"The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
LOC552161	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC552161	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552161	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
LOC552163	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552163	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552163	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
LOC552166	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552166	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552166	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552166	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552166	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552166	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552166	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552166	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552166	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC552167	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552167	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552167	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC552169	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552169	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552169	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552169	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552170	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552172	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552172	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552174	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC552174	GO:0008176_13174_1	tRNA (guanine-N7-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33]	IEA	molecular_function
LOC552175	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552175	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552175	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552175	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552175	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552176	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC552180	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552180	GO:0008817_13174_1	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	"Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17]	IEA	molecular_function
LOC552180	GO:0009236_6281_2	cobalamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552181	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552181	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552182	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552182	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552185	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552185	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552185	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552189	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552189	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC552189	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552189	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC552192	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552192	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552199	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC552199	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552201	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552202	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552202	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552204	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552204	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552205	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552206	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552206	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552206	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552206	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552207	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552207	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552207	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552208	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552208	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552208	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552208	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552209	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552215	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC552215	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552216	GO:0004016_13174_3	adenylate cyclase activity	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]	IEA	molecular_function
LOC552216	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC552216	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552216	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC552216	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552217	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC552220	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552220	GO:0004075_13174_4	biotin carboxylase activity	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]	IEA	molecular_function
LOC552220	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552220	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552220	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC552221	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552221	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC552223	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC552223	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC552223	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC552228	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC552228	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552231	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552236	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552238	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552240	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC552240	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
LOC552240	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
LOC552240	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552244	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC552249	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552249	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC552249	GO:0004559_13174_4	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	IEA	molecular_function
LOC552249	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552249	GO:0006013_6281_3	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	IEA	biological_process
LOC552249	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552249	GO:0015923_13174_3	mannosidase activity	"Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]	IEA	molecular_function
LOC552249	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC552251	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552251	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552251	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552251	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552251	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552251	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC552251	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC552253	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552253	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552253	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552254	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552256	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552256	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC552256	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
LOC552256	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552256	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552256	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552258	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552258	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552258	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552258	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552258	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552261	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552261	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552263	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552263	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552263	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552264	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552264	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552265	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552265	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552265	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC552265	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552265	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC552267	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552267	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552272	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC552272	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552272	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC552272	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC552272	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
LOC552273	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552273	GO:0004749_13174_2	ribose phosphate diphosphokinase activity	"Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]	IEA	molecular_function
LOC552273	GO:0009116_6281_6	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	IEA	biological_process
LOC552273	GO:0009165_6281_3	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	IEA	biological_process
LOC552275	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552279	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552279	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552279	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552279	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552280	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552284	GO:0000290_6281_1	deadenylation-dependent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]	IEA	biological_process
LOC552284	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552284	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552286	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552286	GO:0003989_13174_1	acetyl-CoA carboxylase activity	"Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]	IEA	molecular_function
LOC552286	GO:0004075_13174_4	biotin carboxylase activity	"Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]	IEA	molecular_function
LOC552286	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552286	GO:0006633_6281_4	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552286	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552286	GO:0016874_13174_7	ligase activity	"Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]	IEA	molecular_function
LOC552286	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552289	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552289	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552289	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552289	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC552290	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552291	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552291	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552291	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552291	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC552291	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552293	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552293	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552294	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552295	GO:0005784_3650_1	Sec61 translocon complex	"A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647]	IEA	cellular_component
LOC552295	GO:0006613_6281_1	cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215]	IEA	biological_process
LOC552295	GO:0030176_3650_1	integral to endoplasmic reticulum membrane	"Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]	IEA	cellular_component
LOC552297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552303	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552303	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552303	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552305	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552305	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552307	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552307	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC552307	GO:0004814_13174_4	arginine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]	IEA	molecular_function
LOC552307	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552307	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552307	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC552307	GO:0006420_6281_4	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC552308	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552308	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552310	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552311	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552311	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552311	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552316	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552316	GO:0003920_13174_1	GMP reductase activity	"Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188]	IEA	molecular_function
LOC552316	GO:0009117_6281_1	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	IEA	biological_process
LOC552316	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552316	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552319	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552322	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC552322	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552322	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552322	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552322	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC552322	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC552324	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC552324	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552324	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC552324	GO:0008242_13174_5	omega peptidase activity	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]	IEA	molecular_function
LOC552324	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552326	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552327	GO:0008963_13174_1	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	"Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13]	IEA	molecular_function
LOC552327	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552328	GO:0004373_13174_1	glycogen (starch) synthase activity	"Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]	IEA	molecular_function
LOC552328	GO:0005978_6281_2	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	IEA	biological_process
LOC552334	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552334	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552334	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552336	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552336	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552336	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552339	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552341	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC552341	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552345	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552349	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552349	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552349	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC552349	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552355	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552355	GO:0004540_13174_5	ribonuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552360	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552360	GO:0042765_3650_2	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	IEA	cellular_component
LOC552362	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552363	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC552363	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552363	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC552368	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552368	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552368	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552371	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552371	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552371	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552371	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552371	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552373	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552373	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552375	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
LOC552375	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552375	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552375	GO:0030301_6281_2	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552385	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552387	GO:0000139_3650_4	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	IEA	cellular_component
LOC552387	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
LOC552387	GO:0008643_6281_2	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	IEA	biological_process
LOC552387	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552390	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552390	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552394	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552396	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552396	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552397	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC552397	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552398	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
LOC552398	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
LOC552398	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552399	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552401	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552401	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552404	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC552404	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552404	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC552405	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552406	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552406	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552406	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552409	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552409	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552410	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC552410	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC552410	GO:0033179_3650_3	proton-transporting V-type ATPase, V0 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
LOC552412	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552412	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
LOC552412	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC552412	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
LOC552413	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552413	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552416	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC552416	GO:0004563_13174_3	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	IEA	molecular_function
LOC552416	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552417	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC552419	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552419	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552419	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552419	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552419	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552419	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552419	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552419	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552421	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552423	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552423	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552423	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552423	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552426	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552428	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552431	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552433	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552433	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552433	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552433	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552433	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552433	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552433	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552433	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552437	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552437	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552439	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552441	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC552441	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552441	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC552441	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC552442	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552442	GO:0005801_3650_3	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	IEA	cellular_component
LOC552442	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552442	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
LOC552443	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC552443	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552444	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552448	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552448	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552448	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552448	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552448	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552448	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552448	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552448	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552448	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552452	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552452	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552452	GO:0006955_6281_5	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]	IEA	biological_process
LOC552452	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC552455	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552458	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC552458	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC552458	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC552461	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552464	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552464	GO:0016012_3650_4	sarcoglycan complex	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]	IEA	cellular_component
LOC552464	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552466	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552469	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC552469	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC552469	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC552469	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552469	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC552469	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552474	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552474	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
LOC552474	GO:0019901_13174_10	protein kinase binding	"Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	IEA	molecular_function
LOC552476	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC552476	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC552476	GO:0033180_3650_4	proton-transporting V-type ATPase, V1 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
LOC552476	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
LOC552476	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
LOC552477	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552477	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC552477	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552480	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552480	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552480	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552480	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC552480	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552483	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552484	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552486	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC552486	GO:0008290_3650_2	F-actin capping protein complex	"A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]	IEA	cellular_component
LOC552486	GO:0030036_6281_8	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552487	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552488	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552489	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552489	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552492	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC552492	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
LOC552492	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC552492	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC552493	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552493	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552495	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552495	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552495	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552495	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552495	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552495	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552495	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552495	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552495	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552498	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
LOC552498	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552498	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
LOC552499	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552500	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552501	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552503	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552505	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552505	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552509	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552513	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552514	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552514	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC552514	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552515	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552515	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552515	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552515	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552516	GO:0016757_13174_12	transferase activity, transferring glycosyl groups	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552520	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552520	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552520	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552520	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC552520	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
LOC552521	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC552523	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552523	GO:0004794_13174_1	L-threonine ammonia-lyase activity	"Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]	IEA	molecular_function
LOC552523	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552523	GO:0016597_13174_5	amino acid binding	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	IEA	molecular_function
LOC552523	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552524	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552524	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552524	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552525	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552527	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552527	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552528	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552531	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552531	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552531	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC552532	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552532	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC552532	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552532	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552532	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC552533	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC552535	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC552535	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC552535	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552539	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC552539	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC552546	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552546	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552546	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC552546	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC552546	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC552546	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552547	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552547	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552548	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552548	GO:0004677_13174_1	DNA-dependent protein kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah]	IEA	molecular_function
LOC552548	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552548	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552548	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552548	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552548	GO:0006303_6281_2	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453]	IEA	biological_process
LOC552548	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552548	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC552549	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC552549	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC552549	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC552549	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552549	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC552549	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552550	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552550	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552550	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552552	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC552552	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552552	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552552	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552552	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552552	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
LOC552554	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552556	GO:0016813_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	IEA	molecular_function
LOC552556	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552557	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552557	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552560	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552560	GO:0042325_6281_1	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	IEA	biological_process
LOC552565	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC552565	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
LOC552566	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552566	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552569	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552570	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552570	GO:0005665_3650_2	DNA-directed RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	IEA	cellular_component
LOC552570	GO:0006366_6281_4	transcription from RNA polymerase II promoter	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	IEA	biological_process
LOC552572	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552572	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
LOC552572	GO:0006452_6281_1	translational frameshifting	"A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425]	IEA	biological_process
LOC552572	GO:0008612_6281_2	peptidyl-lysine modification to hypusine	"The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	IEA	biological_process
LOC552572	GO:0043022_13174_2	ribosome binding	"Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]	IEA	molecular_function
LOC552572	GO:0045901_6281_1	positive regulation of translational elongation	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]	IEA	biological_process
LOC552572	GO:0045905_6281_1	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	IEA	biological_process
LOC552573	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552574	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552574	GO:0006887_6281_1	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]	IEA	biological_process
LOC552574	GO:0048278_6281_1	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	IEA	biological_process
LOC552575	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552575	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552575	GO:0006108_6281_3	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC552575	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552575	GO:0016615_13174_3	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	IEA	molecular_function
LOC552575	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC552575	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
LOC552575	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552576	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC552576	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC552576	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC552576	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552576	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552576	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC552576	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552579	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552579	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552579	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC552579	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC552580	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552580	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552580	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552581	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552583	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552583	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC552583	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552584	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552584	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552584	GO:0003916_13174_3	DNA topoisomerase activity	"Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]	IEA	molecular_function
LOC552584	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
LOC552584	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
LOC552584	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552584	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC552585	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552585	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552588	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC552589	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552589	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
LOC552589	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC552589	GO:0007156_6281_20	homophilic cell adhesion	"The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	IEA	biological_process
LOC552589	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552590	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552592	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552592	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552592	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552592	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552592	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552592	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552592	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552596	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552596	GO:0005778_3650_2	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	IEA	cellular_component
LOC552596	GO:0007031_6281_4	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	IEA	biological_process
LOC552596	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552597	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
LOC552597	GO:0016538_13174_2	cyclin-dependent protein kinase regulator activity	"Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875]	IEA	molecular_function
LOC552599	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC552599	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC552599	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC552601	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552602	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552602	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552604	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552604	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552604	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552605	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552605	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552607	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552607	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC552607	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC552612	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552614	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552614	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552614	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC552614	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552616	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC552616	GO:0016226_6281_4	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	IEA	biological_process
LOC552616	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC552617	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC552617	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC552617	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC552617	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552617	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC552617	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552620	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552622	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552622	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
LOC552622	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
LOC552625	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552625	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552625	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552625	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552625	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552625	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC552625	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552625	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552625	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552625	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552630	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552630	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552636	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552636	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC552636	GO:0008239_13174_7	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC552636	GO:0016805_13174_7	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]	IEA	molecular_function
LOC552637	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552638	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552648	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552651	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC552654	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552654	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552654	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
LOC552654	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC552654	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
LOC552654	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC552660	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC552660	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC552661	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC552661	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552661	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552661	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552661	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552661	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
LOC552662	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC552662	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552662	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552662	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC552662	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552663	GO:0008478_13174_1	pyridoxal kinase activity	"Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35]	IEA	molecular_function
LOC552663	GO:0009443_6281_1	pyridoxal 5'-phosphate salvage	"Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl]	IEA	biological_process
LOC552664	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552664	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552664	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552664	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552665	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC552665	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552665	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552665	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552665	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552667	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552667	GO:0009968_6281_1	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	IEA	biological_process
LOC552670	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552671	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552671	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552671	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552671	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552671	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC552678	GO:0000015_3650_2	phosphopyruvate hydratase complex	"A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]	IEA	cellular_component
LOC552678	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552678	GO:0004634_13174_2	phosphopyruvate hydratase activity	"Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]	IEA	molecular_function
LOC552678	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC552681	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
LOC552681	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC552683	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC552683	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC552683	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552683	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552684	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552684	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552684	GO:0005665_3650_2	DNA-directed RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	IEA	cellular_component
LOC552684	GO:0006366_6281_4	transcription from RNA polymerase II promoter	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	IEA	biological_process
LOC552687	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552687	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552687	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552687	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552687	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552688	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552688	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552689	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552689	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552690	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552692	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552692	GO:0003884_13174_2	D-amino-acid oxidase activity	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]	IEA	molecular_function
LOC552692	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC552692	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552692	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552692	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC552692	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552692	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552693	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552695	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552697	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC552697	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552697	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552697	GO:0046873_13174_9	metal ion transmembrane transporter activity	"Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC552697	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC552707	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC552707	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552707	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552707	GO:0007283_6281_2	spermatogenesis	"The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846]	IEA	biological_process
LOC552710	GO:0004066_13174_2	asparagine synthase (glutamine-hydrolyzing) activity	"Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]	IEA	molecular_function
LOC552710	GO:0006529_6281_2	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	IEA	biological_process
LOC552715	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552716	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552717	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552717	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552717	GO:0032934_13174_3	sterol binding	"Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah]	IEA	molecular_function
LOC552723	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552724	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC552724	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552724	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552725	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC552725	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552725	GO:0016620_13174_11	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
LOC552725	GO:0030154_6281_4	cell differentiation	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	IEA	biological_process
LOC552725	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552730	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552730	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552730	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552730	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552730	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC552730	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC552730	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC552730	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC552730	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552730	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552736	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552736	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC552736	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552736	GO:0016868_13174_4	intramolecular transferase activity, phosphotransferases	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	IEA	molecular_function
LOC552738	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC552738	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552738	GO:0030976_13174_4	thiamine pyrophosphate binding	"Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]	IEA	molecular_function
LOC552740	GO:0016763_13174_1	transferase activity, transferring pentosyl groups	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC552743	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC552743	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC552743	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
LOC552745	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC552746	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552746	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552747	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552750	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552750	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552750	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552750	GO:0006303_6281_2	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453]	IEA	biological_process
LOC552753	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552756	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC552756	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC552756	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC552757	GO:0003995_13174_10	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]	IEA	molecular_function
LOC552757	GO:0003997_13174_3	acyl-CoA oxidase activity	"Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]	IEA	molecular_function
LOC552757	GO:0005777_3650_6	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	IEA	cellular_component
LOC552757	GO:0006631_6281_5	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	IEA	biological_process
LOC552757	GO:0006635_6281_4	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	IEA	biological_process
LOC552757	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552757	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC552757	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC552757	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552761	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC552761	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552764	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552765	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552765	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC552766	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC552766	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC552766	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC552766	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC552766	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC552766	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC552766	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC552767	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552768	GO:0000049_13174_4	tRNA binding	"Interacting selectively and non-covalently with transfer RNA." [GOC:ai]	IEA	molecular_function
LOC552768	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552768	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC552768	GO:0004826_13174_3	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	IEA	molecular_function
LOC552768	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552768	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552768	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC552768	GO:0006432_6281_3	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC552768	GO:0043039_6281_8	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	IEA	biological_process
LOC552769	GO:0004659_13174_3	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	IEA	molecular_function
LOC552769	GO:0009234_6281_1	menaquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]	IEA	biological_process
LOC552769	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC552769	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC552771	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
LOC552771	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552771	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552772	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552772	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552772	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC552775	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552780	GO:0004526_13174_2	ribonuclease P activity	"Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]	IEA	molecular_function
LOC552780	GO:0004540_13174_5	ribonuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552780	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC552780	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC552780	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC552784	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552786	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC552787	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552787	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552787	GO:0003916_13174_3	DNA topoisomerase activity	"Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]	IEA	molecular_function
LOC552787	GO:0003917_13174_3	DNA topoisomerase type I activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	IEA	molecular_function
LOC552787	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
LOC552787	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
LOC552787	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552787	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC552790	GO:0005779_3650_1	integral to peroxisomal membrane	"Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]	IEA	cellular_component
LOC552790	GO:0007031_6281_4	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	IEA	biological_process
LOC552795	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC552795	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC552795	GO:0016780_13174_6	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]	IEA	molecular_function
LOC552797	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552797	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552797	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC552800	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552803	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC552806	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552806	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552806	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552807	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC552807	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC552807	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC552811	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC552811	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC552811	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC552812	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552814	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC552814	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552814	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC552814	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC552814	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC552814	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC552815	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC552815	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552820	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC552820	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC552820	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC552823	GO:0006633_6281_4	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC552823	GO:0050080_13174_1	malonyl-CoA decarboxylase activity	"Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]	IEA	molecular_function
LOC552829	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC552829	GO:0016298_13174_5	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]	IEA	molecular_function
LOC552829	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC552831	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC552832	GO:0005542_13174_2	folic acid binding	"Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC552832	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC552832	GO:0006555_6281_2	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC552832	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC552832	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC552832	GO:0017174_13174_1	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	IEA	molecular_function
LOC552839	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC552846	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC552846	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC552847	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC552851	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC724115	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC724120	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724120	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724120	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724120	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724120	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724120	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC724120	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724123	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC724126	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC724126	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724129	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724129	GO:0005730_3650_2	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	IEA	cellular_component
LOC724129	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
LOC724131	GO:0004550_13174_4	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	IEA	molecular_function
LOC724131	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724131	GO:0006165_6281_4	nucleoside diphosphate phosphorylation	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	IEA	biological_process
LOC724131	GO:0006183_6281_4	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724131	GO:0006228_6281_4	UTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724131	GO:0006241_6281_4	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724132	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724132	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724133	GO:0003747_13174_4	translation release factor activity	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]	IEA	molecular_function
LOC724133	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724133	GO:0006415_6281_4	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	IEA	biological_process
LOC724133	GO:0016149_13174_2	translation release factor activity, codon specific	"A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]	IEA	molecular_function
LOC724136	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC724136	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC724136	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC724136	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC724138	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724147	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC724147	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC724147	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC724147	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724148	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724148	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724148	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724148	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724149	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724149	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724149	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724149	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724149	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724149	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724150	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724150	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724156	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724156	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724156	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724159	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC724159	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724159	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724159	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724159	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC724159	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724159	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724159	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC724176	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724179	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724179	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724179	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724179	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724179	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724179	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724179	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC724179	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724179	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC724182	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC724182	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC724183	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724183	GO:0004126_13174_2	cytidine deaminase activity	"Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5]	IEA	molecular_function
LOC724183	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724183	GO:0009972_6281_2	cytidine deamination	"The removal of amino group in the presence of water." [GOC:sm]	IEA	biological_process
LOC724183	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC724195	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724199	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC724199	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC724199	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724201	GO:0003747_13174_4	translation release factor activity	"Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]	IEA	molecular_function
LOC724201	GO:0006415_6281_4	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	IEA	biological_process
LOC724205	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724205	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724206	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC724206	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724206	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC724210	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724212	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC724212	GO:0030529_3650_4	ribonucleoprotein complex	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]	IEA	cellular_component
LOC724213	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724213	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724213	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
LOC724218	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC724225	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC724225	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724227	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724227	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724227	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724227	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724227	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724237	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC724237	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724238	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724238	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724238	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724238	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724238	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724238	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724239	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724239	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724239	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724239	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724239	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC724239	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724239	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724239	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724240	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724240	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724240	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
LOC724240	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC724244	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724244	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC724246	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC724256	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC724258	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724258	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724258	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724260	GO:0003951_13174_4	NAD+ kinase activity	"Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632]	IEA	molecular_function
LOC724260	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724262	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724262	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724264	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
LOC724264	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC724264	GO:0042773_6281_3	ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]	IEA	biological_process
LOC724267	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724268	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724268	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724279	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC724279	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC724279	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724279	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724279	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724279	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC724279	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724279	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724283	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
LOC724283	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724283	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724287	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC724288	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724291	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC724291	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC724291	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC724291	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724291	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC724291	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
LOC724291	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
LOC724292	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724294	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724295	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724297	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724297	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724297	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724297	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724297	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724299	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724300	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724300	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724301	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724301	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724301	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724301	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724301	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724304	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724304	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724304	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724304	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC724304	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC724307	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724307	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724307	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724307	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724307	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724307	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC724307	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724309	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724309	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
LOC724311	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724311	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724311	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724311	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724312	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC724312	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC724315	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724315	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724315	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724321	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724323	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC724323	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC724326	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC724326	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC724329	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC724332	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC724332	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724332	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC724334	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724334	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724336	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724336	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724336	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724337	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724337	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724337	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724337	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724338	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724338	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724338	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724338	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724338	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724338	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724339	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724339	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724339	GO:0017176_13174_2	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	IEA	molecular_function
LOC724341	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC724341	GO:0005788_3650_1	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	IEA	cellular_component
LOC724341	GO:0009306_6281_1	protein secretion	"The controlled release of proteins from a cell or group of cells." [GOC:ai]	IEA	biological_process
LOC724343	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724343	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724343	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC724344	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724344	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC724344	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724344	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724344	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724344	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724344	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724344	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC724352	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724352	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724352	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724356	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724356	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724356	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724359	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724359	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724360	GO:0016813_13174_3	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	IEA	molecular_function
LOC724360	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC724363	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724373	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724373	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724373	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724373	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724373	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724376	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724377	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724379	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724379	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC724379	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724379	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC724388	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724391	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724391	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724395	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC724395	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC724395	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724399	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
LOC724399	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724399	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC724402	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724402	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724402	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724402	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC724402	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724402	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC724412	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724412	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724412	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724412	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724412	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724414	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724415	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC724415	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC724415	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724415	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724415	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724415	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC724415	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724417	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724417	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC724418	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC724420	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724420	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724420	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724420	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724420	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724424	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724424	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC724425	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724427	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724428	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724428	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724428	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724428	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724428	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724429	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724429	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724429	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724429	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724429	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724430	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724430	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724433	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724433	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC724435	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC724436	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
LOC724436	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC724436	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC724436	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
LOC724437	GO:0008013_13174_2	beta-catenin binding	"Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]	IEA	molecular_function
LOC724437	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
LOC724439	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724439	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724440	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724440	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724440	GO:0005388_13174_3	calcium-transporting ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]	IEA	molecular_function
LOC724440	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724440	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC724440	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724440	GO:0006816_6281_3	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724440	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724440	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
LOC724440	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724440	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724440	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC724441	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724441	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724441	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724445	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724459	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724460	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724463	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC724463	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC724463	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC724463	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724464	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC724464	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC724464	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724465	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724465	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724467	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
LOC724467	GO:0016226_6281_4	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	IEA	biological_process
LOC724467	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC724470	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC724470	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724470	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC724470	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC724471	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
LOC724471	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC724471	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC724471	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724471	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC724471	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724473	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC724473	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724474	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724475	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724475	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724475	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724475	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC724478	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724486	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC724486	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724496	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724497	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
LOC724497	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724497	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724498	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724503	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC724503	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC724503	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724503	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724503	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC724503	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724505	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724505	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC724505	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724505	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724505	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724505	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC724506	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724511	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC724511	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724511	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724513	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724513	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724513	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724513	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724513	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724523	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724523	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724523	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724523	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724524	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724524	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724531	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC724531	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724531	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC724531	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC724535	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724535	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724535	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC724536	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724537	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC724537	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC724538	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724538	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724538	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724538	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC724540	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724540	GO:0006012_6281_5	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	IEA	biological_process
LOC724540	GO:0008108_13174_1	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	"Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13992]	IEA	molecular_function
LOC724540	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724541	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC724541	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
LOC724541	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC724541	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724543	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC724543	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC724543	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC724546	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724546	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724546	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724546	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724550	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724550	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724550	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724550	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724550	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
LOC724551	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724552	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724553	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724553	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724553	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724557	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724559	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724559	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC724561	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724562	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC724562	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
LOC724562	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724562	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
LOC724563	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
LOC724563	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
LOC724563	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC724563	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC724564	GO:0016765_13174_2	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724566	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724566	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724570	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724571	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724571	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724571	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724571	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724571	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724571	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC724571	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724571	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC724571	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724574	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724574	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC724574	GO:0046168_6281_4	glycerol-3-phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	IEA	biological_process
LOC724574	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC724574	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724584	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724584	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724584	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724586	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724586	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724590	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC724590	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC724590	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC724590	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724593	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724593	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724593	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724593	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724603	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724603	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724603	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724603	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724603	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724603	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC724603	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724603	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC724603	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724604	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724604	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724604	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724604	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC724604	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724607	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724607	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724607	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724607	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724607	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724607	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724607	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724611	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC724611	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC724618	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
LOC724618	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
LOC724618	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724619	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC724620	GO:0005635_3650_3	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	IEA	cellular_component
LOC724622	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724622	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724623	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724623	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724623	GO:0008967_13174_3	phosphoglycolate phosphatase activity	"Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372]	IEA	molecular_function
LOC724629	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC724629	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724629	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC724629	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC724633	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC724633	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724633	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724633	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC724635	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC724635	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC724637	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724641	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
LOC724641	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724641	GO:0008308_13174_4	voltage-gated anion channel activity	"Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC724641	GO:0044070_6281_4	regulation of anion transport	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
LOC724641	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724647	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC724647	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724651	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724654	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC724660	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724666	GO:0047800_13174_1	cysteamine dioxygenase activity	"Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine." [EC:1.13.11.19, RHEA:14412]	IEA	molecular_function
LOC724666	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724669	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC724672	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724672	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724672	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC724672	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724672	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724672	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724676	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC724676	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724676	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC724676	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC724676	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724678	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC724678	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724678	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724678	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724678	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC724678	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724684	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724684	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724685	GO:0004719_13174_3	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	IEA	molecular_function
LOC724685	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC724686	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724687	GO:0007267_6281_4	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another." [GOC:mah]	IEA	biological_process
LOC724689	GO:0043231_3650_2	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	IEA	cellular_component
LOC724689	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC724690	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC724690	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC724690	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724690	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC724695	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724695	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724695	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724695	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724696	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724699	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC724700	GO:0004047_13174_3	aminomethyltransferase activity	"Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]	IEA	molecular_function
LOC724700	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724700	GO:0006546_6281_3	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	IEA	biological_process
LOC724701	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724705	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724705	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724705	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724706	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724706	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724706	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC724707	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC724707	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC724715	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724716	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724716	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC724716	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC724718	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724718	GO:0004854_13174_1	xanthine dehydrogenase activity	"Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]	IEA	molecular_function
LOC724718	GO:0004855_13174_1	xanthine oxidase activity	"Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2]	IEA	molecular_function
LOC724718	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC724718	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC724718	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724718	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC724718	GO:0043546_13174_2	molybdopterin cofactor binding	"Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	IEA	molecular_function
LOC724718	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC724718	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC724718	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC724718	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC724718	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724721	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724721	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724726	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724727	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724727	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724727	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724727	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724735	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC724738	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724738	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724739	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724739	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724745	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724747	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724747	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724752	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724752	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724754	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
LOC724760	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC724760	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC724760	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC724760	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC724760	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724760	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724762	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC724762	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724762	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC724762	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724762	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724762	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724762	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC724762	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC724762	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724762	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC724762	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC724762	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724762	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724772	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724775	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724778	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724778	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724778	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724778	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724778	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724778	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724779	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724780	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC724780	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC724780	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724781	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724785	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
LOC724788	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724788	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724788	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC724788	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724789	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724793	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC724795	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724798	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724798	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC724798	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC724799	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC724801	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724801	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724801	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724801	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724801	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724803	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724803	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724803	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC724806	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724806	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC724806	GO:0004180_13174_5	carboxypeptidase activity	"Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC724806	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724806	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724806	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC724806	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC724806	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC724806	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC724808	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724809	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724810	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724810	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724815	GO:0006807_6281_12	nitrogen compound metabolic process	"The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC724815	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
LOC724817	GO:0000775_3650_3	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	IEA	cellular_component
LOC724817	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724817	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724822	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724823	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724827	GO:0003954_13174_2	NADH dehydrogenase activity	"Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]	IEA	molecular_function
LOC724827	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC724827	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC724833	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724833	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724833	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724833	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC724833	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724833	GO:0031012_3650_9	extracellular matrix	"A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah]	IEA	cellular_component
LOC724838	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724838	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724839	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC724839	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC724839	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724839	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC724839	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC724839	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC724839	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC724839	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC724839	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724839	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724847	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724849	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724853	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC724853	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC724853	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC724853	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC724853	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724853	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724856	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724856	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724856	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724856	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724865	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC724865	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724865	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724865	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC724865	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC724867	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724869	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC724869	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724869	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724869	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC724870	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
LOC724870	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724870	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724874	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724874	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724874	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724874	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724874	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC724874	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724876	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724876	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724877	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724877	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC724877	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724878	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC724878	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724879	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724879	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724879	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
LOC724879	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
LOC724879	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC724882	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724882	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724882	GO:0051028_6281_3	mRNA transport	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC724890	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC724890	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724890	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724891	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724891	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC724891	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724891	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC724891	GO:0006261_6281_1	DNA-dependent DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC724895	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724895	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724901	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724901	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724907	GO:0003841_13174_2	1-acylglycerol-3-phosphate O-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51]	IEA	molecular_function
LOC724907	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724907	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC724907	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724907	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724908	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724908	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724910	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC724910	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC724910	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC724910	GO:0051087_13174_4	chaperone binding	"Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]	IEA	molecular_function
LOC724914	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724914	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724919	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC724919	GO:0030151_13174_4	molybdenum ion binding	"Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]	IEA	molecular_function
LOC724919	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724925	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC724925	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC724925	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724925	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724925	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC724927	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724927	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724928	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724930	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC724930	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC724930	GO:0006915_6281_8	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	IEA	biological_process
LOC724930	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC724933	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC724933	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC724933	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC724933	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC724933	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC724936	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724937	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC724937	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC724937	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724938	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724938	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724940	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC724940	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC724940	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC724941	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC724941	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC724941	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC724941	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC724941	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724949	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724950	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC724950	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC724950	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724950	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC724950	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
LOC724950	GO:0007229_6281_3	integrin-mediated signaling pathway	"A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
LOC724950	GO:0008305_3650_3	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	IEA	cellular_component
LOC724951	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724951	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724952	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724952	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724952	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724952	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724955	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC724958	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC724958	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC724958	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC724958	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724961	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724961	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724962	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724967	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724967	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC724967	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC724969	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724974	GO:0004835_13174_12	tubulin-tyrosine ligase activity	"Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]	IEA	molecular_function
LOC724974	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC724976	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724979	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724979	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724979	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724980	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC724980	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC724980	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC724983	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC724983	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC724983	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC724983	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC724983	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC724991	GO:0016307_13174_3	phosphatidylinositol phosphate kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]	IEA	molecular_function
LOC724991	GO:0046488_6281_3	phosphatidylinositol metabolic process	"The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732]	IEA	biological_process
LOC724995	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC724995	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC724998	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC724998	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC724998	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC724998	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC724998	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC724998	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725003	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725003	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725008	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC725008	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725011	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725011	GO:0051205_6281_2	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane." [GOC:ai]	IEA	biological_process
LOC725012	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725012	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725014	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725015	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725015	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725015	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725016	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725016	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725016	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725017	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725017	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC725018	GO:0004631_13174_1	phosphomevalonate kinase activity	"Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16344]	IEA	molecular_function
LOC725018	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725018	GO:0006695_6281_1	cholesterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]	IEA	biological_process
LOC725024	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725027	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725027	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC725027	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC725027	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725027	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC725027	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC725027	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725027	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725028	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725028	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
LOC725030	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725031	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725032	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725032	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
LOC725032	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725032	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725032	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
LOC725039	GO:0008190_13174_1	eukaryotic initiation factor 4E binding	"Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732]	IEA	molecular_function
LOC725039	GO:0045947_6281_1	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	IEA	biological_process
LOC725041	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725048	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC725051	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725051	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725051	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725051	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725051	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725051	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725051	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725051	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725053	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725053	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725056	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC725056	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
LOC725056	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725058	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725058	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725058	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725058	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725058	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725065	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725067	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725067	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725067	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC725069	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725069	GO:0006857_6281_1	oligopeptide transport	"The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]	IEA	biological_process
LOC725069	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725074	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC725074	GO:0009405_6281_3	pathogenesis	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]	IEA	biological_process
LOC725074	GO:0019855_13174_1	calcium channel inhibitor activity	"Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah]	IEA	molecular_function
LOC725076	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725076	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725091	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725092	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725092	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725096	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC725096	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC725097	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725105	GO:0006744_6281_5	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	IEA	biological_process
LOC725106	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725106	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC725112	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725113	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725113	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725113	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725118	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC725118	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725118	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC725118	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC725118	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC725125	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725125	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC725125	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725125	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC725130	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725134	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725134	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725134	GO:0051028_6281_3	mRNA transport	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725135	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC725135	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725136	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725136	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725136	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC725136	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725136	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725136	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC725138	GO:0030001_6281_16	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725138	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC725140	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC725140	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC725140	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC725143	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725143	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC725143	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725143	GO:0032040_3650_5	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	IEA	cellular_component
LOC725144	GO:0004861_13174_2	cyclin-dependent protein kinase inhibitor activity	"Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah]	IEA	molecular_function
LOC725144	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725144	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
LOC725146	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725146	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725146	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC725146	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725146	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC725149	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725149	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725149	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC725149	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725150	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725150	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725150	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725150	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725150	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725150	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC725150	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725155	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
LOC725156	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725156	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725157	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC725157	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
LOC725161	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725161	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725161	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725165	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725165	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725165	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725166	GO:0004861_13174_2	cyclin-dependent protein kinase inhibitor activity	"Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah]	IEA	molecular_function
LOC725166	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725166	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
LOC725169	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725169	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725171	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725171	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC725173	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725173	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725174	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725174	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725179	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC725180	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725180	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725189	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725192	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725192	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725194	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725194	GO:0033925_13174_1	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	"Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]	IEA	molecular_function
LOC725198	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725200	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725201	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC725201	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC725201	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725201	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC725201	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC725204	GO:0004838_13174_1	L-tyrosine:2-oxoglutarate aminotransferase activity	"Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5]	IEA	molecular_function
LOC725204	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC725204	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
LOC725204	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC725204	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
LOC725204	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725204	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725208	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725208	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725208	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725208	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC725208	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725210	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC725210	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC725210	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC725212	GO:0016998_6281_3	cell wall macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]	IEA	biological_process
LOC725215	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC725218	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725218	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
LOC725225	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC725225	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725225	GO:0042246_6281_2	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	IEA	biological_process
LOC725228	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725230	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC725230	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725230	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725230	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC725230	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC725238	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC725238	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725238	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725238	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC725240	GO:0006626_6281_5	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	IEA	biological_process
LOC725240	GO:0042719_3650_5	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	IEA	cellular_component
LOC725240	GO:0045039_6281_5	protein import into mitochondrial inner membrane	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]	IEA	biological_process
LOC725245	GO:0005164_13174_2	tumor necrosis factor receptor binding	"Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai]	IEA	molecular_function
LOC725245	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
LOC725245	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725245	GO:0006955_6281_5	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]	IEA	biological_process
LOC725245	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
LOC725245	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725246	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725246	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725246	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725246	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725246	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725247	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725247	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725247	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725251	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725251	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725251	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725254	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725254	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725254	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725255	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725258	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725258	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725262	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725262	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725262	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725262	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725262	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725264	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725268	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725268	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC725268	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC725268	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC725268	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC725269	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725270	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725270	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC725274	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725274	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC725274	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC725274	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725274	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725274	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC725274	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC725274	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC725274	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725278	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725280	GO:0001558_6281_1	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	IEA	biological_process
LOC725280	GO:0005520_13174_1	insulin-like growth factor binding	"Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]	IEA	molecular_function
LOC725280	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC725284	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC725286	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725286	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725287	GO:0016972_13174_2	thiol oxidase activity	"Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]	IEA	molecular_function
LOC725287	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC725287	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725288	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725288	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725289	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725294	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC725294	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725294	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
LOC725294	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC725294	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC725295	GO:0000042_6281_4	protein targeting to Golgi	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]	IEA	biological_process
LOC725295	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725299	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725299	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725299	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC725299	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725299	GO:0019204_13174_1	nucleotide phosphatase activity	"Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]	IEA	molecular_function
LOC725301	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725301	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725302	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725302	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725302	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725302	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725302	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725303	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725303	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725306	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725306	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725306	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725306	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725306	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725306	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725308	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC725308	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725308	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725308	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725308	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC725308	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725311	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725322	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725322	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC725322	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725322	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725322	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC725323	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725323	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725323	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725323	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725323	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC725323	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725323	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC725323	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
LOC725324	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725324	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725324	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725324	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725325	GO:0004345_13174_1	glucose-6-phosphate dehydrogenase activity	"Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]	IEA	molecular_function
LOC725325	GO:0006006_6281_2	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	IEA	biological_process
LOC725325	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
LOC725325	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725326	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC725326	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC725326	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC725326	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC725330	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725330	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC725330	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC725331	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725331	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725336	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725336	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725336	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725336	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725337	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC725337	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC725337	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725337	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC725337	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC725337	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC725341	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
LOC725341	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
LOC725341	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725343	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725343	GO:0008762_13174_2	UDP-N-acetylmuramate dehydrogenase activity	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]	IEA	molecular_function
LOC725343	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725343	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC725343	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC725343	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725345	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC725345	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC725345	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725345	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC725345	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC725345	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC725345	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725345	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725347	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725354	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725358	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725365	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725365	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC725366	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725366	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC725366	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC725374	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725374	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725374	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725374	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725374	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725374	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725376	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725386	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725387	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725387	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC725387	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725389	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725389	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725389	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725389	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725394	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725394	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725394	GO:0008271_13174_3	secondary active sulfate transmembrane transporter activity	"Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]	IEA	molecular_function
LOC725394	GO:0008272_6281_3	sulfate transport	"The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC725394	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725394	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725394	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725396	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725400	GO:0003868_13174_1	4-hydroxyphenylpyruvate dioxygenase activity	"Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]	IEA	molecular_function
LOC725400	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
LOC725400	GO:0016701_13174_1	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC725400	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725403	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725403	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725406	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC725406	GO:0004427_13174_7	inorganic diphosphatase activity	"Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24579]	IEA	molecular_function
LOC725406	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725406	GO:0006796_6281_7	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	IEA	biological_process
LOC725409	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
LOC725409	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725409	GO:0008253_13174_2	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	IEA	molecular_function
LOC725410	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725414	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC725414	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725414	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC725415	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC725415	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725415	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725415	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
LOC725415	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725417	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725419	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725420	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
LOC725420	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
LOC725420	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725421	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725421	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725422	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725422	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725422	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725422	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725422	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC725422	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725423	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725423	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725430	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725430	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725430	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725430	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725430	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725434	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725435	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC725435	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC725435	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725438	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725438	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725438	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725438	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725439	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725440	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC725440	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC725440	GO:0005834_3650_5	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]	IEA	cellular_component
LOC725440	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725440	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC725440	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725440	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC725440	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC725441	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725441	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725441	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725441	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725450	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC725450	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725450	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725450	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725450	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC725450	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725453	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC725453	GO:0005834_3650_5	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]	IEA	cellular_component
LOC725453	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC725455	GO:0004332_13174_2	fructose-bisphosphate aldolase activity	"Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13]	IEA	molecular_function
LOC725455	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
LOC725458	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725460	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725462	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725462	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725463	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725465	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725465	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725465	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725465	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725465	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725465	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725468	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725476	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC725476	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725476	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
LOC725477	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725477	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725478	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC725478	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725481	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725481	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725482	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725482	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725482	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC725482	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725492	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725492	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC725492	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC725494	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725494	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725494	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725494	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725497	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725497	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC725497	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC725498	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
LOC725500	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC725500	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725500	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725502	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725502	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725502	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725502	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725502	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725503	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725503	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725503	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725503	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725503	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725503	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725503	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725503	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
LOC725515	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725515	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725515	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725515	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725517	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725517	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725518	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725518	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725518	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725518	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725518	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC725518	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725520	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725520	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725520	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725524	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725524	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725524	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725527	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
LOC725527	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725527	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC725527	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725533	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725533	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725533	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725533	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725533	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725533	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725533	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725539	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725539	GO:0016868_13174_4	intramolecular transferase activity, phosphotransferases	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	IEA	molecular_function
LOC725543	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725544	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC725546	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725547	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC725550	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725550	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725552	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725552	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC725552	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC725554	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725562	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725562	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725562	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725563	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725565	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
LOC725565	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC725565	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC725566	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC725566	GO:0005740_3650_5	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	IEA	cellular_component
LOC725566	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
LOC725566	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725566	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC725568	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725568	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725569	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725576	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725579	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725579	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC725579	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC725581	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725581	GO:0005452_13174_2	inorganic anion exchanger activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]	IEA	molecular_function
LOC725581	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725581	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725581	GO:0008509_13174_2	anion transmembrane transporter activity	"Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC725581	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725581	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725584	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC725584	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725584	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC725586	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725586	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725586	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC725586	GO:0008408_13174_6	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	IEA	molecular_function
LOC725589	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725590	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725590	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725590	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725590	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725590	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725592	GO:0008318_13174_2	protein prenyltransferase activity	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]	IEA	molecular_function
LOC725592	GO:0018342_6281_2	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	IEA	biological_process
LOC725593	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725593	GO:0003777_13174_43	microtubule motor activity	"Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC725593	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725593	GO:0007018_6281_43	microtubule-based movement	"A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194]	IEA	biological_process
LOC725593	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725593	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725593	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725593	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725593	GO:0030286_3650_16	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	IEA	cellular_component
LOC725593	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725611	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725611	GO:0001882_13174_2	nucleoside binding	"Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]	IEA	molecular_function
LOC725611	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725611	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725611	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC725611	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC725611	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC725617	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725617	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725617	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725617	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725618	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725618	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC725618	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC725619	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725623	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725623	GO:0016798_13174_3	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	IEA	molecular_function
LOC725626	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725628	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC725628	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725629	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725629	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725629	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725631	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725633	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725633	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
LOC725633	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
LOC725633	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC725642	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725642	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725642	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725642	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725646	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725646	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
LOC725647	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC725647	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725647	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC725647	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC725653	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725653	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725653	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725654	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725654	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725656	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725656	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC725656	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725656	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725657	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725665	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725665	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725667	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
LOC725670	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725670	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725670	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725670	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725670	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725670	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725671	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725671	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725671	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725671	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725671	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725680	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725680	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725680	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725680	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725682	GO:0019028_3650_3	viral capsid	"The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732]	IEA	cellular_component
LOC725685	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC725685	GO:0000922_3650_5	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	IEA	cellular_component
LOC725685	GO:0005815_3650_5	microtubule organizing center	"A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]	IEA	cellular_component
LOC725687	GO:0000724_6281_1	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	IEA	biological_process
LOC725687	GO:0003697_13174_2	single-stranded DNA binding	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh]	IEA	molecular_function
LOC725687	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725687	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
LOC725687	GO:0007090_6281_1	regulation of S phase of mitotic cell cycle	"A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators]	IEA	biological_process
LOC725693	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC725693	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725693	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725693	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725694	GO:0001522_6281_10	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]	IEA	biological_process
LOC725694	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725694	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC725694	GO:0009451_6281_12	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	IEA	biological_process
LOC725694	GO:0009982_13174_10	pseudouridine synthase activity	"Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]	IEA	molecular_function
LOC725697	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725697	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725699	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725700	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC725700	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
LOC725702	GO:0006122_6281_5	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	IEA	biological_process
LOC725702	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
LOC725704	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC725705	GO:0006626_6281_5	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	IEA	biological_process
LOC725705	GO:0042719_3650_5	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	IEA	cellular_component
LOC725705	GO:0045039_6281_5	protein import into mitochondrial inner membrane	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]	IEA	biological_process
LOC725706	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC725717	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725717	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725718	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC725718	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725720	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC725720	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC725720	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC725720	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725720	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC725720	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725721	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725721	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC725721	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC725725	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC725725	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC725725	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725735	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC725735	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725735	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725735	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725738	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC725738	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725739	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725744	GO:0008242_13174_5	omega peptidase activity	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]	IEA	molecular_function
LOC725744	GO:0019538_6281_3	protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]	IEA	biological_process
LOC725745	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725748	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725755	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725756	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC725756	GO:0004565_13174_1	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	IEA	molecular_function
LOC725756	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725756	GO:0009341_3650_1	beta-galactosidase complex	"A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161]	IEA	cellular_component
LOC725757	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725757	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725757	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725757	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725757	GO:0016602_3650_2	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851]	IEA	cellular_component
LOC725762	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725768	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725768	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC725768	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725768	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC725769	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
LOC725769	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725769	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC725770	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725770	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725770	GO:0005942_3650_3	phosphatidylinositol 3-kinase complex	"A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K)." [GOC:bf]	IEA	cellular_component
LOC725770	GO:0016303_13174_3	1-phosphatidylinositol-3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]	IEA	molecular_function
LOC725770	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC725770	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC725770	GO:0035004_13174_4	phosphatidylinositol 3-kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069]	IEA	molecular_function
LOC725770	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC725770	GO:0048015_6281_3	phosphatidylinositol-mediated signaling	"A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	biological_process
LOC725776	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725776	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725777	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725779	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
LOC725779	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725779	GO:0042246_6281_2	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	IEA	biological_process
LOC725780	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC725780	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725780	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC725783	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725786	GO:0004721_13174_4	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]	IEA	molecular_function
LOC725786	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725786	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725788	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC725788	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC725788	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725792	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725792	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725792	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725792	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725797	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
LOC725797	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC725803	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725811	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725811	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725816	GO:0008898_13174_2	homocysteine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10]	IEA	molecular_function
LOC725817	GO:0004163_13174_1	diphosphomevalonate decarboxylase activity	"Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735]	IEA	molecular_function
LOC725817	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725817	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC725817	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC725817	GO:0016310_6281_6	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	IEA	biological_process
LOC725819	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC725819	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725819	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC725819	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
LOC725819	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
LOC725819	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725820	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC725820	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC725820	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC725820	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC725826	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725826	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725826	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725826	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725826	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725828	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725835	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725835	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725835	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725840	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725841	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC725841	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725841	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725841	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725842	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725845	GO:0005375_13174_3	copper ion transmembrane transporter activity	"Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC725845	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725845	GO:0035434_6281_3	copper ion transmembrane transport	"The directed movement of copper (Cu) ions across a membrane by means of some agent such as a transporter or pore." [GOC:vw]	IEA	biological_process
LOC725858	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725858	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC725858	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725858	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC725864	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725864	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725870	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725877	GO:0004089_13174_3	carbonate dehydratase activity	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]	IEA	molecular_function
LOC725877	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725881	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
LOC725881	GO:0006120_6281_1	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]	IEA	biological_process
LOC725881	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC725885	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725885	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725886	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725887	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725892	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725898	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725899	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC725899	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC725900	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725900	GO:0015299_13174_5	solute:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	IEA	molecular_function
LOC725900	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725900	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725901	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC725901	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC725901	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725901	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC725901	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC725901	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC725901	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC725901	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC725901	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725901	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725903	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC725903	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725905	GO:0005681_3650_5	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]	IEA	cellular_component
LOC725905	GO:0008380_6281_2	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	IEA	biological_process
LOC725906	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725906	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725908	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC725908	GO:0003908_13174_2	methylated-DNA-[protein]-cysteine S-methyltransferase activity	"Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]	IEA	molecular_function
LOC725908	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725908	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
LOC725909	GO:0004817_13174_2	cysteine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]	IEA	molecular_function
LOC725909	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725909	GO:0006423_6281_2	cysteinyl-tRNA aminoacylation	"The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC725910	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725910	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725925	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC725925	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725925	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
LOC725925	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
LOC725925	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
LOC725925	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725928	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725930	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725930	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC725931	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC725931	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC725941	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725941	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725941	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725945	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725945	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725945	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725945	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725945	GO:0007548_6281_5	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	IEA	biological_process
LOC725945	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725945	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC725946	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC725946	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC725946	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725950	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725950	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC725950	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725950	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725950	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725950	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC725950	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725954	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC725954	GO:0055070_6281_1	copper ion homeostasis	"Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	IEA	biological_process
LOC725955	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC725955	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC725955	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC725955	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725963	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725965	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725965	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725967	GO:0004617_13174_1	phosphoglycerate dehydrogenase activity	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]	IEA	molecular_function
LOC725967	GO:0006564_6281_3	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg]	IEA	biological_process
LOC725967	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725967	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC725967	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
LOC725967	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC725967	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC725970	GO:0005057_13174_4	receptor signaling protein activity	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]	IEA	molecular_function
LOC725970	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC725970	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC725970	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725970	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725970	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC725970	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC725970	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC725978	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725978	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725981	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC725981	GO:0006974_6281_1	response to DNA damage stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	IEA	biological_process
LOC725981	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
LOC725981	GO:0048478_6281_1	replication fork protection	"Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	IEA	biological_process
LOC725983	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725983	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC725983	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC725983	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725986	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC725986	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC725986	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC725987	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725987	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC725987	GO:0004814_13174_4	arginine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]	IEA	molecular_function
LOC725987	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725987	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC725987	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC725987	GO:0006420_6281_4	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC725989	GO:0019211_13174_2	phosphatase activator activity	"Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	IEA	molecular_function
LOC725991	GO:0005391_13174_5	sodium:potassium-exchanging ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]	IEA	molecular_function
LOC725991	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725991	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC725991	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725991	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
LOC725993	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC725993	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC725993	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725993	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725993	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725993	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC725993	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC725993	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725994	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC725994	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC725994	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC725994	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC725994	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC725994	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC725997	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC725997	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC725999	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726009	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC726017	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726024	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726024	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726024	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726024	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726027	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC726027	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726027	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726027	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC726027	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726029	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726034	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726034	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726034	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726034	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726037	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726040	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726040	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726041	GO:0003896_13174_4	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094]	IEA	molecular_function
LOC726041	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC726043	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726045	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726045	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC726045	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC726051	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC726051	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC726051	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726051	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726051	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC726051	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726053	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726063	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726063	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726063	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726063	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC726064	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
LOC726064	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726064	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726066	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726066	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726066	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726073	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC726073	GO:0000922_3650_5	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	IEA	cellular_component
LOC726073	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726073	GO:0005815_3650_5	microtubule organizing center	"A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]	IEA	cellular_component
LOC726074	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC726074	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726074	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726074	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC726077	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726077	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726077	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726077	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726077	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726077	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726080	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726083	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC726083	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726083	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
LOC726085	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC726085	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC726085	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC726088	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726088	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726089	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726089	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726089	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726089	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC726093	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726095	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC726095	GO:0008107_13174_1	galactoside 2-alpha-L-fucosyltransferase activity	"Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69]	IEA	molecular_function
LOC726095	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726106	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726108	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726108	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726110	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726115	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726115	GO:0008762_13174_2	UDP-N-acetylmuramate dehydrogenase activity	"Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]	IEA	molecular_function
LOC726115	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726115	GO:0016614_13174_28	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
LOC726115	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC726115	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726121	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726124	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726124	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726124	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726130	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726130	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726131	GO:0006626_6281_5	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	IEA	biological_process
LOC726131	GO:0042719_3650_5	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	IEA	cellular_component
LOC726131	GO:0045039_6281_5	protein import into mitochondrial inner membrane	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]	IEA	biological_process
LOC726134	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726134	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC726136	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726136	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726136	GO:0006833_6281_3	water transport	"The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726136	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726136	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726136	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726142	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC726145	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726145	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC726147	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC726150	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726150	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726151	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC726151	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC726151	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726151	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC726151	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC726151	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC726152	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726153	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726153	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726153	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726158	GO:0003840_13174_3	gamma-glutamyltransferase activity	"Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]	IEA	molecular_function
LOC726164	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726165	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726165	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726165	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726172	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726172	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726172	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726178	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726179	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726179	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726180	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726180	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726187	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726187	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726187	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726187	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC726187	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726187	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC726187	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
LOC726187	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
LOC726188	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726189	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726189	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC726189	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726192	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC726192	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726195	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC726195	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726195	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726195	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC726202	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726202	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726204	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726204	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726205	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC726212	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC726212	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC726212	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC726212	GO:0008757_13174_1	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	IEA	molecular_function
LOC726215	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726215	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726215	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726218	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726218	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726218	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC726220	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726221	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726222	GO:0000276_3650_5	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]	IEA	cellular_component
LOC726222	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC726222	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
LOC726225	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726225	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC726225	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC726225	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC726230	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726230	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726230	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726230	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC726233	GO:0004550_13174_4	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	IEA	molecular_function
LOC726233	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726233	GO:0006165_6281_4	nucleoside diphosphate phosphorylation	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	IEA	biological_process
LOC726233	GO:0006183_6281_4	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC726233	GO:0006228_6281_4	UTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC726233	GO:0006241_6281_4	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC726234	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726235	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726235	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726235	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726237	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC726239	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726239	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726239	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC726239	GO:0009107_6281_3	lipoate biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC726239	GO:0016415_13174_2	octanoyltransferase activity	"Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC726240	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC726240	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726241	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
LOC726241	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726247	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726247	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726248	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726250	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726252	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726253	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC726253	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC726253	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC726253	GO:0030259_6281_1	lipid glycosylation	"Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]	IEA	biological_process
LOC726254	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
LOC726254	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726254	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726254	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726254	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC726254	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
LOC726254	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC726254	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC726262	GO:0004016_13174_3	adenylate cyclase activity	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]	IEA	molecular_function
LOC726262	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC726262	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726262	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC726262	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726265	GO:0016998_6281_3	cell wall macromolecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]	IEA	biological_process
LOC726278	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726278	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726280	GO:0000123_3650_2	histone acetyltransferase complex	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]	IEA	cellular_component
LOC726280	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC726280	GO:0003713_13174_4	transcription coactivator activity	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC726280	GO:0004402_13174_4	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	IEA	molecular_function
LOC726280	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726280	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726280	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726280	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726280	GO:0016573_6281_2	histone acetylation	"The modification of a histone by the addition of an acetyl group." [GOC:ai]	IEA	biological_process
LOC726284	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC726285	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726285	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
LOC726290	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726290	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726291	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726291	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC726297	GO:0004129_13174_11	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]	IEA	molecular_function
LOC726302	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726302	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726302	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726303	GO:0008080_13174_18	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC726303	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726305	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726305	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726306	GO:0004571_13174_5	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]	IEA	molecular_function
LOC726306	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC726306	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726309	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726310	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726310	GO:0005789_3650_10	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	IEA	cellular_component
LOC726310	GO:0006506_6281_12	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726310	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726310	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC726311	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
LOC726311	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726317	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726318	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726318	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726318	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
LOC726318	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726325	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC726325	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC726325	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC726325	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726325	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC726325	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726326	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726326	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726326	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726326	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
LOC726326	GO:0008094_13174_2	DNA-dependent ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726326	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726332	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC726332	GO:0004402_13174_4	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	IEA	molecular_function
LOC726332	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726332	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726332	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726335	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726335	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726335	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726336	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726348	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726348	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726348	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726349	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
LOC726349	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726349	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726349	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726350	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726350	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726350	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726350	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726350	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726350	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726351	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC726351	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC726351	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726355	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726356	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726356	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726358	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726358	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726362	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726362	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726363	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726363	GO:0017183_6281_3	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040]	IEA	biological_process
LOC726368	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC726368	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC726368	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726368	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC726368	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726368	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726371	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC726371	GO:0017172_13174_1	cysteine dioxygenase activity	"Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20444]	IEA	molecular_function
LOC726371	GO:0046439_6281_1	L-cysteine metabolic process	"The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:ai, GOC:jsg, GOC:mah]	IEA	biological_process
LOC726371	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726373	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726373	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726379	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726380	GO:0004671_13174_1	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]	IEA	molecular_function
LOC726380	GO:0006481_6281_1	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	IEA	biological_process
LOC726380	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726384	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726384	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726384	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726384	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726384	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726386	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
LOC726386	GO:0008479_13174_4	queuine tRNA-ribosyltransferase activity	"Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]	IEA	molecular_function
LOC726386	GO:0008616_6281_4	queuosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC726388	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726388	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC726389	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
LOC726389	GO:0006071_6281_4	glycerol metabolic process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC726389	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC726389	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
LOC726389	GO:0008889_13174_3	glycerophosphodiester phosphodiesterase activity	"Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]	IEA	molecular_function
LOC726389	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726392	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726392	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726392	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726392	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726393	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726393	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726394	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726395	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726395	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726395	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726395	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726395	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726395	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726396	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726396	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726400	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726400	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726400	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726401	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
LOC726401	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC726401	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726401	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726401	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
LOC726401	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
LOC726408	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726408	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726409	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC726409	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC726411	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726412	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726412	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726413	GO:0004045_13174_2	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	IEA	molecular_function
LOC726418	GO:0004499_13174_4	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]	IEA	molecular_function
LOC726418	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC726418	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
LOC726418	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726419	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
LOC726419	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
LOC726419	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726421	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
LOC726421	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726421	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC726424	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC726424	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726424	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726427	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC726428	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC726428	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC726428	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC726431	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726432	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
LOC726432	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726432	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC726432	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726432	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC726434	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726435	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
LOC726435	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
LOC726435	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
LOC726436	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726436	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC726436	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726436	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726436	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC726447	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC726447	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726447	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726447	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC726452	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC726452	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726452	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726452	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC726454	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726455	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726455	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
LOC726455	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
LOC726458	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726458	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726458	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726461	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726464	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726464	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726464	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726464	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726467	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726470	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726470	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726470	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726471	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726478	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC726481	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC726482	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
LOC726482	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
LOC726483	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726483	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC726483	GO:0004822_13174_2	isoleucine-tRNA ligase activity	"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]	IEA	molecular_function
LOC726483	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726483	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726483	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC726483	GO:0006428_6281_2	isoleucyl-tRNA aminoacylation	"The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC726485	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726485	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726485	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726485	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726485	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726485	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726491	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726491	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726492	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726492	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726492	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726492	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726492	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726494	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726494	GO:0004419_13174_1	hydroxymethylglutaryl-CoA lyase activity	"Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407]	IEA	molecular_function
LOC726499	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726500	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC726500	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC726500	GO:0005850_3650_1	eukaryotic translation initiation factor 2 complex	"Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]	IEA	cellular_component
LOC726505	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726505	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726505	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726505	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726505	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726505	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726513	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726513	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726514	GO:0004016_13174_3	adenylate cyclase activity	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]	IEA	molecular_function
LOC726514	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
LOC726514	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726514	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
LOC726514	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726520	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC726520	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726520	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726520	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC726520	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
LOC726522	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC726523	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726523	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726523	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726523	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726523	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726524	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726524	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726524	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726524	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726524	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726524	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726524	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
LOC726528	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726528	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726528	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726528	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC726529	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726532	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726537	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726537	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726537	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726537	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726538	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726538	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726538	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726538	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726538	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726539	GO:0007034_6281_2	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	IEA	biological_process
LOC726539	GO:0030904_3650_2	retromer complex	"A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157]	IEA	cellular_component
LOC726542	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC726542	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726542	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC726544	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726544	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726545	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726545	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726547	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726547	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726547	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726547	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726550	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726550	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726550	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726550	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC726554	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC726554	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726554	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726555	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
LOC726555	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726555	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726560	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726560	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726565	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726565	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC726565	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726566	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726566	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC726568	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726571	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC726572	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726578	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726578	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726582	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726584	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726584	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726584	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC726585	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC726585	GO:0006633_6281_4	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC726585	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726585	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726585	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726586	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726586	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726586	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726586	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726588	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726590	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726590	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726593	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726593	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726593	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726596	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726597	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726597	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726597	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726598	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726598	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726598	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726598	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726599	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726599	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC726599	GO:0008241_13174_4	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC726599	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726600	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726601	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726601	GO:0006826_6281_3	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726601	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
LOC726601	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
LOC726605	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726605	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC726607	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC726607	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726607	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC726608	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726608	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726608	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726611	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726613	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726613	GO:0009405_6281_3	pathogenesis	"The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]	IEA	biological_process
LOC726614	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726614	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726618	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726618	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726618	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
LOC726619	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726619	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726619	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726621	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC726623	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC726623	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC726623	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726625	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726625	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726626	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726626	GO:0004479_13174_1	methionyl-tRNA formyltransferase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]	IEA	molecular_function
LOC726626	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC726626	GO:0016742_13174_3	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]	IEA	molecular_function
LOC726626	GO:0071951_6281_1	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	"The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045]	IEA	biological_process
LOC726627	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726631	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726635	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726635	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726635	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726637	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726637	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726637	GO:0006914_6281_3	autophagy	"The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464]	IEA	biological_process
LOC726648	GO:0043066_6281_1	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	IEA	biological_process
LOC726649	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC726651	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726653	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
LOC726661	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726667	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726667	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726670	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726670	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726670	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726672	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC726672	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC726672	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726680	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
LOC726680	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726680	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726680	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
LOC726680	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC726682	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC726689	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC726689	GO:0016272_3650_9	prefoldin complex	"A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]	IEA	cellular_component
LOC726689	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC726692	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
LOC726692	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726692	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
LOC726699	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726706	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726717	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
LOC726717	GO:0005544_13174_4	calcium-dependent phospholipid binding	"Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	IEA	molecular_function
LOC726718	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC726718	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726719	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726721	GO:0006605_6281_5	protein targeting	"The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	IEA	biological_process
LOC726721	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726721	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726721	GO:0015450_13174_5	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726721	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726727	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
LOC726727	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726727	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
LOC726730	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726730	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726730	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726730	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726730	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726732	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726733	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726735	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726735	GO:0008234_13174_15	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC726737	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC726738	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726740	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
LOC726742	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726742	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
LOC726742	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726742	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726742	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726742	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726743	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726743	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726743	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726743	GO:0007548_6281_5	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	IEA	biological_process
LOC726743	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726747	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
LOC726748	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726748	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726748	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726755	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726755	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726759	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726762	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726762	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726762	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726762	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726762	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726762	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726765	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726765	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726765	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726766	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726766	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726766	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726766	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726766	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726766	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC726766	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726768	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726768	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726768	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726768	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726778	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726778	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726778	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726778	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726778	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726778	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726780	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726783	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC726783	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC726784	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726784	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726790	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC726790	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC726790	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC726790	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726790	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC726790	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726793	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
LOC726793	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
LOC726798	GO:0004806_13174_2	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3]	IEA	molecular_function
LOC726798	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
LOC726799	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726801	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726801	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726805	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726806	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726807	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726807	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726807	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC726807	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726807	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
LOC726814	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726814	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726814	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726814	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726814	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726814	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726814	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726819	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726819	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726819	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726819	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726825	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726825	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726825	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726825	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726825	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726828	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726829	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726832	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
LOC726833	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726839	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC726839	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC726839	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726839	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726839	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC726839	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC726840	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726841	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726842	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726842	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726842	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726843	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726850	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726852	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726852	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC726852	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC726852	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC726852	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726852	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726853	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726853	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726853	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726854	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726858	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
LOC726858	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC726858	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726858	GO:0019001_13174_8	guanyl nucleotide binding	"Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	IEA	molecular_function
LOC726859	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC726860	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726863	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC726870	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726870	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726876	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC726876	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726876	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC726876	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726876	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC726876	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC726876	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
LOC726876	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC726876	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC726876	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC726876	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726879	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726879	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726879	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
LOC726879	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726879	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
LOC726882	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC726882	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726882	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726882	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726882	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726889	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726890	GO:0004089_13174_3	carbonate dehydratase activity	"Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]	IEA	molecular_function
LOC726890	GO:0006730_6281_4	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	IEA	biological_process
LOC726890	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726896	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC726896	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
LOC726899	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726899	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726899	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726901	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726904	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726904	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726904	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726904	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726904	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726904	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726904	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726906	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726906	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726911	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC726911	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726913	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC726915	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726916	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC726916	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726916	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726916	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726918	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726918	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726919	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726919	GO:0004814_13174_4	arginine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]	IEA	molecular_function
LOC726919	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726919	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC726919	GO:0006420_6281_4	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]	IEA	biological_process
LOC726922	GO:0000062_13174_4	fatty-acyl-CoA binding	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726929	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726929	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
LOC726932	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC726932	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC726932	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC726932	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726933	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
LOC726936	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC726936	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726941	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726941	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726941	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726941	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726943	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726943	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC726943	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726943	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726944	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC726944	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC726944	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726944	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC726944	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC726944	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC726949	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726953	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
LOC726953	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
LOC726953	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
LOC726953	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC726953	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726953	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726955	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC726955	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC726955	GO:0008967_13174_3	phosphoglycolate phosphatase activity	"Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14372]	IEA	molecular_function
LOC726965	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC726966	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC726966	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
LOC726966	GO:0008241_13174_4	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	IEA	molecular_function
LOC726966	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC726968	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC726968	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC726969	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC726971	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
LOC726971	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC726971	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC726973	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC726973	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC726973	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726977	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726977	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC726977	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
LOC726977	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC726978	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726978	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726978	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726978	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726989	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726989	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC726993	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726995	GO:0042302_13174_46	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	IEA	molecular_function
LOC726996	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726996	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726996	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726996	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC726999	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC726999	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC726999	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC726999	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC727002	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727008	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727008	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727008	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727008	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC727015	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727024	GO:0003333_6281_8	amino acid transmembrane transport	"The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	IEA	biological_process
LOC727024	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC727024	GO:0006865_6281_3	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727024	GO:0015171_13174_8	amino acid transmembrane transporter activity	"Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC727024	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727024	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727024	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727026	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC727026	GO:0005758_3650_1	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	IEA	cellular_component
LOC727026	GO:0006825_6281_2	copper ion transport	"The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727026	GO:0016531_13174_1	copper chaperone activity	"Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376]	IEA	molecular_function
LOC727030	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
LOC727030	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
LOC727030	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
LOC727030	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC727031	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
LOC727031	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
LOC727033	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC727033	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC727033	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727034	GO:0016884_13174_4	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]	IEA	molecular_function
LOC727047	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727047	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727050	GO:0004609_13174_1	phosphatidylserine decarboxylase activity	"Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20831]	IEA	molecular_function
LOC727050	GO:0008654_6281_10	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
LOC727051	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727051	GO:0004523_13174_5	ribonuclease H activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	IEA	molecular_function
LOC727057	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727057	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC727057	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727057	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC727057	GO:0009360_3650_1	DNA polymerase III complex	"A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977]	IEA	cellular_component
LOC727057	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC727078	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727078	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727079	GO:0005158_13174_6	insulin receptor binding	"Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]	IEA	molecular_function
LOC727085	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727085	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC727085	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727085	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727085	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727085	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
LOC727086	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727088	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727088	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727088	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727088	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
LOC727088	GO:0045893_6281_4	positive regulation of transcription, DNA-dependent	"Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727097	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727108	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727108	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727108	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727108	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC727116	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC727116	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC727116	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727121	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727122	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
LOC727122	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC727123	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727123	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727123	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727123	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC727127	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727129	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC727129	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC727129	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727132	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC727132	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC727132	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727132	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC727132	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC727132	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC727132	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727132	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727135	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727139	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727140	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727140	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727143	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC727143	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727144	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727148	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727148	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727148	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727151	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727162	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
LOC727162	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727162	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
LOC727169	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727178	GO:0004017_13174_4	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	IEA	molecular_function
LOC727178	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727178	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
LOC727178	GO:0016776_13174_4	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC727178	GO:0019201_13174_4	nucleotide kinase activity	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]	IEA	molecular_function
LOC727178	GO:0019205_13174_7	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	IEA	molecular_function
LOC727178	GO:0046939_6281_4	nucleotide phosphorylation	"The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	IEA	biological_process
LOC727179	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
LOC727179	GO:0016597_13174_5	amino acid binding	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	IEA	molecular_function
LOC727179	GO:0016743_13174_2	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC727180	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727185	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727185	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727185	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727185	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC727189	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC727191	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727191	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
LOC727191	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727194	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC727199	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
LOC727199	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC727199	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727202	GO:0008146_13174_13	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators]	IEA	molecular_function
LOC727202	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727224	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC727224	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC727229	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727229	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727229	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727231	GO:0004784_13174_5	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1]	IEA	molecular_function
LOC727231	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
LOC727231	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
LOC727231	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727233	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727233	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
LOC727233	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727234	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727234	GO:0004126_13174_2	cytidine deaminase activity	"Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5]	IEA	molecular_function
LOC727234	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727234	GO:0009972_6281_2	cytidine deamination	"The removal of amino group in the presence of water." [GOC:sm]	IEA	biological_process
LOC727234	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC727235	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727235	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
LOC727240	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727240	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727240	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727251	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727251	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
LOC727251	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
LOC727256	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
LOC727256	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727256	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
LOC727265	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC727265	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727267	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
LOC727267	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
LOC727269	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727269	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727269	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727283	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC727283	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC727283	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC727283	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727284	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727284	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727285	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727285	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727286	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727286	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC727286	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727286	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727286	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC727286	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
LOC727286	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727287	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727287	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727289	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727289	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727289	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727293	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727293	GO:0008892_13174_1	guanine deaminase activity	"Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]	IEA	molecular_function
LOC727293	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC727299	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727301	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727301	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
LOC727301	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
LOC727304	GO:0005795_3650_4	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727304	GO:0008378_13174_9	galactosyltransferase activity	"Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	IEA	molecular_function
LOC727308	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727315	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727315	GO:0004592_13174_1	pantoate-beta-alanine ligase activity	"Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1]	IEA	molecular_function
LOC727315	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC727315	GO:0015940_6281_1	pantothenate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544]	IEA	biological_process
LOC727320	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727321	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC727321	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC727321	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
LOC727321	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727321	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC727321	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727325	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727325	GO:0006535_6281_2	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	IEA	biological_process
LOC727325	GO:0009001_13174_1	serine O-acetyltransferase activity	"Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24563]	IEA	molecular_function
LOC727325	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC727328	GO:0008610_6281_2	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
LOC727328	GO:0008780_13174_1	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity	"Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129]	IEA	molecular_function
LOC727328	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
LOC727330	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC727330	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727330	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727330	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727331	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
LOC727335	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
LOC727349	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
LOC727352	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC727352	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727352	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727366	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727366	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC727366	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727366	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727366	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC727369	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727369	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC727369	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
LOC727369	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC727369	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727370	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727370	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727370	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC727377	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727377	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727377	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC727377	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC727378	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
LOC727378	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
LOC727381	GO:0006388_6281_3	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	IEA	biological_process
LOC727381	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727381	GO:0031177_13174_11	phosphopantetheine binding	"Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah]	IEA	molecular_function
LOC727397	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
LOC727397	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
LOC727397	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
LOC727397	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
LOC727402	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727402	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727402	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727402	GO:0016301_13174_14	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	IEA	molecular_function
LOC727402	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
LOC727402	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC727407	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727408	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727411	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC727411	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727411	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC727415	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
LOC727415	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
LOC727415	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727415	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727415	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
LOC727415	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727418	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727419	GO:0000172_3650_1	ribonuclease MRP complex	"A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]	IEA	cellular_component
LOC727419	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
LOC727419	GO:0004540_13174_5	ribonuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727419	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
LOC727419	GO:0006379_6281_1	mRNA cleavage	"Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]	IEA	biological_process
LOC727419	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
LOC727419	GO:0030677_3650_1	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	IEA	cellular_component
LOC727432	GO:0004864_13174_1	protein phosphatase inhibitor activity	"Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai]	IEA	molecular_function
LOC727432	GO:0009966_6281_4	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	IEA	biological_process
LOC727432	GO:0043666_6281_1	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	IEA	biological_process
LOC727437	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727439	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
LOC727439	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
LOC727439	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
LOC727439	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
LOC727447	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727447	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727451	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727451	GO:0008705_13174_1	methionine synthase activity	"Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11175]	IEA	molecular_function
LOC727451	GO:0009086_6281_1	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC727452	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727452	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
LOC727452	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
LOC727454	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727454	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727455	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727456	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727456	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC727456	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
LOC727456	GO:0030246_13174_13	carbohydrate binding	"Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]	IEA	molecular_function
LOC727461	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727461	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC727461	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727461	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727461	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC727475	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727475	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727476	GO:0000062_13174_4	fatty-acyl-CoA binding	"Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727476	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727479	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
LOC727479	GO:0008324_13174_13	cation transmembrane transporter activity	"Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC727479	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727479	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727485	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
LOC727485	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727485	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
LOC727486	GO:0051087_13174_4	chaperone binding	"Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]	IEA	molecular_function
LOC727489	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727495	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727495	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LOC727495	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727495	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727495	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
LOC727496	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC727496	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC727496	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727496	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727496	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727498	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727499	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727499	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
LOC727499	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
LOC727499	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727499	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
LOC727499	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
LOC727499	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
LOC727499	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727499	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC727504	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727505	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727516	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727521	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC727521	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC727534	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
LOC727535	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
LOC727535	GO:0004568_13174_11	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	IEA	molecular_function
LOC727535	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
LOC727535	GO:0006032_6281_11	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
LOC727536	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727537	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
LOC727537	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
LOC727539	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727539	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
LOC727541	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727541	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727541	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
LOC727541	GO:0009107_6281_3	lipoate biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732]	IEA	biological_process
LOC727541	GO:0016415_13174_2	octanoyltransferase activity	"Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]	IEA	molecular_function
LOC727542	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
LOC727542	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC727542	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727557	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
LOC727557	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
LOC727561	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LOC727561	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727561	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
LOC727561	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727561	GO:0006606_6281_4	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	IEA	biological_process
LOC727561	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
LOC727561	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
LOC727564	GO:0008830_13174_2	dTDP-4-dehydrorhamnose 3,5-epimerase activity	"Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16972]	IEA	molecular_function
LOC727564	GO:0008879_13174_2	glucose-1-phosphate thymidylyltransferase activity	"Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15228]	IEA	molecular_function
LOC727564	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC727564	GO:0009103_6281_4	lipopolysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]	IEA	biological_process
LOC727564	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
LOC727564	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
LOC727565	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
LOC727565	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
LOC727565	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727565	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727565	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727566	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
LOC727566	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
LOC727566	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
LOC727566	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727566	GO:0008460_13174_1	dTDP-glucose 4,6-dehydratase activity	"Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17224]	IEA	molecular_function
LOC727566	GO:0008831_13174_4	dTDP-4-dehydrorhamnose reductase activity	"Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21799]	IEA	molecular_function
LOC727566	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
LOC727566	GO:0009225_6281_1	nucleotide-sugar metabolic process	"The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	IEA	biological_process
LOC727566	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727566	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC727566	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
LOC727566	GO:0045226_6281_6	extracellular polysaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]	IEA	biological_process
LOC727566	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
LOC727566	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727568	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727569	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
LOC727574	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
LOC727580	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727580	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727588	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727588	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727590	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
LOC727590	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727593	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
LOC727593	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
LOC727618	GO:0008299_6281_12	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	IEA	biological_process
LOC727619	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
LOC727619	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
LOC727630	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
LOC727630	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
LOC727630	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
LOC727633	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727633	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
LOC727633	GO:0046168_6281_4	glycerol-3-phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	IEA	biological_process
LOC727633	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
LOC727633	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727634	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LOC727635	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LOC727635	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LOC727635	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
LOC727635	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
LOC727640	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LOC727640	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
LOC727640	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
LOC727640	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
LOC727640	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
LOC727643	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
LOC727643	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
LOC727646	GO:0006835_6281_8	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
LOC727646	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
LOC727646	GO:0017153_13174_8	sodium:dicarboxylate symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]	IEA	molecular_function
LOC727648	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
LOC727648	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
LOC727669	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
LOC727669	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
LOC727669	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
LOC727669	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
loco	GO:0005057_13174_4	receptor signaling protein activity	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]	IEA	molecular_function
loco	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
loco	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
loco	GO:0030695_13174_3	GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]	IEA	molecular_function
loco	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
loj	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
loj	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
lok	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
lok	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
lok	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
lok	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
lok	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
lok	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
lok	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Lop1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Lop1	GO:0007601_6281_5	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	IEA	biological_process
Lop1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
lox2	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
lox2	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
lox2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
lox2	GO:0016641_13174_1	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	IEA	molecular_function
lox2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
lqfR	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
LRIG3	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
LRIG3	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
LRIG3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
LRIG3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
LRIG3	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
LRIG3	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
lt	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
lt	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
lt	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
lt	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
lt	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
lva	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
lva	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
lva	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
lwr	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Lys-3	GO:0003796_13174_1	lysozyme activity	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]	IEA	molecular_function
LZTR1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mad	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Mad	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mad	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Mad	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
Mad	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Mad	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
Madm	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Madm	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Madm	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Madm	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Madm	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Madm	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
mael	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Magi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mago	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mamo	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mamo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mamo	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mamo	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
MAPk-Ak2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
MAPk-Ak2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
MAPk-Ak2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
MAPk-Ak2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
MAPk-Ak2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
MAPk-Ak2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
MAPKKK9	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
MAPKKK9	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
MAPKKK9	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
MAPKKK9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MAPKKK9	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
MAPKKK9	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
MAPKKK9	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
MARCH6	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Marf	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Marf	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Marf	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
Marf	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Marf	GO:0008053_6281_1	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192]	IEA	biological_process
Marf	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
mask	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
mask	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MAST2	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
MAST2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
MAST2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
MAST2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
MAST2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MAST2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
MAST2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
MAST2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
mav	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
mbc	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
mbc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MBD-like	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mbf1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mbf1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Mblk-1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mblk-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mbo	GO:0005351_13174_8	sugar:hydrogen symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]	IEA	molecular_function
mbo	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
mbo	GO:0008965_13174_1	phosphoenolpyruvate-protein phosphotransferase activity	"Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9]	IEA	molecular_function
mbo	GO:0009401_6281_6	phosphoenolpyruvate-dependent sugar phosphotransferase system	"The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]	IEA	biological_process
Mbs	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mbt	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
mbt	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
mbt	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
mbt	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mbt	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mbt	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
mbt	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Mcm10	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Mcm10	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Mcm3	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Mcm3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mcm3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mcm3	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Mcm3	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Mcm5	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Mcm5	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mcm5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mcm5	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Mcm5	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Mcm7	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Mcm7	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mcm7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mcm7	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Mcm7	GO:0015979_6281_4	photosynthesis	"The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]	IEA	biological_process
Mcm7	GO:0015995_6281_4	chlorophyll biosynthetic process	"The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]	IEA	biological_process
Mcm7	GO:0016851_13174_4	magnesium chelatase activity	"Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]	IEA	molecular_function
Mcm7	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Mcm7	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Mctp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mdh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Mdh	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Mdh	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Mdh	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Mdh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
MED14	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
MED14	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MED14	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
MED15	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
MED15	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MED16	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MED26	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
MED26	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
MED26	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
MED31	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
MED31	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MED31	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
MED6	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
MED6	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MED6	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
MED7	GO:0001104_13174_10	RNA polymerase II transcription cofactor activity	"Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
MED7	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MED7	GO:0016592_3650_10	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	IEA	cellular_component
Mef2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mef2	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
mei-41	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
mei-41	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mei-41	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
mei-41	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
mei-W68	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mei-W68	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
mei-W68	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mei-W68	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
mei-W68	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
Mekk1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Mekk1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Mekk1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Mekk1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mekk1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Mekk1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Melt	GO:0004860_13174_1	protein kinase inhibitor activity	"Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	IEA	molecular_function
Melt	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
membrin	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
membrin	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Men	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Men	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Men	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Men	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Men	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Mer	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Mer	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Mer	GO:0008092_13174_4	cytoskeletal protein binding	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	IEA	molecular_function
Mer	GO:0019898_3650_3	extrinsic to membrane	"Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah]	IEA	cellular_component
Mes-4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mes-4	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Mes-4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Mes-4	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
Metap2	GO:0004177_13174_10	aminopeptidase activity	"Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Metap2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Metap2	GO:0008235_13174_9	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]	IEA	molecular_function
Metap2	GO:0009987_6281_8	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	IEA	biological_process
metl	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
metl	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Mgat1	GO:0000139_3650_4	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	IEA	cellular_component
Mgat1	GO:0003827_13174_1	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459]	IEA	molecular_function
Mgat1	GO:0006487_6281_1	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	IEA	biological_process
Mgat2	GO:0005795_3650_4	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Mgat2	GO:0008455_13174_1	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143]	IEA	molecular_function
Mgat2	GO:0009312_6281_1	oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	IEA	biological_process
Mgat2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
mGlutR1	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
mGlutR1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
mGlutR1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
mGlutR2	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
mGlutR2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
mGlutR2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Mhc1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Mhc1	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Mhc1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mhc1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mhc1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Mhc1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Mhc1	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Mhc1	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Mhc1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Mhc2	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Mhc2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mhc2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mhc2	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Mib	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
Mib	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mib	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Mib	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
Mib	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Mical	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mical	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Mical	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Mical	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Mical	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Mical	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
MICAL-like	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MICAL-like	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
mio	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Miro	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Miro	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Miro	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Miro	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Miro	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Miro	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Miro	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Miro	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
mirr	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mirr	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
mirr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mirr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mirr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
mirr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Mkk4	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Mkk4	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Mkk4	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Mkk4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Mkk4	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Mkk4	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Mkp3	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
Mkp3	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
Mkp3	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
Mkp3	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
MKP-4	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
MKP-4	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
MKP-4	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
MKP-4	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
MKP-4	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
Mkrn1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Mkrn1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mkrn1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Mlc2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Mlc-c	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
mle	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
mle	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
mle	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
mle	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mle	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mle	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
MLH1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
MLH1	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
MLH1	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
mmd	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
mmd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mmd	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
mmd	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Mms19	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Mms19	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mmy	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
mmy	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
Mnx1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Mnx1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mnx1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Mnx1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Mnx1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Mocs1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Mocs1	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
Mocs1	GO:0019008_3650_1	molybdopterin synthase complex	"A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]	IEA	cellular_component
Mocs1	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Mocs1	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Mocs1	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Mocs2	GO:0006777_6281_6	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]	IEA	biological_process
Moe	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Moe	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Moe	GO:0008092_13174_4	cytoskeletal protein binding	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	IEA	molecular_function
Moe	GO:0019898_3650_3	extrinsic to membrane	"Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah]	IEA	cellular_component
mof	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mof	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mof	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
mof	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
mof	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
morgue	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
morgue	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
MOX-2	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
MOX-2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MOX-2	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
MOX-2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MOX-2	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Mp20	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mre11	GO:0004519_13174_5	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
mre11	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
mre11	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mre11	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
mre11	GO:0006302_6281_1	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	IEA	biological_process
mre11	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
mre11	GO:0030145_13174_4	manganese ion binding	"Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]	IEA	molecular_function
MrgBP	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
MrgBP	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MrgBP	GO:0043189_3650_1	H4/H2A histone acetyltransferase complex	"A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb]	IEA	cellular_component
mr	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
mr	GO:0031461_3650_6	cullin-RING ubiquitin ligase complex	"Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]	IEA	cellular_component
mr	GO:0031625_13174_6	ubiquitin protein ligase binding	"Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	IEA	molecular_function
Mrjp4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
mRNA-capping-enzyme	GO:0003910_13174_5	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	IEA	molecular_function
mRNA-capping-enzyme	GO:0004484_13174_2	mRNA guanylyltransferase activity	"Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]	IEA	molecular_function
mRNA-capping-enzyme	GO:0004651_13174_1	polynucleotide 5'-phosphatase activity	"Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]	IEA	molecular_function
mRNA-capping-enzyme	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
mRNA-capping-enzyme	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mRNA-capping-enzyme	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mRNA-capping-enzyme	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
mRNA-capping-enzyme	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
mRNA-capping-enzyme	GO:0006370_6281_3	7-methylguanosine mRNA capping	"Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]	IEA	biological_process
mRNA-capping-enzyme	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
mRNA-capping-enzyme	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
mRNA-capping-enzyme	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
mRNA-capping-enzyme	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
mRNA-capping-enzyme	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
mRpL13	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL13	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL13	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL14	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL14	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL14	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL16	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL16	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL16	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL17	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL17	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL17	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL17	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL1	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
mRpL1	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL1	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL1	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
mRpL20	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL20	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL20	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL20	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL20	GO:0019843_13174_4	rRNA binding	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]	IEA	molecular_function
mRpL22	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL22	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL22	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL22	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL24	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL24	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL24	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL24	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL27	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL27	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL27	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL27	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL2	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL2	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL2	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL30	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL30	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL30	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL35	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL35	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL35	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL35	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL39	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
mRpL3	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL3	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL3	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL44	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
mRpL44	GO:0004525_13174_5	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	IEA	molecular_function
mRpL44	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
mRpL45	GO:0005744_3650_2	mitochondrial inner membrane presequence translocase complex	"The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]	IEA	cellular_component
mRpL45	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
mRpL45	GO:0015450_13174_5	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
mRpL46	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
mRpL47	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL47	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL47	GO:0005761_3650_1	mitochondrial ribosome	"A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]	IEA	cellular_component
mRpL47	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL47	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL48	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL48	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpL48	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL48	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpL4	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpL4	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpL4	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS11	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS11	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS11	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS12	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS12	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS12	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS12	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS12	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
mRpS14	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS14	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS14	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS14	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS16	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS16	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS16	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS16	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS18A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS18A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS18A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS18A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS18B	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS18B	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS18B	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS18B	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS2	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS2	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS2	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS2	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
mRpS30	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS30	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
mRpS30	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS30	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS5	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
mRpS5	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS5	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS6	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS6	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
mRpS6	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
mRpS6	GO:0019843_13174_4	rRNA binding	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]	IEA	molecular_function
mRpS7	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
mRpS7	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
mRpS7	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Msh6	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Msh6	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
Msh6	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
msl-3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
msn	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
msn	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
msn	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
msn	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
msn	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
msn	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
msn	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
msps	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
msps	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MsrA	GO:0016671_13174_2	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	IEA	molecular_function
MsrA	GO:0019538_6281_3	protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]	IEA	biological_process
MsrA	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
MsrB	GO:0008113_13174_1	peptide-methionine-(S)-S-oxide reductase activity	"Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920]	IEA	molecular_function
MsrB	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Msx	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Msx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Msx	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Msx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Msx	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
MTA1-like	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
MTA1-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
MTA1-like	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MTA1-like	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
MTA1-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
MTA1-like	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
MTA1-like	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
mtacp1	GO:0000036_13174_6	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	"Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl]	IEA	molecular_function
mtacp1	GO:0048037_13174_7	cofactor binding	"Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]	IEA	molecular_function
mt:CoIII	GO:0005886_3650_17	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	IEA	cellular_component
mt:CoIII	GO:0008827_13174_1	cytochrome o ubiquinol oxidase activity	"Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN]	IEA	molecular_function
mt:CoIII	GO:0015002_13174_1	heme-copper terminal oxidase activity	"Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd]	IEA	molecular_function
mt:CoIII	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
mt:CoIII	GO:0019646_6281_1	aerobic electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]	IEA	biological_process
mtg	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
mtg	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
mtg	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
MTMR2	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
MTMR2	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
MTMR2	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
Mtor	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
Mtor	GO:0006606_6281_4	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	IEA	biological_process
Mtor	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Mtor	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Mtp	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Mtp	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
mts	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
mtSSB	GO:0003697_13174_2	single-stranded DNA binding	"Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh]	IEA	molecular_function
mtSSB	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
mtTFB1	GO:0000154_6281_3	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
mtTFB1	GO:0000179_13174_3	rRNA (adenine-N6,N6-)-dimethyltransferase activity	"Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]	IEA	molecular_function
mtTFB1	GO:0003712_13174_7	transcription cofactor activity	"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
mtTFB1	GO:0005739_3650_12	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]	IEA	cellular_component
mtTFB1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
mtTFB1	GO:0008649_13174_3	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	IEA	molecular_function
mtTFB1	GO:0031167_6281_2	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	IEA	biological_process
mud	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
mud	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
mud	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
mud	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
mud	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
mud	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
mud	GO:0019538_6281_3	protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]	IEA	biological_process
mud	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
mus209	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mus209	GO:0006275_6281_1	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	IEA	biological_process
mus209	GO:0030337_13174_1	DNA polymerase processivity factor activity	"An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]	IEA	molecular_function
mus209	GO:0043626_3650_1	PCNA complex	"A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]	IEA	cellular_component
mus308	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
mus308	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mus308	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
mus308	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
mus308	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mus308	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
mus308	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
mus309	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
mus309	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
mus309	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
mus309	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
mus309	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
mus81	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
mus81	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
mus81	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
muskelin	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
muskelin	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Mvl	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Mvl	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Mvl	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
mwh	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
mwh	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
mwh	GO:0016043_6281_8	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	IEA	biological_process
Mxp	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Mxp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Mxp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Mxp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Mxp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Mxp	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Myb	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Myb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MYCBP2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
MYCBP2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Myd88	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myd88	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Myd88	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Myo15	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo15	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo15	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo15	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Myo15	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo18	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo18	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo18	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo18	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo1A	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo1A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo1A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo1A	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo1B	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Myo1B	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo1B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo1B	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo1B	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo1B	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Myo20	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo20	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo20	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo20	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo21	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo21	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Myo21	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Myo21	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Myo21	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo21	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo21	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Myo21	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo21	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Myo22	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo22	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo22	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo22	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Myo22	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Myo22	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo3	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo3	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Myo3	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Myo3	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Myo3	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
Myo3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo3	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Myo3	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Myo3	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
Myo3	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo3	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Myo5	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Myo5	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Myo5	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo5	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Myo5	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo5	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Myo5	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Myo6	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo6	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo6	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo7	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Myo7	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo7	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Myo7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo7	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Myo7	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Myo7	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo7	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Myo9	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Myo9	GO:0003774_13174_27	motor activity	"Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]	IEA	molecular_function
Myo9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Myo9	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Myo9	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Myo9	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Myo9	GO:0016459_3650_25	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]	IEA	cellular_component
Myo9	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Myo9	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
nAChRa1	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa1	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa1	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa2	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa2	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa2	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa2	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa3	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa3	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa3	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa3	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa4	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa5	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa5	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa5	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa5	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa6	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa6	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa6	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa6	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa6	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa7	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa7	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa7	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa7	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa8	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa8	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa8	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRa8	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRa8	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRa8	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRa9	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRa9	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRa9	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRb1	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRb1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRb1	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nAChRb1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nAChRb1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nAChRb1	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
nAChRb2	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
nAChRb2	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nAChRb2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nahoda	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nak	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Nak	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Nak	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Nak	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Nak	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Nak	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Nan	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Nan	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nan	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nan	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Nan	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
nanos	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
nanos	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
nanos	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
nanos	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
nanos	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
NaPi-T	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NaPi-T	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
nau	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
nau	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
nau	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
nau	GO:0007517_6281_1	muscle organ development	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]	IEA	biological_process
NBAS	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NBEA	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
NBEA	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
nbs	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NC2beta	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
NC2beta	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
NC2beta	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Ncc69	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ncc69	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Ncc69	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Ncc69	GO:0006821_6281_7	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	IEA	biological_process
Ncc69	GO:0015377_13174_3	cation:chloride symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]	IEA	molecular_function
Ncc69	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ncc69	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ncc69	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Ncc69	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
nct	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
nct	GO:0016485_6281_2	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	IEA	biological_process
Ndg	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Ndg	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ndg	GO:0007160_6281_6	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	IEA	biological_process
Ndufa10	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ndufa10	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
Ndufa10	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
Ndufa5	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
Ndufa5	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufa5	GO:0022904_6281_2	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	IEA	biological_process
Ndufa9	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Ndufa9	GO:0003854_13174_12	3-beta-hydroxy-delta5-steroid dehydrogenase activity	"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]	IEA	molecular_function
Ndufa9	GO:0006694_6281_12	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	IEA	biological_process
Ndufa9	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Ndufa9	GO:0044237_6281_24	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	IEA	biological_process
Ndufa9	GO:0050662_13174_19	coenzyme binding	"Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]	IEA	molecular_function
Ndufa9	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufs1	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Ndufs1	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufs1	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Ndufs1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufs2	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufs2	GO:0048038_13174_2	quinone binding	"Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	IEA	molecular_function
Ndufs2	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Ndufs2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufs3	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
Ndufs3	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufs3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufs4	GO:0005743_3650_6	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	IEA	cellular_component
Ndufs4	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufs4	GO:0022900_6281_4	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]	IEA	biological_process
Ndufs7	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
Ndufs7	GO:0048038_13174_2	quinone binding	"Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	IEA	molecular_function
Ndufs7	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Ndufs7	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufs8	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Ndufs8	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ndufs8	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufs8	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Ndufs8	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Ndufs8	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufv1	GO:0008137_13174_11	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]	IEA	molecular_function
Ndufv1	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
Ndufv1	GO:0016651_13174_7	oxidoreductase activity, acting on NADH or NADPH	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
Ndufv1	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Ndufv1	GO:0051539_13174_10	4 iron, 4 sulfur cluster binding	"Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Ndufv1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ndufv2	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Ndufv2	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Ndufv2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Nedd4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nedd4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Nedd4	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Nedd4	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Nedd9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nelf-E	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
nemy	GO:0004359_13174_1	glutaminase activity	"Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2]	IEA	molecular_function
nemy	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
nemy	GO:0006541_6281_2	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	IEA	biological_process
Neos	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Neos	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Neos	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Nep1	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Nep1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Nep1	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Nep2	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Nep2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Nep2	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Nep3	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Nep3	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Nep3	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Nep4	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Nep4	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Nep4	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Nep5	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Nep5	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Nep5	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
neur	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
neur	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Neurochondrin	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Nf1	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
Nf1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Nf1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Nf1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Nf1	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
NFAT	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
NFAT	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NFAT	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
NFAT	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Nf-YB	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Nf-YB	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Nf-YB	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Nf-YB	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Nf-YB	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
N	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
N	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
N	GO:0007219_6281_4	Notch signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	IEA	biological_process
N	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
N	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
N	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
N	GO:0030154_6281_4	cell differentiation	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	IEA	biological_process
N	GO:0050793_6281_2	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	IEA	biological_process
Nhe1	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe1	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe1	GO:0006885_6281_3	regulation of pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
Nhe1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Nhe1	GO:0015299_13174_5	solute:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	IEA	molecular_function
Nhe1	GO:0015385_13174_3	sodium:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	IEA	molecular_function
Nhe1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Nhe1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Nhe2	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe2	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe2	GO:0006885_6281_3	regulation of pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
Nhe2	GO:0015299_13174_5	solute:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	IEA	molecular_function
Nhe2	GO:0015385_13174_3	sodium:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	IEA	molecular_function
Nhe2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Nhe2	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Nhe3	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe3	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Nhe3	GO:0006885_6281_3	regulation of pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
Nhe3	GO:0015299_13174_5	solute:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	IEA	molecular_function
Nhe3	GO:0015385_13174_3	sodium:hydrogen antiporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	IEA	molecular_function
Nhe3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Nhe3	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Nhlrc2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NimA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NimC1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
NimC1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NimC2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NiPp1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nipped-A	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Nipped-A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nipped-A	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Nipped-A	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
Nipped-B	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
nito	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
nito	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
nito	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
nito	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Nle	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nmdar1	GO:0004970_13174_23	ionotropic glutamate receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	IEA	molecular_function
Nmdar1	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Nmdar1	GO:0005234_13174_23	extracellular-glutamate-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Nmdar1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Nmdar1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Nmdar1	GO:0030288_3650_9	outer membrane-bounded periplasmic space	"The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]	IEA	cellular_component
Nmdmc	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Nmdmc	GO:0004488_13174_3	methylenetetrahydrofolate dehydrogenase (NADP+) activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]	IEA	molecular_function
Nmdmc	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
Nmdmc	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
nmdyn-D7	GO:0004550_13174_4	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	IEA	molecular_function
nmdyn-D7	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
nmdyn-D7	GO:0006165_6281_4	nucleoside diphosphate phosphorylation	"The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	IEA	biological_process
nmdyn-D7	GO:0006183_6281_4	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
nmdyn-D7	GO:0006228_6281_4	UTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732]	IEA	biological_process
nmdyn-D7	GO:0006241_6281_4	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	IEA	biological_process
nmo	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
nmo	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
nmo	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
nmo	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
nmo	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
nmo	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
nmo	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Nmt	GO:0004379_13174_2	glycylpeptide N-tetradecanoyltransferase activity	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]	IEA	molecular_function
Nmt	GO:0006499_6281_1	N-terminal protein myristoylation	"The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]	IEA	biological_process
Nnp-1	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
Nnp-1	GO:0030688_3650_1	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	IEA	cellular_component
Noa36	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Noa36	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Noa36	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Noc2	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
NOL10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NOL10	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
nompB	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NompC	GO:0003848_13174_2	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	"Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415]	IEA	molecular_function
NompC	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
NompC	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
NompC	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
NompC	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
NompC	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
NompC	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
norpA2	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
norpA2	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
norpA2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
norpA2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
norpA2	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
norpA2	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
norpA2	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
norpA2	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
norpA2	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
norpA2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
NOS	GO:0004517_13174_1	nitric-oxide synthase activity	"Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]	IEA	molecular_function
NOS	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
NOS	GO:0005516_13174_4	calmodulin binding	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	IEA	molecular_function
NOS	GO:0006809_6281_1	nitric oxide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]	IEA	biological_process
NOS	GO:0010181_13174_8	FMN binding	"Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	IEA	molecular_function
NOS	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
NOS	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
NOS	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
NOS	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
NOS	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Nox	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Nox	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Nox	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Nox	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Nox	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Nox	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Nox	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
NPF	GO:0005179_13174_9	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	IEA	molecular_function
NPF	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
NR1E1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
NR1E1	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
NR1E1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
NR1E1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
NR1E1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
NR1E1	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
NR1E1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
NRD1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
NRD1	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
NRD1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
NRD1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
NRD1	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Nrk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Nrk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Nrk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Nrk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nrk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Nrk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Nrk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
nrm	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
nrv1	GO:0005391_13174_5	sodium:potassium-exchanging ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]	IEA	molecular_function
nrv1	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nrv1	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nrv1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nrv1	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
nrv2	GO:0005391_13174_5	sodium:potassium-exchanging ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]	IEA	molecular_function
nrv2	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nrv2	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
nrv2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
nrv2	GO:0046034_6281_10	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	IEA	biological_process
Nrx-1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Nrx-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ns1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ns1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ns1	GO:0030141_3650_2	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]	IEA	cellular_component
ns2	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ns2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ns3	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ns3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ns4	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ns4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
NT-10	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-10	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-11	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-11	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-11	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-12	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-12	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-12	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-4	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-4	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-4	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-5	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-5	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-6	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-6	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-6	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-7	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-7	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-8	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-8	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-8	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
NT-9	GO:0005328_13174_16	neurotransmitter:sodium symporter activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]	IEA	molecular_function
NT-9	GO:0006836_6281_17	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	IEA	biological_process
NT-9	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
numb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nup107	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
Nup107	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Nup154	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nup214	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nup44A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nup44A	GO:0009168_6281_5	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Nup44A	GO:0019239_13174_5	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]	IEA	molecular_function
NUP50	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
NUP50	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
Nup62	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Nup62	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Nup62	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Nup62	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
Nup62	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Nup62	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Nup62	GO:0017056_13174_1	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]	IEA	molecular_function
Nup98	GO:0005643_3650_7	nuclear pore	"Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	IEA	cellular_component
Nup98	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
nwk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Nxt1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Nxt1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Oa1	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Oa1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
oa2	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
oa2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Oat	GO:0008483_13174_8	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	IEA	molecular_function
Oat	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Oaz	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Oaz	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Oaz	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Obp10	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp11	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp12	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp13	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp16	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp17	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp19	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp1	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp20	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp21	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp2	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp3	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp4	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp5	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp6	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp7	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Obp9	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Octbeta2R	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Octbeta2R	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ogg1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ogg1	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Ogg1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Ogg1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Ogg1	GO:0006284_6281_3	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	IEA	biological_process
Ogg1	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
Ogg1	GO:0008534_13174_1	oxidized purine nucleobase lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]	IEA	molecular_function
onecut	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
onecut	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
onecut	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
onecut	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
onecut	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
onecut	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
onecut	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
onecut	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
opa1-like	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
opa1-like	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Or105	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or105	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or105	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or105	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or106	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or106	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or106	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or106	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or107	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or107	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or107	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or107	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or109	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or109	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or109	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or109	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or10	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or10	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or10	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or10	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or115	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or115	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or115	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or115	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or119	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or119	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or119	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or119	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or11	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or11	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or11	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or11	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or12	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or12	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or12	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or12	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or131	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or131	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or131	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or131	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or13	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or13	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or13	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or13	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or141	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Or141	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Or143	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or143	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or143	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or143	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or148	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or148	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or148	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or148	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or14	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or14	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or14	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or14	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or157	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or157	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or157	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or157	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or15	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or15	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or15	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or15	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or160	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or160	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or160	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or160	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or163	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or163	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or163	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or163	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or163	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Or163	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or167PAR	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or167PAR	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or167PAR	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or167PAR	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or16	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or16	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or16	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or16	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or170	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or170	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or170	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or170	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or17	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or17	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or17	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or17	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or18	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or18	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or18	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or18	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or19	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or19	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or19	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or19	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or1	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or1	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or1	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or20	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or20	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or20	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or20	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or22	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or22	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or22	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or22	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or25	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or25	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or25	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or25	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or26	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or26	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or26	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or26	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or27	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or27	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or27	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or27	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or28P	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or28P	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or28P	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or28P	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or29	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or29	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or29	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or29	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or2	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or2	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or2	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or30	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or30	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or30	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or30	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or31	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or31	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or31	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or31	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or32	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or32	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or32	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or32	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or33	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or33	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or33	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or33	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or34	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or34	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or34	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or34	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or35	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or35	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or35	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or35	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or35	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Or35	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or37	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or37	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or37	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or37	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or3	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or3	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or3	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or41	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or41	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or41	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or41	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or41	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Or41	GO:0050909_6281_18	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or4	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or4	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or4	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or50	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or50	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or50	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or50	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or51	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or51	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or51	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or51	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or52	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or52	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or52	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or52	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or53	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or53	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or53	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or53	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or55	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or55	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or55	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or55	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or56	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or56	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or56	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or56	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or57	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or57	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or57	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or57	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or58	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or58	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or58	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or58	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or5	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or5	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or5	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or63	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or63	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or63	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or63	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or77PAR	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or77PAR	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or77PAR	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Or77PAR	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or77PAR	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or78	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or78	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or78	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or78	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or83	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or83	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or83	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or83	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or87	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or87	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or87	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or87	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or94	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or94	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or94	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or94	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or98	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or98	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or98	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or98	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Or9	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
Or9	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
Or9	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
Or9	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
orb2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
orb2	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
orb2	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
orb2	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
orb2	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
orb2	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
orb2	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
orb2	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
orb2	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
orb	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Orc1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Orc1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Orc1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Orc4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Orc4	GO:0000808_3650_2	origin recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]	IEA	cellular_component
Orc4	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Orc4	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Orc4	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Orc4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
osa	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
osa	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
osa	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Osbp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Oscillin	GO:0004342_13174_1	glucosamine-6-phosphate deaminase activity	"Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]	IEA	molecular_function
Oscillin	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Oscillin	GO:0006044_6281_2	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	IEA	biological_process
Oscp	GO:0015986_6281_12	ATP synthesis coupled proton transport	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	IEA	biological_process
Oscp	GO:0046933_13174_9	hydrogen ion transporting ATP synthase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]	IEA	molecular_function
Osi23	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
Osi23	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Osi23	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
Osi23	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
osm-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
osp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
otd1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
otd1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
otd1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
otd1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
otd1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
otd2	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
otd2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
otd2	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
otd2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
otd2	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
ovo	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
ovo	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ovo	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
oxt	GO:0008375_13174_1	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	IEA	molecular_function
oxt	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
p115	GO:0000139_3650_4	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	IEA	cellular_component
p115	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
p115	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
p115	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
p115	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
p115	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
p115	GO:0048280_6281_1	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	IEA	biological_process
p16-ARC	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
p16-ARC	GO:0030833_6281_4	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	IEA	biological_process
p24-1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
p24-1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
p38b	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
p38b	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
p38b	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
p38b	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
p38b	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
p38b	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
p38b	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
P58IPK	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
P58IPK	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
Pabp2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Pain	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Pain	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pain	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Pain	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Pain	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Pain	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Pain	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
Pain	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Pak	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pak	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pak	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pak	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pak	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pak	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pak	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
pan	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
pan	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PANK4	GO:0004594_13174_3	pantothenate kinase activity	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]	IEA	molecular_function
PANK4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PANK4	GO:0015937_6281_4	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	IEA	biological_process
par-1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
par-1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
par-1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
par-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
par-1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
par-1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
par-6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Para	GO:0001518_3650_1	voltage-gated sodium channel complex	"A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]	IEA	cellular_component
Para	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Para	GO:0005248_13174_1	voltage-gated sodium channel activity	"Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Para	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Para	GO:0006814_6281_23	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Para	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Para	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Parp	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Parp	GO:0003950_13174_3	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	IEA	molecular_function
Parp	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Parp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Parp	GO:0006471_6281_1	protein ADP-ribosylation	"The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]	IEA	biological_process
Parp	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Parp	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
parv1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
parv1	GO:0016853_13174_10	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	IEA	molecular_function
Past1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Past1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Past1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Past1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Past1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Pat1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Patj	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pax-1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Pax-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pax-1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Pban	GO:0005184_13174_4	neuropeptide hormone activity	"The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]	IEA	molecular_function
Pban	GO:0007218_6281_7	neuropeptide signaling pathway	"The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]	IEA	biological_process
Pbgs	GO:0004655_13174_1	porphobilinogen synthase activity	"Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24067]	IEA	molecular_function
Pbgs	GO:0033014_6281_4	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah]	IEA	biological_process
Pbgs	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
pbl	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
pbl	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
pbl	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
pbl	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
pbl	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Pbp45	GO:0004857_13174_6	enzyme inhibitor activity	"Stops, prevents or reduces the activity of an enzyme." [GOC:ai]	IEA	molecular_function
Pbp45	GO:0008073_13174_2	ornithine decarboxylase inhibitor activity	"The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl]	IEA	molecular_function
Pcd	GO:0006729_6281_3	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732]	IEA	biological_process
Pcd	GO:0008124_13174_1	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	"Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11923]	IEA	molecular_function
Pc	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
PCID2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pcl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pcl	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Pcl	GO:0044262_6281_8	cellular carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	IEA	biological_process
Pcl	GO:0046912_13174_3	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	IEA	molecular_function
pcx	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Pde1c	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Pde1c	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
Pde1c	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pde1c	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
Pde9	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Pde9	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
Pde9	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pde9	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
pdfr	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
pdfr	GO:0004930_13174_24	G-protein coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	IEA	molecular_function
pdfr	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
pdfr	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
pdfr	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
pdfr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
PDHB	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
PDHB	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Pdi	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Pdk	GO:0000155_13174_3	two-component sensor activity	"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]	IEA	molecular_function
Pdk	GO:0004673_13174_1	protein histidine kinase activity	"Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah]	IEA	molecular_function
Pdk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pdk	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pdk	GO:0018106_6281_1	peptidyl-histidine phosphorylation	"The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036]	IEA	biological_process
pdm3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
pdm3	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
pdm3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
pdm3	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
pdm3	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Pdp1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Pdp1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Pdp1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Pdp1	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Pdp	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Pdp	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
Pdp	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
Pdp	GO:0008287_3650_7	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	IEA	cellular_component
PEK	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
PEK	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
PEK	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
PEK	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PEK	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
PEK	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
pelle	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
pelle	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
pelle	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
pelle	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
pelle	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
pelle	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
pelle	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
pelle	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
pen	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
pen	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Pepck	GO:0004611_13174_1	phosphoenolpyruvate carboxykinase activity	"Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.-]	IEA	molecular_function
Pepck	GO:0004613_13174_1	phosphoenolpyruvate carboxykinase (GTP) activity	"Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]	IEA	molecular_function
Pepck	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Pepck	GO:0006094_6281_3	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	IEA	biological_process
Pepck	GO:0017076_13174_1	purine nucleotide binding	"Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	IEA	molecular_function
Per	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
Per	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Per	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Per	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pez	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
pfk	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Pfk	GO:0003872_13174_1	6-phosphofructokinase activity	"Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]	IEA	molecular_function
pfk	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pfk	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Pfk	GO:0005945_3650_1	6-phosphofructokinase complex	"A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732]	IEA	cellular_component
Pfk	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
Pfrx	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Pfrx	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Pfrx	GO:0003873_13174_1	6-phosphofructo-2-kinase activity	"Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15656]	IEA	molecular_function
Pfrx	GO:0004331_13174_1	fructose-2,6-bisphosphate 2-phosphatase activity	"Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46]	IEA	molecular_function
Pfrx	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pfrx	GO:0006000_6281_1	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	IEA	biological_process
Pfrx	GO:0006003_6281_1	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	IEA	biological_process
Pfrx	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Pfrx	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Pgd	GO:0004616_13174_4	phosphogluconate dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]	IEA	molecular_function
Pgd	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
Pgd	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Pgd	GO:0016616_13174_48	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	IEA	molecular_function
Pgd	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
Pgd	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Pgk	GO:0004618_13174_1	phosphoglycerate kinase activity	"Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804]	IEA	molecular_function
Pgk	GO:0006096_6281_14	glycolysis	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [GOC:bf, ISBN:0716720094, Wikipedia:Glycolysis]	IEA	biological_process
Pgm1	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
Pgm1	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Pgm1	GO:0016868_13174_4	intramolecular transferase activity, phosphotransferases	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	IEA	molecular_function
Pgm2	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
Pgm2	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Pgm2	GO:0016868_13174_4	intramolecular transferase activity, phosphotransferases	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	IEA	molecular_function
PGRP-LC	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PGRP-LC	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
PGRP-LC	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
PGRP-LC	GO:0016740_13174_22	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	IEA	molecular_function
PGRP-S1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PGRP-S1	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
PGRP-S1	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
Pgrp-s2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Pgrp-s2	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
Pgrp-s2	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
PGRP-S3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PGRP-S3	GO:0008745_13174_6	N-acetylmuramoyl-L-alanine amidase activity	"Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]	IEA	molecular_function
PGRP-S3	GO:0009253_6281_6	peptidoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]	IEA	biological_process
PH4alphaEFB	GO:0004656_13174_1	procollagen-proline 4-dioxygenase activity	"Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]	IEA	molecular_function
PH4alphaEFB	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
PH4alphaEFB	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
PH4alphaEFB	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
PH4alphaEFB	GO:0016702_13174_1	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	IEA	molecular_function
PH4alphaEFB	GO:0016705_13174_70	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	IEA	molecular_function
PH4alphaEFB	GO:0016706_13174_8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	IEA	molecular_function
PH4alphaEFB	GO:0031418_13174_6	L-ascorbic acid binding	"Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah]	IEA	molecular_function
PH4alphaEFB	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
pHCl	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
pHCl	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
pHCl	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
pHCl	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
PHDP	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
PHDP	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PHDP	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
PHDP	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
PHDP	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
PhKgamma	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
PhKgamma	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
PhKgamma	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
PhKgamma	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PhKgamma	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
PhKgamma	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Phlpp	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Phlpp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Phm	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Phm	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
Phm	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
Phm	GO:0016715_13174_3	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
Phm	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
PHRF1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PHRF1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PHRF1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
phr	GO:0003904_13174_1	deoxyribodipyrimidine photo-lyase activity	"Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]	IEA	molecular_function
phr	GO:0003913_13174_3	DNA photolyase activity	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]	IEA	molecular_function
phr	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Pi4k2b	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
Picot	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Picot	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
pita	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
pita	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
pita	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
pita	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
pit	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
pit	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
pit	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
pit	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
PITRM1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
PITRM1	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
PITRM1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
PITRM1	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
PITRM1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PITRM1	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Pitslre	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pitslre	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pitslre	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pitslre	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pitslre	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pitslre	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
pix	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
pix	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
pix	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
pix	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
pix	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
pix	GO:0051536_13174_23	iron-sulfur cluster binding	"Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	IEA	molecular_function
Pka-C1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pka-C1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pka-C1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pka-C1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pka-C1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pka-C1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pka-C2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pka-C2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pka-C2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pka-C2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pka-C2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pka-C2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pka-C3	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pka-C3	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pka-C3	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pka-C3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pka-C3	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pka-C3	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pka-R1	GO:0001932_6281_2	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	IEA	biological_process
Pka-R1	GO:0005952_3650_2	cAMP-dependent protein kinase complex	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]	IEA	cellular_component
Pka-R1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pka-R1	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
Pka-R2	GO:0001932_6281_2	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	IEA	biological_process
Pka-R2	GO:0005952_3650_2	cAMP-dependent protein kinase complex	"An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732]	IEA	cellular_component
Pka-R2	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pka-R2	GO:0008603_13174_6	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	IEA	molecular_function
Pkcdelta	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pkcdelta	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pkcdelta	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pkcdelta	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pkcdelta	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pkcdelta	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pkcdelta	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Pkc	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pkc	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pkc	GO:0004697_13174_1	protein kinase C activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]	IEA	molecular_function
Pkc	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pkc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pkc	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pkc	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pkc	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Pkc	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pkc	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
PKD	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
PKD	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
PKD	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
PKD	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PKD	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PKD	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
PKD	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
PKD	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Pkn	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Pkn	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Pkn	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Pkn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pkn	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pkn	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Pkn	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Pkn	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Pkn	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
PLA2-1	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
PLA2-1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
PLA2-1	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
PLA2-1	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
PLA2-2.2	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
PLA2-2.2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
PLA2-2.2	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
PLA2-2.2	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
PLA2-2.4	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
PLA2-2.4	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
PLA2-2.4	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
PLA2-2.4	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
PLA2-2.4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PLA2-2.4	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
Pla2	GO:0004623_13174_8	phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]	IEA	molecular_function
Pla2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Pla2	GO:0006644_6281_7	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	IEA	biological_process
Pla2	GO:0016042_6281_9	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	IEA	biological_process
Plap	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Plap	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Plc	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
Plc	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
Plc	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Plc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Plc	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
Plc	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Plc	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
Plc	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Pld	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Pld	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pld	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
Pld	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Pld	GO:0035091_13174_22	phosphatidylinositol binding	"Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	IEA	molecular_function
plexA	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
plexA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
plexA	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
plexA	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
plexA	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
plexA	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
plexB	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
plexB	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
plexB	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
plexB	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
plexB	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
plexB	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Plip	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
Plip	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
Plip	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
Plip	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
Plip	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
PMCA	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
PMCA	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
PMCA	GO:0005388_13174_3	calcium-transporting ATPase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]	IEA	molecular_function
PMCA	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PMCA	GO:0006754_6281_7	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
PMCA	GO:0006812_6281_32	cation transport	"The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
PMCA	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
PMCA	GO:0015662_13174_15	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	IEA	molecular_function
PMCA	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
PMCA	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
PMCA	GO:0070588_6281_3	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	IEA	biological_process
PNGase	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PNGase	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
PNGase	GO:0006516_6281_1	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
pnr	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
pnr	GO:0003896_13174_4	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094]	IEA	molecular_function
pnr	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
pnr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
pnr	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
pnr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
PNR-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
PNR-like	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
PNR-like	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
PNR-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
PNR-like	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PNR-like	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
PNR-like	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
pnt	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
pnt	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
pnt	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
pnt	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
pnut	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
pnut	GO:0007049_6281_8	cell cycle	"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]	IEA	biological_process
PNUTS	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
PNUTS	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
PNUTS	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
PNUTS	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Pof	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Pole3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Pole3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Pole3	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
polo	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
polo	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
polo	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
polo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
polo	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
polo	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
polo	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
polybromo	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
polybromo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
polybromo	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
polybromo	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
pontin	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
pontin	GO:0003678_13174_3	DNA helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]	IEA	molecular_function
pontin	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
pontin	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
porin	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
porin	GO:0006820_6281_6	anion transport	"The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
porin	GO:0008308_13174_4	voltage-gated anion channel activity	"Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
porin	GO:0044070_6281_4	regulation of anion transport	"Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
porin	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
POSH	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
POSH	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Poxn	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Poxn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Poxn	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
PpD3	GO:0004721_13174_4	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]	IEA	molecular_function
PpD3	GO:0004722_13174_8	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	IEA	molecular_function
PpD3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PpD3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
PpD3	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
PpD3	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
PpD3	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
PpD3	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Ppib	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
Ppib	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
PPO	GO:0005344_13174_7	oxygen transporter activity	"Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
PPO	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
PPO	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
PPO	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Ppox	GO:0004729_13174_1	oxygen-dependent protoporphyrinogen oxidase activity	"Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25579]	IEA	molecular_function
Ppox	GO:0006779_6281_3	porphyrin-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Ppox	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Ppox	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ppt1	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Ppt1	GO:0008474_13174_2	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	IEA	molecular_function
Ppt2	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Ppt2	GO:0008474_13174_2	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	IEA	molecular_function
PpV	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
PPWD1	GO:0003755_13174_17	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	IEA	molecular_function
PPWD1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PPWD1	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
PrBP	GO:0004114_13174_10	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]	IEA	molecular_function
PrBP	GO:0007601_6281_5	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	IEA	biological_process
Prd	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Prd	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Prd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Prd	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Prd	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Prd	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
PRF	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
PRF	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
PRF	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
Prl-1	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
Prl-1	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
Prl-1	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
Prl-1	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
PRM1	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
PRM1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Pros25	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Pros25	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Pros25	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
Pros25	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Pros25	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
Pros25	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Pros26.4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Pros26.4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Pros26.4	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Pros26.4	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Pros26.4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Pros26.4	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
Pros26	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Pros26	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
Pros26	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Pros29	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Pros29	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
Pros29	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Pros54	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Prosalpha5	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Prosalpha5	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Prosalpha5	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
Prosalpha5	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Prosalpha5	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
Prosalpha5	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Prosalpha7	GO:0004175_13174_11	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Prosalpha7	GO:0004298_13174_13	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
Prosalpha7	GO:0005839_3650_13	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	IEA	cellular_component
Prosalpha7	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Prosalpha7	GO:0019773_3650_6	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	IEA	cellular_component
Prosalpha7	GO:0051603_6281_13	proteolysis involved in cellular protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Pros	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Pros	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pros	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Pros	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Pros	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Pros	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Pros	GO:0031424_6281_13	keratinization	"The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]	IEA	biological_process
PRP17	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Prp19	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
Prp19	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
Prp19	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Prp19	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
Prpf3	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
PRPF4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PRPF4	GO:0008380_6281_2	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	IEA	biological_process
pr-set7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
pr-set7	GO:0018024_13174_10	histone-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]	IEA	molecular_function
Prx5	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
Prx5	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Prx5	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Psa	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Psa	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
PsGEF	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
PsGEF	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PsGEF	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
PsGEF	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
psidin	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
psidin	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
psidin	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
psidin	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
psidin	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Psmd2	GO:0000502_3650_2	proteasome complex	"A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb]	IEA	cellular_component
Psmd2	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Psmd2	GO:0030234_13174_2	enzyme regulator activity	"Modulates the activity of an enzyme." [GOC:mah]	IEA	molecular_function
Psmd2	GO:0042176_6281_2	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	IEA	biological_process
Psn	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
Psn	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Psq	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Psq	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PSR	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ptc	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
ptc	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
ptc	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Pten	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
Pten	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pten	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
Pten	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
Pten	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
Pten	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
PTK2	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
PTK2	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
PTK2	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
PTK2	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
PTK2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
PTK2	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
PTK2	GO:0005925_3650_2	focal adhesion	"Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]	IEA	cellular_component
PTK2	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
PTK2	GO:0007172_6281_1	signal complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]	IEA	biological_process
PTK2	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Ptpa	GO:0019211_13174_2	phosphatase activator activity	"Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	IEA	molecular_function
PTP-ER	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
PTP-ER	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
PTP-ER	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
PTP-ER	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
PTPN4	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
PTPN4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
PTPN4	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
PTPN4	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
PTPN4	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
PTPN4	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
ptr	GO:0005057_13174_4	receptor signaling protein activity	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]	IEA	molecular_function
ptr	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Ptr	GO:0008158_13174_6	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	IEA	molecular_function
Ptr	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ptr	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ptx1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ptx1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Ptx1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ptx1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Ptx1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ptx1	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Ptx1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
puc	GO:0004725_13174_29	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	IEA	molecular_function
puc	GO:0006470_6281_38	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	IEA	biological_process
puc	GO:0008138_13174_15	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	IEA	molecular_function
puc	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
puc	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
pug	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
pug	GO:0004329_13174_1	formate-tetrahydrofolate ligase activity	"Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]	IEA	molecular_function
pug	GO:0004488_13174_3	methylenetetrahydrofolate dehydrogenase (NADP+) activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]	IEA	molecular_function
pug	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
pug	GO:0009396_6281_8	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	IEA	biological_process
pug	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Pu	GO:0003934_13174_1	GTP cyclohydrolase I activity	"Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]	IEA	molecular_function
Pu	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Pu	GO:0046654_6281_1	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	IEA	biological_process
pum	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
pum	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
put	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
put	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
put	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
put	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
put	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
put	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Pvf1	GO:0008083_13174_17	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	IEA	molecular_function
Pvf1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Pvr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
pwn	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
pwn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pxd	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
Pxd	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Pxd	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Pxd	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Pxn	GO:0004601_13174_12	peroxidase activity	"Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7]	IEA	molecular_function
Pxn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pxn	GO:0006979_6281_14	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	IEA	biological_process
Pxn	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Pxn	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
pyd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pygo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pygo	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Pyx2	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Pyx2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Pyx2	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Pyx2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Pyx2	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
qtc	GO:0000042_6281_4	protein targeting to Golgi	"The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]	IEA	biological_process
qtc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
qua	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
qua	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
qua	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
Rab10	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab10	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Rab10	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab10	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab10	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab10	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Rab10	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab10	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab10	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab10	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab10	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
Rab10	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab10	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab11	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab11	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Rab11	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab11	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab11	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Rab11	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab11	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab11	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab11	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab11	GO:0008134_13174_12	transcription factor binding	"Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732]	IEA	molecular_function
Rab11	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab11	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab14	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab14	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab14	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab14	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab14	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab14	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab14	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab14	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab14	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab14	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab21	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab21	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab21	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab21	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab21	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab21	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab21	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab21	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab21	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab21	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab23	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab23	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab23	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab23	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab23	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab23	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab23	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab23	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab23	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab23	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab26	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab26	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab26	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab26	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab26	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab26	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab26	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab26	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab26	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab26	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab39	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab39	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab39	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab39	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab39	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab39	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab39	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab39	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab39	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab39	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab3	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab3	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab3	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab3	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab3	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab3	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab3	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab3	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab5	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab5	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab5	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab5	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab5	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab5	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab5	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab5	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab6	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab6	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab6	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab6	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab6	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab6	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab6	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab6	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab6	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RabGAP10	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP10	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP10	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP11	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP11	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP12	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP12	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
RabGAP12	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP12	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP2	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RabGAP2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP2	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP3	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP3	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP4	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP4	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP5	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP5	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP6	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RabGAP6	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP6	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP7	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP7	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP7	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP8	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP8	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP8	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
RabGAP9	GO:0005097_13174_23	Rab GTPase activator activity	"Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]	IEA	molecular_function
RabGAP9	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabGAP9	GO:0032313_6281_23	regulation of Rab GTPase activity	"Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]	IEA	biological_process
Rab-RP3	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab-RP3	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab-RP3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab-RP3	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab-RP3	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab-RP3	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab-RP3	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab-RP3	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab-RP3	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab-RP3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rab-RP4	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rab-RP4	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rab-RP4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rab-RP4	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rab-RP4	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rab-RP4	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rab-RP4	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rab-RP4	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rab-RP4	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rab-RP4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RabX4	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
RabX4	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RabX4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabX4	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
RabX4	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
RabX4	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
RabX4	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
RabX4	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RabX4	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RabX4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RabX5	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
RabX5	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RabX5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabX5	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
RabX5	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
RabX5	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
RabX5	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
RabX5	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RabX5	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RabX5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RabX6	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
RabX6	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RabX6	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RabX6	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
RabX6	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
RabX6	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
RabX6	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
RabX6	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RabX6	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RabX6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rac	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rac	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rac	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rac	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rac	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rac	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rac	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rac	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rac	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rac	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rack1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rad1	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Rad1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Rad1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Rad1	GO:0008853_13174_1	exodeoxyribonuclease III activity	"Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2]	IEA	molecular_function
rad50	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
rad50	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Rad51	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Rad51	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rad51	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Rad51	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Rad51	GO:0006259_6281_7	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	IEA	biological_process
Rad51	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Rad51	GO:0008094_13174_2	DNA-dependent ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Rad51	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Rad54	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Rad54	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rad54	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Rad54	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
rad	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Raf1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Raf1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Raf1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Raf1	GO:0005057_13174_4	receptor signaling protein activity	"Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]	IEA	molecular_function
Raf1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Raf1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Raf1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Raf1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Raf1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
RagA	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RagA	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
RagA	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
RagA	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RagA	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rala	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rala	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rala	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rala	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rala	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rala	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rala	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rala	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rala	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rala	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ranbp11	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ranbp11	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Ranbp11	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Ranbp16	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ranbp16	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Ranbp16	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Ranbp21	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ranbp21	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Ranbp21	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
RANBP2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RANBP2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RANBP2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
RANBP2	GO:0046907_6281_7	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	IEA	biological_process
ran	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
ran	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
ran	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ran	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
ran	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
ran	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
ran	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
ran	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
ran	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
ran	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rap2l	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rap2l	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rap2l	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rap2l	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rap2l	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rap2l	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rap2l	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rap2l	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rap2l	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rap2l	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rapgap1	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
Rapgap1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rapgap1	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
raps	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
raps	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
raps	GO:0030695_13174_3	GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]	IEA	molecular_function
Rasa3	GO:0005096_13174_14	GTPase activator activity	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	IEA	molecular_function
Rasa3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rasa3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rasa3	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rasa3	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Rasa3	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
ras	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
ras	GO:0003938_13174_1	IMP dehydrogenase activity	"Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]	IEA	molecular_function
ras	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ras	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
ras	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Rassf	GO:0003913_13174_3	DNA photolyase activity	"Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]	IEA	molecular_function
Rassf	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Rassf	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rassf	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Rbcn-3A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rbcn-3B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rbf	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Rbf	GO:0051726_6281_9	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Rbsn-5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rbsn-5	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Rbsn-5	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
rdgA	GO:0004143_13174_8	diacylglycerol kinase activity	"Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]	IEA	molecular_function
rdgA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
rdgA	GO:0007205_6281_8	protein kinase C-activating G-protein coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	IEA	biological_process
rdgA	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
rdgBbeta	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
rdgBbeta	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
rdgB	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
rdgB	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
rdgB	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Rdl	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rdl	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
rec	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
rec	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
rec	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
rec	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
rec	GO:0015979_6281_4	photosynthesis	"The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]	IEA	biological_process
rec	GO:0015995_6281_4	chlorophyll biosynthetic process	"The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]	IEA	biological_process
rec	GO:0016851_13174_4	magnesium chelatase activity	"Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]	IEA	molecular_function
rec	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
rec	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Reck	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Reck	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
RecQ4	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RecQ4	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
RecQ4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
RecQ4	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
RecQ4	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
RecQ4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
RecQ5	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RecQ5	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
RecQ5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
RecQ5	GO:0006310_6281_20	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	IEA	biological_process
RecQ5	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
ref(2)P	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ref(2)P	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
rempA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
repo	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
repo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
repo	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
repo	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
repo	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Reps	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Reps	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Reptin	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Reptin	GO:0003678_13174_3	DNA helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]	IEA	molecular_function
Reptin	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Reptin	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Rev1	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
Rev1	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Rev1	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
Rev1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rev1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Rev1	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
Rfabg	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Rfabg	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Rfabg	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Rfabg	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Rfabg	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
Rfabg	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
RfC38	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
RfC38	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RfC38	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
RfC38	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
RfC4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
RfC4	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RfC4	GO:0003689_13174_6	DNA clamp loader activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]	IEA	molecular_function
RfC4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
RfC4	GO:0005663_3650_6	DNA replication factor C complex	"A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]	IEA	cellular_component
RfC4	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
RfC4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
RFeSP	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
RFeSP	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
RFeSP	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
RFeSP	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Rfwd3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rfwd3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Rga	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Rga	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Rgk1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rgk1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rgk1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rgk1	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rgk1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rgk1	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rgk1	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rgk1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rgl	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
Rgl	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rgl	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rgl	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rgl	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
R	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
R	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
R	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
R	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
R	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
R	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
R	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
R	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
R	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
R	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rheb	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rheb	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rheb	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rheb	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rheb	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rheb	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rheb	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rheb	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Rho1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Rho1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Rho1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rho1	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Rho1	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rho1	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Rho1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Rho1	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Rho1	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Rho1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
rho-5	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
rho-5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
rho-6	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
rho-6	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
rho-7	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
rho-7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
RhoBTB	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
RhoBTB	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RhoBTB	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RhoBTB	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RhoBTB	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
RhoBTB	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
RhoBTB	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RhoBTB	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RhoBTB	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RhoGAPp190	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
RhoGAPp190	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
RhoGAPp190	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RhoGAPp190	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
RhoGAPp190	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
RhoGAPp190	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
RhoGAPp190	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RhoGAPp190	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RhoGDI	GO:0005094_13174_1	Rho GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]	IEA	molecular_function
RhoGDI	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
RhoGEF2	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
RhoGEF2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RhoGEF2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RhoGEF2	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
RhoGEF2	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
RhoGEF2	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
RhoGEF2	GO:0038032_6281_14	termination of G-protein coupled receptor signaling pathway	"The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]	IEA	biological_process
RhoGEF4	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
RhoGEF4	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
RhoGEF4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RhoGEF4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RhoGEF4	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
RhoGEF4	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
ric8a	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Ric	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
Ric	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
Ric	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Ric	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
Ric	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Ric	GO:0006913_6281_43	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	IEA	biological_process
Ric	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Ric	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Ric	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Ric	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
rin	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
rin	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
rin	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Rip11	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RIP1	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
Ripk5	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Ripk5	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Ripk5	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Ripk5	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ripk5	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Ripk5	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
rl	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
rl	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
rl	GO:0004707_13174_6	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	IEA	molecular_function
rl	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
rl	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
rl	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
rl	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Rme-8	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Rme-8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rme-8	GO:0031072_13174_29	heat shock protein binding	"Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]	IEA	molecular_function
RNaseX25	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RNaseX25	GO:0033897_13174_1	ribonuclease T2 activity	"Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1]	IEA	molecular_function
Rnf19	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rnf19	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Rnft2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rnft2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
rnh1	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
rnh1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
rnh1	GO:0004523_13174_5	ribonuclease H activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	IEA	molecular_function
rno	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
rno	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
rno	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Rnp4F	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Rnp4F	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rnp4F	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
RnpS1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RnrL	GO:0004748_13174_2	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	"Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]	IEA	molecular_function
RnrL	GO:0005971_3650_1	ribonucleoside-diphosphate reductase complex	"An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1]	IEA	cellular_component
RnrL	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
RnrL	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
RnrS	GO:0004748_13174_2	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	"Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]	IEA	molecular_function
RnrS	GO:0009186_6281_1	deoxyribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
RnrS	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
RnrS	GO:0046914_13174_11	transition metal ion binding	"Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	IEA	molecular_function
RnrS	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
robo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Roc1a	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Roc1a	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Roc2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Roc2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Roe1	GO:0000774_13174_1	adenyl-nucleotide exchange factor activity	"Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]	IEA	molecular_function
Roe1	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Roe1	GO:0042803_13174_1	protein homodimerization activity	"Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]	IEA	molecular_function
Roe1	GO:0051087_13174_4	chaperone binding	"Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]	IEA	molecular_function
rok	GO:0000910_6281_1	cytokinesis	"A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai]	IEA	biological_process
rok	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
rok	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
rok	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
rok	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
rok	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
rok	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
rok	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
rok	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Rop	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
Rop	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
roq	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
roq	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
roq	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ror	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Ror	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Ror	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Ror	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
Ror	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ror	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Ror	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Ror	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
Ror	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ror	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Rox8	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RPA2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RpA-70	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RpA-70	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpA-70	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
RpA-70	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
Rpb10	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rpb10	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
Rpb10	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
Rpb11	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rpb11	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
Rpb11	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
Rpb11	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Rpb8	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RPC5	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RPC5	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
RPC5	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
Rph	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Rph	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Rph	GO:0017137_13174_2	Rab GTPase binding	"Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]	IEA	molecular_function
RpI135	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpI135	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpI135	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
RpI135	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RpI1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpI1	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpI1	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
Rpia	GO:0004751_13174_1	ribose-5-phosphate isomerase activity	"Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660]	IEA	molecular_function
Rpia	GO:0009052_6281_1	pentose-phosphate shunt, non-oxidative branch	"The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]	IEA	biological_process
RpII140	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpII140	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpII140	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RpII15	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RpII15	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpII15	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpII15	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RpII15	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
RpII215	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpII215	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpII215	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RpIII128	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
RpIII128	GO:0003899_13174_31	DNA-directed RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]	IEA	molecular_function
RpIII128	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
RpL10Ab	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpL10Ab	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL10Ab	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL10Ab	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
RpL10	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL10	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL10	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL10	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL11	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL11	GO:0004984_13174_190	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	IEA	molecular_function
RpL11	GO:0005549_13174_211	odorant binding	"Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	IEA	molecular_function
RpL11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL11	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL11	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
RpL11	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL11	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
RpL11	GO:0007608_6281_190	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]	IEA	biological_process
RpL11	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RpL11	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
RpL12	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL12	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL12	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL13A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL13A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL13A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL13A	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
RpL13	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL13	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL13	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL13	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL14	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL14	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL14	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL14	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL15	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL15	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL15	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL15	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL17	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL17	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL17	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL17	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL17	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
RpL18A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL18A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL18A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL18	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL18	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL18	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL18	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL19	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL19	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL19	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL19	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL21	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL21	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL21	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL21	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL22	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL22	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL22	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL22	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL23A	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpL23A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL23A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL23A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL23A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL23	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL23	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL23	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL26	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL26	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL26	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL26	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL26	GO:0015934_3650_6	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	IEA	cellular_component
RpL27	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL27	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL27	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL27	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL28	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL28	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL28	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL28	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL29	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL29	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL29	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL29	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL31	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL31	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL31	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL31	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL32	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL32	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL32	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL32	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL34	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL34	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL34	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL34	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL35A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL35A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL35A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL35A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL36A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL36A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL36A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL36A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL36	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL36	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL36	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL36	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL37A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL37A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL37A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL37A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL37	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL37	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL37	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL37	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL38	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL38	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL38	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL38	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Rpl39	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
Rpl39	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rpl39	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
Rpl39	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL3	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL3	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL3	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL40	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL40	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RpL40	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL40	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL4	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL4	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL4	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL5	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL5	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL5	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL5	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL6	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL6	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL6	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL6	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL7A	GO:0030529_3650_4	ribonucleoprotein complex	"A macromolecular complex containing both protein and RNA molecules." [GOC:krc]	IEA	cellular_component
RpL7A	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
RpL7	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL7	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL7	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL7	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL8	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL8	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL8	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL8	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL9	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpL9	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpL9	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpL9	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpL9	GO:0019843_13174_4	rRNA binding	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]	IEA	molecular_function
RpLP0	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpLP0	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpLP0	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpLP0	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
RpLP0	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
RpLP1	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpLP1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpLP1	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpLP1	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
RpLP2	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpLP2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpLP2	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpLP2	GO:0006414_6281_12	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	IEA	biological_process
Rpn11	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rpn1	GO:0004579_13174_3	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	"Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]	IEA	molecular_function
Rpn1	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
Rpn1	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
Rpn1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Rpn3	GO:0000502_3650_2	proteasome complex	"A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb]	IEA	cellular_component
Rpn3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rpn3	GO:0030234_13174_2	enzyme regulator activity	"Modulates the activity of an enzyme." [GOC:mah]	IEA	molecular_function
Rpn3	GO:0042176_6281_2	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	IEA	biological_process
Rpn5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rpn9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RpS11	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS11	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS11	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS12	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS12	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS12	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS12	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS13	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS13	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS13	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS13	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Rps14	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
Rps14	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rps14	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
Rps14	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS15	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS15	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS15	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS15	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS15	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS16	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS16	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS16	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS16	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS17	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS17	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS17	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS17	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS18	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
RpS18	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS18	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS18	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS18	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS18	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS19a	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS19a	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS19a	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS19a	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS20	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS20	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS20	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS20	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS20	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS26	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS26	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS26	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS26	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS27A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS27A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RpS27A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS27A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS27A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS27	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS27	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS27	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS27	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS2	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS2	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS2	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS2	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS2	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS2	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS30	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS30	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RpS30	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS30	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS30	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS3A	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS3A	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS3A	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS3A	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS3	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS3	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS3	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS3	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS3	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS5a	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS5a	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS5a	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS5a	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS7	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS7	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS7	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpS7	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
Rps8	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
Rps8	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rps8	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
Rps8	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS9	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
RpS9	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpS9	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpS9	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpS9	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
RpS9	GO:0019843_13174_4	rRNA binding	"Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]	IEA	molecular_function
RpSA	GO:0003735_13174_121	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	IEA	molecular_function
RpSA	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RpSA	GO:0005840_3650_115	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	IEA	cellular_component
RpSA	GO:0006412_6281_122	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	IEA	biological_process
RpSA	GO:0015935_3650_10	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	IEA	cellular_component
Rpt1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Rpt1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Rpt1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Rpt1	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Rpt1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Rpt1	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
RPTOR	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
RPTOR	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rrp1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rrp1	GO:0004518_13174_9	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	IEA	molecular_function
Rrp1	GO:0004519_13174_5	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Rrp1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Rrp1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Rsf1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Rtc1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Rtc1	GO:0005730_3650_2	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	IEA	cellular_component
Rtc1	GO:0042254_6281_10	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]	IEA	biological_process
rtet	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
rtet	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Rtf1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rtf1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Rtf1	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
Rtf1	GO:0016570_6281_1	histone modification	"The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	IEA	biological_process
rtGEF	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
rtGEF	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
rtGEF	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
rtGEF	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
rump	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Rx	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Rx	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Rx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Rx	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Rx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Rx	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Rx	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
RYBP	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
RYBP	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
RyR	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
RyR	GO:0005219_13174_1	ryanodine-sensitive calcium-release channel activity	"Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]	IEA	molecular_function
RyR	GO:0005262_13174_2	calcium channel activity	"Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	IEA	molecular_function
RyR	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
RyR	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
RyR	GO:0006874_6281_1	cellular calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]	IEA	biological_process
RyR	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
RyR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
RyR	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
RyR	GO:0070588_6281_3	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	IEA	biological_process
S6kII	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
S6kII	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
S6kII	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
S6kII	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
S6kII	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
S6kII	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
S6kII	GO:0007243_6281_1	intracellular protein kinase cascade	"A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components." [GOC:bf, GOC:jl, GOC:signaling]	IEA	biological_process
S6kII	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Sac1	GO:0042578_13174_5	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	IEA	molecular_function
SAK	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
SAK	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
SAK	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
SAK	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
SAK	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
SAK	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Sans	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sap-r	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
Sara	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
sax	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
sax	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
sax	GO:0004675_13174_5	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	IEA	molecular_function
sax	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
sax	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
sax	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
sax	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
sax	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Sbf	GO:0004190_13174_12	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	IEA	molecular_function
Sbf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sbf	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Sbf	GO:0016311_6281_35	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	IEA	biological_process
Sbf	GO:0016791_13174_46	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators]	IEA	molecular_function
Sbf	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
sca	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
sca	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
sca	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Scamp	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Scamp	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
scat	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
scat	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
scat	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
scat	GO:0042147_6281_1	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	IEA	biological_process
Sce	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sce	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
scf	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Scgalpha	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Scgalpha	GO:0016012_3650_4	sarcoglycan complex	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]	IEA	cellular_component
Scgalpha	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Scgdelta	GO:0007010_6281_12	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Scgdelta	GO:0016012_3650_4	sarcoglycan complex	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]	IEA	cellular_component
Scgdelta	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Scm	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Scm	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Scm	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Scm	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Scm	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Scp1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Scp2	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
scra	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SCR-B10	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B10	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B1	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B2	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B2	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B4	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B4	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B5	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B5	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B6	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B7	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B8	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B8	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-B9	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
SCR-B9	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-C	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
SCR-C	GO:0006955_6281_5	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]	IEA	biological_process
SCR-C	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
SCR-C	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SCR-C	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
SCR-C	GO:0030247_13174_2	polysaccharide binding	"Interacting selectively and non-covalently with any polysaccharide, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [GOC:mah]	IEA	molecular_function
Scr	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Scr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Scr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Scr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Scr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Scsalpha	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Scsalpha	GO:0003878_13174_2	ATP citrate synthase activity	"Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163]	IEA	molecular_function
Scsalpha	GO:0004775_13174_2	succinate-CoA ligase (ADP-forming) activity	"Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]	IEA	molecular_function
Scsalpha	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Scsalpha	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Sdc	GO:0008092_13174_4	cytoskeletal protein binding	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	IEA	molecular_function
Sdc	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
sd	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
sd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sd	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
sd	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
SdhA	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
SdhA	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
SdhA	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
SdhA	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
SdhA	GO:0022900_6281_4	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]	IEA	biological_process
SdhA	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
SdhA	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
SdhC	GO:0000104_13174_1	succinate dehydrogenase activity	"Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd]	IEA	molecular_function
SdhC	GO:0006099_6281_16	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	IEA	biological_process
SdhC	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
SdhC	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SdhC	GO:0016627_13174_18	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	IEA	molecular_function
SdhC	GO:0045282_3650_1	plasma membrane succinate dehydrogenase complex	"A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]	IEA	cellular_component
sec15	GO:0000145_3650_2	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]	IEA	cellular_component
sec15	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
sec31	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sec61alpha	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Sec61alpha	GO:0015450_13174_5	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Sec61alpha	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
sec6	GO:0004784_13174_5	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1]	IEA	molecular_function
sec6	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
sec6	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
sec6	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
sec71	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
sec71	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
sec71	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
sec71	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
SelD	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SelD	GO:0004756_13174_1	selenide, water dikinase activity	"Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18740]	IEA	molecular_function
SelD	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Sema-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sema-1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Sema-2a	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sema-5c	GO:0004872_13174_13	receptor activity	"Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Sema-5c	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sema-5c	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Sema-5c	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ser	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Ser	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ser	GO:0007154_6281_27	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	IEA	biological_process
Ser	GO:0007219_6281_4	Notch signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	IEA	biological_process
Ser	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Ser	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Ser	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ser	GO:0030154_6281_4	cell differentiation	"The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	IEA	biological_process
Ser	GO:0030414_13174_13	peptidase inhibitor activity	"Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	IEA	molecular_function
serp	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
serp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
serp	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
serp	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
serp	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
serp	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
serp	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
serpin-3	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
serpin-3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
serpin-3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
serpin-3	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
serpin-3	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
serpin-3	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
serpin-3	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
serpin-3	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
sev	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
sev	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
sev	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
sev	GO:0004714_13174_8	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	IEA	molecular_function
sev	GO:0004896_13174_2	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	IEA	molecular_function
sev	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sev	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
sev	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
sev	GO:0007169_6281_9	transmembrane receptor protein tyrosine kinase signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	IEA	biological_process
sev	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
sev	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
SF3A1	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
SF3A1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SF3A1	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
SF3A3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
SF3A3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
SF3A3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
SF3A3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SF3B3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
SF3B3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SF3B3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Sfmbt	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sfmbt	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Sfmbt	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Sfmbt	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Sfrs7	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Sfrs7	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
sGCbeta-3	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
sGCbeta-3	GO:0004383_13174_4	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	IEA	molecular_function
sGCbeta-3	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
sGCbeta-3	GO:0006182_6281_4	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	IEA	biological_process
sGCbeta-3	GO:0006306_6281_11	DNA methylation	"The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	IEA	biological_process
sGCbeta-3	GO:0009190_6281_20	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
sGCbeta-3	GO:0016849_13174_20	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	IEA	molecular_function
sGCbeta-3	GO:0020037_13174_97	heme binding	"Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai]	IEA	molecular_function
sGCbeta-3	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
sgg	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
sgg	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
sgg	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
sgg	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
sgg	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
sgg	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Sgt1	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Sgt	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Shal	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Shal	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Shal	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Shal	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Shal	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Shal	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
Shal	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Shal	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Shaw	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Shaw	GO:0005249_13174_12	voltage-gated potassium channel activity	"Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Shaw	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Shaw	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Shaw	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Shaw	GO:0008076_3650_11	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	IEA	cellular_component
Shaw	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Shaw	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
shi	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
shi	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
shi	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
shn	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
shn	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
shot	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
shot	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
shot	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
shot	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
shot	GO:0007050_6281_6	cell cycle arrest	"A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]	IEA	biological_process
shot	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
shot	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
shrb	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Shroom	GO:0000902_6281_1	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	IEA	biological_process
Shroom	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
shroud	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
shroud	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
shu	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SIFR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
SIFR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
sim	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
sim	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sim	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
sim	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Sin3A	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Sin3A	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
sina	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sina	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
sina	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
sina	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
sina	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sir2	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sir2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sir2	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Sirt2	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sirt2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sirt2	GO:0016811_13174_2	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	IEA	molecular_function
Sirt2	GO:0051287_13174_22	NAD binding	"Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	IEA	molecular_function
Sirt2	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Sirt4	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sirt4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sirt4	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Sirt5	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sirt5	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sirt5	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Sirt6	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sirt6	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sirt6	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Sirt7	GO:0006476_6281_6	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	IEA	biological_process
Sirt7	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sirt7	GO:0070403_13174_6	NAD+ binding	"Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	IEA	molecular_function
Six4	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Six4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Six4	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Six4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Six4	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
siz	GO:0005086_13174_7	ARF guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
siz	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
siz	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
siz	GO:0032012_6281_7	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	IEA	biological_process
skf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SK	GO:0005516_13174_4	calmodulin binding	"Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	IEA	molecular_function
SK	GO:0006813_6281_22	potassium ion transport	"The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
SK	GO:0015269_13174_4	calcium-activated potassium channel activity	"Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	IEA	molecular_function
SK	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
SKIP	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
skp1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
skp1	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Skp2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
slbo	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
slbo	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
slbo	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
slbo	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
slbo	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Slc35b1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Slc5a12	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Slc5a12	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Slc5a12	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Slc5a12	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
sl	GO:0004435_13174_8	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]	IEA	molecular_function
sl	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
sl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sl	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
sl	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
sl	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
sl	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
sli	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
sli	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Slip1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sll	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
slmb	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
slou	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
slou	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
slou	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
slou	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
slou	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
slp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
slp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
slp	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Slu7	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Slu7	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SMAD3	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
SMAD3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SMAD3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
SMAD3	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
SMAD3	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
SMAD3	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
Smad4	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Smad4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Smad4	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Smad4	GO:0005667_3650_10	transcription factor complex	"A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]	IEA	cellular_component
Smad4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Smad4	GO:0007179_6281_7	transforming growth factor beta receptor signaling pathway	"A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	IEA	biological_process
SMC1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SMC1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
SMC1	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
SMC1	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
SMC1	GO:0051276_6281_4	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
SMC2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SMC2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
SMC2	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
SMC2	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
SMC2	GO:0051276_6281_4	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
SMC4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
SMC4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SMC4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
SMC4	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
SMC4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
SMC4	GO:0051276_6281_4	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
smid	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
smid	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
smid	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
smid	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
smo	GO:0004888_13174_16	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	IEA	molecular_function
smo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
smo	GO:0007166_6281_18	cell surface receptor signaling pathway	"A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]	IEA	biological_process
smo	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SMSr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SMSr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
SMSr	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
smt3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Smyd5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Smyd5	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Snail	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Snail	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Snail	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Snail	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Snap	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Snap	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
SNF1A	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
SNF1A	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
SNF1A	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
SNF1A	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
SNF1A	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
SNF1A	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Snf	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
sn	GO:0030674_13174_1	protein binding, bridging	"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah]	IEA	molecular_function
sn	GO:0051015_13174_2	actin filament binding	"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	IEA	molecular_function
sni	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
sni	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Snoo	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Snoo	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Snoo	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Snr1	GO:0000228_3650_2	nuclear chromosome	"A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah]	IEA	cellular_component
Snr1	GO:0006338_6281_2	chromatin remodeling	"Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820]	IEA	biological_process
Snr1	GO:0016585_3650_2	chromatin remodeling complex	"Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]	IEA	cellular_component
snRNP70K	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Snrpc	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Snrpc	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Snrpc	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Socs-5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Socs-5	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Socs7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Socs7	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Sod1	GO:0004784_13174_5	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1]	IEA	molecular_function
Sod1	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
Sod1	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Sod1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Sod2	GO:0004784_13174_5	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1]	IEA	molecular_function
Sod2	GO:0006801_6281_6	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl]	IEA	biological_process
Sod2	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
Sod2	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
sog	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sog	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
sol	GO:0004197_13174_24	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
sol	GO:0004198_13174_4	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	IEA	molecular_function
sol	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
sol	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
sol	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sop2	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
Sop2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sop2	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
Sop2	GO:0030833_6281_4	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	IEA	biological_process
SORL1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
SORL1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SORL1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Sos	GO:0000786_3650_27	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	IEA	cellular_component
Sos	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Sos	GO:0005085_13174_20	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]	IEA	molecular_function
Sos	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
Sos	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sos	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Sos	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Sos	GO:0006334_6281_27	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	IEA	biological_process
Sos	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Sos	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
Sos	GO:0051056_6281_19	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	IEA	biological_process
Sox14	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Sox14	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sox15	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Sox15	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP10	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP10	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP10	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP11	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP11	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP11	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP13	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP13	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP13	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP14	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP14	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP14	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP15	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP15	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP15	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP16	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP16	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP16	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP17	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP17	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP17	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP18	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP18	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP18	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP1	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP20	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP20	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP20	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP20	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP21	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP21	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP21	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP22	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP22	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP22	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP23	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP23	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP23	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
SP23	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
SP23	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP23	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
SP23	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
SP23	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP23	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
SP23	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SP24	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP24	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP24	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP25	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP25	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP25	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP26	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP26	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP26	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP27	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP27	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP27	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP28	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP28	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP28	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP29	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP29	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP29	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP2	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP2	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP30	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
SP30	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP30	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP30	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
SP30	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP30	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP30	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SP30	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SP31	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP31	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP31	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP32	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP32	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP32	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP33	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP33	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP33	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP34	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP34	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP34	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP35	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP35	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP35	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP36	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP36	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP36	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP38	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP38	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP38	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP3	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP3	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP3	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP40	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP40	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP40	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP40	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
SP40	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP40	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
SP40	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
SP40	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SP44	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP44	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP44	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP45	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP45	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP45	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP45	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP46	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP46	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP46	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP47	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP47	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP47	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP48	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP48	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP48	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP49	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP49	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP49	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SP49	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP4	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
SP4	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
SP4	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP4	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
SP4	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP5	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP5	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP5	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP6	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP6	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP6	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP7	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP7	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP7	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP8	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP8	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP8	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SP9	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SP9	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SP9	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
spag	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Spase18-21	GO:0006465_6281_5	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	IEA	biological_process
Spase18-21	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
Spase18-21	GO:0008236_13174_15	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
Spase18-21	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Spase18-21	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Spase22-23	GO:0005787_3650_4	signal peptidase complex	"A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]	IEA	cellular_component
Spase22-23	GO:0006465_6281_5	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	IEA	biological_process
Spase22-23	GO:0008233_13174_18	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	IEA	molecular_function
Spase22-23	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
spas	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
spas	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
spas	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
spas	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
SPATA20	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SpdS	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Spec2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
spel1	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
spel1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
spel1	GO:0006298_6281_7	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	IEA	biological_process
spel1	GO:0030983_13174_6	mismatched DNA binding	"Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]	IEA	molecular_function
SPH19	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH19	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH19	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH37	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH37	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH37	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH41	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH41	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH41	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH42	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH42	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH42	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH50	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH50	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH50	GO:0004629_13174_12	phospholipase C activity	"Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]	IEA	molecular_function
SPH50	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH50	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
SPH50	GO:0008081_13174_25	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators]	IEA	molecular_function
SPH50	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
SPH51	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH51	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH51	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH52	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH52	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH52	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH53	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH53	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH53	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH54	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH54	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH54	GO:0005044_13174_8	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	IEA	molecular_function
SPH54	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SPH54	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH54	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
SPH55	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH55	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH55	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH56	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH56	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH56	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
SPH56	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
SPH57	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
SPH57	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
SPH57	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Sply	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Sply	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Sply	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Sply	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
spn-E	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
spn-E	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
spn-E	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
spn-E	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
spn-E	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
spn-E	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Spn	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Spred	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Spred	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Spred	GO:0009966_6281_4	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	IEA	biological_process
Spred	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
spt4	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
spt4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
spt4	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
spt4	GO:0032786_6281_1	positive regulation of DNA-dependent transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	IEA	biological_process
Spt5	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Spt5	GO:0032784_6281_3	regulation of DNA-dependent transcription, elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	IEA	biological_process
Spt5	GO:0032968_6281_1	positive regulation of transcription elongation from RNA polymerase II promoter	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	IEA	biological_process
Spt-I	GO:0009058_6281_41	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	IEA	biological_process
Spt-I	GO:0016769_13174_14	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Spt-I	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Spx	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
sqz	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
sqz	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sra-1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
sra	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
sra	GO:0019722_6281_1	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	IEA	biological_process
Srp14	GO:0005786_3650_1	signal recognition particle, endoplasmic reticulum targeting	"A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]	IEA	cellular_component
Srp14	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
Srp14	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
Srp14	GO:0030942_13174_1	endoplasmic reticulum signal peptide binding	"Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]	IEA	molecular_function
Srp14	GO:0045900_6281_2	negative regulation of translational elongation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]	IEA	biological_process
Srp14	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
Srp19	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
Srp19	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
Srp19	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
Srp54	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Srp9	GO:0006614_6281_14	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	IEA	biological_process
Srp9	GO:0008312_13174_6	7S RNA binding	"Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]	IEA	molecular_function
Srp9	GO:0045900_6281_2	negative regulation of translational elongation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]	IEA	biological_process
Srp9	GO:0048500_3650_6	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	IEA	cellular_component
SrpRbeta	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
SrpRbeta	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
SrpRbeta	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
SrpRbeta	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
Ssadh	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Ssadh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Ssadh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Ssb-c31a	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ssb-c31a	GO:0003713_13174_4	transcription coactivator activity	"Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]	IEA	molecular_function
Ssb-c31a	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ssdp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ss	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
ss	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ss	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
ss	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Ssl1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ssl1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Ssl1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Ssl1	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Ssl1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Ssl1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Ssl1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
ssp3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
ssp3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
ssp3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SsRbeta	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
SsRbeta	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ssrp	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ssrp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Ssrp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Stam	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Stam	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
StARD13	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
StARD13	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
STAT92E-like	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
STAT92E-like	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
STAT92E-like	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
STAT92E-like	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
STAT92E-like	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
STAT92E-like	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
stau	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
stau	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Stg-1	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
Stg-1	GO:0005923_3650_3	tight junction	"An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]	IEA	cellular_component
Stg-1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
st	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
st	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
st	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
st	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
st	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Stim	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Stip	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Stip	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Stk6	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Stk6	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Stk6	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Stk6	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Stk6	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Stk6	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
stmA	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
stmA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
stnB	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
stnB	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
stnB	GO:0006897_6281_3	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363]	IEA	biological_process
stnB	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
stnB	GO:0030131_3650_9	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	IEA	cellular_component
STXBP5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
STXBP5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
STXBP5	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
sty	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
sty	GO:0009966_6281_4	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	IEA	biological_process
sty	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Su(dx)	GO:0004553_13174_40	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	IEA	molecular_function
Su(dx)	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Su(dx)	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Su(dx)	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Su(dx)	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Su(dx)	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Sug	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Sug	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Su(H)	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Su(H)	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Su(H)	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Su(H)	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Su(H)	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
su(Hw)	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
su(Hw)	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
su(Hw)	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Sulf1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Sulf1	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Sulf1	GO:0008484_13174_9	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	IEA	molecular_function
Sur-8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Surf1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Surf4	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Sur	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Sur	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Sur	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Sur	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Sur	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Sur	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Sur	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Sur	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Sur	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Sur	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Sur	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Sur	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Sur	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Su(var)3-3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Su(var)3-3	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Su(var)3-3	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Su(var)3-3	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Su(var)3-3	GO:0016577_6281_1	histone demethylation	"The modification of histones by removal of methyl groups." [GOC:ai]	IEA	biological_process
Su(var)3-3	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Su(var)3-3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
su(w[a])	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
su(w[a])	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Su(z)12	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Su(z)12	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SVP	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
SVP	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
SVP	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
SVP	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
SVP	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
SVP	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
SVP	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
swi2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
swm	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
swm	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
swm	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
sws	GO:0004622_13174_1	lysophospholipase activity	"Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]	IEA	molecular_function
sws	GO:0006629_6281_44	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	IEA	biological_process
sws	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
sws	GO:0046470_6281_1	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	IEA	biological_process
sxc	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
sxc	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
sxc	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Sxl	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
syd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syn1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Synd	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Synd	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Synd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Synd	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Synd	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Synd	GO:0006418_6281_40	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	IEA	biological_process
Syn	GO:0007269_6281_1	neurotransmitter secretion	"The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph]	IEA	biological_process
Syn	GO:0008021_3650_1	synaptic vesicle	"A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]	IEA	cellular_component
synj	GO:0042578_13174_5	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	IEA	molecular_function
synj	GO:0046854_6281_14	phosphatidylinositol phosphorylation	"The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732]	IEA	biological_process
Syt12	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syt14	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syt1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syt20	GO:0003993_13174_18	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	IEA	molecular_function
Syt20	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syt4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syt7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Sytalpha	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx13	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
Syx13	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx13	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Syx13	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx13	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx16	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
Syx16	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx16	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Syx16	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx16	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx17	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx17	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx17	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx18	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx18	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx1A	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
Syx1A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx1A	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Syx1A	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx1A	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx6	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
Syx6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx6	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Syx6	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx6	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx6	GO:0048193_6281_1	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	IEA	biological_process
Syx7	GO:0005484_13174_6	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	IEA	molecular_function
Syx7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Syx7	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Syx7	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Syx7	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Syx8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
T3dh	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
T3dh	GO:0046872_13174_94	metal ion binding	"Interacting selectively and non-covalently with any metal ion." [GOC:ai]	IEA	molecular_function
T3dh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Tab	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tab	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Tab	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Taf11	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Taf11	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Taf11	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Taf11	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
Taf11	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Taf12	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Taf12	GO:0005669_3650_3	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	IEA	cellular_component
Taf12	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
Taf13	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Taf13	GO:0006366_6281_4	transcription from RNA polymerase II promoter	"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	IEA	biological_process
Taf1	GO:0004812_13174_45	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	IEA	molecular_function
Taf1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Taf1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Taf1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Taf1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Taf2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Taf2	GO:0008168_13174_58	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	IEA	molecular_function
Taf2	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
Taf2	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Taf2	GO:0032259_6281_21	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	IEA	biological_process
Taf5	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Taf5	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Taf5	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Taf6	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Taf6	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Taf6	GO:0006352_6281_14	DNA-dependent transcription, initiation	"Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161]	IEA	biological_process
Taf6	GO:0051090_6281_1	regulation of sequence-specific DNA binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	IEA	biological_process
Taf7	GO:0005669_3650_3	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	IEA	cellular_component
Taf7	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Taf7	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
Taf7	GO:0008092_13174_4	cytoskeletal protein binding	"Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	IEA	molecular_function
Taf7	GO:0019898_3650_3	extrinsic to membrane	"Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah]	IEA	cellular_component
Tak1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Tak1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Tak1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Tak1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tak1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Tak1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tal	GO:0004801_13174_1	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	"Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2]	IEA	molecular_function
Tal	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Tal	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
Tal	GO:0006098_6281_6	pentose-phosphate shunt	"The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	IEA	biological_process
tam	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
tam	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
tam	GO:0003887_13174_16	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]	IEA	molecular_function
tam	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
tam	GO:0006260_6281_41	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	IEA	biological_process
tam	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
tam	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Tango10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tango1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tango4	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tango7	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tango7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tango9	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Tango9	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
tankyrase	GO:0003950_13174_3	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	IEA	molecular_function
tankyrase	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tao-1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Tao-1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Tao-1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Tao-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tao-1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Tao-1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tap42	GO:0009966_6281_4	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	IEA	biological_process
Tapdelta	GO:0005783_3650_14	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	IEA	cellular_component
Tapdelta	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Taz	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Taz	GO:0016746_13174_25	transferase activity, transferring acyl groups	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tbh	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Tbh	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
Tbh	GO:0005507_13174_16	copper ion binding	"Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]	IEA	molecular_function
Tbh	GO:0016715_13174_3	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
Tbh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
TBL3	GO:0005230_13174_26	extracellular ligand-gated ion channel activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
TBL3	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TBL3	GO:0006364_6281_13	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	IEA	biological_process
TBL3	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
TBL3	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
TBL3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
TBL3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
TBL3	GO:0032040_3650_5	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	IEA	cellular_component
TBL3	GO:0045211_3650_20	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	IEA	cellular_component
Tbp-1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Tbp-1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tbp-1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Tbp-1	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Tbp-1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Tbp-1	GO:0030163_6281_11	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	IEA	biological_process
Tcp-1eta	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tcp-1eta	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Tcp-1eta	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
Tcp-1eta	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Tcp-1zeta	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tcp-1zeta	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Tcp-1zeta	GO:0044267_6281_10	cellular protein metabolic process	"The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]	IEA	biological_process
Tcp-1zeta	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Tdc1	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Tdc1	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Tdc1	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tdc2	GO:0006520_6281_15	cellular amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732]	IEA	biological_process
Tdc2	GO:0016829_13174_6	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]	IEA	molecular_function
Tdc2	GO:0016831_13174_13	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]	IEA	molecular_function
Tdc2	GO:0019752_6281_11	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	IEA	biological_process
Tdc2	GO:0030170_13174_43	pyridoxal phosphate binding	"Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tektin-C	GO:0000226_6281_11	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
Tektin-C	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
ten-M	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
ten-M	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TEP7	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
TEP7	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
TEP7	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
TEPA	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
TEPA	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TEPA	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
TEPA	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
TEPB	GO:0004866_13174_7	endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]	IEA	molecular_function
TEPB	GO:0005615_3650_7	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	IEA	cellular_component
TER94	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
TER94	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
TER94	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
TER94	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
TER94	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
TER94	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Tesk1	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Tesk1	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Tesk1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Tesk1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tesk1	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Tesk1	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tfb2	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Tfb2	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Tfb2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Tfb4	GO:0000439_3650_1	core TFIIH complex	"The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]	IEA	cellular_component
Tfb4	GO:0006281_6281_42	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	IEA	biological_process
Tfb4	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Tf	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TfIIA-L	GO:0005672_3650_2	transcription factor TFIIA complex	"A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]	IEA	cellular_component
TfIIA-L	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
TfIIA-S	GO:0005672_3650_2	transcription factor TFIIA complex	"A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]	IEA	cellular_component
TfIIA-S	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
TfIIB	GO:0003743_13174_20	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	IEA	molecular_function
TfIIB	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
TfIIB	GO:0006413_6281_19	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	IEA	biological_process
TfIIB	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
TfIIEalpha	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
TfIIFbeta	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
TfIIFbeta	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
TfIIFbeta	GO:0005674_3650_1	transcription factor TFIIF complex	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]	IEA	cellular_component
TfIIFbeta	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
TfIIS	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
TfIIS	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
TfIIS	GO:0003746_13174_11	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	IEA	molecular_function
TfIIS	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
TfIIS	GO:0006351_6281_48	transcription, DNA-dependent	"The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH]	IEA	biological_process
TfIIS	GO:0006354_6281_1	DNA-dependent transcription, elongation	"The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]	IEA	biological_process
TfIIS	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
TfIIS	GO:0006357_6281_13	regulation of transcription from RNA polymerase II promoter	"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
TfIIS	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
TfIIS	GO:0032784_6281_3	regulation of DNA-dependent transcription, elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	IEA	biological_process
Tg	GO:0003810_13174_3	protein-glutamine gamma-glutamyltransferase activity	"Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]	IEA	molecular_function
Tg	GO:0018149_6281_3	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	IEA	biological_process
t	GO:0042318_6281_1	penicillin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]	IEA	biological_process
tgo	GO:0004871_13174_47	signal transducer activity	"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]	IEA	molecular_function
tgo	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
tgo	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
tgo	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
tgo	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
tgo	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
tgo	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Tgt	GO:0006400_6281_7	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	IEA	biological_process
Tgt	GO:0008033_6281_20	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	IEA	biological_process
Tgt	GO:0008479_13174_4	queuine tRNA-ribosyltransferase activity	"Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]	IEA	molecular_function
Tgt	GO:0008616_6281_4	queuosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732]	IEA	biological_process
TH1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
TH1	GO:0045892_6281_5	negative regulation of transcription, DNA-dependent	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
thoc6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tie	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Tie	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Tie	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Tie	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Tie	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Tie	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tim10	GO:0006626_6281_5	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	IEA	biological_process
Tim10	GO:0042719_3650_5	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	IEA	cellular_component
Tim10	GO:0045039_6281_5	protein import into mitochondrial inner membrane	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]	IEA	biological_process
Tim8	GO:0006626_6281_5	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	IEA	biological_process
Tim8	GO:0042719_3650_5	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	IEA	cellular_component
Tim8	GO:0045039_6281_5	protein import into mitochondrial inner membrane	"The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]	IEA	biological_process
Tip60	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Tip60	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Tip60	GO:0016747_13174_12	transferase activity, transferring acyl groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
tj	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
tj	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
tj	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
tj	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
tj	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
tkv	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
tkv	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
tkv	GO:0004675_13174_5	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	IEA	molecular_function
tkv	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
tkv	GO:0005024_13174_4	transforming growth factor beta-activated receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	IEA	molecular_function
tkv	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
tkv	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
tkv	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
tkv	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
tlk	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
tlk	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
tlk	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
tlk	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
tlk	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
tlk	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tll	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Tll	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Tll	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Tll	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Tll	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Tll	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Tll	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
TM9SF3	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
TM9SF3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
TM9SF3	GO:0051715_6281_1	cytolysis in other organism	"The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai]	IEA	biological_process
tmod	GO:0005523_13174_1	tropomyosin binding	"Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194]	IEA	molecular_function
tmod	GO:0005856_3650_36	cytoskeleton	"Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]	IEA	cellular_component
TMS1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
tna	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
toc	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
toc	GO:0007021_6281_6	tubulin complex assembly	"The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]	IEA	biological_process
toc	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
tok	GO:0004222_13174_50	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	IEA	molecular_function
tok	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
tok	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
tok	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
tok	GO:0008237_13174_33	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]	IEA	molecular_function
tok	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Toll-10	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Toll-10	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Toll-10	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Toll-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Toll-1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Toll-1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Toll-6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Toll-6	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Toll-6	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Toll-8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Toll-8	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Toll-8	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Tollip	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tom34	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tom34	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tom70	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tom70	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Tom70	GO:0006396_6281_34	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	IEA	biological_process
Tom7	GO:0005741_3650_6	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	IEA	cellular_component
Tom7	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Tom7	GO:0015450_13174_5	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	"Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Top1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Top1	GO:0003917_13174_3	DNA topoisomerase type I activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	IEA	molecular_function
Top1	GO:0003918_13174_3	DNA topoisomerase (ATP-hydrolyzing) activity	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]	IEA	molecular_function
Top1	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
Top1	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
Top2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Top2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Top2	GO:0003918_13174_3	DNA topoisomerase (ATP-hydrolyzing) activity	"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]	IEA	molecular_function
Top2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Top2	GO:0005694_3650_11	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	IEA	cellular_component
Top2	GO:0006265_6281_6	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	IEA	biological_process
Top2	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Tor	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tor	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tor	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tor	GO:0016773_13174_36	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	IEA	molecular_function
torp4a	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
torp4a	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
torp4a	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
torp4a	GO:0051085_6281_1	chaperone mediated protein folding requiring cofactor	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	IEA	biological_process
Toy	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Toy	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Toy	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Toy	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Toy	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Tpcn1	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Tpcn1	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Tpcn1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Tpcn1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Tpi	GO:0004807_13174_1	triose-phosphate isomerase activity	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18588]	IEA	molecular_function
Tpi	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
TpnCI	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
TpnCIIa	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
TpnCIIb	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
TpnCIIIa	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
TppII	GO:0004252_13174_79	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
TppII	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Tps1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Tps1	GO:0005992_6281_1	trehalose biosynthetic process	"The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]	IEA	biological_process
Tps1	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Tpx-1	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
Tpx-1	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Tpx-1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Tpx-3	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
Tpx-3	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Tpx-3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Tpx-4	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
Tpx-4	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Tpx-4	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Tpx-5	GO:0016209_13174_7	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	IEA	molecular_function
Tpx-5	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Tpx-5	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
tra2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Traf6	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
Traf6	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
Traf6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Traf6	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Traf6	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
Trap1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Trap1	GO:0006457_6281_60	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	IEA	biological_process
Trap1	GO:0006950_6281_6	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	IEA	biological_process
Trap1	GO:0051082_13174_39	unfolded protein binding	"Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]	IEA	molecular_function
Trappc1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Trappc1	GO:0005801_3650_3	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	IEA	cellular_component
Trappc1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Trappc1	GO:0006888_6281_6	ER to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	IEA	biological_process
Trax	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
trbd	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
trbd	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
trbl	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
trbl	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
trbl	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
trbl	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
trbl	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
trbl	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Trc8	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Trc8	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
trc	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
trc	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
trc	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
trc	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
trc	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
trc	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Tret1	GO:0005215_13174_105	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	IEA	molecular_function
Tret1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Tret1	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Tret1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tret1	GO:0022857_13174_46	transmembrane transporter activity	"Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Tret1	GO:0022891_13174_9	substrate-specific transmembrane transporter activity	"Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Tret1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Trf2	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Trf2	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Trf2	GO:0006367_6281_13	transcription initiation from RNA polymerase II promoter	"Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH]	IEA	biological_process
Trh	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
Trh	GO:0004510_13174_1	tryptophan 5-monooxygenase activity	"Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4]	IEA	molecular_function
Trh	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
Trh	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Trh	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
Trh	GO:0016597_13174_5	amino acid binding	"Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	IEA	molecular_function
Trh	GO:0016714_13174_4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
Trh	GO:0042427_6281_1	serotonin biosynthetic process	"The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Trh	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Trim9	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Trim9	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Trim9	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Trim9	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
trio	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
trio	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
trio	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
trio	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
Trip1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Trl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Trl	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Trl	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Trn-SR	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Trp1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Trp1	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Trp1	GO:0008565_13174_21	protein transporter activity	"Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732]	IEA	molecular_function
Trp1	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Trp1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Trp1	GO:0035556_6281_109	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782]	IEA	biological_process
Trp1	GO:0042626_13174_21	ATPase activity, coupled to transmembrane movement of substances	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Trp1	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
trpgamma	GO:0004664_13174_1	prephenate dehydratase activity	"Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51]	IEA	molecular_function
trpgamma	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
trpgamma	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
trpgamma	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
trpgamma	GO:0009094_6281_1	L-phenylalanine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah]	IEA	biological_process
trpgamma	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
trpgamma	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
trpgamma	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
TRP	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
TRP	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TRP	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
TRP	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
TRP	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
TRP	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
TRPL	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
TRPL	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
TRPL	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
TRPL	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
TRPL	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
TRPL	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
Trpm3	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Trpm3	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Trpm3	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Trpm3	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
TRPML	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
TRPML	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
TRPML	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
TRPML	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
trr	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
trr	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
trr	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
trr	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
trsn	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
trus	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Trx-1	GO:0006662_6281_2	glycerol ether metabolic process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]	IEA	biological_process
Trx-1	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Trx-1	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Trx-1	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trx1-like1	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trx1-like2	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trx1-like3	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trx-2	GO:0006662_6281_2	glycerol ether metabolic process	"The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]	IEA	biological_process
Trx-2	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Trx-2	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Trx-2	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
trx	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
trx	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
trx	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
trx	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
trx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
trx	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
trx	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Trx/Gtx	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
Trx/Gtx	GO:0015035_13174_7	protein disulfide oxidoreductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]	IEA	molecular_function
Trx/Gtx	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trxr-1	GO:0004791_13174_1	thioredoxin-disulfide reductase activity	"Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348]	IEA	molecular_function
Trxr-1	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Trxr-1	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Trxr-1	GO:0016668_13174_3	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	IEA	molecular_function
Trxr-1	GO:0045454_6281_33	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	IEA	biological_process
Trxr-1	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Trxr-1	GO:0050661_13174_10	NADP binding	"Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	IEA	molecular_function
Trxr-1	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Trxr-3	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Trxr-3	GO:0050660_13174_55	flavin adenine dinucleotide binding	"Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]	IEA	molecular_function
Trxr-3	GO:0051537_13174_17	2 iron, 2 sulfur cluster binding	"Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	IEA	molecular_function
Trxr-3	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
Tsc1	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Tsf1	GO:0004185_13174_4	serine-type carboxypeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]	IEA	molecular_function
Tsf1	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Tsf1	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Tsf1	GO:0006826_6281_3	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Tsf1	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
Tsf1	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
Tsf2	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Tsf2	GO:0006826_6281_3	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Tsf2	GO:0006879_6281_6	cellular iron ion homeostasis	"Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah]	IEA	biological_process
Tsf2	GO:0008199_13174_6	ferric iron binding	"Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]	IEA	molecular_function
TSG101	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
TSG101	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Ts	GO:0004799_13174_1	thymidylate synthase activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]	IEA	molecular_function
Ts	GO:0006231_6281_1	dTMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]	IEA	biological_process
Tspan10	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan11	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan12	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan13	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan14	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan17	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan1	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan2	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan3	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan4	GO:0004867_13174_10	serine-type endopeptidase inhibitor activity	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]	IEA	molecular_function
Tspan4	GO:0009611_6281_1	response to wounding	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]	IEA	biological_process
Tspan4	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan5	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan6	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan8	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tspan9	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Tsp	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
Tsp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Tsp	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Tsp	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
tst	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
tst	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
tst	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
tst	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
tst	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
tst	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
tsu	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
TTC21B	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ttv	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
ttv	GO:0016758_13174_26	transferase activity, transferring hexosyl groups	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	IEA	molecular_function
ttv	GO:0031227_3650_9	intrinsic to endoplasmic reticulum membrane	"Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]	IEA	cellular_component
TUBG1	GO:0003924_13174_107	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]	IEA	molecular_function
TUBG1	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
TUBG1	GO:0005874_3650_26	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	IEA	cellular_component
TUBG1	GO:0006184_6281_86	GTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732]	IEA	biological_process
TUBG1	GO:0007017_6281_19	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	IEA	biological_process
TUBG1	GO:0043234_3650_15	protein complex	"Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]	IEA	cellular_component
TUBG1	GO:0051258_6281_15	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	IEA	biological_process
Tudor-SN	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Tudor-SN	GO:0016442_3650_1	RNA-induced silencing complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	IEA	cellular_component
Tudor-SN	GO:0016788_13174_22	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	IEA	molecular_function
Tudor-SN	GO:0031047_6281_1	gene silencing by RNA	"Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]	IEA	biological_process
tup	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
tup	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
tup	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
tup	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
tup	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
tup	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
twf	GO:0003779_13174_44	actin binding	"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	IEA	molecular_function
twf	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
tws	GO:0000159_3650_3	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	IEA	cellular_component
tws	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
tws	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
tws	GO:0008601_13174_3	protein phosphatase type 2A regulator activity	"Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]	IEA	molecular_function
TyHyd	GO:0004497_13174_7	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]	IEA	molecular_function
TyHyd	GO:0004511_13174_1	tyrosine 3-monooxygenase activity	"Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2]	IEA	molecular_function
TyHyd	GO:0005506_13174_87	iron ion binding	"Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]	IEA	molecular_function
TyHyd	GO:0009072_6281_7	aromatic amino acid family metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	IEA	biological_process
TyHyd	GO:0016714_13174_4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	IEA	molecular_function
TyHyd	GO:0042423_6281_1	catecholamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]	IEA	biological_process
TyHyd	GO:0055114_6281_375	oxidation-reduction process	"A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]	IEA	biological_process
TyrR	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
TyrR	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
U2af38	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
U2af38	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
U2af50	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
U2af50	GO:0003723_13174_109	RNA binding	"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]	IEA	molecular_function
U2af50	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
U2af50	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
U2af50	GO:0006397_6281_17	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	IEA	biological_process
U2af50	GO:0016887_13174_91	ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
U2A	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
U3-55K	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Uba1	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Uba1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Uba1	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Uba1	GO:0008641_13174_3	small protein activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	IEA	molecular_function
Uba2	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
Uba2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Uba2	GO:0006464_6281_40	cellular protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]	IEA	biological_process
Uba2	GO:0008641_13174_3	small protein activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	IEA	molecular_function
Ubc13	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
UbcD2	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
UbcD6	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Ubc-E2H	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Ube2g1	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
UBE4B	GO:0000151_3650_13	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]	IEA	cellular_component
UBE4B	GO:0004842_13174_24	ubiquitin-protein ligase activity	"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]	IEA	molecular_function
UBE4B	GO:0016567_6281_18	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	IEA	biological_process
Ubx	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Ubx	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Ubx	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Uch	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
Uch	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Uch	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Uch-L3	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
Uch-L3	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Uch-L3	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Uch-L3	GO:0008242_13174_5	omega peptidase activity	"Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]	IEA	molecular_function
Ufd1-like	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
UGP	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
UGP	GO:0016779_13174_16	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	IEA	molecular_function
Ugt	GO:0003980_13174_1	UDP-glucose:glycoprotein glucosyltransferase activity	"Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828]	IEA	molecular_function
Ugt	GO:0006486_6281_13	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	IEA	biological_process
UHRF1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
UHRF1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
UHRF1	GO:0042393_13174_2	histone binding	"Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]	IEA	molecular_function
unc5-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
unc5-1	GO:0007165_6281_215	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	IEA	biological_process
Unc-89	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Unc-89	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Unc-89	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Unc-89	GO:0005089_13174_27	Rho guanyl-nucleotide exchange factor activity	"Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]	IEA	molecular_function
Unc-89	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Unc-89	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Unc-89	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Unc-89	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Unc-89	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Unc-89	GO:0035023_6281_27	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	IEA	biological_process
Unr	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Unr	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Unr	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Updo	GO:0004853_13174_1	uroporphyrinogen decarboxylase activity	"Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37]	IEA	molecular_function
Updo	GO:0006779_6281_3	porphyrin-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732]	IEA	biological_process
Upf1	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Upf1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Upf1	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Upf1	GO:0016787_13174_106	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]	IEA	molecular_function
Upf1	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Upf2	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Upf2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Upf2	GO:0006122_6281_5	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	IEA	biological_process
Upf2	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
Upf2	GO:0016070_6281_11	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	IEA	biological_process
Uqcr11	GO:0008121_13174_9	ubiquinol-cytochrome-c reductase activity	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]	IEA	molecular_function
Uqcr11	GO:0009055_13174_100	electron carrier activity	"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]	IEA	molecular_function
usnp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
usnp	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
usnp	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
usnp	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Usp7	GO:0004221_13174_26	ubiquitin thiolesterase activity	"Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]	IEA	molecular_function
Usp7	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Usp7	GO:0006511_6281_45	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	IEA	biological_process
Usp	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Usp	GO:0003707_13174_25	steroid hormone receptor activity	"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]	IEA	molecular_function
Usp	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Usp	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Usp	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Usp	GO:0043401_6281_25	steroid hormone mediated signaling pathway	"A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	IEA	biological_process
Usp	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Uvop	GO:0007186_6281_118	G-protein coupled receptor signaling pathway	"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, Wikipedia:G_protein-coupled_receptor]	IEA	biological_process
Uvop	GO:0007601_6281_5	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	IEA	biological_process
Uvop	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Vamp4	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Vamp4	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Vamp7	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Vamp7	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Vamp7	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Vapa	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
vari	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
vas	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
vas	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
vas	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
vas	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
verm	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
verm	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
verm	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
verm	GO:0005975_6281_107	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]	IEA	biological_process
verm	GO:0006030_6281_41	chitin metabolic process	"The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	biological_process
verm	GO:0008061_13174_41	chitin binding	"Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
verm	GO:0016810_13174_17	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	IEA	molecular_function
Vg	GO:0004181_13174_17	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]	IEA	molecular_function
Vg	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Vg	GO:0006508_6281_225	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	IEA	biological_process
Vg	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
Vg	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Vha13	GO:0015992_6281_5	proton transport	"The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	IEA	biological_process
Vha13	GO:0016471_3650_1	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
Vha13	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
Vha16	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
Vha16	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Vha16	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
Vha16	GO:0033179_3650_3	proton-transporting V-type ATPase, V0 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
Vha26	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Vha26	GO:0033178_3650_8	proton-transporting two-sector ATPase complex, catalytic domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]	IEA	cellular_component
Vha26	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Vha44	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
Vha44	GO:0016820_13174_11	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	"Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]	IEA	molecular_function
Vha44	GO:0033180_3650_4	proton-transporting V-type ATPase, V1 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
VhaAC39	GO:0015078_13174_17	hydrogen ion transmembrane transporter activity	"Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]	IEA	molecular_function
VhaAC39	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
VhaAC39	GO:0033177_3650_11	proton-transporting two-sector ATPase complex, proton-transporting domain	"A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]	IEA	cellular_component
VhaAC39	GO:0033179_3650_3	proton-transporting V-type ATPase, V0 domain	"A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]	IEA	cellular_component
VhaSFD	GO:0000221_3650_1	vacuolar proton-transporting V-type ATPase, V1 domain	"The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]	IEA	cellular_component
VhaSFD	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
VhaSFD	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
VhaSFD	GO:0015991_6281_22	ATP hydrolysis coupled proton transport	"The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw]	IEA	biological_process
VhaSFD	GO:0046961_13174_10	proton-transporting ATPase activity, rotational mechanism	"Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]	IEA	molecular_function
Vhdl	GO:0005319_13174_12	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	IEA	molecular_function
Vhdl	GO:0006869_6281_13	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	IEA	biological_process
vib	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
vib	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
vih	GO:0016881_13174_44	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	IEA	molecular_function
Vinc	GO:0005198_13174_28	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]	IEA	molecular_function
Vinc	GO:0007155_6281_52	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	IEA	biological_process
Vinc	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
vir	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
Vkr	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Vkr	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Vkr	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Vkr	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Vkr	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Vkr	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
vls	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Vps16A	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Vps16A	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
Vps24	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Vps26	GO:0007034_6281_2	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	IEA	biological_process
Vps26	GO:0030904_3650_2	retromer complex	"A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157]	IEA	cellular_component
Vps33B	GO:0006904_6281_12	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid]	IEA	biological_process
Vps33B	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
Vps4	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Vps4	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Vps4	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Vri	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Vri	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Vri	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Vri	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Vrp1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
vtd	GO:0000228_3650_2	nuclear chromosome	"A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah]	IEA	cellular_component
vtd	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
wapl	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
WASp	GO:0005083_13174_8	small GTPase regulator activity	"Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]	IEA	molecular_function
WASp	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
WASp	GO:0006461_6281_5	protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]	IEA	biological_process
WASp	GO:0008154_6281_2	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	IEA	biological_process
WASp	GO:0015629_3650_9	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	IEA	cellular_component
WDR79	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
wds	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
wee	GO:0000287_13174_38	magnesium ion binding	"Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]	IEA	molecular_function
wee	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
wee	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
wee	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
wee	GO:0004715_13174_2	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]	IEA	molecular_function
wee	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
wee	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
wee	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
wee	GO:0007067_6281_4	mitosis	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]	IEA	biological_process
wee	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
wgn	GO:0005488_13174_267	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	IEA	molecular_function
WIF-1	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
WIF-1	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
WIF-1	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
wit	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
wit	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
wit	GO:0004675_13174_5	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	IEA	molecular_function
wit	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
wit	GO:0005024_13174_4	transforming growth factor beta-activated receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	IEA	molecular_function
wit	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
wit	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
wit	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
wit	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Wnt10	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt10	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt10	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt10	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt11	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt11	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt11	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt11	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt1	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt1	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt1	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt1	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt4	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt4	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt4	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt4	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt5	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt5	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt5	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt5	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt6	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt6	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt6	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt6	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wnt7	GO:0005102_13174_13	receptor binding	"Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	IEA	molecular_function
Wnt7	GO:0005576_3650_94	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	IEA	cellular_component
Wnt7	GO:0007275_6281_39	multicellular organismal development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	IEA	biological_process
Wnt7	GO:0016055_6281_9	Wnt receptor signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]	IEA	biological_process
Wsck	GO:0004672_13174_224	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]	IEA	molecular_function
Wsck	GO:0004674_13174_225	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]	IEA	molecular_function
Wsck	GO:0004713_13174_213	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]	IEA	molecular_function
Wsck	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Wsck	GO:0006468_6281_233	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	IEA	biological_process
Wsck	GO:0016772_13174_262	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	IEA	molecular_function
Wtrw	GO:0005216_13174_43	ion channel activity	"Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]	IEA	molecular_function
Wtrw	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Wtrw	GO:0006811_6281_64	ion transport	"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
Wtrw	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Wtrw	GO:0055085_6281_271	transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid]	IEA	biological_process
wun	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
wun	GO:0016020_3650_796	membrane	"Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]	IEA	cellular_component
Wwox	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Wwox	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
Wwox	GO:0016491_13174_222	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	IEA	molecular_function
Xbp1	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Xbp1	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
Xbp1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
Xbp1	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Xbp1	GO:0046983_13174_28	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	IEA	molecular_function
Xpac	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Xpac	GO:0003684_13174_11	damaged DNA binding	"Interacting selectively and non-covalently with damaged DNA." [GOC:jl]	IEA	molecular_function
Xpac	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Xpac	GO:0006289_6281_7	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	IEA	biological_process
Xpd	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
Xpd	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Xpd	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
Xpd	GO:0004003_13174_7	ATP-dependent DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Xpd	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
Xpd	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
Xpd	GO:0006139_6281_32	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	IEA	biological_process
Xpd	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
Xpd	GO:0016817_13174_10	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	IEA	molecular_function
Xpd	GO:0016818_13174_12	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	IEA	molecular_function
Xpd	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
XRN1	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
XRN1	GO:0003725_13174_18	double-stranded RNA binding	"Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]	IEA	molecular_function
XRN1	GO:0004527_13174_12	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
XRN1	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Ykt6	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
Ykt6	GO:0016021_3650_560	integral to membrane	"Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]	IEA	cellular_component
Ykt6	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
YL-1	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
YL-1	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
yl	GO:0005509_13174_173	calcium ion binding	"Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]	IEA	molecular_function
yl	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
yps	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
yps	GO:0003677_13174_453	DNA binding	"Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	IEA	molecular_function
yps	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
YTHDC2	GO:0000166_13174_274	nucleotide binding	"Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	IEA	molecular_function
YTHDC2	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
YTHDC2	GO:0004386_13174_84	helicase activity	"Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]	IEA	molecular_function
YTHDC2	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
YTHDC2	GO:0005524_13174_709	ATP binding	"Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	IEA	molecular_function
YTHDC2	GO:0008026_13174_68	ATP-dependent helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]	IEA	molecular_function
YTHDC2	GO:0017111_13174_184	nucleoside-triphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]	IEA	molecular_function
Zasp66	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
ZC3H3	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
ZC3H3	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Zdhhc6	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
Zdhhc6	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
zetaCOP	GO:0006810_6281_207	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]	IEA	biological_process
zetaCOP	GO:0006886_6281_128	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	IEA	biological_process
zetaCOP	GO:0016192_6281_66	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	IEA	biological_process
zetaCOP	GO:0030117_3650_12	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	IEA	cellular_component
Zfrp8	GO:0005737_3650_192	cytoplasm	"All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	IEA	cellular_component
Zfrp8	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
Zn72D	GO:0003676_13174_435	nucleic acid binding	"Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]	IEA	molecular_function
Zn72D	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
Zn72D	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
zormin	GO:0003700_13174_272	sequence-specific DNA binding transcription factor activity	"Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]	IEA	molecular_function
zormin	GO:0005515_13174_2011	protein binding	"Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]	IEA	molecular_function
zormin	GO:0006355_6281_379	regulation of transcription, DNA-dependent	"Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators, GOC:txnOH]	IEA	biological_process
zormin	GO:0043565_13174_239	sequence-specific DNA binding	"Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	IEA	molecular_function
Zpr1	GO:0008270_13174_775	zinc ion binding	"Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]	IEA	molecular_function
zuc	GO:0003824_13174_397	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]	IEA	molecular_function
zuc	GO:0005525_13174_159	GTP binding	"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]	IEA	molecular_function
zuc	GO:0005622_3650_780	intracellular	"The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	IEA	cellular_component
zuc	GO:0007264_6281_99	small GTPase mediated signal transduction	"Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]	IEA	biological_process
zuc	GO:0008152_6281_329	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	IEA	biological_process
zuc	GO:0015031_6281_97	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	IEA	biological_process
zw10	GO:0000775_3650_3	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	IEA	cellular_component
zw10	GO:0005634_3650_411	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	IEA	cellular_component
zw10	GO:0007067_6281_4	mitosis	"A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]	IEA	biological_process