|
Heparan sulfate (HS) is a glycosaminoglycan with the basic disaccharide unit GlcNAc(a1-4)GlcA(b1-4), containing N- and O-sulfate esters at various positions. HS is covalently attached to serine residues in a proteoglycan core protein via the linkage tetrasaccharide. The addition of the first GlcNAc residue is catalyzed by EXTL3 glycosyltransferase, followed by the polymerization steps catalyzed by EXT1 and EXT2 transferases. As the chains polymerize, HS undergoes a series of modification reactions catalyzed by at least four families of sulfotransferases and one epimerase. |
Glycosaminoglycan biosynthesis - heparan sulfate - Danio rerio (zebrafish)
