EpilepsyGene

Biological process

Gene type	GO term	GO term name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	P-Value	Adjusted P-Value
green	GO:0006811	ion transport	797	27	2.99	9.02	3.73e-20	8.88E-18
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|CACNB4\| KCNT1\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|GNAO1\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0051234	establishment of localization	2816	38	10.58	3.59	7.69e-16	6.10E-14
SCN1A\|SCN8A\|CHRNB2\|SLC25A12\|GABRG2\|NECAP1\|STX1B\|CACNB4\|KCNT1\|PTEN\|SCN1B\|SYN1\|GRIN2A\|SCN2A\|STXBP1\| MYO5A\|CHRNA7\|CLCN4\|DNM1\|VPS37A\|KCNQ3\|KCNH5\|DNAJC6\|MRS2\|CACNA1A\|RYR2\|PRICKLE1\|SLC25A22\|HCN2\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SLC9A6\|GNAO1\|ATP6V0C\|HCN1\|ARFGEF2 \|
green	GO:0006810	transport	2792	38	10.49	3.62	5.72e-16	6.10E-14
SCN1A\|SCN8A\|CHRNB2\|SLC25A12\|GABRG2\|NECAP1\|STX1B\|CACNB4\|KCNT1\|PTEN\|SCN1B\|SYN1\|GRIN2A\|SCN2A\|STXBP1\| MYO5A\|CHRNA7\|CLCN4\|DNM1\|VPS37A\|KCNQ3\|KCNH5\|DNAJC6\|MRS2\|CACNA1A\|RYR2\|PRICKLE1\|SLC25A22\|HCN2\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SLC9A6\|GNAO1\|ATP6V0C\|HCN1\|ARFGEF2 \|
green	GO:0030001	metal ion transport	498	19	1.87	10.15	7.66e-15	4.56E-13
CHRNA7\|SCN1A\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\|SCN1B\|GNAO1\| SLC9A6\|SCN2A\|GRIN2A\|HCN1 \|
green	GO:0006812	cation transport	591	20	2.22	9.01	1.21e-14	5.76E-13
CHRNA7\|SCN1A\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\|SCN1B\|GNAO1\| SLC9A6\|ATP6V0C\|SCN2A\|GRIN2A\|HCN1 \|
green	GO:0051179	localization	3194	38	12.00	3.17	5.68e-14	2.25E-12
SCN1A\|SCN8A\|CHRNB2\|SLC25A12\|GABRG2\|NECAP1\|STX1B\|CACNB4\|KCNT1\|PTEN\|SCN1B\|SYN1\|GRIN2A\|SCN2A\|STXBP1\| MYO5A\|CHRNA7\|CLCN4\|DNM1\|VPS37A\|KCNQ3\|KCNH5\|DNAJC6\|MRS2\|CACNA1A\|RYR2\|PRICKLE1\|SLC25A22\|HCN2\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SLC9A6\|GNAO1\|ATP6V0C\|HCN1\|ARFGEF2 \|
green	GO:0019226	transmission of nerve impulse	400	15	1.50	9.98	1.16e-11	3.94E-10
LGI1\|SCN1A\|GABRD\|GABRB3\|KCNQ3\|SCN1B\|SCN8A\|CACNA1A\|SYN1\|CHRNB2\|STX1B\|GRIN2A\|STXBP1\|CACNB4\|GRIN2B \|
green	GO:0055085	transmembrane transport	579	16	2.18	7.35	2.00e-10	5.95E-09
SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|RYR2\|SLC25A12\|SLC25A22\|HCN2\|CACNB4\|SLC9A6\|ATP6V0C\|SCN2A\| HCN1 \|
green	GO:0007268	synaptic transmission	346	13	1.30	10.00	3.32e-10	8.78E-09
LGI1\|GABRD\|GABRB3\|KCNQ3\|SCN1B\|CACNA1A\|SYN1\|CHRNB2\|STX1B\|GRIN2A\|CACNB4\|STXBP1\|GRIN2B \|
green	GO:0042391	regulation of membrane potential	132	8	0.50	16.13	2.99e-08	7.12E-07
SCN1A\|SCN8A\|CACNA1A\|CHRNB2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0015672	monovalent inorganic cation transport	335	11	1.26	8.74	3.67e-08	7.94E-07
SCN1A\|KCNQ3\|SCN1B\|SLC9A6\|KCNH5\|SCN8A\|ATP6V0C\|HCN2\|SCN2A\|HCN1\|KCNT1 \|
green	GO:0007267	cell-cell signaling	679	14	2.55	5.49	1.35e-07	2.68E-06
LGI1\|GABRD\|GABRB3\|KCNQ3\|SCN1B\|CACNA1A\|SYN1\|CHRNB2\|HCN2\|STX1B\|GRIN2A\|CACNB4\|STXBP1\|GRIN2B \|
green	GO:0007613	memory	35	5	0.13	38.02	1.85e-07	3.39E-06
CHRNA7\|GRIN2A\|PTEN\|GRIN2B\|CHRNB2 \|
green	GO:0006816	calcium ion transport	173	8	0.65	12.31	2.44e-07	4.08E-06
RYR2\|CHRNA7\|GRIN2A\|CACNB4\|GNAO1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0050801	ion homeostasis	406	11	1.53	7.21	2.57e-07	4.08E-06
CHRNA7\|SCN1A\|SLC9A6\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0070838	divalent metal ion transport	176	8	0.66	12.10	2.78e-07	4.14E-06
RYR2\|CHRNA7\|GRIN2A\|CACNB4\|GNAO1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0003008	system process	1557	20	5.85	3.42	3.75e-07	5.25E-06
LGI1\|CHRNA7\|SCN1A\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|STX1B\|CACNB4\|GRIN2B\|GABRD\|GABRB3\|PTEN\| SCN1B\|GNAO1\|SYN1\|GRIN2A\|STXBP1 \|
green	GO:0007214	gamma-aminobutyric acid signaling pathway	20	4	0.08	53.22	8.25e-07	1.08E-05
GABRA1\|GABRG2\|CACNB4\|CACNA1A \|
green	GO:0006814	sodium ion transport	140	7	0.53	13.31	8.66e-07	1.08E-05
SCN1A\|HCN2\|SCN2A\|HCN1\|SCN1B\|SLC9A6\|SCN8A \|
green	GO:0015674	di-, tri-valent inorganic cation transport	207	8	0.78	10.28	9.54e-07	1.14E-05
RYR2\|CHRNA7\|GRIN2A\|CACNB4\|GNAO1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0006873	cellular ion homeostasis	373	10	1.40	7.13	1.06e-06	1.20E-05
CHRNA7\|SCN1A\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0055082	cellular chemical homeostasis	378	10	1.42	7.04	1.20e-06	1.30E-05
CHRNA7\|SCN1A\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0050877	neurological system process	1229	17	4.62	3.68	1.40e-06	1.45E-05
LGI1\|CHRNA7\|SCN1A\|GABRD\|GABRB3\|KCNQ3\|SCN1B\|PTEN\|SCN8A\|CACNA1A\|SYN1\|CHRNB2\|STX1B\|GRIN2A\|STXBP1\| CACNB4\|GRIN2B \|
green	GO:0048878	chemical homeostasis	506	11	1.90	5.79	2.25e-06	2.23E-05
CHRNA7\|SCN1A\|SLC9A6\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0007270	nerve-nerve synaptic transmission	59	5	0.22	22.55	2.66e-06	2.53E-05
GABRB3\|STXBP1\|CACNB4\|CACNA1A\|CHRNB2 \|
green	GO:0050804	regulation of synaptic transmission	119	6	0.45	13.42	5.31e-06	4.86E-05
LGI1\|GRIN2A\|STXBP1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0001508	regulation of action potential	69	5	0.26	19.28	5.81e-06	5.12E-05
SCN1A\|GRIN2A\|SCN8A\|GRIN2B\|CHRNB2 \|
green	GO:0019725	cellular homeostasis	462	10	1.74	5.76	7.20e-06	6.12E-05
CHRNA7\|SCN1A\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|GRIN2A\|CACNB4\|GRIN2B \|
green	GO:0051969	regulation of transmission of nerve impulse	129	6	0.48	12.38	8.45e-06	6.93E-05
LGI1\|GRIN2A\|STXBP1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0031644	regulation of neurological system process	135	6	0.51	11.83	1.10e-05	8.73E-05
LGI1\|GRIN2A\|STXBP1\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0010646	regulation of cell communication	1003	14	3.77	3.71	1.38e-05	0.0001
LGI1\|CHRNA7\|SYNGAP1\|PTEN\|CACNA1A\|CHRNB2\|IQSEC2\|GRIN2A\|STXBP1\|ARHGEF9\|HIPK3\|ARFGEF2\|GRIN2B\|FARP2 \|
green	GO:0051899	membrane depolarization	40	4	0.15	26.61	1.47e-05	0.0001
GRIN2A\|CACNA1A\|GRIN2B\|CHRNB2 \|
green	GO:0043279	response to alkaloid	47	4	0.18	22.65	2.82e-05	0.0002
RYR2\|CHRNA7\|GNAO1\|CHRNB2 \|
green	GO:0051049	regulation of transport	414	9	1.56	5.79	2.11e-05	0.0002
PTEN\|GNAO1\|CACNA1A\|CHRNB2\|RYR2\|STX1B\|CACNB4\|STXBP1\|GRIN2B \|
green	GO:0050905	neuromuscular process	55	4	0.21	19.35	5.27e-05	0.0003
SCN1A\|GRIN2A\|CACNA1A\|GRIN2B \|
green	GO:0007611	learning or memory	103	5	0.39	12.92	4.11e-05	0.0003
CHRNA7\|GRIN2A\|PTEN\|GRIN2B\|CHRNB2 \|
green	GO:0007610	behavior	458	9	1.72	5.23	4.66e-05	0.0003
CHRNA7\|SCN1A\|PTEN\|CACNA1A\|CHRNB2\|GRIN2A\|CACNB4\|EPM2A\|GRIN2B \|
green	GO:0014070	response to organic cyclic substance	113	5	0.42	11.77	6.40e-05	0.0004
RYR2\|CHRNA7\|PTEN\|GNAO1\|CHRNB2 \|
green	GO:0007628	adult walking behavior	21	3	0.08	38.02	6.36e-05	0.0004
SCN1A\|CACNB4\|CACNA1A \|
green	GO:0045471	response to ethanol	64	4	0.24	16.63	9.57e-05	0.0005
GRIN2A\|PTEN\|GRIN2B\|CHRNB2 \|
brown	GO:0008344	adult locomotory behavior	48	3	0.09	33.26	9.67e-05	0.0097
CLN8\|CSTB\|ATP1A2\| \|

Cellular component

Gene type	GO term accession	GO term name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	P-Value	Adjusted P-Value
green	GO:0034702	ion channel complex	203	14	0.65	21.39	1.86e-15	1.34E-13
GABRA1\|CHRNA7\|SCN1A\|GABRD\|GABRB3\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|SCN2A\|CACNB4 \|
green	GO:0045211	postsynaptic membrane	135	8	0.44	18.38	1.08e-08	2.59E-07
GABRA1\|CHRNA7\|GABRG2\|GABRD\|GABRB3\|GRIN2A\|GRIN2B\|CHRNB2 \|
green	GO:0034703	cation channel complex	130	8	0.42	19.09	8.02e-09	2.59E-07
RYR2\|SCN1A\|HCN2\|KCNQ3\|SCN2A\|CACNB4\|SCN8A\|CACNA1A \|
green	GO:0044456	synapse part	242	9	0.78	11.53	6.98e-08	1.26E-06
GABRA1\|CHRNA7\|GABRG2\|GABRD\|GABRB3\|GRIN2A\|SYN1\|GRIN2B\|CHRNB2 \|
green	GO:0045202	synapse	345	10	1.11	8.99	1.26e-07	1.81E-06
GABRA1\|LGI1\|CHRNA7\|GABRD\|GABRB3\|SYN1\|CHRNB2\|GABRG2\|GRIN2A\|GRIN2B \|
green	GO:0030054	cell junction	505	11	1.63	6.76	4.81e-07	5.77E-06
GABRA1\|CHRNA7\|SCN1A\|GABRD\|GABRB3\|SYN1\|CHRNB2\|GABRG2\|GRIN2A\|SCN2A\|GRIN2B \|
green	GO:0043234	protein complex	2489	23	8.03	2.87	7.16e-07	7.36E-06
CHRNA7\|SCN1A\|DNM1\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|NECAP1\|HCN2\|CACNB4\|GRIN2B\|GABRA1\|GABRD\| GABRB3\|GNAO1\|EEF1A2\|ATP6V0C\|SCN2A\|GRIN2A\|STXBP1\|MYO5A \|
green	GO:0016020	membrane	7186	40	23.17	1.73	1.97e-06	1.77E-05
SCN1A\|SCN8A\|CHRNB2\|SLC25A12\|GABRG2\|NECAP1\|PRRT2\|STX1B\|CACNB4\|KCNT1\|EPM2A\|TK2\|SCN1B\|SYN1\|PRICKLE2\| SCN2A\|GRIN2A\|STXBP1\|FARP2\|CHRNA7\|CLCN4\|VPS37A\|KCNQ3\|KCNH5\|MRS2\|CACNA1A\|RYR2\|PRICKLE1\|SLC25A22\|HCN2\| ST3GAL5\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SLC9A6\|GNAO1\|ATP6V0C\|HCN1\|ARFGEF2 \|
green	GO:0005887	integral to plasma membrane	1183	15	3.81	3.93	2.96e-06	2.37E-05
GABRA1\|CHRNA7\|SCN1A\|GABRD\|GABRB3\|KCNQ3\|SCN8A\|CHRNB2\|GABRG2\|HCN2\|STX1B\|GRIN2A\|SCN2A\|ST3GAL5\|GRIN2B \|
green	GO:0031226	intrinsic to plasma membrane	1206	15	3.89	3.86	3.76e-06	2.52E-05
GABRA1\|CHRNA7\|SCN1A\|GABRD\|GABRB3\|KCNQ3\|SCN8A\|CHRNB2\|GABRG2\|HCN2\|STX1B\|GRIN2A\|SCN2A\|ST3GAL5\|GRIN2B \|
green	GO:0044459	plasma membrane part	1918	19	6.18	3.07	3.85e-06	2.52E-05
CHRNA7\|SCN1A\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|GABRG2\|HCN2\|STX1B\|CACNB4\|ST3GAL5\|GRIN2B\|GABRA1\|GABRD\|GABRB3\| SYN1\|PRICKLE2\|GRIN2A\|SCN2A \|
green	GO:0032991	macromolecular complex	3040	24	9.80	2.45	6.42e-06	3.78E-05
CHRNA7\|SCN1A\|DNM1\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|NECAP1\|HCN2\|CACNB4\|EPM2A\|GRIN2B\|GABRA1\| GABRD\|GABRB3\|GNAO1\|EEF1A2\|ATP6V0C\|GRIN2A\|SCN2A\|STXBP1\|MYO5A \|
green	GO:0001518	voltage-gated sodium channel complex	12	3	0.04	77.53	6.82e-06	3.78E-05
SCN1A\|SCN2A\|SCN8A \|
green	GO:0043005	neuron projection	318	8	1.03	7.80	7.40e-06	3.81E-05
SCN1A\|GABRB3\|SCN2A\|GRIN2A\|HCN1\|CACNA1A\|MYO5A\|GRIN2B \|
green	GO:0005886	plasma membrane	3650	26	11.77	2.21	1.40e-05	6.30E-05
CHRNA7\|SCN1A\|KCNQ3\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|NECAP1\|HCN2\|STX1B\|CACNB4\|KCNT1\|ST3GAL5\|EPM2A\| GRIN2B\|GABRA1\|GABRD\|GABRB3\|GNAO1\|SLC9A6\|SYN1\|PRICKLE2\|GRIN2A\|SCN2A\|STXBP1 \|
green	GO:0034706	sodium channel complex	15	3	0.05	62.03	1.40e-05	6.30E-05
SCN1A\|SCN2A\|SCN8A \|
blue	GO:0001518	voltage-gated sodium channel complex	12	3	0.03	103.38	2.83e-06	0.0001
SCN9A\|SCN5A\|SCN3A \|
blue	GO:0034706	sodium channel complex	15	3	0.04	82.70	5.83e-06	0.0001
SCN9A\|SCN5A\|SCN3A \|
green	GO:0034707	chloride channel complex	55	4	0.18	22.56	2.90e-05	0.0001
GABRA1\|GABRG2\|GABRD\|GABRB3 \|
blue	GO:0034703	cation channel complex	130	5	0.31	15.90	1.46e-05	0.0002
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
green	GO:0044425	membrane part	6381	35	20.57	1.70	4.70e-05	0.0002
SCN1A\|SCN8A\|CHRNB2\|SLC25A12\|GABRG2\|NECAP1\|PRRT2\|STX1B\|CACNB4\|KCNT1\|SCN1B\|SYN1\|PRICKLE2\|GRIN2A\|SCN2A\| STXBP1\|FARP2\|CHRNA7\|CLCN4\|VPS37A\|KCNQ3\|KCNH5\|MRS2\|CACNA1A\|RYR2\|SLC25A22\|HCN2\|ST3GAL5\|GRIN2B\|GABRA1\| GABRD\|GABRB3\|SLC9A6\|ATP6V0C\|HCN1 \|
green	GO:0034704	calcium channel complex	27	3	0.09	34.46	8.76e-05	0.0003
RYR2\|CACNB4\|CACNA1A \|
green	GO:0019717	synaptosome	80	4	0.26	15.51	0.0001	0.0003
RYR2\|GRIN2A\|GNAO1\|GRIN2B \|
green	GO:0031090	organelle membrane	1056	12	3.40	3.52	0.0001	0.0003
SLC9A6\|MRS2\|SYN1\|SLC25A12\|PRICKLE2\|RYR2\|PRICKLE1\|SLC25A22\|NECAP1\|ST3GAL5\|TK2\|ARFGEF2 \|
blue	GO:0034702	ion channel complex	203	5	0.49	10.19	0.0001	0.0012
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
green	GO:0016021	integral to membrane	5261	29	16.96	1.71	0.0005	0.0016
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|PRRT2\| STX1B\|CACNB4\|KCNT1\|ST3GAL5\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0043235	receptor complex	113	4	0.36	10.98	0.0005	0.0016
CHRNA7\|GRIN2A\|GRIN2B\|CHRNB2 \|
green	GO:0031224	intrinsic to membrane	5451	29	17.58	1.65	0.0009	0.0027
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|PRRT2\| STX1B\|CACNB4\|KCNT1\|ST3GAL5\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0042995	cell projection	653	8	2.11	3.80	0.0011	0.0032
SCN1A\|GABRB3\|SCN2A\|GRIN2A\|HCN1\|CACNA1A\|MYO5A\|GRIN2B \|
green	GO:0030424	axon	148	4	0.48	8.38	0.0013	0.0036
SCN1A\|GABRB3\|SCN2A\|HCN1 \|
green	GO:0012505	endomembrane system	745	8	2.40	3.33	0.0025	0.0067
PRICKLE1\|RYR2\|PRICKLE2\|NECAP1\|SLC9A6\|ST3GAL5\|SYN1\|ARFGEF2 \|
green	GO:0005624	membrane fraction	775	8	2.50	3.20	0.0032	0.0082
SCN1A\|GNAO1\|SLC9A6\|RYR2\|STX1B\|GRIN2A\|SCN2A\|GRIN2B \|
green	GO:0005626	insoluble fraction	803	8	2.59	3.09	0.0039	0.0097
SCN1A\|GNAO1\|SLC9A6\|RYR2\|STX1B\|GRIN2A\|SCN2A\|GRIN2B \|

Molecular Function

Gene type	GO term accession	GO term name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	P-Value	Adjusted P-Value
green	GO:0022836	gated channel activity	306	22	1.04	21.24	2.84e-24	2.61E-22
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SCN1B\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0005216	ion channel activity	379	22	1.28	17.15	3.18e-22	1.46E-20
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SCN1B\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0022838	substrate-specific channel activity	390	22	1.32	16.67	5.95e-22	1.82E-20
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SCN1B\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0015267	channel activity	404	22	1.37	16.09	1.29e-21	2.50E-20
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SCN1B\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0022803	passive transmembrane transporter activity	405	22	1.37	16.05	1.36e-21	2.50E-20
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|SCN1B\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0022891	substrate-specific transmembrane transporter activity	816	27	2.76	9.78	3.37e-21	5.17E-20
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|STX1B\| CACNB4\|KCNT1\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0022857	transmembrane transporter activity	889	27	3.01	8.97	3.13e-20	4.11E-19
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|STX1B\| CACNB4\|KCNT1\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0015075	ion transmembrane transporter activity	709	25	2.40	10.42	3.90e-20	4.48E-19
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|GABRG2\|HCN2\|STX1B\|CACNB4\|KCNT1\| GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0022892	substrate-specific transporter activity	955	27	3.23	8.35	1.99e-19	2.03E-18
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|STX1B\| CACNB4\|KCNT1\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0005215	transporter activity	1160	28	3.93	7.13	2.04e-18	1.88E-17
CHRNA7\|SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|SLC25A12\|GABRG2\|SLC25A22\|HCN2\|STX1B\| CACNB4\|KCNT1\|GRIN2B\|GABRA1\|GABRD\|GABRB3\|SCN1B\|SLC9A6\|SYN1\|ATP6V0C\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0046873	metal ion transmembrane transporter activity	320	17	1.08	15.70	1.94e-16	1.62E-15
CHRNA7\|SCN1A\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\|SCN1B\|SCN2A\| GRIN2A\|HCN1 \|
green	GO:0005261	cation channel activity	269	16	0.91	17.57	2.94e-16	2.25E-15
CHRNA7\|SCN1A\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|CHRNB2\|RYR2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\|SCN1B\|SCN2A\|GRIN2A\| HCN1 \|
green	GO:0008324	cation transmembrane transporter activity	541	19	1.83	10.38	4.63e-15	3.28E-14
CHRNA7\|SCN1A\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|CHRNB2\|RYR2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\|SCN1B\|SLC9A6\| ATP6V0C\|SCN2A\|GRIN2A\|HCN1 \|
green	GO:0022832	voltage-gated channel activity	190	12	0.64	18.66	1.21e-12	7.42E-12
SCN1A\|CLCN4\|KCNQ3\|SCN1B\|KCNH5\|SCN8A\|CACNA1A\|HCN2\|GRIN2A\|SCN2A\|HCN1\|CACNB4 \|
green	GO:0005244	voltage-gated ion channel activity	190	12	0.64	18.66	1.21e-12	7.42E-12
SCN1A\|CLCN4\|KCNQ3\|SCN1B\|KCNH5\|SCN8A\|CACNA1A\|HCN2\|GRIN2A\|SCN2A\|HCN1\|CACNB4 \|
green	GO:0022843	voltage-gated cation channel activity	143	11	0.48	22.73	1.34e-12	7.71E-12
SCN1A\|KCNQ3\|SCN1B\|KCNH5\|SCN8A\|CACNA1A\|HCN2\|GRIN2A\|SCN2A\|HCN1\|CACNB4 \|
green	GO:0005230	extracellular ligand-gated ion channel activity	73	9	0.25	36.43	2.32e-12	1.26E-11
GABRA1\|CHRNA7\|GABRG2\|GABRD\|GABRB3\|GRIN2A\|STX1B\|GRIN2B\|CHRNB2 \|
green	GO:0015276	ligand-gated ion channel activity	127	10	0.43	23.26	1.23e-11	5.96E-11
GABRA1\|CHRNA7\|GABRD\|GABRB3\|CHRNB2\|GABRG2\|RYR2\|STX1B\|GRIN2A\|GRIN2B \|
green	GO:0022834	ligand-gated channel activity	127	10	0.43	23.26	1.23e-11	5.96E-11
GABRA1\|CHRNA7\|GABRD\|GABRB3\|CHRNB2\|GABRG2\|RYR2\|STX1B\|GRIN2A\|GRIN2B \|
green	GO:0005272	sodium channel activity	32	6	0.11	55.40	9.46e-10	4.35E-09
SCN1A\|HCN2\|SCN2A\|HCN1\|SCN1B\|SCN8A \|
green	GO:0031420	alkali metal ion binding	227	10	0.77	13.02	3.74e-09	1.64E-08
SCN1A\|KCNQ3\|SCN1B\|SLC9A6\|KCNH5\|SCN8A\|HCN2\|SCN2A\|HCN1\|KCNT1 \|
green	GO:0031402	sodium ion binding	117	7	0.40	17.68	1.25e-07	5.23E-07
SCN1A\|HCN2\|SCN2A\|HCN1\|SCN1B\|SLC9A6\|SCN8A \|
green	GO:0005248	voltage-gated sodium channel activity	15	4	0.05	78.79	1.55e-07	6.20E-07
SCN1A\|SCN2A\|SCN1B\|SCN8A \|
green	GO:0004890	GABA-A receptor activity	19	4	0.06	62.20	4.35e-07	1.67E-06
GABRA1\|GABRG2\|GABRD\|GABRB3 \|
green	GO:0005231	excitatory extracellular ligand-gated ion channel activity	48	5	0.16	30.78	5.59e-07	2.06E-06
CHRNA7\|GRIN2A\|STX1B\|GRIN2B\|CHRNB2 \|
green	GO:0016917	GABA receptor activity	22	4	0.07	53.72	8.16e-07	2.89E-06
GABRA1\|GABRG2\|GABRD\|GABRB3 \|
grey	GO:0022836	gated channel activity	306	7	0.48	14.64	3.00e-07	1.20E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|CHRFAM7A\|KCND2\|CACNA2D2\| \|
green	GO:0005254	chloride channel activity	72	5	0.24	20.52	4.30e-06	1.47E-05
GABRA1\|GABRG2\|GABRD\|CLCN4\|GABRB3 \|
grey	GO:0015267	channel activity	404	7	0.63	11.09	1.94e-06	1.58E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|CHRFAM7A\|KCND2\|CACNA2D2\| \|
grey	GO:0022838	substrate-specific channel activity	390	7	0.61	11.49	1.53e-06	1.58E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|CHRFAM7A\|KCND2\|CACNA2D2\| \|
grey	GO:0005216	ion channel activity	379	7	0.59	11.82	1.27e-06	1.58E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|CHRFAM7A\|KCND2\|CACNA2D2\| \|
grey	GO:0022803	passive transmembrane transporter activity	405	7	0.63	11.06	1.97e-06	1.58E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|CHRFAM7A\|KCND2\|CACNA2D2\| \|
green	GO:0005262	calcium channel activity	77	5	0.26	19.19	5.99e-06	1.78E-05
RYR2\|GRIN2A\|CACNB4\|CACNA1A\|GRIN2B \|
green	GO:0031404	chloride ion binding	77	5	0.26	19.19	5.99e-06	1.78E-05
GABRA1\|GABRG2\|GABRD\|CLCN4\|GABRB3 \|
green	GO:0042165	neurotransmitter binding	76	5	0.26	19.44	5.62e-06	1.78E-05
CHRNA7\|GABRG2\|GRIN2A\|GRIN2B\|CHRNB2 \|
green	GO:0005253	anion channel activity	77	5	0.26	19.19	5.99e-06	1.78E-05
GABRA1\|GABRG2\|GABRD\|CLCN4\|GABRB3 \|
grey	GO:0005261	cation channel activity	269	6	0.42	14.28	2.81e-06	1.87E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|KCND2\|CACNA2D2\| \|
grey	GO:0015075	ion transmembrane transporter activity	709	8	1.11	7.22	7.53e-06	3.40E-05
KCNQ2\|CHRNA4\|KCNV2\|SLC35A2\|CHRFAM7A\|KCND2\|CACNA2D2\|CHRNA2\| \|
grey	GO:0046873	metal ion transmembrane transporter activity	320	6	0.50	12.00	7.64e-06	3.40E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|KCND2\|CACNA2D2\| \|
grey	GO:0022892	substrate-specific transporter activity	955	9	1.49	6.03	7.45e-06	3.40E-05
KCNQ2\|CHRNA4\|KCNV2\|AP3S2\|SLC35A2\|CHRFAM7A\|KCND2\|CACNA2D2\|CHRNA2\| \|
green	GO:0043168	anion binding	92	5	0.31	16.06	1.44e-05	4.14E-05
GABRA1\|GABRG2\|GABRD\|CLCN4\|GABRB3 \|
grey	GO:0008324	cation transmembrane transporter activity	541	7	0.85	8.28	1.33e-05	5.32E-05
KCNQ2\|CHRNA2\|CHRNA4\|KCNV2\|SLC35A2\|KCND2\|CACNA2D2\| \|
grey	GO:0022891	substrate-specific transmembrane transporter activity	816	8	1.27	6.28	2.10e-05	7.64E-05
KCNQ2\|CHRNA4\|KCNV2\|SLC35A2\|CHRFAM7A\|KCND2\|CACNA2D2\|CHRNA2\| \|
green	GO:0005234	extracellular-glutamate-gated ion channel activity	19	3	0.06	46.65	3.41e-05	9.51E-05
GRIN2A\|STX1B\|GRIN2B \|
grey	GO:0022857	transmembrane transporter activity	889	8	1.39	5.76	3.90e-05	0.0001
KCNQ2\|CHRNA4\|KCNV2\|SLC35A2\|CHRFAM7A\|KCND2\|CACNA2D2\|CHRNA2\| \|
grey	GO:0005215	transporter activity	1160	9	1.81	4.97	3.57e-05	0.0001
KCNQ2\|CHRNA4\|KCNV2\|AP3S2\|SLC35A2\|CHRFAM7A\|KCND2\|CACNA2D2\|CHRNA2\| \|
green	GO:0030955	potassium ion binding	127	5	0.43	11.63	6.79e-05	0.0002
HCN2\|KCNQ3\|HCN1\|KCNT1\|KCNH5 \|
green	GO:0005267	potassium channel activity	129	5	0.44	11.45	7.31e-05	0.0002
HCN2\|KCNQ3\|HCN1\|KCNT1\|KCNH5 \|
blue	GO:0005248	voltage-gated sodium channel activity	15	3	0.04	83.05	5.73e-06	0.0003
SCN9A\|SCN5A\|SCN3A \|
green	GO:0008509	anion transmembrane transporter activity	146	5	0.49	10.12	0.0001	0.0003
GABRA1\|GABRG2\|GABRD\|CLCN4\|GABRB3 \|
grey	GO:0005244	voltage-gated ion channel activity	190	4	0.30	13.48	0.0002	0.0005
KCNQ2\|KCNV2\|KCND2\|CACNA2D2\| \|
grey	GO:0022832	voltage-gated channel activity	190	4	0.30	13.48	0.0002	0.0005
KCNQ2\|KCNV2\|KCND2\|CACNA2D2\| \|
grey	GO:0005230	extracellular ligand-gated ion channel activity	73	3	0.11	26.31	0.0002	0.0005
CHRNA2\|CHRNA4\|CHRFAM7A\| \|
blue	GO:0022843	voltage-gated cation channel activity	143	5	0.34	14.52	2.23e-05	0.0007
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
green	GO:0005249	voltage-gated potassium channel activity	97	4	0.33	12.18	0.0003	0.0007
HCN2\|KCNQ3\|HCN1\|KCNH5 \|
grey	GO:0005249	voltage-gated potassium channel activity	97	3	0.15	19.80	0.0004	0.0009
KCNQ2\|KCNV2\|KCND2\| \|
blue	GO:0005244	voltage-gated ion channel activity	190	5	0.46	10.93	8.67e-05	0.0011
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
blue	GO:0022832	voltage-gated channel activity	190	5	0.46	10.93	8.67e-05	0.0011
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
blue	GO:0005272	sodium channel activity	32	3	0.08	38.93	6.08e-05	0.0011
SCN9A\|SCN5A\|SCN3A \|
green	GO:0043176	amine binding	109	4	0.37	10.84	0.0005	0.0012
CHRNA7\|GRIN2A\|GRIN2B\|CHRNB2 \|
grey	GO:0005267	potassium channel activity	129	3	0.20	14.89	0.0010	0.0019
KCNQ2\|KCNV2\|KCND2\| \|
grey	GO:0015276	ligand-gated ion channel activity	127	3	0.20	15.12	0.0010	0.0019
CHRNA2\|CHRNA4\|CHRFAM7A\| \|
grey	GO:0022834	ligand-gated channel activity	127	3	0.20	15.12	0.0010	0.0019
CHRNA2\|CHRNA4\|CHRFAM7A\| \|
grey	GO:0030955	potassium ion binding	127	3	0.20	15.12	0.0010	0.0019
KCNQ2\|KCNV2\|KCND2\| \|
grey	GO:0022843	voltage-gated cation channel activity	143	3	0.22	13.43	0.0014	0.0025
KCNQ2\|KCNV2\|KCND2\| \|
green	GO:0043167	ion binding	4232	25	14.32	1.75	0.0013	0.003
SCN1A\|CLCN4\|KCNQ3\|KCNH5\|SCN8A\|CACNA1A\|MRS2\|PRICKLE1\|RYR2\|SLC25A12\|GABRG2\|HCN2\|CACNB4\|KCNT1\|GRIN2B\| GABRA1\|GABRD\|GABRB3\|PTEN\|SCN1B\|SLC9A6\|PRICKLE2\|GRIN2A\|SCN2A\|HCN1 \|
green	GO:0005516	calmodulin binding	140	4	0.47	8.44	0.0013	0.003
RYR2\|KCNH5\|CACNA1A\|MYO5A \|
blue	GO:0005261	cation channel activity	269	5	0.65	7.72	0.0004	0.0041
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
blue	GO:0022836	gated channel activity	306	5	0.74	6.79	0.0008	0.007
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
blue	GO:0046873	metal ion transmembrane transporter activity	320	5	0.77	6.49	0.0010	0.0076
SCN9A\|KCTD7\|SCN5A\|SCN3A\|CACNA1H \|
grey	GO:0031420	alkali metal ion binding	227	3	0.35	8.46	0.0051	0.0089
KCNQ2\|KCNV2\|KCND2\| \|