A genetic resource for genes and mutations related to epilepsy
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Pathway commons enrichment analysis
| Gene type | Term | Number of reference genes | Number of genes | Expecteed number | Ratio of enrichment | P-Value | Adjusted P-Value | Genes related |
|---|---|---|---|---|---|---|---|---|
| blue | p75(NTR)-mediated signaling | 153 | 4 | 0.14 | 28.22 | 1.26e-05 | 7.56E-05 | |
| blue | Neurotrophic factor-mediated Trk receptor signaling | 82 | 3 | 0.08 | 39.49 | 6.22e-05 | 0.0002 | |
| blue | Proteogylcan syndecan-mediated signaling events | 153 | 3 | 0.14 | 21.17 | 0.0004 | 0.0008 | |
| green | Signalling by NGF | 119 | 3 | 0.14 | 20.78 | 0.0004 | 0.0016 | |
| blue | IFN-gamma pathway | 342 | 3 | 0.32 | 9.47 | 0.0039 | 0.0059 | |
| green | Regulation of beta-cell development | 280 | 3 | 0.34 | 8.83 | 0.0048 | 0.0064 | |
| green | Regulation of gene expression in beta cells | 269 | 3 | 0.33 | 9.19 | 0.0043 | 0.0064 | |
| green | Diabetes pathways | 317 | 3 | 0.38 | 7.80 | 0.0068 | 0.0068 | |
| blue | Glypican 1 network | 404 | 3 | 0.37 | 8.02 | 0.0062 | 0.0074 | |
| blue | Glypican pathway | 436 | 3 | 0.40 | 7.43 | 0.0077 | 0.0077 | |
KEGG pathway
| Gene type | Term | Number of reference genes | Number of genes | Expecteed number | Ratio of enrichment | P-Value | Adjusted P-Value | Genes related |
|---|---|---|---|---|---|---|---|---|
| green | Neuroactive ligand-receptor interaction | 256 | 6 | 0.31 | 19.32 | 7.03e-07 | 3.52E-06 | |
| grey | Lysosome | 117 | 3 | 0.06 | 48.44 | 3.26e-05 | 6.52E-05 | |
| green | Cardiac muscle contraction | 79 | 3 | 0.10 | 31.30 | 0.0001 | 0.0001 | |
| green | Endocytosis | 187 | 4 | 0.23 | 17.63 | 8.11e-05 | 0.0001 | |
| green | Calcium signaling pathway | 178 | 4 | 0.22 | 18.52 | 6.70e-05 | 0.0001 | |
| grey | Metabolic pathways | 1104 | 5 | 0.58 | 8.56 | 0.0002 | 0.0002 | |
| blue | Ubiquitin mediated proteolysis | 138 | 3 | 0.13 | 23.47 | 0.0003 | 0.0006 | |
| blue | MAPK signaling pathway | 269 | 3 | 0.25 | 12.04 | 0.0020 | 0.002 | |
| brown | Metabolic pathways | 1104 | 4 | 0.73 | 5.48 | 0.0058 | 0.0058 | |
WIKI pathway
| Gene type | Term | Number of reference genes | Number of genes | Expecteed number | Ratio of enrichment | P-Value | Adjusted P-Value | Genes related |
|---|---|---|---|---|---|---|---|---|
| green | Calcium Regulation in the Cardiac Cell | 148 | 3 | 0.18 | 16.71 | 0.0008 | 0.0008 | |
| RYR2|GNAO1|CACNA1A | | ||||||||