Neuropsychiatric De novo Mutations Database

Pathway Commons

Other pathways: Gene Ontology Transcription Factor Target MicroRNA Target KEGG Wikipathways Pathway Commons

Including 209 pathway commons in ASD, 31 in ID, 130 in EE and 190 in SCZ.

pc accession	pc pathway name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	Raw P_Value	Adjusted P_Value	Other disease
DB_ID:1637	Proteoglycan syndecan-mediated signaling events	1345	36	10.45	3.45	1.49e-10	4.25e-08	ID SCZ
DNMT3A \| TSC2 \| TCF3 \| PPM1D \| DGKA \| NCKAP1 \| PRKCA \| PSEN1 \| TF \| CSDE1 \| CHD7 \| CAD \| SUV420H1 \| EPHB2 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| CASK \| APH1A \| TBL1XR1 \| LRP1 \| CUL3 \| ITGA5 \| EIF4A1 \| SMARCC2 \| TCF7L1 \| HSPA4 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1499	Integrin family cell surface interactions	1378	35	10.70	3.27	1.08e-09	1.54e-07	ID SCZ
DNMT3A \| TSC2 \| TCF3 \| PPM1D \| DGKA \| NCKAP1 \| PRKCA \| TF \| LAMB3 \| CAD \| CSDE1 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| C3 \| TBL1XR1 \| LRP1 \| CUL3 \| ITGA5 \| EIF4A1 \| SMARCC2 \| TCF7L1 \| PAOX \| HSPA4 \| FBN1 \| SVIL \| TLE1 \| PDGFD \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:143	Neuronal System	188	13	1.46	8.90	3.38e-09	2.19e-07	EE ID SCZ
GABRB3 \| RIMS1 \| ADCY5 \| KCNMA1 \| SLC6A3 \| KCND2 \| KCNC1 \| SLC6A1 \| STXBP1 \| SLC6A13 \| RPS6KA3 \| KCNS1
DB_ID:1619	Endothelins	1307	33	10.15	3.25	3.85e-09	2.19e-07	ID SCZ
DNMT3A \| TSC2 \| TCF3 \| PPM1D \| DGKA \| NCKAP1 \| PRKCA \| TF \| CAD \| CSDE1 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| TBL1XR1 \| LRP1 \| CUL3 \| ITGA5 \| EIF4A1 \| SMARCC2 \| GNAS \| TCF7L1 \| HSPA4 \| ADCY5 \| TLE1 \| PDGFD \| SVIL \| MAPK13 \| ROCK1 \| APAF1 \| RPS6KA3
DB_ID:1517	Beta1 integrin cell surface interactions	1351	34	10.49	3.24	2.39e-09	2.19e-07	ID SCZ
DNMT3A \| TSC2 \| TCF3 \| PPM1D \| DGKA \| NCKAP1 \| PRKCA \| TF \| LAMB3 \| CAD \| CSDE1 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| TBL1XR1 \| LRP1 \| CUL3 \| ITGA5 \| EIF4A1 \| SMARCC2 \| TCF7L1 \| PAOX \| HSPA4 \| FBN1 \| TLE1 \| PDGFD \| SVIL \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1480	TRAIL signaling pathway	1328	33	10.32	3.20	5.66e-09	2.69e-07	ID SCZ
DNMT3A \| TSC2 \| SLK \| TCF3 \| PPM1D \| DGKA \| NCKAP1 \| PRKCA \| TF \| CAD \| CSDE1 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| TBL1XR1 \| LRP1 \| CUL3 \| ITGA5 \| EIF4A1 \| SMARCC2 \| TCF7L1 \| HSPA4 \| MADD \| TLE1 \| PDGFD \| SVIL \| MAPK13 \| ROCK1 \| APAF1 \| RPS6KA3
DB_ID:1665	NOTCH	57	8	0.44	18.07	1.45e-08	2.87e-07	SCZ
HIVEP3 \| DLL1 \| APH1A \| TCF3 \| PIK3R2 \| TLE1 \| NOTCH3
DB_ID:1556	Plasma membrane estrogen receptor signaling	1301	32	10.11	3.17	1.24e-08	2.87e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| GNAS \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1573	ErbB receptor signaling network	1312	32	10.19	3.14	1.51e-08	2.87e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| GRIN2B \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1516	Signaling events mediated by VEGFR1 and VEGFR2	1296	32	10.07	3.18	1.13e-08	2.87e-07	ID SCZ
DNMT3A \| MYOF \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1472	Nectin adhesion pathway	1295	32	10.06	3.18	1.11e-08	2.87e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| PTPRM \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1635	Sphingosine 1-phosphate (S1P) pathway	1311	32	10.18	3.14	1.48e-08	2.87e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| MADD \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1575	VEGF and VEGFR signaling network	1304	32	10.13	3.16	1.31e-08	2.87e-07	ID SCZ
DNMT3A \| MYOF \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1578	Alpha9 beta1 integrin signaling events	1305	32	10.14	3.16	1.33e-08	2.87e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| PAOX \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1454	Syndecan-1-mediated signaling events	1300	32	10.10	3.17	1.22e-08	2.87e-07	ID SCZ
CASK \| DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1540	PDGFR-beta signaling pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1466	Insulin Pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1497	PDGF receptor signaling network	1293	31	10.04	3.09	3.77e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1553	Class I PI3K signaling events	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1509	Internalization of ErbB1	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1627	IL5-mediated signaling events	1292	31	10.04	3.09	3.71e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1648	Class I PI3K signaling events mediated by Akt	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1554	Arf6 signaling events	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1461	GMCSF-mediated signaling events	1292	31	10.04	3.09	3.71e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1564	IL3-mediated signaling events	1295	31	10.06	3.08	3.90e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1585	Arf6 downstream pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1550	EGF receptor (ErbB1) signaling pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1531	PAR1-mediated thrombin signaling events	1299	31	10.09	3.07	4.18e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1552	Thrombin/protease-activated receptor (PAR) pathway	1300	31	10.10	3.07	4.26e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1603	EGFR-dependent Endothelin signaling events	1289	31	10.01	3.10	3.52e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1602	ErbB1 downstream signaling	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1571	mTOR signaling pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1529	IFN-gamma pathway	1296	31	10.07	3.08	3.97e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1459	Glypican pathway	1338	32	10.39	3.08	2.38e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CHD7 \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1482	IGF1 pathway	1291	31	10.03	3.09	3.64e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1594	S1P1 pathway	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1519	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1615	Arf6 trafficking events	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1491	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	1293	31	10.04	3.09	3.77e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1492	Glypican 1 network	1299	31	10.09	3.07	4.18e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1574	Signaling events mediated by focal adhesion kinase	1288	31	10.00	3.10	3.46e-08	2.96e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1649	LKB1 signaling events	1308	31	10.16	3.05	4.88e-08	3.31e-07	ID SCZ
DNMT3A \| TSC2 \| TBL1XR1 \| TCF3 \| PPM1D \| CUL3 \| DGKA \| LRP1 \| ITGA5 \| EIF4A1 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| CAD \| CSDE1 \| TCF7L1 \| HSPA4 \| SUV420H1 \| PTEN \| CHD8 \| ITGB3 \| PAK2 \| SVIL \| PDGFD \| TLE1 \| MAPK13 \| APAF1 \| ROCK1 \| RPS6KA3
DB_ID:1488	CDC42 signaling events	757	22	5.88	3.74	1.61e-07	1.07e-06	ID SCZ
ABI2 \| TSC2 \| TBL1XR1 \| TCF3 \| TRIO \| CUL3 \| DGKA \| SPATA13 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| TCF7L1 \| SUV420H1 \| PTEN \| CHD8 \| PAK2 \| SVIL \| TLE1 \| MAPK13 \| ROCK1
DB_ID:20	Axon guidance	219	12	1.70	7.05	1.77e-07	1.15e-06	ID SCZ
EPHB2 \| ANK2 \| PAK2 \| ITGB3 \| MYH9 \| CACNA1S \| ROCK1 \| CACNA1D \| MYH10 \| PLXNB1 \| RPS6KA3
DB_ID:1456	Regulation of CDC42 activity	770	22	5.98	3.68	2.15e-07	1.36e-06	ID SCZ
ABI2 \| TSC2 \| TBL1XR1 \| TCF3 \| TRIO \| CUL3 \| DGKA \| SPATA13 \| NCKAP1 \| SMARCC2 \| PRKCA \| TF \| TCF7L1 \| SUV420H1 \| PTEN \| CHD8 \| PAK2 \| SVIL \| TLE1 \| MAPK13 \| ROCK1
DB_ID:150	Transmission across Chemical Synapses	121	9	0.94	9.58	4.87e-07	3.02e-06	EE ID SCZ
GABRB3 \| RIMS1 \| ADCY5 \| SLC6A3 \| SLC6A1 \| STXBP1 \| SLC6A13 \| RPS6KA3
DB_ID:1604	Syndecan-4-mediated signaling events	209	11	1.62	6.78	8.58e-07	5.20e-06	ID SCZ
CHD7 \| TCF7L1 \| TBL1XR1 \| CHD8 \| CUL3 \| SVIL \| ITGA5 \| TLE1 \| ROCK1 \| PRKCA
DB_ID:1546	Integrin-linked kinase signaling	656	18	5.10	3.53	4.83e-06	2.87e-05	ID SCZ
TSC2 \| TBL1XR1 \| TCF3 \| NACA \| CUL3 \| DGKA \| SMARCC2 \| PRKCA \| TF \| TCF7L1 \| SUV420H1 \| CHD8 \| PTEN \| PAK2 \| SVIL \| TLE1 \| MAPK13
DB_ID:164	GABA synthesis, release, reuptake and degradation	17	4	0.13	30.29	7.86e-06	4.57e-05	ID
SLC6A1 \| RIMS1 \| STXBP1
DB_ID:1565	AP-1 transcription factor network	623	17	4.84	3.51	9.52e-06	5.43e-05	ID SCZ
TSC2 \| TBL1XR1 \| TCF3 \| CUL3 \| DGKA \| SMARCC2 \| PRKCA \| TF \| TCF7L1 \| SUV420H1 \| CHD8 \| PTEN \| PAK2 \| SVIL \| TLE1 \| MAPK13
DB_ID:965	Na+/Cl- dependent neurotransmitter transporters	18	4	0.14	28.61	1.00e-05	5.59e-05	-
SLC6A1 \| SLC6A13 \| SLC6A3
DB_ID:1535	Noncanonical Wnt signaling pathway	182	9	1.41	6.37	1.41e-05	7.73e-05	ID SCZ
CHD7 \| TCF7L1 \| TBL1XR1 \| CHD8 \| CUL3 \| SVIL \| TLE1 \| ROCK1
DB_ID:18	Sema4D induced cell migration and growth-cone collapse	22	4	0.17	23.41	2.34e-05	0.0001	SCZ
MYH9 \| ROCK1 \| MYH10
DB_ID:863	Deadenylation of mRNA	22	4	0.17	23.41	2.34e-05	0.0001	-
EIF4A1 \| CNOT6 \| CNOT4
DB_ID:1572	RAC1 signaling pathway	205	9	1.59	5.65	3.60e-05	0.0002	ID
ABI2 \| PTEN \| PAK2 \| TRIO \| CUL3 \| SPATA13 \| ROCK1 \| NCKAP1
DB_ID:466	Signaling by PDGF	78	6	0.61	9.90	3.37e-05	0.0002	SCZ
NOTCH3 \| PRKCA \| TSC2 \| PTEN \| ADCY5
DB_ID:16	Sema4D in semaphorin signaling	27	4	0.21	19.07	5.45e-05	0.0002	SCZ
MYH9 \| ROCK1 \| MYH10
DB_ID:937	Transmembrane transport of small molecules	379	12	2.94	4.08	4.83e-05	0.0002	EE
GNAS \| GABRB3 \| SLC7A7 \| ADCY5 \| SLC6A3 \| SLC6A5 \| SLC6A1 \| SLC4A2 \| SLC5A1 \| TF \| ATP10D
DB_ID:11	Developmental Biology	433	13	3.36	3.87	4.06e-05	0.0002	ID SCZ
EPHB2 \| ANK2 \| TCF3 \| PAK2 \| ITGB3 \| MYH9 \| CACNA1S \| ROCK1 \| CACNA1D \| MYH10 \| PLXNB1 \| RPS6KA3
DB_ID:1435	Wnt signaling network	200	9	1.55	5.79	2.97e-05	0.0002	ID SCZ
CHD7 \| TCF7L1 \| TBL1XR1 \| CHD8 \| CUL3 \| SVIL \| TLE1 \| ROCK1
DB_ID:1647	RhoA signaling pathway	205	9	1.59	5.65	3.60e-05	0.0002	ID
ABI2 \| PTEN \| PAK2 \| TRIO \| CUL3 \| SPATA13 \| ROCK1 \| NCKAP1
DB_ID:1530	Regulation of RAC1 activity	205	9	1.59	5.65	3.60e-05	0.0002	ID
ABI2 \| PTEN \| PAK2 \| TRIO \| CUL3 \| SPATA13 \| ROCK1 \| NCKAP1
DB_ID:157	Neurotransmitter Release Cycle	26	4	0.20	19.81	4.67e-05	0.0002	ID
SLC6A1 \| RIMS1 \| STXBP1
DB_ID:1650	Regulation of RhoA activity	205	9	1.59	5.65	3.60e-05	0.0002	ID
ABI2 \| PTEN \| PAK2 \| TRIO \| CUL3 \| SPATA13 \| ROCK1 \| NCKAP1
DB_ID:1471	Glypican 3 network	206	9	1.60	5.62	3.74e-05	0.0002	ID SCZ
CHD7 \| TCF7L1 \| TBL1XR1 \| CHD8 \| CUL3 \| SVIL \| TLE1 \| ROCK1
DB_ID:646	Amine compound SLC transporters	29	4	0.23	17.76	7.29e-05	0.0003	-
SLC6A1 \| SLC6A13 \| SLC6A3
DB_ID:254	Signalling by NGF	143	7	1.11	6.30	0.0001	0.0004	SCZ
PRKCA \| TSC2 \| PTEN \| PSEN1 \| ADCY5 \| RPS6KA3
DB_ID:21	Semaphorin interactions	64	5	0.50	10.06	0.0001	0.0004	SCZ
MYH9 \| ROCK1 \| MYH10 \| PLXNB1
DB_ID:1457	Notch-mediated HES/HEY network	94	6	0.73	8.22	9.63e-05	0.0004	ID SCZ
TLE1 \| NOTCH3 \| DLL1 \| PSEN1 \| APH1A
DB_ID:634	Metabolism	824	18	6.40	2.81	9.53e-05	0.0004	SCZ
SUCLA2 \| EIF4A1 \| PRKCA \| NAPRT1 \| SDHA \| CYP4F3 \| ETFB \| CNOT3 \| TPK1 \| GNAS \| CAD \| PAOX \| ADCY5 \| CNOT6 \| STXBP1 \| CNOT4 \| CHRM3
DB_ID:331	Signal Transduction	1231	23	9.56	2.41	0.0001	0.0004	-
C3 \| TSC2 \| DGKA \| ITGA5 \| LAMC3 \| PRKCA \| PSEN1 \| HRH2 \| PLXNB1 \| GNAS \| DLL1 \| FBN1 \| PTEN \| GRM7 \| ADCY5 \| VIP \| ITGB3 \| PIK3R2 \| OPRL1 \| ROCK1 \| NOTCH3 \| CHRM3
DB_ID:1625	Notch signaling pathway	94	6	0.73	8.22	9.63e-05	0.0004	ID SCZ
TLE1 \| NOTCH3 \| DLL1 \| PSEN1 \| APH1A
DB_ID:851	Regulation of Insulin Secretion by Acetylcholine	3	2	0.02	85.82	0.0002	0.0007	-
PRKCA
DB_ID:289	NGF signalling via TRKA from the plasma membrane	107	6	0.83	7.22	0.0002	0.0007	SCZ
PRKCA \| TSC2 \| PTEN \| ADCY5 \| RPS6KA3
DB_ID:64	Hemostasis	376	11	2.92	3.77	0.0002	0.0007	-
GNAS \| TTN \| PRCP \| EHD2 \| KCNMA1 \| PIK3R2 \| ITGB3 \| DGKA \| ITGA5 \| PRKCA
DB_ID:1542	Canonical Wnt signaling pathway	155	7	1.20	5.81	0.0002	0.0007	ID SCZ
SVIL \| TLE1 \| TCF7L1 \| TBL1XR1 \| CHD8 \| RPS6KA3
DB_ID:1467	C-MYC pathway	149	7	1.16	6.05	0.0002	0.0007	SCZ
CSDE1 \| CAD \| EIF4A1 \| HSPA4 \| DNMT3A \| TSC2
DB_ID:467	Downstream signal transduction	75	5	0.58	8.58	0.0003	0.0011	SCZ
PRKCA \| TSC2 \| PTEN \| ADCY5
DB_ID:1490	Syndecan-3-mediated signaling events	17	3	0.13	22.72	0.0003	0.0011	-
CASK \| PSEN1
DB_ID:161	Reuptake of GABA	4	2	0.03	64.37	0.0004	0.0014	-
SLC6A1
DB_ID:1621	Presenilin action in Notch and Wnt signaling	46	4	0.36	11.19	0.0005	0.0017	-
TLE1 \| DLL1 \| PSEN1
DB_ID:862	Deadenylation-dependent mRNA decay	46	4	0.36	11.19	0.0005	0.0017	-
EIF4A1 \| CNOT6 \| CNOT4
DB_ID:812	Integration of energy metabolism	83	5	0.64	7.76	0.0005	0.0017	SCZ
GNAS \| PRKCA \| STXBP1 \| ADCY5
DB_ID:809	Regulation of Insulin Secretion	48	4	0.37	10.73	0.0005	0.0017	-
GNAS \| PRKCA \| STXBP1
DB_ID:482	G alpha (12/13) signalling events	21	3	0.16	18.39	0.0006	0.0020	-
ROCK1 \| PLXNB1
DB_ID:1600	TNF receptor signaling pathway	299	9	2.32	3.88	0.0006	0.0020	ID
TSC2 \| SLK \| TCF3 \| PAK2 \| MADD \| DGKA \| MAPK13 \| APAF1
DB_ID:450	Signaling by Notch	21	3	0.16	18.39	0.0006	0.0020	-
NOTCH3 \| DLL1
DB_ID:1547	Regulation of nuclear beta catenin signaling and target gene transcription	135	6	1.05	5.72	0.0007	0.0023	ID SCZ
SVIL \| TLE1 \| TCF7L1 \| TBL1XR1 \| CHD8
DB_ID:56	Platelet activation, signaling and aggregation	139	6	1.08	5.56	0.0008	0.0026	-
TTN \| PRKCA \| TF \| PIK3R2 \| ITGB3
DB_ID:973	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	95	5	0.74	6.78	0.0009	0.0029	ID
SLC6A1 \| SLC5A1 \| SLC6A13 \| SLC6A3
DB_ID:562	Vitamin D (calciferol) metabolism	7	2	0.05	36.78	0.0012	0.0037	-
CUBN
DB_ID:1498	EphrinB-EPHB pathway	60	4	0.47	8.58	0.0012	0.0037	-
ROCK1 \| EPHB2 \| TF
DB_ID:1469	Stabilization and expansion of the E-cadherin adherens junction	275	8	2.14	3.75	0.0015	0.0045	ID SCZ
TCF7L1 \| TBL1XR1 \| CHD8 \| TLE1 \| SVIL \| ROCK1 \| NCKAP1
DB_ID:956	Nephrin interactions	29	3	0.23	13.32	0.0015	0.0045	-
CASK \| KIRREL3
DB_ID:1544	E-cadherin signaling in the nascent adherens junction	275	8	2.14	3.75	0.0015	0.0045	ID SCZ
TCF7L1 \| TBL1XR1 \| CHD8 \| TLE1 \| SVIL \| ROCK1 \| NCKAP1
DB_ID:910	Import of palmitoyl-CoA into the mitochondrial matrix	8	2	0.06	32.18	0.0016	0.0046	-
ACACB
DB_ID:241	PI3K/AKT activation	30	3	0.23	12.87	0.0016	0.0046	EE
TSC2 \| PTEN
DB_ID:446	Notch receptor binds with a ligand	8	2	0.06	32.18	0.0016	0.0046	-
NOTCH3
DB_ID:463	A third proteolytic cleavage releases NICD	8	2	0.06	32.18	0.0016	0.0046	-
NOTCH3
DB_ID:1617	E-cadherin signaling events	280	8	2.17	3.68	0.0017	0.0048	ID SCZ
TCF7L1 \| TBL1XR1 \| CHD8 \| TLE1 \| SVIL \| ROCK1 \| NCKAP1
DB_ID:472	Signaling by SCF-KIT	66	4	0.51	7.80	0.0018	0.0050	-
PRKCA \| TSC2 \| PTEN
DB_ID:325	Downstream signaling of activated FGFR	66	4	0.51	7.80	0.0018	0.0050	SCZ
PRKCA \| TSC2 \| PTEN
DB_ID:462	Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor	9	2	0.07	28.61	0.0021	0.0056	-
NOTCH3
DB_ID:159	Serotonin Neurotransmitter Release Cycle	9	2	0.07	28.61	0.0021	0.0056	-
RIMS1
DB_ID:1644	BMP receptor signaling	226	7	1.76	3.99	0.0021	0.0056	-
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2 \| RGMA
DB_ID:1641	Effects of Botulinum toxin	9	2	0.07	28.61	0.0021	0.0056	-
RIMS1
DB_ID:155	Dopamine Neurotransmitter Release Cycle	9	2	0.07	28.61	0.0021	0.0056	-
RIMS1
DB_ID:530	Integrin cell surface interactions	72	4	0.56	7.15	0.0024	0.0063	-
ITGA5 \| LAMC3 \| FBN1
DB_ID:178	Potassium Channels	76	4	0.59	6.78	0.0030	0.0078	EE ID
KCNC1 \| KCNMA1 \| KCND2
DB_ID:158	Glutamate Neurotransmitter Release Cycle	11	2	0.09	23.41	0.0032	0.0081	-
RIMS1
DB_ID:154	Acetylcholine Neurotransmitter Release Cycle	11	2	0.09	23.41	0.0032	0.0081	-
RIMS1
DB_ID:156	Norepinephrine Neurotransmitter Release Cycle	11	2	0.09	23.41	0.0032	0.0081	-
RIMS1
DB_ID:44	L1CAM interactions	79	4	0.61	6.52	0.0034	0.0085	ID
EPHB2 \| ANK2 \| RPS6KA3
DB_ID:943	SLC-mediated transmembrane transport	248	7	1.93	3.63	0.0034	0.0085	ID
SLC6A1 \| SLC4A2 \| SLC7A7 \| SLC5A1 \| SLC6A13 \| SLC6A3
DB_ID:171	Voltage gated Potassium channels	39	3	0.30	9.90	0.0035	0.0087	EE ID
KCNC1 \| KCND2
DB_ID:73	Response to elevated platelet cytosolic Ca2+	40	3	0.31	9.66	0.0037	0.0089	EE
TTN \| PRKCA
DB_ID:1545	EPHB forward signaling	40	3	0.31	9.66	0.0037	0.0089	-
ROCK1 \| EPHB2
DB_ID:1494	N-cadherin signaling events	251	7	1.95	3.59	0.0037	0.0089	ID SCZ
SVIL \| TLE1 \| TCF7L1 \| ROCK1 \| TBL1XR1 \| CHD8
DB_ID:1549	p38 MAPK signaling pathway	189	6	1.47	4.09	0.0037	0.0089	-
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2
DB_ID:919	Fatty acid, triacylglycerol, and ketone body metabolism	83	4	0.64	6.20	0.0041	0.0097	-
ACACB \| TBL1XR1 \| ELOVL1
DB_ID:984	Metabolism of lipids and lipoproteins	258	7	2.00	3.49	0.0043	0.0101	-
SCP2 \| CUBN \| ACACB \| TBL1XR1 \| ELOVL1 \| CPT2
DB_ID:130	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	89	4	0.69	5.79	0.0052	0.0121	EE ID SCZ
GABRB3 \| ADCY5 \| RPS6KA3
DB_ID:1475	Validated nuclear estrogen receptor beta network	15	2	0.12	17.16	0.0059	0.0137	-
C3
DB_ID:1660	Alpha6Beta4Integrin	48	3	0.37	8.05	0.0062	0.0143	-
DST \| PRKCA
DB_ID:306	Signaling by FGFR	95	4	0.74	5.42	0.0065	0.0148	SCZ
PRKCA \| TSC2 \| PTEN
DB_ID:479	Glucagon-type ligand receptors	16	2	0.12	16.09	0.0067	0.0149	-
GNAS
DB_ID:1659	Hedgehog	16	2	0.12	16.09	0.0067	0.0149	-
STK36
DB_ID:1438	LPA4-mediated signaling events	16	2	0.12	16.09	0.0067	0.0149	SCZ
GNAS
DB_ID:516	TCR signaling	50	3	0.39	7.72	0.0070	0.0155	-
PTEN \| PAK2
DB_ID:330	Signaling by EGFR	98	4	0.76	5.25	0.0073	0.0160	SCZ
PRKCA \| TSC2 \| PTEN
DB_ID:847	PKA activation in glucagon signalling	17	2	0.13	15.15	0.0076	0.0165	SCZ
GNAS
DB_ID:1501	Caspase cascade in apoptosis	52	3	0.40	7.43	0.0077	0.0166	ID
APAF1 \| SLK
DB_ID:759	Activated AMPK stimulates fatty-acid oxidation in muscle	18	2	0.14	14.30	0.0085	0.0182	-
ACACB
DB_ID:1006	Costimulation by the CD28 family	55	3	0.43	7.02	0.0090	0.0191	-
PDCD1 \| PAK2
DB_ID:1536	Regulation of p38-alpha and p38-beta	164	5	1.27	3.92	0.0094	0.0197	-
PRKCA \| TSC2 \| TCF3 \| PAK2
DB_ID:872	Citric acid cycle (TCA cycle)	19	2	0.15	13.55	0.0094	0.0197	-
SUCLA2
DB_ID:1512	Posttranslational regulation of adherens junction stability and dissassembly	231	6	1.79	3.34	0.0097	0.0202	ID SCZ
SVIL \| TLE1 \| TCF7L1 \| TBL1XR1 \| CHD8
DB_ID:22	NCAM signaling for neurite out-growth	57	3	0.44	6.78	0.0100	0.0207	-
CACNA1D \| CACNA1S
DB_ID:1500	IL1-mediated signaling events	234	6	1.82	3.30	0.0103	0.0211	-
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2
DB_ID:864	Metabolism of mRNA	235	6	1.83	3.29	0.0105	0.0214	-
EIF4A1 \| CNOT6 \| PRKCA \| CNOT4 \| CNOT3
DB_ID:1458	p38 signaling mediated by MAPKAP kinases	21	2	0.16	12.26	0.0115	0.0231	-
TSC2
DB_ID:302	PIP3 activates AKT signaling	21	2	0.16	12.26	0.0115	0.0231	EE
TSC2
DB_ID:515	Adaptive Immune System	243	6	1.89	3.18	0.0122	0.0243	-
C3 \| PDCD1 \| PTEN \| SEC24D \| PAK2
DB_ID:484	G alpha (z) signalling events	22	2	0.17	11.70	0.0125	0.0247	SCZ
GNAS
DB_ID:458	Signaling by GPCR	823	13	6.39	2.03	0.0130	0.0256	-
GNAS \| C3 \| GRM7 \| ADCY5 \| VIP \| PIK3R2 \| DGKA \| OPRL1 \| ROCK1 \| PRKCA \| HRH2 \| CHRM3
DB_ID:1444	Validated targets of C-MYC transcriptional repression	63	3	0.49	6.13	0.0131	0.0256	-
CSDE1 \| DNMT3A
DB_ID:935	Cell-Cell communication	117	4	0.91	4.40	0.0133	0.0258	-
CASK \| KIRREL3 \| PIK3R2
DB_ID:116	NCAM1 interactions	23	2	0.18	11.19	0.0137	0.0264	SCZ
CACNA1D
DB_ID:981	Regulation of Water Balance by Renal Aquaporins	24	2	0.19	10.73	0.0148	0.0283	SCZ
GNAS
DB_ID:339	CaM pathway	25	2	0.19	10.30	0.0160	0.0300	SCZ
PRKCA
DB_ID:1070	Steroid hormones	25	2	0.19	10.30	0.0160	0.0300	-
CUBN
DB_ID:338	Calmodulin induced events	25	2	0.19	10.30	0.0160	0.0300	SCZ
PRKCA
DB_ID:459	GPCR ligand binding	338	7	2.63	2.67	0.0171	0.0319	-
GNAS \| C3 \| OPRL1 \| GRM7 \| VIP \| HRH2
DB_ID:493	Ca-dependent events	27	2	0.21	9.54	0.0186	0.0335	SCZ
PRKCA
DB_ID:336	DAG and IP3 signaling	27	2	0.21	9.54	0.0186	0.0335	SCZ
PRKCA
DB_ID:321	PI-3K cascade	27	2	0.21	9.54	0.0186	0.0335	EE
TSC2
DB_ID:68	Cell surface interactions at the vascular wall	72	3	0.56	5.36	0.0187	0.0335	-
ITGA5 \| PIK3R2
DB_ID:323	Phospholipase C-mediated cascade	27	2	0.21	9.54	0.0186	0.0335	SCZ
PRKCA
DB_ID:992	Aquaporin-mediated transport	27	2	0.21	9.54	0.0186	0.0335	SCZ
GNAS
DB_ID:1559	FAS (CD95) signaling pathway	130	4	1.01	3.96	0.0189	0.0337	ID
APAF1 \| PRKCA \| SLK
DB_ID:166	CREB phosphorylation through the activation of Ras	28	2	0.22	9.20	0.0199	0.0352	ID
RPS6KA3
DB_ID:71	Platelet degranulation	29	2	0.23	8.88	0.0213	0.0370	EE
TTN
DB_ID:1523	Reelin signaling pathway	29	2	0.23	8.88	0.0213	0.0370	ID SCZ
RELN
DB_ID:337	EGFR interacts with phospholipase C-gamma	29	2	0.23	8.88	0.0213	0.0370	SCZ
PRKCA
DB_ID:1581	Syndecan-2-mediated signaling events	77	3	0.60	5.02	0.0223	0.0385	-
ITGA5 \| CASK
DB_ID:240	PLC-gamma1 signalling	30	2	0.23	8.58	0.0227	0.0387	SCZ
PRKCA
DB_ID:1548	Ephrin B reverse signaling	30	2	0.23	8.58	0.0227	0.0387	-
EPHB2
DB_ID:1664	EGFR1	138	4	1.07	3.73	0.0230	0.0390	SCZ
KRT7 \| PRKCA \| RPS6KA3
DB_ID:865	Metabolism of RNA	282	6	2.19	2.74	0.0235	0.0396	-
EIF4A1 \| CNOT6 \| PRKCA \| CNOT4 \| CNOT3
DB_ID:1484	Lissencephaly gene (LIS1) in neuronal migration and development	31	2	0.24	8.31	0.0241	0.0399	-
RELN
DB_ID:546	Pyruvate metabolism and Citric Acid (TCA) cycle	31	2	0.24	8.31	0.0241	0.0399	-
SUCLA2
DB_ID:476	G alpha (s) signalling events	31	2	0.24	8.31	0.0241	0.0399	SCZ
GNAS
DB_ID:576	Metabolism of steroid hormones and vitamins A and D	32	2	0.25	8.05	0.0256	0.0410	-
CUBN
DB_ID:1493	Validated targets of C-MYC transcriptional activation	81	3	0.63	4.77	0.0254	0.0410	ID SCZ
CAD \| EIF4A1
DB_ID:308	GAB1 signalosome	32	2	0.25	8.05	0.0256	0.0410	EE
TSC2
DB_ID:580	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	32	2	0.25	8.05	0.0256	0.0410	-
TBL1XR1
DB_ID:475	G alpha (i) signalling events	32	2	0.25	8.05	0.0256	0.0410	SCZ
GNAS
DB_ID:43	Recycling pathway of L1	32	2	0.25	8.05	0.0256	0.0410	-
RPS6KA3
DB_ID:846	Glucagon signaling in metabolic regulation	33	2	0.26	7.80	0.0271	0.0431	SCZ
GNAS
DB_ID:1560	C-MYB transcription factor network	85	3	0.66	4.54	0.0287	0.0442	-
SND1 \| PAX5
DB_ID:140	Activation of NMDA receptor upon glutamate binding and postsynaptic events	34	2	0.26	7.57	0.0287	0.0442	ID SCZ
RPS6KA3
DB_ID:1024	RNA Polymerase III Abortive And Retractive Initiation	34	2	0.26	7.57	0.0287	0.0442	-
SNAPC5
DB_ID:1569	Glucocorticoid receptor signaling	85	3	0.66	4.54	0.0287	0.0442	SCZ
GNAS \| SUV420H1
DB_ID:1023	RNA Polymerase III Transcription	34	2	0.26	7.57	0.0287	0.0442	-
SNAPC5
DB_ID:142	Post NMDA receptor activation events	34	2	0.26	7.57	0.0287	0.0442	ID SCZ
RPS6KA3
DB_ID:27	Signal transduction by L1	35	2	0.27	7.36	0.0302	0.0460	-
ANK2
DB_ID:1005	Downstream TCR signaling	35	2	0.27	7.36	0.0302	0.0460	-
PTEN
DB_ID:495	Amine ligand-binding receptors	36	2	0.28	7.15	0.0319	0.0479	-
HRH2
DB_ID:1000	CD28 co-stimulation	36	2	0.28	7.15	0.0319	0.0479	-
PAK2
DB_ID:192	GABA receptor activation	36	2	0.28	7.15	0.0319	0.0479	EE SCZ
GABRB3
DB_ID:1611	Regulation of nuclear SMAD2/3 signaling	305	6	2.37	2.53	0.0327	0.0483	SCZ
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2
DB_ID:1440	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	305	6	2.37	2.53	0.0327	0.0483	SCZ
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2
DB_ID:1510	TGF-beta receptor signaling	305	6	2.37	2.53	0.0327	0.0483	SCZ
MAPK13 \| PRKCA \| TSC2 \| TCF3 \| PAK2 \| DGKA

Pathway Commons pathway

pc accession	pc pathway name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	Raw P_Value	Adjusted P_Value	Other disease
DB_ID:143	Neuronal System	188	8	0.45	17.65	2.02e-08	1.59e-06	EE ASD SCZ
KCNQ3 \| KCNA1 \| DLG4 \| SLC6A1 \| GRIN2A \| STXBP1 \| CAMK2G
DB_ID:141	Unblocking of NMDA receptor, glutamate binding and activation	11	4	0.03	150.79	1.04e-08	1.59e-06	-
DLG4 \| GRIN2A \| CAMK2G
DB_ID:197	CREB phosphorylation through the activation of CaMKII	15	4	0.04	110.58	4.27e-08	2.23e-06	-
DLG4 \| GRIN2A \| CAMK2G
DB_ID:167	Ras activation uopn Ca2+ infux through NMDA receptor	17	4	0.04	97.57	7.41e-08	2.91e-06	-
DLG4 \| GRIN2A \| CAMK2G
DB_ID:1573	ErbB receptor signaling network	1312	15	3.16	4.74	6.19e-07	1.24e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DLG4 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G \| GRIN2B
DB_ID:1662	TGFBR	125	6	0.30	19.90	6.32e-07	1.24e-05	SCZ
CTCF \| RB1 \| CTNNB1 \| SMAD6 \| RBL2
DB_ID:166	CREB phosphorylation through the activation of Ras	28	4	0.07	59.24	6.25e-07	1.24e-05	ASD
DLG4 \| GRIN2A \| CAMK2G
DB_ID:150	Transmission across Chemical Synapses	121	6	0.29	20.56	5.22e-07	1.24e-05	EE ASD SCZ
SLC6A1 \| DLG4 \| GRIN2A \| STXBP1 \| CAMK2G
DB_ID:140	Activation of NMDA receptor upon glutamate binding and postsynaptic events	34	4	0.08	48.79	1.40e-06	2.20e-05	ASD SCZ
DLG4 \| GRIN2A \| CAMK2G
DB_ID:142	Post NMDA receptor activation events	34	4	0.08	48.79	1.40e-06	2.20e-05	ASD SCZ
DLG4 \| GRIN2A \| CAMK2G
DB_ID:1037	Apoptotic cleavage of cell adhesion proteins	12	3	0.03	103.67	2.95e-06	4.21e-05	-
CTNNB1 \| DSP
DB_ID:1480	TRAIL signaling pathway	1328	14	3.20	4.37	3.87e-06	5.06e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G \| MAP3K1
DB_ID:1564	IL3-mediated signaling events	1295	13	3.12	4.16	1.48e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1575	VEGF and VEGFR signaling network	1304	13	3.14	4.13	1.59e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1619	Endothelins	1307	13	3.15	4.12	1.63e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1603	EGFR-dependent Endothelin signaling events	1289	13	3.11	4.18	1.41e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1553	Class I PI3K signaling events	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1497	PDGF receptor signaling network	1293	13	3.12	4.17	1.46e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1578	Alpha9 beta1 integrin signaling events	1305	13	3.15	4.13	1.60e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1519	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1491	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	1293	13	3.12	4.17	1.46e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1540	PDGFR-beta signaling pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1649	LKB1 signaling events	1308	13	3.15	4.12	1.64e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1516	Signaling events mediated by VEGFR1 and VEGFR2	1296	13	3.13	4.16	1.49e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1602	ErbB1 downstream signaling	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1482	IGF1 pathway	1291	13	3.11	4.18	1.43e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1556	Plasma membrane estrogen receptor signaling	1301	13	3.14	4.14	1.55e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1552	Thrombin/protease-activated receptor (PAR) pathway	1300	13	3.13	4.15	1.54e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1615	Arf6 trafficking events	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1509	Internalization of ErbB1	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1550	EGF receptor (ErbB1) signaling pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1472	Nectin adhesion pathway	1295	13	3.12	4.16	1.48e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1529	IFN-gamma pathway	1296	13	3.13	4.16	1.49e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1571	mTOR signaling pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1585	Arf6 downstream pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1454	Syndecan-1-mediated signaling events	1300	13	3.13	4.15	1.54e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1648	Class I PI3K signaling events mediated by Akt	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1466	Insulin Pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1554	Arf6 signaling events	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:389	Cell Cycle, Mitotic	318	7	0.77	9.13	1.28e-05	5.60e-05	-
DYNC1H1 \| RB1 \| TUBA1A \| STAG1 \| RBL2 \| PSMA7
DB_ID:1492	Glypican 1 network	1299	13	3.13	4.15	1.53e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1531	PAR1-mediated thrombin signaling events	1299	13	3.13	4.15	1.53e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1461	GMCSF-mediated signaling events	1292	13	3.12	4.17	1.44e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1627	IL5-mediated signaling events	1292	13	3.12	4.17	1.44e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1574	Signaling events mediated by focal adhesion kinase	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1594	S1P1 pathway	1288	13	3.11	4.19	1.40e-05	5.60e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1635	Sphingosine 1-phosphate (S1P) pathway	1311	13	3.16	4.11	1.68e-05	5.61e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1459	Glypican pathway	1338	13	3.23	4.03	2.08e-05	6.80e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1637	Proteoglycan syndecan-mediated signaling events	1345	13	3.24	4.01	2.20e-05	7.05e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1517	Beta1 integrin cell surface interactions	1351	13	3.26	3.99	2.30e-05	7.22e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:1499	Integrin family cell surface interactions	1378	13	3.32	3.91	2.83e-05	8.71e-05	ASD SCZ
UBTF \| RB1 \| RAPGEF1 \| CTNNB1 \| TCF4 \| SLC2A1 \| LRP1 \| DSP \| RBL2 \| SMAD6 \| KDM1A \| CAMK2G
DB_ID:99	DNA Replication	261	6	0.63	9.53	4.29e-05	0.0001	-
DYNC1H1 \| RB1 \| TUBA1A \| STAG1 \| PSMA7
DB_ID:1523	Reelin signaling pathway	29	3	0.07	42.90	4.76e-05	0.0001	ASD SCZ
RAPGEF1 \| GRIN2A
DB_ID:1657	Wnt	82	4	0.20	20.23	4.83e-05	0.0001	SCZ
DLG4 \| CTNNB1 \| CAMK2G
DB_ID:130	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	89	4	0.21	18.64	6.66e-05	0.0002	EE ASD SCZ
DLG4 \| GRIN2A \| CAMK2G
DB_ID:1035	Apoptotic cleavage of cellular proteins	39	3	0.09	31.90	0.0001	0.0003	-
CTNNB1 \| DSP
DB_ID:1040	Apoptotic execution phase	48	3	0.12	25.92	0.0002	0.0006	-
CTNNB1 \| DSP
DB_ID:96	Mitotic M-M/G1 phases	242	5	0.58	8.57	0.0003	0.0008	-
DYNC1H1 \| TUBA1A \| STAG1 \| PSMA7
DB_ID:1494	N-cadherin signaling events	251	5	0.61	8.26	0.0004	0.0010	ASD SCZ
CTNNB1 \| DSP \| TCF4 \| CAMK2G
DB_ID:1506	Coregulation of Androgen receptor activity	61	3	0.15	20.39	0.0004	0.0010	-
CTNNB1 \| TCF4
DB_ID:1544	E-cadherin signaling in the nascent adherens junction	275	5	0.66	7.54	0.0006	0.0014	ASD SCZ
RAPGEF1 \| CTNNB1 \| DSP \| TCF4
DB_ID:1068	Apoptosis	158	4	0.38	10.50	0.0006	0.0014	-
CTNNB1 \| DSP \| PSMA7
DB_ID:1469	Stabilization and expansion of the E-cadherin adherens junction	275	5	0.66	7.54	0.0006	0.0014	ASD SCZ
RAPGEF1 \| CTNNB1 \| DSP \| TCF4
DB_ID:1617	E-cadherin signaling events	280	5	0.68	7.41	0.0006	0.0014	ASD SCZ
RAPGEF1 \| CTNNB1 \| DSP \| TCF4
DB_ID:97	M Phase	158	4	0.38	10.50	0.0006	0.0014	-
DYNC1H1 \| TUBA1A \| STAG1
DB_ID:11	Developmental Biology	433	6	1.04	5.75	0.0007	0.0017	ASD SCZ
DLG4 \| MYH9 \| MED13L \| CTNNB1 \| CAP1
DB_ID:164	GABA synthesis, release, reuptake and degradation	17	2	0.04	48.79	0.0008	0.0019	ASD
SLC6A1
DB_ID:1546	Integrin-linked kinase signaling	656	7	1.58	4.42	0.0011	0.0025	ASD SCZ
RB1 \| CTNNB1 \| TCF4 \| ELMO2 \| KDM1A \| SLC2A1
DB_ID:137	Trafficking of AMPA receptors	21	2	0.05	39.49	0.0012	0.0027	-
DLG4
DB_ID:136	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	21	2	0.05	39.49	0.0012	0.0027	-
DLG4
DB_ID:91	Mitotic Metaphase/Anaphase Transition	22	2	0.05	37.70	0.0013	0.0029	-
STAG1
DB_ID:1572	RAC1 signaling pathway	205	4	0.49	8.09	0.0016	0.0033	ASD
RB1 \| CTNNB1 \| NGEF
DB_ID:1530	Regulation of RAC1 activity	205	4	0.49	8.09	0.0016	0.0033	ASD
RB1 \| CTNNB1 \| NGEF
DB_ID:1650	Regulation of RhoA activity	205	4	0.49	8.09	0.0016	0.0033	ASD
RB1 \| CTNNB1 \| NGEF
DB_ID:1647	RhoA signaling pathway	205	4	0.49	8.09	0.0016	0.0033	ASD
RB1 \| CTNNB1 \| NGEF
DB_ID:157	Neurotransmitter Release Cycle	26	2	0.06	31.90	0.0018	0.0037	ASD
SLC6A1
DB_ID:20	Axon guidance	219	4	0.53	7.57	0.0020	0.0041	ASD SCZ
DLG4 \| MYH9 \| CAP1
DB_ID:1636	Regulation of Androgen receptor activity	108	3	0.26	11.52	0.0023	0.0046	SCZ
CTNNB1 \| TCF4
DB_ID:1488	CDC42 signaling events	757	7	1.83	3.83	0.0024	0.0047	ASD SCZ
RB1 \| CTNNB1 \| TCF4 \| KDM1A \| SLC2A1 \| NGEF
DB_ID:1512	Posttranslational regulation of adherens junction stability and dissassembly	231	4	0.56	7.18	0.0024	0.0047	ASD SCZ
CTNNB1 \| DSP \| TCF4
DB_ID:384	G1 Phase	31	2	0.07	26.75	0.0026	0.0050	-
RB1
DB_ID:1456	Regulation of CDC42 activity	770	7	1.86	3.77	0.0027	0.0050	ASD SCZ
RB1 \| CTNNB1 \| TCF4 \| KDM1A \| SLC2A1 \| NGEF
DB_ID:1584	ErbB4 signaling events	32	2	0.08	25.92	0.0027	0.0050	-
DLG4
DB_ID:394	Cyclin D associated events in G1	31	2	0.07	26.75	0.0026	0.0050	-
RB1
DB_ID:1559	FAS (CD95) signaling pathway	130	3	0.31	9.57	0.0039	0.0071	ASD
RB1 \| MAP3K1
DB_ID:1618	Androgen-mediated signaling	130	3	0.31	9.57	0.0039	0.0071	SCZ
CTNNB1 \| TCF4
DB_ID:171	Voltage gated Potassium channels	39	2	0.09	21.27	0.0040	0.0072	EE ASD
KCNQ3
DB_ID:1565	AP-1 transcription factor network	623	6	1.50	3.99	0.0041	0.0073	ASD SCZ
RB1 \| CTNNB1 \| TCF4 \| KDM1A \| SLC2A1
DB_ID:1547	Regulation of nuclear beta catenin signaling and target gene transcription	135	3	0.33	9.22	0.0043	0.0076	ASD SCZ
CTNNB1 \| TCF4
DB_ID:388	Mitotic G1-G1/S phases	141	3	0.34	8.82	0.0049	0.0085	-
RB1 \| RBL2
DB_ID:756	Meiotic Synapsis	47	2	0.11	17.65	0.0058	0.0100	SCZ
STAG1
DB_ID:1557	FoxO family signaling	49	2	0.12	16.93	0.0063	0.0106	EE
CTNNB1
DB_ID:1522	Ceramide signaling pathway	49	2	0.12	16.93	0.0063	0.0106	-
RB1
DB_ID:1542	Canonical Wnt signaling pathway	155	3	0.37	8.03	0.0064	0.0107	ASD SCZ
CTNNB1 \| TCF4
DB_ID:1501	Caspase cascade in apoptosis	52	2	0.13	15.95	0.0071	0.0117	ASD
MAP3K1
DB_ID:351	Loss of Nlp from mitotic centrosomes	61	2	0.15	13.60	0.0096	0.0155	-
DYNC1H1
DB_ID:1535	Noncanonical Wnt signaling pathway	182	3	0.44	6.84	0.0099	0.0155	ASD SCZ
CTNNB1 \| TCF4
DB_ID:354	Loss of proteins required for interphase microtubule organizationÃÂ from the centrosome	61	2	0.15	13.60	0.0096	0.0155	-
DYNC1H1
DB_ID:94	Mitotic Prophase	62	2	0.15	13.38	0.0099	0.0155	-
DYNC1H1
DB_ID:95	Golgi Cisternae Pericentriolar Stack Reorganization	62	2	0.15	13.38	0.0099	0.0155	-
DYNC1H1
DB_ID:1623	Regulation of retinoblastoma protein	66	2	0.16	12.57	0.0112	0.0174	-
UBTF
DB_ID:1513	BCR signaling pathway	67	2	0.16	12.38	0.0115	0.0177	-
CAMK2G
DB_ID:372	Centrosome maturation	70	2	0.17	11.85	0.0125	0.0189	-
DYNC1H1
DB_ID:371	Recruitment of mitotic centrosome proteins and complexes	70	2	0.17	11.85	0.0125	0.0189	-
DYNC1H1
DB_ID:1435	Wnt signaling network	200	3	0.48	6.22	0.0127	0.0190	ASD SCZ
CTNNB1 \| TCF4
DB_ID:758	Meiosis	72	2	0.17	11.52	0.0132	0.0196	SCZ
STAG1
DB_ID:1626	E2F transcription factor network	73	2	0.18	11.36	0.0135	0.0198	-
RB1
DB_ID:1471	Glypican 3 network	206	3	0.50	6.04	0.0137	0.0199	ASD SCZ
CTNNB1 \| TCF4
DB_ID:527	Signaling by Wnt	75	2	0.18	11.06	0.0143	0.0202	-
CTNNB1
DB_ID:528	Degradation of beta-catenin by the destruction complex	75	2	0.18	11.06	0.0143	0.0202	-
CTNNB1
DB_ID:1604	Syndecan-4-mediated signaling events	209	3	0.50	5.95	0.0143	0.0202	ASD SCZ
CTNNB1 \| TCF4
DB_ID:178	Potassium Channels	76	2	0.18	10.91	0.0146	0.0205	EE ASD
KCNQ3
DB_ID:684	Asparagine N-linked glycosylation	77	2	0.19	10.77	0.0150	0.0208	-
TUSC3
DB_ID:380	Cyclin E associated events during G1/S transition	78	2	0.19	10.63	0.0154	0.0208	-
RB1
DB_ID:1656	AndrogenReceptor	78	2	0.19	10.63	0.0154	0.0208	-
RB1
DB_ID:1561	p73 transcription factor network	78	2	0.19	10.63	0.0154	0.0208	-
RB1
DB_ID:44	L1CAM interactions	79	2	0.19	10.50	0.0157	0.0211	ASD
DLG4
DB_ID:1493	Validated targets of C-MYC transcriptional activation	81	2	0.20	10.24	0.0165	0.0220	ASD SCZ
UBTF
DB_ID:439	Switching of origins to a post-replicative state	83	2	0.20	9.99	0.0173	0.0226	-
RB1
DB_ID:440	Orc1 removal from chromatin	83	2	0.20	9.99	0.0173	0.0226	-
RB1
DB_ID:431	Removal of licensing factors from origins	85	2	0.20	9.76	0.0181	0.0235	-
RB1
DB_ID:433	Regulation of DNA replication	88	2	0.21	9.42	0.0193	0.0248	-
RB1
DB_ID:383	Cyclin A:Cdk2-associated events at S phase entry	90	2	0.22	9.22	0.0201	0.0257	-
RB1
DB_ID:1457	Notch-mediated HES/HEY network	94	2	0.23	8.82	0.0218	0.0274	ASD SCZ
RB1
DB_ID:1625	Notch signaling pathway	94	2	0.23	8.82	0.0218	0.0274	ASD SCZ
RB1
DB_ID:973	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	95	2	0.23	8.73	0.0222	0.0277	ASD
SLC6A1
DB_ID:943	SLC-mediated transmembrane transport	248	3	0.60	5.02	0.0224	0.0277	ASD
SLC6A1 \| SLC26A9
DB_ID:366	G2/M Transition	96	2	0.23	8.64	0.0227	0.0278	-
DYNC1H1
DB_ID:364	Mitotic G2-G2/M phases	99	2	0.24	8.38	0.0240	0.0290	-
DYNC1H1
DB_ID:93	Mitotic Prometaphase	99	2	0.24	8.38	0.0240	0.0290	-
STAG1
DB_ID:1476	Neurotrophic factor-mediated Trk receptor signaling	101	2	0.24	8.21	0.0249	0.0298	-
RAPGEF1
DB_ID:437	Synthesis of DNA	109	2	0.26	7.61	0.0287	0.0341	-
RB1
DB_ID:702	Post-translational protein modification	114	2	0.27	7.28	0.0311	0.0367	-
TUSC3
DB_ID:381	G1/S Transition	118	2	0.28	7.03	0.0332	0.0389	-
RB1
DB_ID:382	S Phase	121	2	0.29	6.85	0.0347	0.0404	-
RB1
DB_ID:1600	TNF receptor signaling pathway	299	3	0.72	4.16	0.0360	0.0416	ASD
RB1 \| MAP3K1
DB_ID:1599	ATM pathway	307	3	0.74	4.05	0.0384	0.0440	SCZ
RB1 \| RBL2
DB_ID:522	Immune System	532	4	1.28	3.12	0.0402	0.0457	SCZ
RAPGEF1 \| PSMA7 \| MAP3K1 \| SPTAN1

Pathway Commons pathway

pc accession	pc pathway name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	Raw P_Value	Adjusted P_Value	Other disease
DB_ID:143	Neuronal System	188	8	0.47	16.99	2.72e-08	3.54e-06	ID ASD SCZ
KCNQ2 \| GABRB1 \| KCNB1 \| GABRB3 \| KCNQ3 \| STXBP1 \| KCNH5
DB_ID:171	Voltage gated Potassium channels	39	4	0.10	40.96	2.86e-06	0.0002	ID ASD
KCNQ2 \| KCNB1 \| KCNQ3
DB_ID:178	Potassium Channels	76	4	0.19	21.02	4.15e-05	0.0018	ID ASD
KCNQ2 \| KCNB1 \| KCNQ3
DB_ID:187	GABA A receptor activation	5	2	0.01	159.73	6.18e-05	0.0020	-
GABRB1
DB_ID:978	Ion channel transport	46	3	0.12	26.04	0.0002	0.0043	-
GABRB1 \| GABRB3
DB_ID:1570	Hedgehog signaling events mediated by Gli proteins	48	3	0.12	24.96	0.0002	0.0043	-
IFT172 \| GNAO1
DB_ID:150	Transmission across Chemical Synapses	121	4	0.30	13.20	0.0003	0.0056	ID ASD SCZ
GABRB1 \| GABRB3 \| STXBP1
DB_ID:1446	Signaling events mediated by the Hedgehog family	65	3	0.16	18.43	0.0006	0.0097	-
IFT172 \| GNAO1
DB_ID:985	Ligand-gated ion channel transport	17	2	0.04	46.98	0.0008	0.0116	-
GABRB1
DB_ID:130	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	89	3	0.22	13.46	0.0015	0.0163	ID ASD SCZ
GABRB1 \| GABRB3
DB_ID:1593	CXCR4-mediated signaling events	192	4	0.48	8.32	0.0014	0.0163	SCZ
FLNA \| PTEN \| MTOR
DB_ID:302	PIP3 activates AKT signaling	21	2	0.05	38.03	0.0013	0.0163	ASD
PTEN
DB_ID:321	PI-3K cascade	27	2	0.07	29.58	0.0021	0.0210	ASD
PTEN
DB_ID:71	Platelet degranulation	29	2	0.07	27.54	0.0024	0.0219	ASD
TTN
DB_ID:241	PI3K/AKT activation	30	2	0.08	26.62	0.0026	0.0219	ASD
PTEN
DB_ID:937	Transmembrane transport of small molecules	379	5	0.95	5.27	0.0027	0.0219	ASD
GABRB1 \| GABRB3 \| SLC35A2 \| ATP2B4
DB_ID:308	GAB1 signalosome	32	2	0.08	24.96	0.0029	0.0222	ASD
PTEN
DB_ID:192	GABA receptor activation	36	2	0.09	22.18	0.0037	0.0267	ASD SCZ
GABRB1
DB_ID:1437	CXCR3-mediated signaling events	37	2	0.09	21.59	0.0039	0.0267	-
MTOR
DB_ID:73	Response to elevated platelet cytosolic Ca2+	40	2	0.10	19.97	0.0046	0.0299	ASD
TTN
DB_ID:1557	FoxO family signaling	49	2	0.12	16.30	0.0068	0.0421	ID
CSNK1E \| YWHAG

pc accession	pc pathway name	Number of reference genes	Number of genes	Expected number	Ratio of entrichment	Raw P_Value	Adjusted P_Value	Other disease
DB_ID:1517	Beta1 integrin cell surface interactions	1351	37	8.77	4.22	1.92e-13	4.48e-11	ID ASD
MAPK8 \| SMAD7 \| CAMK4 \| BCAT1 \| COL3A1 \| ICAM1 \| ASAP2 \| ASAP1 \| HUWE1 \| CHD8 \| PYCARD \| ACTA2 \| HSP90AA1 \| TGM2 \| ITSN1 \| NOS3 \| ADCY7 \| COL6A2 \| RB1CC1 \| HSPA8 \| CUL3 \| LRP1 \| ACTN1 \| RUNX3 \| CD14 \| LAMA2 \| SMARCC2 \| NUP214 \| BLNK \| KPNA1 \| TRRAP \| EPHA2 \| HIF1A \| GNAO1 \| PML \| PTK2B
DB_ID:1499	Integrin family cell surface interactions	1378	37	8.95	4.14	3.47e-13	4.48e-11	ID ASD
MAPK8 \| SMAD7 \| CAMK4 \| BCAT1 \| COL3A1 \| ICAM1 \| ASAP2 \| ASAP1 \| HUWE1 \| CHD8 \| PYCARD \| ACTA2 \| HSP90AA1 \| TGM2 \| ITSN1 \| NOS3 \| ADCY7 \| COL6A2 \| RB1CC1 \| HSPA8 \| CUL3 \| LRP1 \| ACTN1 \| RUNX3 \| CD14 \| LAMA2 \| SMARCC2 \| NUP214 \| BLNK \| KPNA1 \| TRRAP \| EPHA2 \| HIF1A \| GNAO1 \| PML \| PTK2B
DB_ID:1619	Endothelins	1307	34	8.49	4.01	8.07e-12	5.31e-10	ID ASD
MAPK8 \| SMAD7 \| CAMK4 \| BCAT1 \| COL3A1 \| ICAM1 \| ASAP2 \| ASAP1 \| HUWE1 \| CHD8 \| PYCARD \| ADCY9 \| ACTA2 \| HSP90AA1 \| ITSN1 \| NOS3 \| ADCY7 \| RB1CC1 \| HSPA8 \| CUL3 \| LRP1 \| ACTN1 \| RUNX3 \| SMARCC2 \| NUP214 \| BLNK \| TRRAP \| KPNA1 \| EPHA2 \| HIF1A \| GNAO1 \| PML \| PTK2B
DB_ID:1649	LKB1 signaling events	1308	34	8.49	4.00	8.24e-12	5.31e-10	ID ASD
MAPK8 \| SMAD7 \| CAMK4 \| BCAT1 \| ICAM1 \| MARK4 \| ASAP2 \| ASAP1 \| HUWE1 \| CHD8 \| BRSK1 \| PYCARD \| ACTA2 \| HSP90AA1 \| ITSN1 \| NOS3 \| ADCY7 \| RB1CC1 \| HSPA8 \| CUL3 \| LRP1 \| ACTN1 \| RUNX3 \| SMARCC2 \| NUP214 \| BLNK \| TRRAP \| KPNA1 \| EPHA2 \| HIF1A \| GNAO1 \| PML \| PTK2B
DB_ID:1459	Glypican pathway	1338	34	8.69	3.91	1.52e-11	7.84e-10	ID ASD
MAPK8 \| SMAD7 \| CAMK4 \| BCAT1 \| ICAM1 \| ASAP2 \| ASAP1 \| HUWE1 \| CHD8 \| PYCARD \| ACTA2 \| HSP90AA1 \| SLIT2 \| ITSN1 \| NOS3 \| ADCY7 \| RB1CC1 \| HSPA8 \| CUL3 \| LRP1 \| LRP5 \| ACTN1 \| RUNX3 \| SMARCC2 \| NUP214 \| BLNK \| TRRAP \| KPNA1 \| EPHA2 \| HIF1A \| GNAO1 \| PML \| PTK2B
DB_ID:1556	Plasma membrane estrogen receptor signaling	1301	33	8.45	3.91	3.25e-11	9.08e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| ESR2 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1575	VEGF and VEGFR signaling network	1304	33	8.47	3.90	3.45e-11	9.08e-10	ID ASD
MAPK8 \| MYOF \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1516	Signaling events mediated by VEGFR1 and VEGFR2	1296	33	8.41	3.92	2.94e-11	9.08e-10	ID ASD
MAPK8 \| MYOF \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1492	Glypican 1 network	1299	33	8.43	3.91	3.12e-11	9.08e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| SLIT2 \| ITSN1 \| NOS3
DB_ID:1578	Alpha9 beta1 integrin signaling events	1305	33	8.47	3.89	3.52e-11	9.08e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| TGM2 \| ITSN1 \| NOS3
DB_ID:1564	IL3-mediated signaling events	1295	32	8.41	3.81	1.27e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1454	Syndecan-1-mediated signaling events	1300	32	8.44	3.79	1.40e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1497	PDGF receptor signaling network	1293	32	8.39	3.81	1.23e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1574	Signaling events mediated by focal adhesion kinase	1288	32	8.36	3.83	1.11e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1466	Insulin Pathway	1288	32	8.36	3.83	1.11e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1491	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	1293	32	8.39	3.81	1.23e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1519	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling	1288	32	8.36	3.83	1.11e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1540	PDGFR-beta signaling pathway	1288	32	8.36	3.83	1.11e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1627	IL5-mediated signaling events	1292	32	8.39	3.81	1.20e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3
DB_ID:1461	GMCSF-mediated signaling events	1292	32	8.39	3.81	1.20e-10	9.76e-10	ID ASD
MAPK8 \| RB1CC1 \| HSPA8 \| SMAD7 \| LRP1 \| CUL3 \| CAMK4 \| RUNX3 \| ACTN1 \| BCAT1 \| SMARCC2 \| NUP214 \| BLNK \| ICAM1 \| KPNA1 \| ASAP2 \| TRRAP \| EPHA2 \| HIF1A \| ASAP1 \| HUWE1 \| CHD8 \| GNAO1 \| PYCARD \| PML \| ACTA2 \| PTK2B \| SERPINI1 \| HSP90AA1 \| ITSN1 \| NOS3